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feat: update unique indices combinator to return array of objects

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  2. logs/di_content/di_content_20250604_140737.txt +0 -3663
  3. logs/di_content/di_content_20250604_141118.txt +0 -0
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  31. src/.DS_Store +0 -0
  32. src/agents/__pycache__/field_mapper_agent.cpython-312.pyc +0 -0
  33. src/agents/field_mapper_agent.py +14 -6
  34. src/agents/unique_indices_combinator.py +145 -0
  35. src/app.py +29 -4
  36. src/config/prompts.yaml +14 -1
  37. src/orchestrator/__pycache__/executor.cpython-312.pyc +0 -0
  38. src/orchestrator/__pycache__/planner.cpython-312.pyc +0 -0
  39. src/orchestrator/executor.py +57 -1
  40. src/orchestrator/planner.py +51 -12
  41. src/services/__pycache__/azure_di_service.cpython-312.pyc +0 -0
  42. src/services/azure_di_service.py +98 -85
  43. src/ui/strategy_selector.py +1 -1
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logs/di_content/di_content_20250604_140737.txt DELETED
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- <figure>
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-
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- IGE-ABDEG LEAD SELECTION - STRESS TEST
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-
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- Argenx - P1429-R01-v01 - 30 JUL 2020
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-
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- </figure>
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-
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-
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- <figure>
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-
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- RIC
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-
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- biologics
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-
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- </figure>
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-
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-
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
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- <!-- PageHeader="Table of contents" -->
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-
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- · Project information
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-
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- · Scope
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-
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- · Test samples
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-
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- · Method
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-
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- · Results
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-
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- · Conclusions
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-
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-
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- <figure>
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-
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- RIC
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-
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- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="2" -->
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
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- # Project information
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-
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-
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- <table>
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- <tr>
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- <td>· Project code:</td>
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- <td>P1429</td>
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- </tr>
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- <tr>
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- <td>· LNB number:</td>
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- <td>2020.007</td>
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- </tr>
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- <tr>
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- <td>· Project manager:</td>
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- <td>Gianni Vandenborre</td>
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- </tr>
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- <tr>
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- <td>· Report name:</td>
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- <td>P1429-R01_v01</td>
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- </tr>
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- <tr>
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- <td>· Report issue date:</td>
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- <td>30-JUL-2020</td>
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- </tr>
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- </table>
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-
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-
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- <figure>
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-
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- <!-- PageFooter="RIC" -->
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-
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- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="3" -->
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
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- # Scope
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-
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- · Relative quantification of the PTMs present in several mAb batches that
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- were derived from a forced degradation study by reduced peptide map
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- analysis to assist argenx in the selection of a lead candidate
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-
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-
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- <figure>
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-
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- RIC
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-
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- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="4" -->
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
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- # Test samples
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-
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-
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- <table>
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- <tr>
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- <th>Test sample ID client</th>
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- <th>Batch No.</th>
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- <th>Volume (LL)</th>
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- <th>Protein concentration</th>
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- </tr>
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- <tr>
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- <td>18E2 HIS2 ABDEG T0</td>
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- <td rowspan="2">UPX 3429</td>
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- <td>60</td>
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- <td>1 mg/mL</td>
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- </tr>
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- <tr>
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- <td>18E2 HIS2 ABDEG T6w 37℃</td>
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- <td>60</td>
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- <td></td>
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- </tr>
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- <tr>
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- <td>18E2VL HIS LALA ABDEG T0</td>
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- <td rowspan="2">UPX 3423</td>
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- <td>60</td>
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- <td>1 mg/ml</td>
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- </tr>
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- <tr>
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- <td>18E2VL HIS LALA ABDEG T6w 37℃</td>
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- <td>60</td>
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- <td></td>
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- </tr>
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- <tr>
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- <td>Ligelizumab mAB37 T0</td>
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- <td rowspan="2">D27/01/2020</td>
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- <td>60</td>
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- <td>1 mg/ml</td>
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- </tr>
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- <tr>
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- <td>Ligelizumab mAB37 T6w 37℃</td>
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- <td>60</td>
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- <td></td>
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- </tr>
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- <tr>
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- <td>OmaVH15W100b_VL3 T0</td>
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- <td rowspan="2">Evitria 801689.2</td>
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- <td>60</td>
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- <td>1 mg/mL</td>
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- </tr>
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- <tr>
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- <td>OmaVH15W100b_VL3 T4w 37℃</td>
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- <td>60</td>
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- <td></td>
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- </tr>
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- <tr>
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- <td>OmaVH15G55H_VL3S31H T0</td>
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- <td rowspan="2">Evitria 801689.1</td>
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- <td>60</td>
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- <td>1 mg/mL</td>
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- </tr>
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- <tr>
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- <td>OmaVH15G55H_VL3S31H T4w 37℃</td>
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- <td>60</td>
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- <td></td>
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- </tr>
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- </table>
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-
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-
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- · Formulation buffer: PBS + PS20 0.02%
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-
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-
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- <figure>
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-
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- RIC
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-
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- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="5" -->
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
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- # Method
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-
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- · Rebuffering using Amicon Ultra Centrifugal Filter (0.5 mL, MWCO 10 kDa)
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-
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- · 3x conditioning step using 500 uL 100 mM Tris pH 7.5, followed by centrifugation
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-
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- · 450 µL 100 mM pH 7.5 + 25 uL mAb sample (at 1 ug/uL) followed by centrifugation
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-
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- · 3x buffer exchange steps using 450 µL 100 mM Tris pH 7.5 followed by centrifugation
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-
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- · Invert spin of the membrane filter to collect 50 uL (so already 1/2 dilution)
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-
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- · Tryptic digestion of the mAb
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-
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- . 25 µg protein was used (50 uL at concentration of 0,5 µg/uL + 16.3 uL 100 mM Tris-HCI pH 7.5)
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-
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- · Addition of 26.3 uL Rapigest 0.2% in 100 mM Tris-HCI pH 7.5
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-
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- · Reduction using 2.4 uL 400 mM DTT in 100 mM Tris-HCI pH 7.5
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-
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- · Incubation at 60℃ for 30 min
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-
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- · Alkylation using 5 uL 400 mM IAA in 100 mM Tris-HCI pH 7.5
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-
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- · Incubation at 37°℃ for 60 min
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-
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- · Proteolysis using 5 uL trypsin (0.4 ug/uL, enzyme/protein: 1/12,5)
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-
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- · Overnight Incubation at 37℃
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-
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-
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- <figure>
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-
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- RIC
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-
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- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="6" -->
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
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- # Method
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-
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-
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- ## · Peptide map method
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-
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- · Column: AdvanceBio Peptide Map column (2.1 x 250 mm, 2.7 um particles)
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-
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- · Mobile phase A: 0.05% TFA in H2O (v/v) (or 0.1% FA)
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-
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- · Mobile phase B: 0.05% TFA in acetonitrile (v/v) (or 0.1% FA)
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-
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- · Flow rate: 300 uL/min
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-
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- · Injection volume: 15 uL
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-
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- · Column temperature: 60℃
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-
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- · Gradient:
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-
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-
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- <table>
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- <tr>
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- <th>Time (min)</th>
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- <th>%A</th>
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- <th>%B</th>
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- </tr>
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- <tr>
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- <td>0.0</td>
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- <td>99</td>
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- <td>1</td>
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- </tr>
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- <tr>
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- <td>2.0</td>
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- <td>99</td>
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- <td>1</td>
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- </tr>
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- <tr>
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- <td>35.0</td>
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- <td>55</td>
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- <td>45</td>
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- </tr>
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- <tr>
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- <td>36.0</td>
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- <td>10</td>
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- <td>90</td>
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- </tr>
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- <tr>
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- <td>42.0</td>
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- <td>10</td>
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- <td>90</td>
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- </tr>
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- <tr>
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- <td>43.0</td>
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- <td>99</td>
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- <td>1</td>
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- </tr>
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- <tr>
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- <td>56.0</td>
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- <td>99</td>
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- <td>1</td>
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- </tr>
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- <tr>
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- <td>28.0</td>
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- <td>99</td>
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- <td>1</td>
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- </tr>
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- </table>
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-
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-
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- <figure>
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-
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- RIC
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-
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- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="7" -->
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
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- # Results (UV 214 nm chromatograms TFA runs)
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-
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-
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- <figure>
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-
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- x10 2 DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P1429_19JUN2020_PM_TFA_RAT_MS_18E2HIS2 ABDEG.d
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-
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- 18E2HIS2 ABDEG
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-
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- 1
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-
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- M
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-
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- 0
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-
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- ×10
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-
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- 10 2 DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P1429_19JUN2020_PM_TFA_RAT_MS_18E2HIS2 ABDEG_T6w.d
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-
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- 18E2HIS2 ABDEG
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- T6w
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-
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- 1
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-
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- 0
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-
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- M
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-
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- x10 2 DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P1429_19JUN2020_PM_TFA_RAT_MS_18E2VL HIS LALA ABDEG.d
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-
372
- 18E2VL HIS LALA
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- ABDEG
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-
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- 1
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-
377
- M
378
-
379
- 0
380
-
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- ×10
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-
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- 2 DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P1429_19JUN2020_PM_TFA_RAT_MS_18E2VL HIS LALA ABDEG_T6w.d
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-
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- 18E2VL HIS LALA
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- ABDEG
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- T6w
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-
389
- 1
390
-
391
- 0
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-
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- ×10 2
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-
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- DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P1429_19JUN2020_PM_TFA_RAT_MS_Ligelizumab mAb 37.d
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-
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- Ligelizumab
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-
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- 1
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-
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- 0
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-
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- x10 2
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-
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- DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P1429_19JUN2020_PM_TFA_RAT_MS_Ligelizumab mAb 37_T6w.d
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-
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- Ligelizumab
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- T6w
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-
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- 1
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-
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- 0
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- 8
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- 1
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- 2
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- Response Units vs. Acquisition Time (min)
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-
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- </figure>
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-
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-
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
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- ## Results (UV 214 nm chromatograms TFA runs)
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-
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-
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- <figure>
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-
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- x10 2
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-
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- DAD1 - A:Sig=214.0,8.0 Ref=360.0, 100.0 P1429_19JUN2020_PM_TFA_RAT_MS_OmaVH15G55H_VL3S31H.d
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-
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- OmaVH15G55H_VL3S31H
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-
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- 2.5
510
-
511
- 2
512
-
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- 1.5
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-
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- 1
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-
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- 0.5
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-
519
- 0
520
-
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- x10 2 DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P1429_19JUN2020_PM_TFA_RAT_MS_OmaVH15G55H_VL3S31H_T4w.d
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-
523
- OmaVH15G55H_VL3S31H
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- T4w
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-
526
- 2.5
527
-
528
- 2
529
-
530
- 1.5
531
-
532
- 1
533
-
534
- Complete sample degradation upon storage
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-
536
- 0.5
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-
538
- 0
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-
540
- x10 2
541
-
542
- DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P1429_19JUN2020_PM_TFA_RAT_MS_OmaVH15W100b_VL3.d
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-
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- OmaVH15W100b_VL3
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-
546
- 2.5
547
-
548
- 2
549
-
550
- 1.5
551
-
552
- 1
553
-
554
- 0.5
555
-
556
- 0
557
-
558
- x10 2 DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P1429_19JUN2020_PM_TFA_RAT_MS_OmaVH15W100b_VL3_T4w.d
559
-
560
- OmaVH15W100b_VL3
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-
562
- T4w
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-
564
- 2.5
565
-
566
- 2
567
-
568
- 1.5
569
-
570
- 1
571
-
572
- Complete sample degradation upon storage
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-
574
- 0.5
575
-
576
- 0
577
-
578
- 9
579
-
580
- 1
581
-
582
- 2
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-
584
- 3
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586
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- Response Units vs. Acquisition Time (min)
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-
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- </figure>
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-
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-
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- <!-- PageBreak -->
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-
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-
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- <figure>
659
- </figure>
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-
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-
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- # Results Ligelizumab mAb 37- Identity
663
-
664
-
665
- <table>
666
- <tr>
667
- <th>RT</th>
668
- <th>Mass</th>
669
- <th>Sequence</th>
670
- <th>Seq Loc</th>
671
- <th>Tgt Seq Mass</th>
672
- <th>Diff (Bio, ppm)</th>
673
- <th>Pred Mods</th>
674
- </tr>
675
- <tr>
676
- <td>22.08</td>
677
- <td>1954.0192</td>
678
- <td>QVQLVQSGAEVMKPGSSVK</td>
679
- <td>HC(001-019)</td>
680
- <td>1954.0194</td>
681
- <td>-0.09</td>
682
- <td>pyroGlu</td>
683
- </tr>
684
- <tr>
685
- <td>5.72</td>
686
- <td>492.2353</td>
687
- <td>VSCK</td>
688
- <td>HC(020-023)</td>
689
- <td>492.2366</td>
690
- <td>-2.69</td>
691
- <td></td>
692
- </tr>
693
- <tr>
694
- <td>27.24</td>
695
- <td>1900.8885</td>
696
- <td>ASGYTFSWYHLEWVR</td>
697
- <td>HC(024-038)</td>
698
- <td>1900.8897</td>
699
- <td>-0.6</td>
700
- <td></td>
701
- </tr>
702
- <tr>
703
- <td>25.13</td>
704
- <td>2791.2548</td>
705
- <td>QAPGHGLEWMGEIDPGTFTTNYNEK</td>
706
- <td>HC(039-063)</td>
707
- <td>2791.2548</td>
708
- <td>-0.01</td>
709
- <td></td>
710
- </tr>
711
- <tr>
712
- <td>8.34</td>
713
- <td>293.1737</td>
714
- <td>FK</td>
715
- <td>HC(064-065)</td>
716
- <td>293.1739</td>
717
- <td>-0.98</td>
718
- <td></td>
719
- </tr>
720
- <tr>
721
- <td>2.01</td>
722
- <td>245.1483</td>
723
- <td>AR</td>
724
- <td>HC(066-067)</td>
725
- <td>245.1488</td>
726
- <td>-2.18</td>
727
- <td></td>
728
- </tr>
729
- <tr>
730
- <td>24.88</td>
731
- <td>2180.0311</td>
732
- <td>VTFTADTSTSTAYMELSSLR</td>
733
- <td>HC(068-087)</td>
734
- <td>2180.0307</td>
735
- <td>0.16</td>
736
- <td></td>
737
- </tr>
738
- <tr>
739
- <td>15.70</td>
740
- <td>1333.5591</td>
741
- <td>SEDTAVYYCAR</td>
742
- <td>HC(088-098)</td>
743
- <td>1333.5609</td>
744
- <td>-1.36</td>
745
- <td></td>
746
- </tr>
747
- <tr>
748
- <td>24.80</td>
749
- <td>3224.4449</td>
750
- <td>FSHFSGSNHDYFDYWGQGTLVTVSSASTK</td>
751
- <td>HC(099-127)</td>
752
- <td>3224.4476</td>
753
- <td>-0.82</td>
754
- <td></td>
755
- </tr>
756
- <tr>
757
- <td>22.47</td>
758
- <td>1185.6394</td>
759
- <td>GPSVFPLAPSSK</td>
760
- <td>HC(128-139)</td>
761
- <td>1185.6394</td>
762
- <td>-0.02</td>
763
- <td></td>
764
- </tr>
765
- <tr>
766
- <td>20.35</td>
767
- <td>1320.6699</td>
768
- <td>STSGGTAALGCLVK</td>
769
- <td>HC(140-153)</td>
770
- <td>1320.6708</td>
771
- <td>-0.63</td>
772
- <td></td>
773
- </tr>
774
- <tr>
775
- <td>31.68</td>
776
- <td>8014.9553</td>
777
- <td>STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTK</td>
778
- <td>HC(140-216)</td>
779
- <td>8014.9674</td>
780
- <td>-1.5</td>
781
- <td></td>
782
- </tr>
783
- <tr>
784
- <td>30.99</td>
785
- <td>6712.3060</td>
786
- <td>DYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTK</td>
787
- <td>HC(154-216)</td>
788
- <td>6712.3072</td>
789
- <td>-0.18</td>
790
- <td></td>
791
- </tr>
792
- <tr>
793
- <td>3.77</td>
794
- <td>360.2002</td>
795
- <td>VDK</td>
796
- <td>HC(217-219)</td>
797
- <td>360.2009</td>
798
- <td>-1.87</td>
799
- <td></td>
800
- </tr>
801
- <tr>
802
- <td>3.06</td>
803
- <td>488.2955</td>
804
- <td>VDKK</td>
805
- <td>HC(217-220)</td>
806
- <td>488.2959</td>
807
- <td>-0.65</td>
808
- <td></td>
809
- </tr>
810
- <tr>
811
- <td>8.41</td>
812
- <td>599.3643</td>
813
- <td>KVEPK</td>
814
- <td>HC(220-224)</td>
815
- <td>599.3643</td>
816
- <td>-0.02</td>
817
- <td></td>
818
- </tr>
819
- <tr>
820
- <td>7.89</td>
821
- <td>471.2683</td>
822
- <td>VEPK</td>
823
- <td>HC(221-224)</td>
824
- <td>471.2693</td>
825
- <td>-2.08</td>
826
- <td></td>
827
- </tr>
828
- <tr>
829
- <td>2.05</td>
830
- <td>508.1940</td>
831
- <td>SCDK</td>
832
- <td>HC(225-228)</td>
833
- <td>508.1952</td>
834
- <td>-2.27</td>
835
- <td></td>
836
- </tr>
837
- <tr>
838
- <td>27.42</td>
839
- <td>3333.6280</td>
840
- <td>SCDKTHTCPPCPAPELLGGPSVFLFPPKPK</td>
841
- <td>HC(225-254)</td>
842
- <td>3333.6349</td>
843
- <td>-2.07</td>
844
- <td></td>
845
- </tr>
846
- <tr>
847
- <td>28.13</td>
848
- <td>2843.4478</td>
849
- <td>THTCPPCPAPELLGGPSVFLFPPKPK</td>
850
- <td>HC(229-254)</td>
851
- <td>2843.4503</td>
852
- <td>-0.87</td>
853
- <td></td>
854
- </tr>
855
- <tr>
856
- <td>17.74</td>
857
- <td>880.4646</td>
858
- <td>DTLYITR</td>
859
- <td>HC(255-261)</td>
860
- <td>880.4654</td>
861
- <td>-1.01</td>
862
- <td></td>
863
- </tr>
864
- <tr>
865
- <td>22.01</td>
866
- <td>2166.0153</td>
867
- <td>EPEVTCVVVDVSHEDPEVK</td>
868
- <td>HC(262-280)</td>
869
- <td>2166.0151</td>
870
- <td>0.1</td>
871
- <td></td>
872
- </tr>
873
- <tr>
874
- <td>22.33</td>
875
- <td>1676.7946</td>
876
- <td>FNWYVDGVEVHNAK</td>
877
- <td>HC(281-294)</td>
878
- <td>1676.7947</td>
879
- <td>-0.08</td>
880
- <td></td>
881
- </tr>
882
- <tr>
883
- <td>4.62</td>
884
- <td>500.3064</td>
885
- <td>TKPR</td>
886
- <td>HC(295-298)</td>
887
- <td>500.3071</td>
888
- <td>-1.34</td>
889
- <td></td>
890
- </tr>
891
- <tr>
892
- <td>11.17</td>
893
- <td>2633.0333</td>
894
- <td>EEQYNSTYR</td>
895
- <td>HC(299-307)</td>
896
- <td>2633.0386</td>
897
- <td>-2.04</td>
898
- <td>G0F</td>
899
- </tr>
900
- <tr>
901
- <td>28.69</td>
902
- <td>1806.9974</td>
903
- <td>VVSVLTVLHQDWLNGK</td>
904
- <td>HC(308-323)</td>
905
- <td>1806.9992</td>
906
- <td>-0.99</td>
907
- <td></td>
908
- </tr>
909
- <tr>
910
- <td>27.74</td>
911
- <td>2227.1996</td>
912
- <td>VVSVLTVLHQDWLNGKEYK</td>
913
- <td>HC(308-326)</td>
914
- <td>2227.2001</td>
915
- <td>-0.24</td>
916
- <td></td>
917
- </tr>
918
- <tr>
919
- <td>6.58</td>
920
- <td>438.2106</td>
921
- <td>EYK</td>
922
- <td>HC(324-326)</td>
923
- <td>438.2115</td>
924
- <td>-1.96</td>
925
- <td></td>
926
- </tr>
927
- <tr>
928
- <td>1.98</td>
929
- <td>306.1355</td>
930
- <td>CK</td>
931
- <td>HC(327-328)</td>
932
- <td>306.1362</td>
933
- <td>-2.24</td>
934
- <td></td>
935
- </tr>
936
- <tr>
937
- <td>3.17</td>
938
- <td>446.2480</td>
939
- <td>VSNK</td>
940
- <td>HC(329-332)</td>
941
- <td>446.2489</td>
942
- <td>-1.93</td>
943
- <td></td>
944
- </tr>
945
- <tr>
946
- <td>17.99</td>
947
- <td>837.4955</td>
948
- <td>ALPAPIEK</td>
949
- <td>HC(333-340)</td>
950
- <td>837.4960</td>
951
- <td>-0.59</td>
952
- <td></td>
953
- </tr>
954
- <tr>
955
- <td>8.03</td>
956
- <td>447.2685</td>
957
- <td>TISK</td>
958
- <td>HC(341-344)</td>
959
- <td>447.2693</td>
960
- <td>-1.69</td>
961
- <td></td>
962
- </tr>
963
- <tr>
964
- <td>6.37</td>
965
- <td>655.3768</td>
966
- <td>AKGQPR</td>
967
- <td>HC(345-350)</td>
968
- <td>655.3766</td>
969
- <td>0.34</td>
970
- <td></td>
971
- </tr>
972
- </table>
973
-
974
-
975
- <figure>
976
-
977
- RIC
978
-
979
- </figure>
980
-
981
-
982
- <!-- PageFooter="biologics" -->
983
- <!-- PageNumber="10" -->
984
- <!-- PageBreak -->
985
-
986
-
987
- <figure>
988
- </figure>
989
-
990
-
991
- # Results Ligelizumab mAb 37- Identity
992
-
993
-
994
- <table>
995
- <tr>
996
- <th>RT</th>
997
- <th>Mass</th>
998
- <th>Sequence</th>
999
- <th>Seq Loc</th>
1000
- <th>Tgt Seq Mass</th>
1001
- <th>Diff (Bio, ppm)</th>
1002
- <th>Pred Mods</th>
1003
- </tr>
1004
- <tr>
1005
- <td>5.33</td>
1006
- <td>456.2435</td>
1007
- <td>GQPR</td>
1008
- <td>HC(347-350)</td>
1009
- <td>456.2445</td>
1010
- <td>-2.18</td>
1011
- <td></td>
1012
- </tr>
1013
- <tr>
1014
- <td>18.59</td>
1015
- <td>1285.6662</td>
1016
- <td>EPQVYTLPPSR</td>
1017
- <td>HC(351-361)</td>
1018
- <td>1285.6667</td>
1019
- <td>-0.32</td>
1020
- <td></td>
1021
- </tr>
1022
- <tr>
1023
- <td>19.68</td>
1024
- <td>1871.9613</td>
1025
- <td>EPQVYTLPPSRDELTK</td>
1026
- <td>HC(351-366)</td>
1027
- <td>1871.9629</td>
1028
- <td>-0.85</td>
1029
- <td></td>
1030
- </tr>
1031
- <tr>
1032
- <td>10.34</td>
1033
- <td>604.3060</td>
1034
- <td>DELTK</td>
1035
- <td>HC(362-366)</td>
1036
- <td>604.3068</td>
1037
- <td>-1.39</td>
1038
- <td></td>
1039
- </tr>
1040
- <tr>
1041
- <td>21.70</td>
1042
- <td>1160.6224</td>
1043
- <td>NQVSLTCLVK</td>
1044
- <td>HC(367-376)</td>
1045
- <td>1160.6224</td>
1046
- <td>0</td>
1047
- <td></td>
1048
- </tr>
1049
- <tr>
1050
- <td>24.21</td>
1051
- <td>2543.1234</td>
1052
- <td>GFYPSDIAVEWESNGQPENNYK</td>
1053
- <td>HC(377-398)</td>
1054
- <td>2543.1241</td>
1055
- <td>-0.27</td>
1056
- <td></td>
1057
- </tr>
1058
- <tr>
1059
- <td>25.93</td>
1060
- <td>1872.9143</td>
1061
- <td>TTPPVLDSDGSFFLYSK</td>
1062
- <td>HC(399-415)</td>
1063
- <td>1872.9146</td>
1064
- <td>-0.14</td>
1065
- <td></td>
1066
- </tr>
1067
- <tr>
1068
- <td>12.40</td>
1069
- <td>574.3323</td>
1070
- <td>LTVDK</td>
1071
- <td>HC(416-420)</td>
1072
- <td>574.3326</td>
1073
- <td>-0.6</td>
1074
- <td></td>
1075
- </tr>
1076
- <tr>
1077
- <td>23.22</td>
1078
- <td>2019.9295</td>
1079
- <td>WQQGNVFSCSVMHEALK</td>
1080
- <td>HC(423-439)</td>
1081
- <td>2019.9295</td>
1082
- <td>0.02</td>
1083
- <td></td>
1084
- </tr>
1085
- <tr>
1086
- <td>12.49</td>
1087
- <td>822.4022</td>
1088
- <td>FHYTQK</td>
1089
- <td>HC(440-445)</td>
1090
- <td>822.4024</td>
1091
- <td>-0.26</td>
1092
- <td></td>
1093
- </tr>
1094
- <tr>
1095
- <td>18.19</td>
1096
- <td>659.3484</td>
1097
- <td>SLSLSPG</td>
1098
- <td>HC(446-452)</td>
1099
- <td>659.3490</td>
1100
- <td>-0.99</td>
1101
- <td></td>
1102
- </tr>
1103
- <tr>
1104
- <td>16.86</td>
1105
- <td>787.4437</td>
1106
- <td>SLSLSPGK</td>
1107
- <td>HC(446-453)</td>
1108
- <td>787.4440</td>
1109
- <td>-0.36</td>
1110
- <td></td>
1111
- </tr>
1112
- <tr>
1113
- <td>21.23</td>
1114
- <td>1900.9548</td>
1115
- <td>EIVMTQSPATLSVSPGER</td>
1116
- <td>LC(001-018)</td>
1117
- <td>1900.9564</td>
1118
- <td>-0.87</td>
1119
- <td></td>
1120
- </tr>
1121
- <tr>
1122
- <td>11.12</td>
1123
- <td>706.3424</td>
1124
- <td>ATLSCR</td>
1125
- <td>LC(019-024)</td>
1126
- <td>706.3432</td>
1127
- <td>-1.12</td>
1128
- <td></td>
1129
- </tr>
1130
- <tr>
1131
- <td>19.07</td>
1132
- <td>2366.1878</td>
1133
- <td>ASQSIGTNIHWYQQKPGQAPR</td>
1134
- <td>LC(025-045)</td>
1135
- <td>2366.1880</td>
1136
- <td>-0.08</td>
1137
- <td></td>
1138
- </tr>
1139
- <tr>
1140
- <td>25.77</td>
1141
- <td>1751.9464</td>
1142
- <td>LLIYYASESISGIPAR</td>
1143
- <td>LC(046-061)</td>
1144
- <td>1751.9458</td>
1145
- <td>0.34</td>
1146
- <td></td>
1147
- </tr>
1148
- <tr>
1149
- <td>30.53</td>
1150
- <td>4601.0567</td>
1151
- <td>FSGSGSGTEFTLTISSLQSEDFAVYYCQQSWSWPTTFGGGTK</td>
1152
- <td>LC(062-103)</td>
1153
- <td>4601.0646</td>
1154
- <td>-1.72</td>
1155
- <td></td>
1156
- </tr>
1157
- <tr>
1158
- <td>12.43</td>
1159
- <td>487.3001</td>
1160
- <td>VEIK</td>
1161
- <td>LC(104-107)</td>
1162
- <td>487.3006</td>
1163
- <td>-1.08</td>
1164
- <td></td>
1165
- </tr>
1166
- <tr>
1167
- <td>11.85</td>
1168
- <td>643.4010</td>
1169
- <td>VEIKR</td>
1170
- <td>LC(104-108)</td>
1171
- <td>643.4017</td>
1172
- <td>-1.04</td>
1173
- <td></td>
1174
- </tr>
1175
- <tr>
1176
- <td>26.29</td>
1177
- <td>2101.1184</td>
1178
- <td>RTVAAPSVFIFPPSDEQLK</td>
1179
- <td>LC(108-126)</td>
1180
- <td>2101.1208</td>
1181
- <td>-1.16</td>
1182
- <td></td>
1183
- </tr>
1184
- <tr>
1185
- <td>27.42</td>
1186
- <td>1945.0183</td>
1187
- <td>TVAAPSVFIFPPSDEQLK</td>
1188
- <td>LC(109-126)</td>
1189
- <td>1945.0197</td>
1190
- <td>-0.71</td>
1191
- <td></td>
1192
- </tr>
1193
- <tr>
1194
- <td>33.07</td>
1195
- <td>3723.8910</td>
1196
- <td>TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR</td>
1197
- <td>LC(109-142)</td>
1198
- <td>3723.8971</td>
1199
- <td>-1.64</td>
1200
- <td></td>
1201
- </tr>
1202
- <tr>
1203
- <td>28.60</td>
1204
- <td>1796.8863</td>
1205
- <td>SGTASVVCLLNNFYPR</td>
1206
- <td>LC(127-142)</td>
1207
- <td>1796.8880</td>
1208
- <td>-0.92</td>
1209
- <td></td>
1210
- </tr>
1211
- <tr>
1212
- <td>1.98</td>
1213
- <td>346.1845</td>
1214
- <td>EAK</td>
1215
- <td>LC(143-145)</td>
1216
- <td>346.1852</td>
1217
- <td>-2.12</td>
1218
- <td></td>
1219
- </tr>
1220
- <tr>
1221
- <td>14.20</td>
1222
- <td>559.3115</td>
1223
- <td>VQWK</td>
1224
- <td>LC(146-149)</td>
1225
- <td>559.3118</td>
1226
- <td>-0.58</td>
1227
- <td></td>
1228
- </tr>
1229
- <tr>
1230
- <td>13.95</td>
1231
- <td>2134.9593</td>
1232
- <td>VDNALQSGNSQESVTEQDSK</td>
1233
- <td>LC(150-169)</td>
1234
- <td>2134.9615</td>
1235
- <td>-1.01</td>
1236
- <td></td>
1237
- </tr>
1238
- <tr>
1239
- <td>21.54</td>
1240
- <td>3618.6975</td>
1241
- <td>VDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSK</td>
1242
- <td>LC(150-183)</td>
1243
- <td>3618.7021</td>
1244
- <td>-1.26</td>
1245
- <td></td>
1246
- </tr>
1247
- <tr>
1248
- <td>21.61</td>
1249
- <td>1501.7507</td>
1250
- <td>DSTYSLSSTLTLSK</td>
1251
- <td>LC(170-183)</td>
1252
- <td>1501.7512</td>
1253
- <td>-0.34</td>
1254
- <td></td>
1255
- </tr>
1256
- <tr>
1257
- <td>8.49</td>
1258
- <td>624.2752</td>
1259
- <td>ADYEK</td>
1260
- <td>LC(184-188)</td>
1261
- <td>624.2755</td>
1262
- <td>-0.47</td>
1263
- <td></td>
1264
- </tr>
1265
- <tr>
1266
- <td>17.03</td>
1267
- <td>2140.0696</td>
1268
- <td>HKVYACEVTHQGLSSPVTK</td>
1269
- <td>LC(189-207)</td>
1270
- <td>2140.0735</td>
1271
- <td>-1.84</td>
1272
- <td></td>
1273
- </tr>
1274
- <tr>
1275
- <td>17.75</td>
1276
- <td>1874.9187</td>
1277
- <td>VYACEVTHQGLSSPVTK</td>
1278
- <td>LC(191-207)</td>
1279
- <td>1874.9197</td>
1280
- <td>-0.5</td>
1281
- <td></td>
1282
- </tr>
1283
- <tr>
1284
- <td>10.15</td>
1285
- <td>522.2544</td>
1286
- <td>SFNR</td>
1287
- <td>LC(208-211)</td>
1288
- <td>522.2551</td>
1289
- <td>-1.22</td>
1290
- <td></td>
1291
- </tr>
1292
- <tr>
1293
- <td>2.06</td>
1294
- <td>364.1044</td>
1295
- <td>GEC</td>
1296
- <td>LC(212-214)</td>
1297
- <td>364.1053</td>
1298
- <td>-2.35</td>
1299
- <td></td>
1300
- </tr>
1301
- </table>
1302
-
1303
-
1304
- <figure>
1305
- </figure>
1306
-
1307
-
1308
- RIC
1309
-
1310
- <!-- PageFooter="biologics" -->
1311
- <!-- PageNumber="11" -->
1312
- <!-- PageBreak -->
1313
-
1314
-
1315
- <figure>
1316
- </figure>
1317
-
1318
-
1319
- # Results Ligelizumab mAb 37- Identity
1320
-
1321
- \>HEAVY CHAIN: Ligelizumab mAb 37
1322
-
1323
- QVQLVQSGAEVMKPGSSVKVSCKASGYTFSWYHLEWVRQAPGHGLEWMGEIDPGTFTTNYNEKFKARVTFTADTSTSTAYMELSSLR
1324
- SEDTAVYYCARFSHESGSNHDYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVH
1325
- TFPAVLOSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITR
1326
- EPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQ
1327
- PREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMH
1328
- EALKFHYTOKSLSLSPGK
1329
-
1330
- \>LIGHT CHAIN: Ligelizumab mAb 37
1331
-
1332
- EIVMTQSPATLSVSPGERATLSCRASOSIGTNIHWYQQKPGQAPRLLIYYASESISGIPARFSGSGSGTEFTLTISSLOSEDFAVYY
1333
- COOSWSWPTTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYS
1334
- LSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
1335
-
1336
- Sequence coverage of 99.7%
1337
-
1338
-
1339
- <figure>
1340
-
1341
- RIC
1342
-
1343
- </figure>
1344
-
1345
-
1346
- <!-- PageFooter="biologics" -->
1347
- <!-- PageNumber="12" -->
1348
- <!-- PageBreak -->
1349
-
1350
-
1351
- <figure>
1352
- </figure>
1353
-
1354
-
1355
- # Results Ligelizumab mAb 37- Modifications (oxidation)
1356
-
1357
-
1358
- <table>
1359
- <tr>
1360
- <th>Sequence</th>
1361
- <th>Seq Loc</th>
1362
- <th>Modification</th>
1363
- <th>Ligelizumab</th>
1364
- <th>Ligelizumab T6w</th>
1365
- </tr>
1366
- <tr>
1367
- <td rowspan="2">pyroQVQLVQSGAEVMKPGSSVK</td>
1368
- <td rowspan="2">HC(1-19)</td>
1369
- <td rowspan="2">Oxidation</td>
1370
- <td rowspan="2">1.6 98.4</td>
1371
- <td>20.3</td>
1372
- </tr>
1373
- <tr>
1374
- <td>79.7</td>
1375
- </tr>
1376
- <tr>
1377
- <td rowspan="2">ASGYTFSWYHLEWVR</td>
1378
- <td rowspan="2">HC(24-38)</td>
1379
- <td rowspan="2">Oxidation</td>
1380
- <td rowspan="2">1.5 98.5</td>
1381
- <td>5.5</td>
1382
- </tr>
1383
- <tr>
1384
- <td>94.5</td>
1385
- </tr>
1386
- <tr>
1387
- <td rowspan="2">QAPGHGLEWMGEIDPGTFTTNYNEK</td>
1388
- <td rowspan="2">HC(36-63)</td>
1389
- <td rowspan="2">Oxidation</td>
1390
- <td>0.8</td>
1391
- <td>0.7</td>
1392
- </tr>
1393
- <tr>
1394
- <td>99.2</td>
1395
- <td>99.3</td>
1396
- </tr>
1397
- <tr>
1398
- <td>VTFTADTSTSTAYMELSSLR</td>
1399
- <td>HC(68-87)</td>
1400
- <td>Oxidation</td>
1401
- <td>0.9 99.1</td>
1402
- <td>1.2 98.8</td>
1403
- </tr>
1404
- <tr>
1405
- <td>FSHFSGSNHDYFDYWGQGTLVTVSSASTK</td>
1406
- <td>HC(99-127)</td>
1407
- <td>Oxidation</td>
1408
- <td>0.5 99.5</td>
1409
- <td>0.7 99.3</td>
1410
- </tr>
1411
- <tr>
1412
- <td>WQQGNVFSCSVMHEALK</td>
1413
- <td>HC(423-439)</td>
1414
- <td>Oxidation</td>
1415
- <td>2.3 97.7</td>
1416
- <td>10.6 89.4</td>
1417
- </tr>
1418
- <tr>
1419
- <td>EIVMTQSPATLSVSPGER</td>
1420
- <td>LC(1-18)</td>
1421
- <td>Oxidation</td>
1422
- <td>1.8 98.2</td>
1423
- <td>2.2 97.8</td>
1424
- </tr>
1425
- </table>
1426
-
1427
- BOLD: relevant increase upon stressing
1428
-
1429
- Note: Only modifications > 0.5% are reported
1430
-
1431
-
1432
- <figure>
1433
- </figure>
1434
-
1435
-
1436
- RIC
1437
- biologics
1438
-
1439
- <!-- PageNumber="13" -->
1440
- <!-- PageBreak -->
1441
-
1442
-
1443
- <figure>
1444
- </figure>
1445
-
1446
-
1447
- # Results Ligelizumab mAb 37- Modifications (deam/isoD)
1448
-
1449
-
1450
- <table>
1451
- <tr>
1452
- <th>Sequence</th>
1453
- <th>Seq Loc</th>
1454
- <th>Modification</th>
1455
- <th>Ligelizumab</th>
1456
- <th>Ligelizumab T6w</th>
1457
- </tr>
1458
- <tr>
1459
- <td rowspan="2">FNWYVDGVEVHNAK</td>
1460
- <td rowspan="2">HC(281-294)</td>
1461
- <td>IsoD</td>
1462
- <td>0.7</td>
1463
- <td>1.6</td>
1464
- </tr>
1465
- <tr>
1466
- <td></td>
1467
- <td>99.3</td>
1468
- <td>98.4</td>
1469
- </tr>
1470
- <tr>
1471
- <td rowspan="3">VVSVLTVLHQDWLNGK</td>
1472
- <td rowspan="3">HC(308-323)</td>
1473
- <td>Deam</td>
1474
- <td>1.0</td>
1475
- <td>1.4</td>
1476
- </tr>
1477
- <tr>
1478
- <td></td>
1479
- <td>97.4</td>
1480
- <td>96.1</td>
1481
- </tr>
1482
- <tr>
1483
- <td>Succ</td>
1484
- <td>1.6</td>
1485
- <td>2.5</td>
1486
- </tr>
1487
- <tr>
1488
- <td rowspan="2">NQVSLTCLVK</td>
1489
- <td rowspan="2">HC(367-376)</td>
1490
- <td>Deam</td>
1491
- <td>2.5</td>
1492
- <td>3.5</td>
1493
- </tr>
1494
- <tr>
1495
- <td></td>
1496
- <td>97.5</td>
1497
- <td>96.5</td>
1498
- </tr>
1499
- <tr>
1500
- <td rowspan="2">GFYPSDIAVEWESNGQPENNYK</td>
1501
- <td rowspan="2">HC(377-398)</td>
1502
- <td>Deam</td>
1503
- <td>4.4</td>
1504
- <td>24.6</td>
1505
- </tr>
1506
- <tr>
1507
- <td></td>
1508
- <td>95.6</td>
1509
- <td>75.4</td>
1510
- </tr>
1511
- <tr>
1512
- <td>TVAAPSVFIFPPSDEQLK</td>
1513
- <td>LC(109-126)</td>
1514
- <td>IsoD</td>
1515
- <td>0.0 100.0</td>
1516
- <td>0.9 99.1</td>
1517
- </tr>
1518
- <tr>
1519
- <td></td>
1520
- <td rowspan="2">LC(127-142)</td>
1521
- <td>Deam</td>
1522
- <td>0.9</td>
1523
- <td>0.8</td>
1524
- </tr>
1525
- <tr>
1526
- <td>SGTASVVCLLNNFYPR</td>
1527
- <td></td>
1528
- <td>99.1</td>
1529
- <td>99.2</td>
1530
- </tr>
1531
- <tr>
1532
- <td>VDNALQSGNSQESVTEQDSK</td>
1533
- <td>LC(150-169)</td>
1534
- <td>IsoD</td>
1535
- <td>0.5 99.5</td>
1536
- <td>1.0 99.0</td>
1537
- </tr>
1538
- </table>
1539
-
1540
- BOLD: relevant increase upon stressing
1541
-
1542
- Note: Only modifications > 0.5% are reported
1543
-
1544
-
1545
- <figure>
1546
- </figure>
1547
-
1548
-
1549
- RIC
1550
- biologics
1551
-
1552
- <!-- PageNumber="14" -->
1553
- <!-- PageBreak -->
1554
-
1555
-
1556
- <figure>
1557
- </figure>
1558
-
1559
-
1560
- # Results Ligelizumab mAb 37 - Modifications (pyroE)
1561
-
1562
-
1563
- <table>
1564
- <tr>
1565
- <th>Sequence</th>
1566
- <th>Seq Loc</th>
1567
- <th>Modification</th>
1568
- <th>Ligelizumab</th>
1569
- <th>Ligelizumab T6w</th>
1570
- </tr>
1571
- <tr>
1572
- <td>QVQLVQSGAEVMKPGSSVK</td>
1573
- <td>HC(1-19)</td>
1574
- <td>PyroE</td>
1575
- <td>100.0 0.0</td>
1576
- <td>100.0 0.0</td>
1577
- </tr>
1578
- <tr>
1579
- <td>EIVMTQSPATLSVSPGER</td>
1580
- <td>LC(1-18)</td>
1581
- <td>PyroE</td>
1582
- <td>1.1 98.9</td>
1583
- <td>2.0 98.0</td>
1584
- </tr>
1585
- </table>
1586
-
1587
-
1588
- <figure>
1589
-
1590
- RIC
1591
-
1592
- </figure>
1593
-
1594
-
1595
- <!-- PageFooter="biologics" -->
1596
- <!-- PageNumber="15" -->
1597
- <!-- PageBreak -->
1598
-
1599
-
1600
- <figure>
1601
- </figure>
1602
-
1603
-
1604
- ## Results Ligelizumab mAB 37- Modifications
1605
-
1606
- \>HEAVY CHAIN: Ligelizumab
1607
-
1608
- QVQLVQSGAEVMKPGSSVKVSCKASGYTFSWYHLEWVRQAPGHGLEWMGEIDPGTFTTNYNEKFKARVTFTADTSTSTAYMELSSL
1609
- RSEDTAVYYCARFSHFSGSNHDYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV
1610
- HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYIT
1611
- REPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKG
1612
- QPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSV
1613
- MHEALKFHYTOKSLSLSPGK
1614
-
1615
- \>LIGHT CHAIN: Ligelizumab
1616
-
1617
- EIVMTQSPATLSVSPGERATLSCRASOSIGTNIHWYQQKPGQAPRLLIYYASESISGIPARFSGSGSGTEFTLTISSLOSEDFAVYY
1618
- COOSWSWPTTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYS
1619
- LSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
1620
-
1621
-
1622
- <figure>
1623
-
1624
- RIC
1625
-
1626
- </figure>
1627
-
1628
-
1629
- <!-- PageFooter="biologics" -->
1630
-
1631
- RED: relevant increase upon stressing
1632
-
1633
- <!-- PageNumber="16" -->
1634
- <!-- PageBreak -->
1635
-
1636
-
1637
- <figure>
1638
- </figure>
1639
-
1640
-
1641
- ## Results 18E2 HIS2 ABDEG - Identity
1642
-
1643
-
1644
- <table>
1645
- <tr>
1646
- <th>RT</th>
1647
- <th>Mass</th>
1648
- <th>Sequence</th>
1649
- <th>Seq Loc</th>
1650
- <th>Tgt Seq Mass</th>
1651
- <th>Diff (Bio, ppm)</th>
1652
- <th>Pred Mods</th>
1653
- </tr>
1654
- <tr>
1655
- <td>23.52</td>
1656
- <td>1895.0106</td>
1657
- <td>EVQLLESGGGLVQPGGSLR</td>
1658
- <td>HC(001-019)</td>
1659
- <td>1895.0113</td>
1660
- <td>-0.33</td>
1661
- <td></td>
1662
- </tr>
1663
- <tr>
1664
- <td>29.08</td>
1665
- <td>2205.0150</td>
1666
- <td>LSCAASGFTFSSYVMHWVR</td>
1667
- <td>HC(020-038)</td>
1668
- <td>2205.0136</td>
1669
- <td>0.67</td>
1670
- <td></td>
1671
- </tr>
1672
- <tr>
1673
- <td>31.91</td>
1674
- <td>5241.4455</td>
1675
- <td>LSCAASGFTFSSYVMHWVRQAPGKGLEWVSSIYHDGSHTYYADFVK</td>
1676
- <td>HC(020-065)</td>
1677
- <td>5241.4542</td>
1678
- <td>-1.66</td>
1679
- <td></td>
1680
- </tr>
1681
- <tr>
1682
- <td>6.07</td>
1683
- <td>499.2752</td>
1684
- <td>QAPGK</td>
1685
- <td>HC(039-043)</td>
1686
- <td>499.2755</td>
1687
- <td>-0.47</td>
1688
- <td></td>
1689
- </tr>
1690
- <tr>
1691
- <td>25.58</td>
1692
- <td>2573.1878</td>
1693
- <td>GLEWVSSIYHDGSHTYYADFVK</td>
1694
- <td>HC(044-065)</td>
1695
- <td>2573.1863</td>
1696
- <td>0.56</td>
1697
- <td></td>
1698
- </tr>
1699
- <tr>
1700
- <td>15.94</td>
1701
- <td>835.4666</td>
1702
- <td>GRFTISR</td>
1703
- <td>HC(066-072)</td>
1704
- <td>835.4664</td>
1705
- <td>0.2</td>
1706
- <td></td>
1707
- </tr>
1708
- <tr>
1709
- <td>16.06</td>
1710
- <td>622.3440</td>
1711
- <td>FTISR</td>
1712
- <td>HC(068-072)</td>
1713
- <td>622.3439</td>
1714
- <td>0.21</td>
1715
- <td></td>
1716
- </tr>
1717
- <tr>
1718
- <td>2.31</td>
1719
- <td>462.2077</td>
1720
- <td>DNSK</td>
1721
- <td>HC(073-076)</td>
1722
- <td>462.2074</td>
1723
- <td>0.47</td>
1724
- <td></td>
1725
- </tr>
1726
- <tr>
1727
- <td>22.53</td>
1728
- <td>1351.6908</td>
1729
- <td>NTLYLQMNSLR</td>
1730
- <td>HC(077-087)</td>
1731
- <td>1351.6918</td>
1732
- <td>-0.78</td>
1733
- <td></td>
1734
- </tr>
1735
- <tr>
1736
- <td>15.52</td>
1737
- <td>1289.5593</td>
1738
- <td>AEDTAVYYCAK</td>
1739
- <td>HC(088-098)</td>
1740
- <td>1289.5598</td>
1741
- <td>-0.41</td>
1742
- <td></td>
1743
- </tr>
1744
- <tr>
1745
- <td>28.16</td>
1746
- <td>3400.5399</td>
1747
- <td>GTSYSGSYYYTDPFFGSWGQGTLVTVSSASTK</td>
1748
- <td>HC(099-130)</td>
1749
- <td>3400.5412</td>
1750
- <td>-0.39</td>
1751
- <td></td>
1752
- </tr>
1753
- <tr>
1754
- <td>22.49</td>
1755
- <td>1185.6381</td>
1756
- <td>GPSVFPLAPSSK</td>
1757
- <td>HC(131-142)</td>
1758
- <td>1185.6394</td>
1759
- <td>-1.08</td>
1760
- <td></td>
1761
- </tr>
1762
- <tr>
1763
- <td>20.36</td>
1764
- <td>1320.6693</td>
1765
- <td>STSGGTAALGCLVK</td>
1766
- <td>HC(143-156)</td>
1767
- <td>1320.6708</td>
1768
- <td>-1.13</td>
1769
- <td></td>
1770
- </tr>
1771
- <tr>
1772
- <td>31.67</td>
1773
- <td>8014.9598</td>
1774
- <td>STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTK</td>
1775
- <td>HC(143-219)</td>
1776
- <td>8014.9674</td>
1777
- <td>-0.95</td>
1778
- <td></td>
1779
- </tr>
1780
- <tr>
1781
- <td>30.97</td>
1782
- <td>6712.2931</td>
1783
- <td>DYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTK</td>
1784
- <td>HC(157-219)</td>
1785
- <td>6712.3072</td>
1786
- <td>-2.1</td>
1787
- <td></td>
1788
- </tr>
1789
- <tr>
1790
- <td>3.07</td>
1791
- <td>488.2955</td>
1792
- <td>VDKK</td>
1793
- <td>HC(220-223)</td>
1794
- <td>488.2959</td>
1795
- <td>-0.72</td>
1796
- <td></td>
1797
- </tr>
1798
- <tr>
1799
- <td>8.41</td>
1800
- <td>599.3646</td>
1801
- <td>KVEPK</td>
1802
- <td>HC(223-227)</td>
1803
- <td>599.3643</td>
1804
- <td>0.52</td>
1805
- <td></td>
1806
- </tr>
1807
- <tr>
1808
- <td>7.89</td>
1809
- <td>471.2689</td>
1810
- <td>VEPK</td>
1811
- <td>HC(224-227)</td>
1812
- <td>471.2693</td>
1813
- <td>-0.94</td>
1814
- <td></td>
1815
- </tr>
1816
- <tr>
1817
- <td>2.06</td>
1818
- <td>508.1946</td>
1819
- <td>SCDK</td>
1820
- <td>HC(228-231)</td>
1821
- <td>508.1952</td>
1822
- <td>-1.19</td>
1823
- <td></td>
1824
- </tr>
1825
- <tr>
1826
- <td>27.38</td>
1827
- <td>3333.6341</td>
1828
- <td>SCDKTHTCPPCPAPELLGGPSVFLFPPKPK</td>
1829
- <td>HC(228-257)</td>
1830
- <td>3333.6349</td>
1831
- <td>-0.22</td>
1832
- <td></td>
1833
- </tr>
1834
- <tr>
1835
- <td>28.10</td>
1836
- <td>2843.4509</td>
1837
- <td>THTCPPCPAPELLGGPSVFLFPPKPK</td>
1838
- <td>HC(232-257)</td>
1839
- <td>2843.4503</td>
1840
- <td>0.21</td>
1841
- <td></td>
1842
- </tr>
1843
- <tr>
1844
- <td>17.76</td>
1845
- <td>880.4659</td>
1846
- <td>DTLYITR</td>
1847
- <td>HC(258-264)</td>
1848
- <td>880.4654</td>
1849
- <td>0.54</td>
1850
- <td></td>
1851
- </tr>
1852
- <tr>
1853
- <td>22.02</td>
1854
- <td>2166.0145</td>
1855
- <td>EPEVTCVVVDVSHEDPEVK</td>
1856
- <td>HC(265-283)</td>
1857
- <td>2166.0151</td>
1858
- <td>-0.25</td>
1859
- <td></td>
1860
- </tr>
1861
- <tr>
1862
- <td>22.34</td>
1863
- <td>1676.7950</td>
1864
- <td>FNWYVDGVEVHNAK</td>
1865
- <td>HC(284-297)</td>
1866
- <td>1676.7947</td>
1867
- <td>0.16</td>
1868
- <td></td>
1869
- </tr>
1870
- <tr>
1871
- <td>4.63</td>
1872
- <td>500.3070</td>
1873
- <td>TKPR</td>
1874
- <td>HC(298-301)</td>
1875
- <td>500.3071</td>
1876
- <td>-0.23</td>
1877
- <td></td>
1878
- </tr>
1879
- <tr>
1880
- <td>11.96</td>
1881
- <td>1188.5050</td>
1882
- <td>EEQYNSTYR</td>
1883
- <td>HC(302-310)</td>
1884
- <td>1188.5047</td>
1885
- <td>0.24</td>
1886
- <td></td>
1887
- </tr>
1888
- <tr>
1889
- <td>11.18</td>
1890
- <td>2633.0396</td>
1891
- <td>EEQYNSTYR</td>
1892
- <td>HC(302-310)</td>
1893
- <td>2633.0386</td>
1894
- <td>0.38</td>
1895
- <td>G0F</td>
1896
- </tr>
1897
- <tr>
1898
- <td>28.68</td>
1899
- <td>1806.9994</td>
1900
- <td>VVSVLTVLHQDWLNGK</td>
1901
- <td>HC(311-326)</td>
1902
- <td>1806.9992</td>
1903
- <td>0.08</td>
1904
- <td></td>
1905
- </tr>
1906
- <tr>
1907
- <td>27.71</td>
1908
- <td>2227.2001</td>
1909
- <td>VVSVLTVLHQDWLNGKEYK</td>
1910
- <td>HC(311-329)</td>
1911
- <td>2227.2001</td>
1912
- <td>0.01</td>
1913
- <td></td>
1914
- </tr>
1915
- <tr>
1916
- <td>6.58</td>
1917
- <td>438.2110</td>
1918
- <td>EYK</td>
1919
- <td>HC(327-329)</td>
1920
- <td>438.2115</td>
1921
- <td>-0.95</td>
1922
- <td></td>
1923
- </tr>
1924
- <tr>
1925
- <td>1.97</td>
1926
- <td>306.1361</td>
1927
- <td>CK</td>
1928
- <td>HC(330-331)</td>
1929
- <td>306.1362</td>
1930
- <td>-0.37</td>
1931
- <td></td>
1932
- </tr>
1933
- <tr>
1934
- <td>3.05</td>
1935
- <td>446.2485</td>
1936
- <td>VSNK</td>
1937
- <td>HC(332-335)</td>
1938
- <td>446.2489</td>
1939
- <td>-0.91</td>
1940
- <td></td>
1941
- </tr>
1942
- <tr>
1943
- <td>18.00</td>
1944
- <td>837.4964</td>
1945
- <td>ALPAPIEK</td>
1946
- <td>HC(336-343)</td>
1947
- <td>837.4960</td>
1948
- <td>0.51</td>
1949
- <td></td>
1950
- </tr>
1951
- </table>
1952
-
1953
-
1954
- <figure>
1955
- </figure>
1956
-
1957
-
1958
- RIC
1959
-
1960
- <!-- PageFooter="biologics" -->
1961
- <!-- PageNumber="17" -->
1962
- <!-- PageBreak -->
1963
-
1964
-
1965
- <figure>
1966
- </figure>
1967
-
1968
-
1969
- ### Results 18E2 HIS2 ABDEG - Identity
1970
-
1971
-
1972
- <table>
1973
- <tr>
1974
- <th>RT</th>
1975
- <th>Mass</th>
1976
- <th>Sequence</th>
1977
- <th>Seq Loc</th>
1978
- <th>Tgt Seq Mass</th>
1979
- <th>Diff (Bio, ppm)</th>
1980
- <th>Pred Mods</th>
1981
- </tr>
1982
- <tr>
1983
- <td>8.04</td>
1984
- <td>447.2689</td>
1985
- <td>TISK</td>
1986
- <td>HC(344-347)</td>
1987
- <td>447.2693</td>
1988
- <td>-0.89</td>
1989
- <td></td>
1990
- </tr>
1991
- <tr>
1992
- <td>6.37</td>
1993
- <td>655.3762</td>
1994
- <td>AKGQPR</td>
1995
- <td>HC(348-353)</td>
1996
- <td>655.3766</td>
1997
- <td>-0.53</td>
1998
- <td></td>
1999
- </tr>
2000
- <tr>
2001
- <td>5.34</td>
2002
- <td>456.2436</td>
2003
- <td>GQPR</td>
2004
- <td>HC(350-353)</td>
2005
- <td>456.2445</td>
2006
- <td>-2</td>
2007
- <td></td>
2008
- </tr>
2009
- <tr>
2010
- <td>18.62</td>
2011
- <td>1285.6659</td>
2012
- <td>EPQVYTLPPSR</td>
2013
- <td>HC(354-364)</td>
2014
- <td>1285.6667</td>
2015
- <td>-0.59</td>
2016
- <td></td>
2017
- </tr>
2018
- <tr>
2019
- <td>19.70</td>
2020
- <td>1871.9625</td>
2021
- <td>EPQVYTLPPSRDELTK</td>
2022
- <td>HC(354-369)</td>
2023
- <td>1871.9629</td>
2024
- <td>-0.2</td>
2025
- <td></td>
2026
- </tr>
2027
- <tr>
2028
- <td>10.35</td>
2029
- <td>604.3067</td>
2030
- <td>DELTK</td>
2031
- <td>HC(365-369)</td>
2032
- <td>604.3068</td>
2033
- <td>-0.24</td>
2034
- <td></td>
2035
- </tr>
2036
- <tr>
2037
- <td>21.71</td>
2038
- <td>1160.6228</td>
2039
- <td>NQVSLTCLVK</td>
2040
- <td>HC(370-379)</td>
2041
- <td>1160.6224</td>
2042
- <td>0.4</td>
2043
- <td></td>
2044
- </tr>
2045
- <tr>
2046
- <td>24.22</td>
2047
- <td>2543.1244</td>
2048
- <td>GFYPSDIAVEWESNGQPENNYK</td>
2049
- <td>HC(380-401)</td>
2050
- <td>2543.1241</td>
2051
- <td>0.12</td>
2052
- <td></td>
2053
- </tr>
2054
- <tr>
2055
- <td>25.93</td>
2056
- <td>1872.9139</td>
2057
- <td>TTPPVLDSDGSFFLYSK</td>
2058
- <td>HC(402-418)</td>
2059
- <td>1872.9146</td>
2060
- <td>-0.35</td>
2061
- <td></td>
2062
- </tr>
2063
- <tr>
2064
- <td>12.41</td>
2065
- <td>574.3327</td>
2066
- <td>LTVDK</td>
2067
- <td>HC(419-423)</td>
2068
- <td>574.3326</td>
2069
- <td>0.12</td>
2070
- <td></td>
2071
- </tr>
2072
- <tr>
2073
- <td>1.97</td>
2074
- <td>261.1431</td>
2075
- <td>SR</td>
2076
- <td>HC(424-425)</td>
2077
- <td>261.1437</td>
2078
- <td>-2.18</td>
2079
- <td></td>
2080
- </tr>
2081
- <tr>
2082
- <td>33.08</td>
2083
- <td>2263.0592</td>
2084
- <td>SRWQQGNVFSCSVMHEALK</td>
2085
- <td>HC(424-442)</td>
2086
- <td>2263.0627</td>
2087
- <td>-1.54</td>
2088
- <td></td>
2089
- </tr>
2090
- <tr>
2091
- <td>23.63</td>
2092
- <td>3067.4465</td>
2093
- <td>SRWQQGNVFSCSVMHEALKFHYTQK</td>
2094
- <td>HC(424-448)</td>
2095
- <td>3067.4545</td>
2096
- <td>-2.63</td>
2097
- <td></td>
2098
- </tr>
2099
- <tr>
2100
- <td>23.22</td>
2101
- <td>2019.9271</td>
2102
- <td>WQQGNVFSCSVMHEALK</td>
2103
- <td>HC(426-442)</td>
2104
- <td>2019.9295</td>
2105
- <td>-1.18</td>
2106
- <td></td>
2107
- </tr>
2108
- <tr>
2109
- <td>12.52</td>
2110
- <td>822.4028</td>
2111
- <td>FHYTQK</td>
2112
- <td>HC(443-448)</td>
2113
- <td>822.4024</td>
2114
- <td>0.43</td>
2115
- <td></td>
2116
- </tr>
2117
- <tr>
2118
- <td>18.20</td>
2119
- <td>659.3486</td>
2120
- <td>SLSLSPG</td>
2121
- <td>HC(449-455)</td>
2122
- <td>659.3490</td>
2123
- <td>-0.58</td>
2124
- <td></td>
2125
- </tr>
2126
- <tr>
2127
- <td>22.64</td>
2128
- <td>1957.0099</td>
2129
- <td>SSELTQDPAVSVALGQTVR</td>
2130
- <td>LC(001-019)</td>
2131
- <td>1957.0116</td>
2132
- <td>-0.91</td>
2133
- <td></td>
2134
- </tr>
2135
- <tr>
2136
- <td>8.99</td>
2137
- <td>848.3799</td>
2138
- <td>ITCQGDR</td>
2139
- <td>LC(020-026)</td>
2140
- <td>848.3811</td>
2141
- <td>-1.4</td>
2142
- <td></td>
2143
- </tr>
2144
- <tr>
2145
- <td>8.03</td>
2146
- <td>431.2486</td>
2147
- <td>LGSR</td>
2148
- <td>LC(027-030)</td>
2149
- <td>431.2492</td>
2150
- <td>-1.39</td>
2151
- <td></td>
2152
- </tr>
2153
- <tr>
2154
- <td>24.57</td>
2155
- <td>2703.3443</td>
2156
- <td>YIHWYQQKPGQAPVLVIYDDDR</td>
2157
- <td>LC(031-052)</td>
2158
- <td>2703.3445</td>
2159
- <td>-0.08</td>
2160
- <td></td>
2161
- </tr>
2162
- <tr>
2163
- <td>23.74</td>
2164
- <td>3581.8172</td>
2165
- <td>YIHWYQQKPGQAPVLVIYDDDRRPSGIPDR</td>
2166
- <td>LC(031-060)</td>
2167
- <td>3581.8168</td>
2168
- <td>0.13</td>
2169
- <td></td>
2170
- </tr>
2171
- <tr>
2172
- <td>13.04</td>
2173
- <td>896.4826</td>
2174
- <td>RPSGIPDR</td>
2175
- <td>LC(053-060)</td>
2176
- <td>896.4828</td>
2177
- <td>-0.25</td>
2178
- <td></td>
2179
- </tr>
2180
- <tr>
2181
- <td>25.10</td>
2182
- <td>5127.3123</td>
2183
- <td>FSGSSSGNTASLTITGAQAEDEADYYCQSADSSGNPVFGGGTQLTVLGQPK</td>
2184
- <td>LC(061-111)</td>
2185
- <td>5127.3164</td>
2186
- <td>-0.8</td>
2187
- <td></td>
2188
- </tr>
2189
- <tr>
2190
- <td>23.58</td>
2191
- <td>1985.0103</td>
2192
- <td>AAPSVTLFPPSSEELQANK</td>
2193
- <td>LC(112-130)</td>
2194
- <td>1985.0106</td>
2195
- <td>-0.13</td>
2196
- <td></td>
2197
- </tr>
2198
- <tr>
2199
- <td>34.71</td>
2200
- <td>4177.1390</td>
2201
- <td>AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWK</td>
2202
- <td>LC(112-150)</td>
2203
- <td>4177.1446</td>
2204
- <td>-1.33</td>
2205
- <td></td>
2206
- </tr>
2207
- <tr>
2208
- <td>33.08</td>
2209
- <td>2210.1419</td>
2210
- <td>ATLVCLISDFYPGAVTVAWK</td>
2211
- <td>LC(131-150)</td>
2212
- <td>2210.1446</td>
2213
- <td>-1.2</td>
2214
- <td></td>
2215
- </tr>
2216
- <tr>
2217
- <td>10.21</td>
2218
- <td>702.3549</td>
2219
- <td>ADSSPVK</td>
2220
- <td>LC(151-157)</td>
2221
- <td>702.3548</td>
2222
- <td>0.14</td>
2223
- <td></td>
2224
- </tr>
2225
- <tr>
2226
- <td>11.55</td>
2227
- <td>989.5031</td>
2228
- <td>AGVETTTPSK</td>
2229
- <td>LC(158-167)</td>
2230
- <td>989.5029</td>
2231
- <td>0.15</td>
2232
- <td></td>
2233
- </tr>
2234
- <tr>
2235
- <td>1.96</td>
2236
- <td>589.2819</td>
2237
- <td>QSNNK</td>
2238
- <td>LC(168-172)</td>
2239
- <td>589.2820</td>
2240
- <td>-0.15</td>
2241
- <td></td>
2242
- </tr>
2243
- <tr>
2244
- <td>24.34</td>
2245
- <td>1742.8513</td>
2246
- <td>YAASSYLSLTPEQWK</td>
2247
- <td>LC(173-187)</td>
2248
- <td>1742.8516</td>
2249
- <td>-0.14</td>
2250
- <td></td>
2251
- </tr>
2252
- <tr>
2253
- <td>2.10</td>
2254
- <td>398.2021</td>
2255
- <td>SHR</td>
2256
- <td>LC(188-190)</td>
2257
- <td>398.2026</td>
2258
- <td>-1.29</td>
2259
- <td></td>
2260
- </tr>
2261
- <tr>
2262
- <td>13.38</td>
2263
- <td>1710.7519</td>
2264
- <td>SYSCQVTHEGSTVEK</td>
2265
- <td>LC(191-205)</td>
2266
- <td>1710.7519</td>
2267
- <td>-0.03</td>
2268
- <td></td>
2269
- </tr>
2270
- <tr>
2271
- <td>11.73</td>
2272
- <td>863.3695</td>
2273
- <td>TVAPTECS</td>
2274
- <td>LC(206-213)</td>
2275
- <td>863.3695</td>
2276
- <td>0.06</td>
2277
- <td></td>
2278
- </tr>
2279
- </table>
2280
-
2281
-
2282
- <figure>
2283
-
2284
- RIC
2285
-
2286
- <!-- PageFooter="biologics" -->
2287
-
2288
- </figure>
2289
-
2290
-
2291
- <!-- PageNumber="18" -->
2292
- <!-- PageBreak -->
2293
-
2294
-
2295
- <figure>
2296
- </figure>
2297
-
2298
-
2299
- ## Results 18E2 HIS2 ABDEG - Identity
2300
-
2301
-
2302
- ### >HEAVY CHAIN: 18E2HIS2
2303
-
2304
- EVOLLESGGGLVQPGGSLRLSCAASGFTFSSYVMHWVRQAPGKGLEWVSSIYHDGSHTYYADFVKGRFTISRDNSKNTLYLQ
2305
- MNSLRAEDTAVYYCAKGTSYSGSYYYTDPFFGSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT
2306
- VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGG
2307
- PSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEY
2308
- KCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD
2309
- GSFFLYSKLTVDKSRWQQGNVFSCSVMHEALKFHYTOKSLSLSPGK
2310
-
2311
-
2312
- ### >LIGHT CHAIN : 18E2HIS2
2313
-
2314
- SSELTQDPAVSVALGQTVRITCQGDRLGSRYIHWYQQKPGQAPVLVIYDDDRRPSGIPDRFSGSSSGNTASLTITGAQAEDE
2315
- ADYYCOSADSSGNPVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTT
2316
- PSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
2317
-
2318
- Sequence coverage of 99.8%
2319
-
2320
-
2321
- <figure>
2322
-
2323
- RIC
2324
-
2325
- </figure>
2326
-
2327
-
2328
- <!-- PageFooter="biologics" -->
2329
- <!-- PageNumber="19" -->
2330
- <!-- PageBreak -->
2331
-
2332
-
2333
- <figure>
2334
- </figure>
2335
-
2336
-
2337
- ## Results 18E2 HIS2 ABDEG - Modifications (oxidation)
2338
-
2339
-
2340
- <table>
2341
- <tr>
2342
- <th>Sequence</th>
2343
- <th>Seq Loc</th>
2344
- <th>Modification</th>
2345
- <th>18E2 HIS2 ABDEG</th>
2346
- <th>18E2 HIS2 ABDEG T6w</th>
2347
- </tr>
2348
- <tr>
2349
- <td rowspan="2">WQQGNVFSCSVMHEALK</td>
2350
- <td rowspan="2">HC(426-442)</td>
2351
- <td rowspan="2">Oxidation</td>
2352
- <td>3.7</td>
2353
- <td rowspan="2">18.2 81.8</td>
2354
- </tr>
2355
- <tr>
2356
- <td>96.3</td>
2357
- </tr>
2358
- </table>
2359
-
2360
- BOLD: relevant increase upon stressing
2361
- Note: Only modifications > 0.5% are reported
2362
-
2363
-
2364
- <figure>
2365
-
2366
- RIC
2367
-
2368
- </figure>
2369
-
2370
-
2371
- <!-- PageFooter="biologics" -->
2372
- <!-- PageNumber="20" -->
2373
- <!-- PageBreak -->
2374
-
2375
-
2376
- <figure>
2377
- </figure>
2378
-
2379
-
2380
- ## Results 18E2 HIS2 ABDEG - Modifications (deam/isoD)
2381
-
2382
-
2383
- <table>
2384
- <tr>
2385
- <th>Sequence</th>
2386
- <th>Seq Loc</th>
2387
- <th>Modification</th>
2388
- <th>18E2 HIS2 ABDEG</th>
2389
- <th>18E2 HIS2 ABDEG T6w</th>
2390
- </tr>
2391
- <tr>
2392
- <td rowspan="2">EVQLLESGGGLVQPGGSLR</td>
2393
- <td rowspan="2">HC(1-19)</td>
2394
- <td>Deamidation</td>
2395
- <td>2.5</td>
2396
- <td>2.0</td>
2397
- </tr>
2398
- <tr>
2399
- <td></td>
2400
- <td>97.5</td>
2401
- <td>98.0</td>
2402
- </tr>
2403
- <tr>
2404
- <td rowspan="2">NTLYLQMNSLR</td>
2405
- <td rowspan="2">HC(77-87)</td>
2406
- <td rowspan="2">Deamidation</td>
2407
- <td>1.5</td>
2408
- <td>2.2</td>
2409
- </tr>
2410
- <tr>
2411
- <td>98.5</td>
2412
- <td>97.8</td>
2413
- </tr>
2414
- <tr>
2415
- <td rowspan="2">FNWYVDGVEVHNAK</td>
2416
- <td rowspan="2">HC(284-297)</td>
2417
- <td>IsoD</td>
2418
- <td>0.8</td>
2419
- <td>1.7</td>
2420
- </tr>
2421
- <tr>
2422
- <td></td>
2423
- <td>99.2</td>
2424
- <td>98.3</td>
2425
- </tr>
2426
- <tr>
2427
- <td rowspan="3">VVSVLTVLHQDWLNGK</td>
2428
- <td rowspan="3">HC(311-326)</td>
2429
- <td>Deamidation</td>
2430
- <td>0.9</td>
2431
- <td>1.5</td>
2432
- </tr>
2433
- <tr>
2434
- <td></td>
2435
- <td>97.1</td>
2436
- <td>96.2</td>
2437
- </tr>
2438
- <tr>
2439
- <td>Succinimide</td>
2440
- <td>2.0</td>
2441
- <td>2.3</td>
2442
- </tr>
2443
- <tr>
2444
- <td rowspan="2">NQVSLTCLVK</td>
2445
- <td rowspan="2">HC(370-379)</td>
2446
- <td>Deamidation</td>
2447
- <td>4.0</td>
2448
- <td>4.9</td>
2449
- </tr>
2450
- <tr>
2451
- <td></td>
2452
- <td>96.0</td>
2453
- <td>95.1</td>
2454
- </tr>
2455
- <tr>
2456
- <td rowspan="2">GFYPSDIAVEWESNGQPENNYK</td>
2457
- <td rowspan="2">HC(380-401)</td>
2458
- <td>Deamidation</td>
2459
- <td>6.1</td>
2460
- <td>24.5</td>
2461
- </tr>
2462
- <tr>
2463
- <td></td>
2464
- <td>93.9</td>
2465
- <td>75.5</td>
2466
- </tr>
2467
- <tr>
2468
- <td>TTPPVLDSDGSFFLYSK</td>
2469
- <td>HC(402-418)</td>
2470
- <td>IsoD</td>
2471
- <td>0.7 99.3</td>
2472
- <td>1.6 98.4</td>
2473
- </tr>
2474
- </table>
2475
-
2476
- BOLD: relevant increase upon stressing
2477
-
2478
- Note: Only modifications > 0.5% are reported
2479
-
2480
-
2481
- <figure>
2482
- </figure>
2483
-
2484
-
2485
- RIC
2486
- biologics
2487
-
2488
- <!-- PageNumber="21" -->
2489
- <!-- PageBreak -->
2490
-
2491
-
2492
- <figure>
2493
- </figure>
2494
-
2495
-
2496
- ### Results 18E2 HIS2 ABDEG - Modifications (pyroE)
2497
-
2498
-
2499
- <table>
2500
- <tr>
2501
- <th>Sequence</th>
2502
- <th>Seq Loc</th>
2503
- <th>Modification</th>
2504
- <th>18E2 HIS2 ABDEG</th>
2505
- <th>18E2 HIS2 ABDEG T6w</th>
2506
- </tr>
2507
- <tr>
2508
- <td>EVQLLESGGGLVQPGGSLR</td>
2509
- <td>HC(1-19)</td>
2510
- <td>PyroE</td>
2511
- <td>2.2 97.8</td>
2512
- <td>11.1 89.0</td>
2513
- </tr>
2514
- </table>
2515
-
2516
-
2517
- <figure>
2518
-
2519
- RIC
2520
-
2521
- </figure>
2522
-
2523
-
2524
- <!-- PageFooter="biologics" -->
2525
- <!-- PageNumber="22" -->
2526
- <!-- PageBreak -->
2527
-
2528
-
2529
- <figure>
2530
- </figure>
2531
-
2532
-
2533
- ## Results 18E2 HIS2 ABDEG - Modifications
2534
-
2535
-
2536
- ### >HEAVY CHAIN : 18E2HIS2
2537
-
2538
- EVOLLESGGGLVQPGGSLRLSCAASGFTFSSYVMHWVRQAPGKGLEWVSSIYHDGSHTYYADFVKGRFTISRDNSKNTLYLQ
2539
- MNSLRAEDTAVYYCAKGTSYSGSYYYTDPFFGSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT
2540
- VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGG
2541
- PSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEY
2542
- KCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD
2543
- GSFFLYSKLTVDKSRWQQGNVFSCSVMHEALKFHYTQKSLSLSPGK
2544
-
2545
-
2546
- ### >LIGHT CHAIN : 18E2HIS2
2547
-
2548
- SSELTQDPAVSVALGQTVRITCQGDRLGSRYIHWYQQKPGQAPVLVIYDDDRRPSGIPDRFSGSSSGNTASLTITGAQAEDE
2549
- ADYYCOSADSSGNPVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTT
2550
- PSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
2551
-
2552
-
2553
- <figure>
2554
-
2555
- RIC
2556
-
2557
- </figure>
2558
-
2559
-
2560
- <!-- PageFooter="biologics" -->
2561
- <!-- PageFooter="RED: relevant increase upon stressing" -->
2562
- <!-- PageNumber="23" -->
2563
- <!-- PageBreak -->
2564
-
2565
-
2566
- <figure>
2567
- </figure>
2568
-
2569
-
2570
- ## Results 18E2VL HIS LALA ABDEG - Identity
2571
-
2572
-
2573
- <table>
2574
- <tr>
2575
- <th>RT</th>
2576
- <th>Mass</th>
2577
- <th>Sequence</th>
2578
- <th>Seq Loc</th>
2579
- <th>Tgt Seq Mass</th>
2580
- <th>Diff (Bio, ppm)</th>
2581
- <th>Pred Mods</th>
2582
- </tr>
2583
- <tr>
2584
- <td>23.53</td>
2585
- <td>1895.0099</td>
2586
- <td>EVQLLESGGGLVQPGGSLR</td>
2587
- <td>HC(001-019)</td>
2588
- <td>1895.0113</td>
2589
- <td>-0.71</td>
2590
- <td></td>
2591
- </tr>
2592
- <tr>
2593
- <td>30.89</td>
2594
- <td>2154.9844</td>
2595
- <td>LSCAASGFTFSSYVMSWVR</td>
2596
- <td>HC(020-038)</td>
2597
- <td>2154.9867</td>
2598
- <td>-1.06</td>
2599
- <td></td>
2600
- </tr>
2601
- <tr>
2602
- <td>33.75</td>
2603
- <td>5191.4234</td>
2604
- <td>LSCAASGFTFSSYVMSWVRQAPGKGLEWVSSIYHDGSHTYYADFVK</td>
2605
- <td>HC(020-065)</td>
2606
- <td>5191.4273</td>
2607
- <td>-0.77</td>
2608
- <td></td>
2609
- </tr>
2610
- <tr>
2611
- <td>6.08</td>
2612
- <td>499.2755</td>
2613
- <td>QAPGK</td>
2614
- <td>HC(039-043)</td>
2615
- <td>499.2755</td>
2616
- <td>0.01</td>
2617
- <td></td>
2618
- </tr>
2619
- <tr>
2620
- <td>25.60</td>
2621
- <td>2573.1851</td>
2622
- <td>GLEWVSSIYHDGSHTYYADFVK</td>
2623
- <td>HC(044-065)</td>
2624
- <td>2573.1863</td>
2625
- <td>-0.48</td>
2626
- <td></td>
2627
- </tr>
2628
- <tr>
2629
- <td>25.93</td>
2630
- <td>3390.6398</td>
2631
- <td>GLEWVSSIYHDGSHTYYADFVKGRFTISR</td>
2632
- <td>HC(044-072)</td>
2633
- <td>3390.6422</td>
2634
- <td>-0.72</td>
2635
- <td></td>
2636
- </tr>
2637
- <tr>
2638
- <td>1.98</td>
2639
- <td>231.1327</td>
2640
- <td>GR</td>
2641
- <td>HC(066-067)</td>
2642
- <td>231.1331</td>
2643
- <td>-1.81</td>
2644
- <td></td>
2645
- </tr>
2646
- <tr>
2647
- <td>15.94</td>
2648
- <td>835.4666</td>
2649
- <td>GRFTISR</td>
2650
- <td>HC(066-072)</td>
2651
- <td>835.4664</td>
2652
- <td>0.19</td>
2653
- <td></td>
2654
- </tr>
2655
- <tr>
2656
- <td>16.06</td>
2657
- <td>622.3441</td>
2658
- <td>FTISR</td>
2659
- <td>HC(068-072)</td>
2660
- <td>622.3439</td>
2661
- <td>0.33</td>
2662
- <td></td>
2663
- </tr>
2664
- <tr>
2665
- <td>22.54</td>
2666
- <td>1351.6916</td>
2667
- <td>NTLYLQMNSLR</td>
2668
- <td>HC(077-087)</td>
2669
- <td>1351.6918</td>
2670
- <td>-0.13</td>
2671
- <td></td>
2672
- </tr>
2673
- <tr>
2674
- <td>15.52</td>
2675
- <td>1289.5586</td>
2676
- <td>AEDTAVYYCAK</td>
2677
- <td>HC(088-098)</td>
2678
- <td>1289.5598</td>
2679
- <td>-0.93</td>
2680
- <td></td>
2681
- </tr>
2682
- <tr>
2683
- <td>28.17</td>
2684
- <td>3400.5377</td>
2685
- <td>GTSYSGSYYYTDPFFGSWGQGTLVTVSSASTK</td>
2686
- <td>HC(099-130)</td>
2687
- <td>3400.5412</td>
2688
- <td>-1.03</td>
2689
- <td></td>
2690
- </tr>
2691
- <tr>
2692
- <td>22.50</td>
2693
- <td>1185.6390</td>
2694
- <td>GPSVFPLAPSSK</td>
2695
- <td>HC(131-142)</td>
2696
- <td>1185.6394</td>
2697
- <td>-0.35</td>
2698
- <td></td>
2699
- </tr>
2700
- <tr>
2701
- <td>20.37</td>
2702
- <td>1320.6709</td>
2703
- <td>STSGGTAALGCLVK</td>
2704
- <td>HC(143-156)</td>
2705
- <td>1320.6708</td>
2706
- <td>0.11</td>
2707
- <td></td>
2708
- </tr>
2709
- <tr>
2710
- <td>31.67</td>
2711
- <td>8014.9558</td>
2712
- <td>STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTK</td>
2713
- <td>HC(143-219)</td>
2714
- <td>8014.9674</td>
2715
- <td>-1.44</td>
2716
- <td></td>
2717
- </tr>
2718
- <tr>
2719
- <td>30.98</td>
2720
- <td>6712.2902</td>
2721
- <td>DYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTK</td>
2722
- <td>HC(157-219)</td>
2723
- <td>6712.3072</td>
2724
- <td>-2.53</td>
2725
- <td></td>
2726
- </tr>
2727
- <tr>
2728
- <td>3.78</td>
2729
- <td>360.2002</td>
2730
- <td>VDK</td>
2731
- <td>HC(220-222)</td>
2732
- <td>360.2009</td>
2733
- <td>-1.91</td>
2734
- <td></td>
2735
- </tr>
2736
- <tr>
2737
- <td>3.06</td>
2738
- <td>488.2956</td>
2739
- <td>VDKK</td>
2740
- <td>HC(220-223)</td>
2741
- <td>488.2959</td>
2742
- <td>-0.57</td>
2743
- <td></td>
2744
- </tr>
2745
- <tr>
2746
- <td>8.41</td>
2747
- <td>599.3647</td>
2748
- <td>KVEPK</td>
2749
- <td>HC(223-227)</td>
2750
- <td>599.3643</td>
2751
- <td>0.73</td>
2752
- <td></td>
2753
- </tr>
2754
- <tr>
2755
- <td>7.89</td>
2756
- <td>471.2691</td>
2757
- <td>VEPK</td>
2758
- <td>HC(224-227)</td>
2759
- <td>471.2693</td>
2760
- <td>-0.5</td>
2761
- <td></td>
2762
- </tr>
2763
- <tr>
2764
- <td>2.06</td>
2765
- <td>508.1944</td>
2766
- <td>SCDK</td>
2767
- <td>HC(228-231)</td>
2768
- <td>508.1952</td>
2769
- <td>-1.57</td>
2770
- <td></td>
2771
- </tr>
2772
- <tr>
2773
- <td>22.03</td>
2774
- <td>3249.5197</td>
2775
- <td>SCDKTHTCPPCPAPEAAGGPSVFLFPPKPK</td>
2776
- <td>HC(228-257)</td>
2777
- <td>3249.5410</td>
2778
- <td>-6.55</td>
2779
- <td></td>
2780
- </tr>
2781
- <tr>
2782
- <td>24.58</td>
2783
- <td>2759.3550</td>
2784
- <td>THTCPPCPAPEAAGGPSVFLFPPKPK</td>
2785
- <td>HC(232-257)</td>
2786
- <td>2759.3564</td>
2787
- <td>-0.5</td>
2788
- <td></td>
2789
- </tr>
2790
- <tr>
2791
- <td>17.75</td>
2792
- <td>880.4653</td>
2793
- <td>DTLYITR</td>
2794
- <td>HC(258-264)</td>
2795
- <td>880.4654</td>
2796
- <td>-0.18</td>
2797
- <td></td>
2798
- </tr>
2799
- <tr>
2800
- <td>22.03</td>
2801
- <td>2166.0157</td>
2802
- <td>EPEVTCVVVDVSHEDPEVK</td>
2803
- <td>HC(265-283)</td>
2804
- <td>2166.0151</td>
2805
- <td>0.29</td>
2806
- <td></td>
2807
- </tr>
2808
- <tr>
2809
- <td>22.35</td>
2810
- <td>1676.7944</td>
2811
- <td>FNWYVDGVEVHNAK</td>
2812
- <td>HC(284-297)</td>
2813
- <td>1676.7947</td>
2814
- <td>-0.16</td>
2815
- <td></td>
2816
- </tr>
2817
- <tr>
2818
- <td>4.64</td>
2819
- <td>500.3070</td>
2820
- <td>TKPR</td>
2821
- <td>HC(298-301)</td>
2822
- <td>500.3071</td>
2823
- <td>-0.22</td>
2824
- <td></td>
2825
- </tr>
2826
- <tr>
2827
- <td>11.96</td>
2828
- <td>1188.5044</td>
2829
- <td>EEQYNSTYR</td>
2830
- <td>HC(302-310)</td>
2831
- <td>1188.5047</td>
2832
- <td>-0.27</td>
2833
- <td></td>
2834
- </tr>
2835
- <tr>
2836
- <td>11.18</td>
2837
- <td>2633.0350</td>
2838
- <td>EEQYNSTYR</td>
2839
- <td>HC(302-310)</td>
2840
- <td>2633.0386</td>
2841
- <td>-1.39</td>
2842
- <td>G0F</td>
2843
- </tr>
2844
- <tr>
2845
- <td>28.70</td>
2846
- <td>1806.9988</td>
2847
- <td>VVSVLTVLHQDWLNGK</td>
2848
- <td>HC(311-326)</td>
2849
- <td>1806.9992</td>
2850
- <td>-0.26</td>
2851
- <td></td>
2852
- </tr>
2853
- <tr>
2854
- <td>27.74</td>
2855
- <td>2227.1974</td>
2856
- <td>VVSVLTVLHQDWLNGKEYK</td>
2857
- <td>HC(311-329)</td>
2858
- <td>2227.2001</td>
2859
- <td>-1.23</td>
2860
- <td></td>
2861
- </tr>
2862
- <tr>
2863
- <td>6.58</td>
2864
- <td>438.2111</td>
2865
- <td>EYK</td>
2866
- <td>HC(327-329)</td>
2867
- <td>438.2115</td>
2868
- <td>-0.78</td>
2869
- <td></td>
2870
- </tr>
2871
- <tr>
2872
- <td>1.98</td>
2873
- <td>306.1358</td>
2874
- <td>CK</td>
2875
- <td>HC(330-331)</td>
2876
- <td>306.1362</td>
2877
- <td>-1.29</td>
2878
- <td></td>
2879
- </tr>
2880
- </table>
2881
-
2882
-
2883
- <figure>
2884
-
2885
- RIC
2886
-
2887
- <!-- PageFooter="biologics" -->
2888
-
2889
- </figure>
2890
-
2891
-
2892
- <!-- PageNumber="24" -->
2893
- <!-- PageBreak -->
2894
-
2895
-
2896
- <figure>
2897
- </figure>
2898
-
2899
-
2900
- ## Results 18E2VL HIS LALA ABDEG - Identity
2901
-
2902
-
2903
- <table>
2904
- <tr>
2905
- <th>RT</th>
2906
- <th>Mass</th>
2907
- <th>Sequence</th>
2908
- <th>Seq Loc</th>
2909
- <th>Tgt Seq Mass</th>
2910
- <th>Diff (Bio, ppm)</th>
2911
- <th>Pred Mods</th>
2912
- </tr>
2913
- <tr>
2914
- <td>3.05</td>
2915
- <td>446.2487</td>
2916
- <td>VSNK</td>
2917
- <td>HC(332-335)</td>
2918
- <td>446.2489</td>
2919
- <td>-0.55</td>
2920
- <td></td>
2921
- </tr>
2922
- <tr>
2923
- <td>28.16</td>
2924
- <td>1695.0096</td>
2925
- <td>VSNKALPAPIEKTISK</td>
2926
- <td>HC(332-347)</td>
2927
- <td>1694.9931</td>
2928
- <td>9.77</td>
2929
- <td></td>
2930
- </tr>
2931
- <tr>
2932
- <td>18.00</td>
2933
- <td>837.4958</td>
2934
- <td>ALPAPIEK</td>
2935
- <td>HC(336-343)</td>
2936
- <td>837.4960</td>
2937
- <td>-0.21</td>
2938
- <td></td>
2939
- </tr>
2940
- <tr>
2941
- <td>8.04</td>
2942
- <td>447.2690</td>
2943
- <td>TISK</td>
2944
- <td>HC(344-347)</td>
2945
- <td>447.2693</td>
2946
- <td>-0.75</td>
2947
- <td></td>
2948
- </tr>
2949
- <tr>
2950
- <td>6.37</td>
2951
- <td>655.3759</td>
2952
- <td>AKGQPR</td>
2953
- <td>HC(348-353)</td>
2954
- <td>655.3766</td>
2955
- <td>-1.07</td>
2956
- <td></td>
2957
- </tr>
2958
- <tr>
2959
- <td>5.31</td>
2960
- <td>456.2435</td>
2961
- <td>GQPR</td>
2962
- <td>HC(350-353)</td>
2963
- <td>456.2445</td>
2964
- <td>-2.09</td>
2965
- <td></td>
2966
- </tr>
2967
- <tr>
2968
- <td>18.66</td>
2969
- <td>1285.6660</td>
2970
- <td>EPQVYTLPPSR</td>
2971
- <td>HC(354-364)</td>
2972
- <td>1285.6667</td>
2973
- <td>-0.5</td>
2974
- <td></td>
2975
- </tr>
2976
- <tr>
2977
- <td>19.69</td>
2978
- <td>1871.9618</td>
2979
- <td>EPQVYTLPPSRDELTK</td>
2980
- <td>HC(354-369)</td>
2981
- <td>1871.9629</td>
2982
- <td>-0.59</td>
2983
- <td></td>
2984
- </tr>
2985
- <tr>
2986
- <td>10.34</td>
2987
- <td>604.3071</td>
2988
- <td>DELTK</td>
2989
- <td>HC(365-369)</td>
2990
- <td>604.3068</td>
2991
- <td>0.48</td>
2992
- <td></td>
2993
- </tr>
2994
- <tr>
2995
- <td>21.72</td>
2996
- <td>1160.6226</td>
2997
- <td>NQVSLTCLVK</td>
2998
- <td>HC(370-379)</td>
2999
- <td>1160.6224</td>
3000
- <td>0.17</td>
3001
- <td></td>
3002
- </tr>
3003
- <tr>
3004
- <td>24.23</td>
3005
- <td>2543.1202</td>
3006
- <td>GFYPSDIAVEWESNGQPENNYK</td>
3007
- <td>HC(380-401)</td>
3008
- <td>2543.1241</td>
3009
- <td>-1.55</td>
3010
- <td></td>
3011
- </tr>
3012
- <tr>
3013
- <td>25.94</td>
3014
- <td>1872.9129</td>
3015
- <td>TTPPVLDSDGSFFLYSK</td>
3016
- <td>HC(402-418)</td>
3017
- <td>1872.9146</td>
3018
- <td>-0.88</td>
3019
- <td></td>
3020
- </tr>
3021
- <tr>
3022
- <td>12.41</td>
3023
- <td>574.3326</td>
3024
- <td>LTVDK</td>
3025
- <td>HC(419-423)</td>
3026
- <td>574.3326</td>
3027
- <td>-0.09</td>
3028
- <td></td>
3029
- </tr>
3030
- <tr>
3031
- <td>16.06</td>
3032
- <td>261.1445</td>
3033
- <td>SR</td>
3034
- <td>HC(424-425)</td>
3035
- <td>261.1437</td>
3036
- <td>2.98</td>
3037
- <td></td>
3038
- </tr>
3039
- <tr>
3040
- <td>23.23</td>
3041
- <td>2019.9271</td>
3042
- <td>WQQGNVFSCSVMHEALK</td>
3043
- <td>HC(426-442)</td>
3044
- <td>2019.9295</td>
3045
- <td>-1.2</td>
3046
- <td></td>
3047
- </tr>
3048
- <tr>
3049
- <td>24.16</td>
3050
- <td>2824.3141</td>
3051
- <td>WQQGNVFSCSVMHEALKFHYTQK</td>
3052
- <td>HC(426-448)</td>
3053
- <td>2824.3214</td>
3054
- <td>-2.58</td>
3055
- <td></td>
3056
- </tr>
3057
- <tr>
3058
- <td>12.51</td>
3059
- <td>822.4014</td>
3060
- <td>FHYTQK</td>
3061
- <td>HC(443-448)</td>
3062
- <td>822.4024</td>
3063
- <td>-1.25</td>
3064
- <td></td>
3065
- </tr>
3066
- <tr>
3067
- <td>18.196</td>
3068
- <td>659.3479</td>
3069
- <td>SLSLSPG</td>
3070
- <td>HC(449-455)</td>
3071
- <td>659.3490</td>
3072
- <td>-1.68</td>
3073
- <td></td>
3074
- </tr>
3075
- <tr>
3076
- <td>16.87</td>
3077
- <td>787.4415</td>
3078
- <td>SLSLSPGK</td>
3079
- <td>HC(449-456)</td>
3080
- <td>787.4440</td>
3081
- <td>-3.09</td>
3082
- <td></td>
3083
- </tr>
3084
- <tr>
3085
- <td>22.65</td>
3086
- <td>1957.0108</td>
3087
- <td>SSELTQDPAVSVALGQTVR</td>
3088
- <td>LC(001-019)</td>
3089
- <td>1957.0116</td>
3090
- <td>-0.45</td>
3091
- <td></td>
3092
- </tr>
3093
- <tr>
3094
- <td>8.99</td>
3095
- <td>848.3805</td>
3096
- <td>ITCQGDR</td>
3097
- <td>LC(020-026)</td>
3098
- <td>848.3811</td>
3099
- <td>-0.67</td>
3100
- <td></td>
3101
- </tr>
3102
- <tr>
3103
- <td>8.03</td>
3104
- <td>431.2489</td>
3105
- <td>LGSR</td>
3106
- <td>LC(027-030)</td>
3107
- <td>431.2492</td>
3108
- <td>-0.69</td>
3109
- <td></td>
3110
- </tr>
3111
- <tr>
3112
- <td>24.59</td>
3113
- <td>2703.3425</td>
3114
- <td>YIHWYQQKPGQAPVLVIYDDDR</td>
3115
- <td>LC(031-052)</td>
3116
- <td>2703.3445</td>
3117
- <td>-0.75</td>
3118
- <td></td>
3119
- </tr>
3120
- <tr>
3121
- <td>23.77</td>
3122
- <td>3581.8139</td>
3123
- <td>YIHWYQQKPGQAPVLVIYDDDRRPSGIPDR</td>
3124
- <td>LC(031-060)</td>
3125
- <td>3581.8168</td>
3126
- <td>-0.82</td>
3127
- <td></td>
3128
- </tr>
3129
- <tr>
3130
- <td>13.04</td>
3131
- <td>896.4835</td>
3132
- <td>RPSGIPDR</td>
3133
- <td>LC(053-060)</td>
3134
- <td>896.4828</td>
3135
- <td>0.79</td>
3136
- <td></td>
3137
- </tr>
3138
- <tr>
3139
- <td>25.11</td>
3140
- <td>5127.3093</td>
3141
- <td>FSGSSSGNTASLTITGAQAEDEADYYCQSADSSGNPVFGGGTQLTVLGQPK</td>
3142
- <td>LC(061-111)</td>
3143
- <td>5127.3164</td>
3144
- <td>-1.38</td>
3145
- <td></td>
3146
- </tr>
3147
- <tr>
3148
- <td>23.58</td>
3149
- <td>1985.0087</td>
3150
- <td>AAPSVTLFPPSSEELQANK</td>
3151
- <td>LC(112-130)</td>
3152
- <td>1985.0106</td>
3153
- <td>-0.96</td>
3154
- <td></td>
3155
- </tr>
3156
- <tr>
3157
- <td>34.69</td>
3158
- <td>4177.1399</td>
3159
- <td>AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWK</td>
3160
- <td>LC(112-150)</td>
3161
- <td>4177.1446</td>
3162
- <td>-1.11</td>
3163
- <td></td>
3164
- </tr>
3165
- <tr>
3166
- <td>33.08</td>
3167
- <td>2210.1433</td>
3168
- <td>ATLVCLISDFYPGAVTVAWK</td>
3169
- <td>LC(131-150)</td>
3170
- <td>2210.1446</td>
3171
- <td>-0.59</td>
3172
- <td></td>
3173
- </tr>
3174
- <tr>
3175
- <td>10.21</td>
3176
- <td>702.3546</td>
3177
- <td>ADSSPVK</td>
3178
- <td>LC(151-157)</td>
3179
- <td>702.3548</td>
3180
- <td>-0.26</td>
3181
- <td></td>
3182
- </tr>
3183
- <tr>
3184
- <td>11.55</td>
3185
- <td>989.5026</td>
3186
- <td>AGVETTTPSK</td>
3187
- <td>LC(158-167)</td>
3188
- <td>989.5029</td>
3189
- <td>-0.31</td>
3190
- <td></td>
3191
- </tr>
3192
- <tr>
3193
- <td>1.96</td>
3194
- <td>589.2812</td>
3195
- <td>QSNNK</td>
3196
- <td>LC(168-172)</td>
3197
- <td>589.2820</td>
3198
- <td>-1.34</td>
3199
- <td></td>
3200
- </tr>
3201
- <tr>
3202
- <td>24.35</td>
3203
- <td>1742.8504</td>
3204
- <td>YAASSYLSLTPEQWK</td>
3205
- <td>LC(173-187)</td>
3206
- <td>1742.8516</td>
3207
- <td>-0.67</td>
3208
- <td></td>
3209
- </tr>
3210
- <tr>
3211
- <td>2.10</td>
3212
- <td>398.2022</td>
3213
- <td>SHR</td>
3214
- <td>LC(188-190)</td>
3215
- <td>398.2026</td>
3216
- <td>-1.16</td>
3217
- <td></td>
3218
- </tr>
3219
- <tr>
3220
- <td>13.39</td>
3221
- <td>1710.7512</td>
3222
- <td>SYSCQVTHEGSTVEK</td>
3223
- <td>LC(191-205)</td>
3224
- <td>1710.7519</td>
3225
- <td>-0.45</td>
3226
- <td></td>
3227
- </tr>
3228
- <tr>
3229
- <td>11.73</td>
3230
- <td>863.3683</td>
3231
- <td>TVAPTECS</td>
3232
- <td>LC(206-213)</td>
3233
- <td>863.3695</td>
3234
- <td>-1.39</td>
3235
- <td></td>
3236
- </tr>
3237
- </table>
3238
-
3239
-
3240
- <figure>
3241
-
3242
- RIC
3243
-
3244
- </figure>
3245
-
3246
-
3247
- <!-- PageFooter="biologics" -->
3248
- <!-- PageNumber="25" -->
3249
- <!-- PageBreak -->
3250
-
3251
-
3252
- <figure>
3253
- </figure>
3254
-
3255
-
3256
- ## Results 18E2VL HIS LALA ABDEG - Identity
3257
-
3258
-
3259
- ### >HEAVY CHAIN: 18E2VLHIS LALA ABDEG
3260
-
3261
- EVOLLESGGGLVQPGGSLRLSCAASGFTFSSYVMSWVRQAPGKGLEWVSSIYHDGSHTYYADFVKGRFTISRDNSKNTLYLOMN
3262
- SLRAEDTAVYYCAKGTSYSGSYYYTDPFFGSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
3263
- SGALTSGVHTFPAVLOSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLF
3264
- PPKPKDTLYITREPEVTCVVVDVSHEDPEVKENWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKA
3265
- LPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT
3266
- VDKSRWQQGNVFSCSVMHEALKFHYTOKSLSLSPGK
3267
-
3268
-
3269
- ### >LIGHT CHAIN: 18E2VLHIS LALA ABDEG
3270
-
3271
- SSELTQDPAVSVALGQTVRITCQGDRLGSRYIHWYQQKPGQAPVLVIYDDDRRPSGIPDRFSGSSSGNTASLTITGAQAEDEAD
3272
- YYCOSADSSGNPVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQ
3273
- SNNKYAASSYLSLTPEQWKSHRSYSCOVTHEGSTVEKTVAPTECS
3274
-
3275
- Sequence coverage of 99.4%
3276
-
3277
-
3278
- <figure>
3279
-
3280
- RIC
3281
-
3282
- </figure>
3283
-
3284
-
3285
- <!-- PageFooter="biologics" -->
3286
- <!-- PageNumber="26" -->
3287
- <!-- PageBreak -->
3288
-
3289
-
3290
- <figure>
3291
- </figure>
3292
-
3293
-
3294
- ## Results 18E2VL HIS LALA ABDEG - Modifications (oxidation)
3295
-
3296
-
3297
- <table>
3298
- <tr>
3299
- <th>Sequence</th>
3300
- <th>Seq Loc</th>
3301
- <th>Modification</th>
3302
- <th>18E2VL LALA ABDEG</th>
3303
- <th>18E2VL LALA ABDEG T6w</th>
3304
- </tr>
3305
- <tr>
3306
- <td>WQQGNVFSCSVMHEALK</td>
3307
- <td>HC(426-442)</td>
3308
- <td>Oxidation</td>
3309
- <td>2.8 97.2</td>
3310
- <td>13.3 86.7</td>
3311
- </tr>
3312
- </table>
3313
-
3314
- BOLD: relevant increase upon stressing
3315
- Note: Only modifications > 0.5% are reported
3316
-
3317
-
3318
- <figure>
3319
- </figure>
3320
-
3321
-
3322
- RIC
3323
- biologics
3324
-
3325
- <!-- PageNumber="27" -->
3326
- <!-- PageBreak -->
3327
-
3328
-
3329
- <figure>
3330
- </figure>
3331
-
3332
-
3333
- ## Results 18E2VL HIS LALA ABDEG - Modifications (deam/isoD)
3334
-
3335
-
3336
- <table>
3337
- <tr>
3338
- <th>Sequence</th>
3339
- <th>Seq Loc</th>
3340
- <th>Modification</th>
3341
- <th>18E2VL LALA ABDEG</th>
3342
- <th>18E2VL LALA ABDEG T6w</th>
3343
- </tr>
3344
- <tr>
3345
- <td rowspan="2">EVQLLESGGGLVQPGGSLR</td>
3346
- <td rowspan="2">HC(1-19)</td>
3347
- <td>Deamidation</td>
3348
- <td>2.4</td>
3349
- <td>2.4</td>
3350
- </tr>
3351
- <tr>
3352
- <td></td>
3353
- <td>97.6</td>
3354
- <td>97.6</td>
3355
- </tr>
3356
- <tr>
3357
- <td rowspan="2">NTLYLQMNSLR</td>
3358
- <td rowspan="2">HC(77-87)</td>
3359
- <td rowspan="2">Deamidation</td>
3360
- <td>1.9</td>
3361
- <td>3.2</td>
3362
- </tr>
3363
- <tr>
3364
- <td>98.1</td>
3365
- <td>96.8</td>
3366
- </tr>
3367
- <tr>
3368
- <td rowspan="2">FNWYVDGVEVHNAK</td>
3369
- <td rowspan="2">HC(284-297)</td>
3370
- <td>IsoD</td>
3371
- <td>0.7</td>
3372
- <td>1.7</td>
3373
- </tr>
3374
- <tr>
3375
- <td></td>
3376
- <td>99.3</td>
3377
- <td>98.3</td>
3378
- </tr>
3379
- <tr>
3380
- <td rowspan="3">VVSVLTVLHQDWLNGK</td>
3381
- <td rowspan="3">HC(311-326)</td>
3382
- <td>Deamidation</td>
3383
- <td>0.7</td>
3384
- <td>1.7</td>
3385
- </tr>
3386
- <tr>
3387
- <td></td>
3388
- <td>96.9</td>
3389
- <td>95.8</td>
3390
- </tr>
3391
- <tr>
3392
- <td>Succinimide</td>
3393
- <td>2.4</td>
3394
- <td>2.5</td>
3395
- </tr>
3396
- <tr>
3397
- <td rowspan="2">NQVSLTCLVK</td>
3398
- <td rowspan="2">HC(370-379)</td>
3399
- <td>Deamidation</td>
3400
- <td>3.7</td>
3401
- <td>5.9</td>
3402
- </tr>
3403
- <tr>
3404
- <td></td>
3405
- <td>96.3</td>
3406
- <td>94.1</td>
3407
- </tr>
3408
- <tr>
3409
- <td rowspan="2">GFYPSDIAVEWESNGQPENNYK</td>
3410
- <td rowspan="2">HC(380-401)</td>
3411
- <td rowspan="2">Deamidation</td>
3412
- <td>6.9</td>
3413
- <td>27.4</td>
3414
- </tr>
3415
- <tr>
3416
- <td>93.1</td>
3417
- <td>72.6</td>
3418
- </tr>
3419
- <tr>
3420
- <td>TTPPVLDSDGSFFLYSK</td>
3421
- <td>HC(402-418)</td>
3422
- <td>IsoD</td>
3423
- <td>1.0 99.0</td>
3424
- <td>1.5 98.5</td>
3425
- </tr>
3426
- </table>
3427
-
3428
- BOLD: relevant increase upon stressing
3429
-
3430
- Note: Only modifications > 0.5% are reported
3431
-
3432
-
3433
- <figure>
3434
- </figure>
3435
-
3436
-
3437
- RIC
3438
- biologics
3439
-
3440
- <!-- PageNumber="28" -->
3441
- <!-- PageBreak -->
3442
-
3443
-
3444
- <figure>
3445
- </figure>
3446
-
3447
-
3448
- <!-- PageHeader="Results 18E2VL HIS LALA ABDEG - Modifications (pyroE)" -->
3449
-
3450
-
3451
- <table>
3452
- <tr>
3453
- <th>Sequence</th>
3454
- <th>Seq Loc</th>
3455
- <th>Modification</th>
3456
- <th>18E2VL LALA ABDEG</th>
3457
- <th>18E2VL LALA ABDEG T6w</th>
3458
- </tr>
3459
- <tr>
3460
- <td>EVQLLESGGGLVQPGGSLR</td>
3461
- <td>HC(1-19)</td>
3462
- <td>PyroE</td>
3463
- <td>2.1 97.9</td>
3464
- <td>11.1 88.9</td>
3465
- </tr>
3466
- </table>
3467
-
3468
-
3469
- <figure>
3470
-
3471
- RIC
3472
-
3473
- </figure>
3474
-
3475
-
3476
- <!-- PageFooter="biologics" -->
3477
- <!-- PageNumber="29" -->
3478
- <!-- PageBreak -->
3479
-
3480
-
3481
- <figure>
3482
- </figure>
3483
-
3484
-
3485
- ## Results 18E2VL HIS LALA ABDEG - Modifications
3486
-
3487
-
3488
- ### >HEAVY CHAIN: 18E2VLHIS
3489
-
3490
- EVOLLESGGGLVQPGGSLRLSCAASGFTFSSYVMSWVRQAPGKGLEWVSSIYHDGSHTYYADFVKGRFTISRDNSKNTLYLQMN
3491
- SLRAEDTAVYYCAKGTSYSGSYYYTDPFFGSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
3492
- SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLF
3493
- PPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKA
3494
- LPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT
3495
- VDKSRWQQGNVFSCSVMHEALKFHYTQKSLSLSPGK
3496
-
3497
-
3498
- ### >LIGHT CHAIN : 18E2VLHIS
3499
-
3500
- SSELTQDPAVSVALGQTVRITCQGDRLGSRYIHWYQQKPGQAPVLVIYDDDRRPSGIPDRFSGSSSGNTASLTITGAQAEDEAD
3501
- YYCOSADSSGNPVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQ
3502
- SNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
3503
-
3504
-
3505
- <figure>
3506
-
3507
- RIC
3508
-
3509
- </figure>
3510
-
3511
-
3512
- <!-- PageFooter="biologics" -->
3513
- <!-- PageNumber="30" -->
3514
- <!-- PageBreak -->
3515
-
3516
-
3517
- <figure>
3518
- </figure>
3519
-
3520
-
3521
- ## Conclusions
3522
-
3523
- · Near complete sequence coverage obtained for all molecules studied
3524
-
3525
- . Nevertheless, partially digested material observed in samples 18E2HIS2-ABDEG and 18E2VLHIS-LALA-
3526
- ABDEG (not hampering data interpretation)
3527
-
3528
- · Peptide mapping of Ligelizumab mAB 37reveals
3529
-
3530
- · 4 sites prone to oxidation upon stressing of which three located in the variable part of the heavy chain
3531
-
3532
- · 1 site located in the conserved region of the heavy chain prone to deamidation upon stressing
3533
-
3534
- · Heavy chain N-terminus is fully cyclic (pyroE) and C-terminus predominantly lysine truncated
3535
-
3536
- · Peptide mapping of 18E2HIS2-ABDEG and 18E2VLHIS-LALA-ABDEG reveals
3537
-
3538
- · 1 site located in the conserved region of the heavy chain prone to oxidation upon stressing
3539
-
3540
- · 1 site located in the conserved region of the heavy chain prone to deamidation upon stressing
3541
-
3542
- · Partial cyclization of the heavy chain N-terminus observed upon stressing
3543
-
3544
- · No major liabilities detected in the CDRs upon stressing
3545
-
3546
- · Peptide mapping of OMA VH15G55H VL3S31H reveals
3547
-
3548
- · Complete degradation upon storage
3549
-
3550
-
3551
- <figure>
3552
-
3553
- RIC
3554
-
3555
- </figure>
3556
-
3557
-
3558
- <!-- PageFooter="biologics" -->
3559
- <!-- PageNumber="31" -->
3560
- <!-- PageBreak -->
3561
-
3562
-
3563
- <figure>
3564
- </figure>
3565
-
3566
-
3567
- ## Signature section RIC
3568
-
3569
-
3570
- ### Author
3571
-
3572
-
3573
- <table>
3574
- <tr>
3575
- <td>Gianni Vandenborre</td>
3576
- <td>Date: 15 FEB 2021</td>
3577
- </tr>
3578
- <tr>
3579
- <td>Sr Scientist Biologics | Project Manager</td>
3580
- <td>10 Signature:</td>
3581
- </tr>
3582
- <tr>
3583
- <td colspan="2">Reviewer</td>
3584
- </tr>
3585
- <tr>
3586
- <td>An Cerdobbel Ph.D.</td>
3587
- <td>Date: 16 FEB 2021</td>
3588
- </tr>
3589
- <tr>
3590
- <td>Head of Biologics Department</td>
3591
- <td>Signature: Cedobre</td>
3592
- </tr>
3593
- <tr>
3594
- <td colspan="2">Approver</td>
3595
- </tr>
3596
- <tr>
3597
- <td>Koen Sandra Ph.D.</td>
3598
- <td>Date: 1 MAR 2021</td>
3599
- </tr>
3600
- <tr>
3601
- <td>Scientific Director</td>
3602
- <td>Signature:</td>
3603
- </tr>
3604
- </table>
3605
-
3606
-
3607
- <figure>
3608
-
3609
- RIC
3610
-
3611
- </figure>
3612
-
3613
-
3614
- <!-- PageFooter="biologics" -->
3615
- <!-- PageNumber="32" -->
3616
- <!-- PageBreak -->
3617
-
3618
-
3619
- <figure>
3620
- </figure>
3621
-
3622
-
3623
- # Version control
3624
-
3625
-
3626
- <table>
3627
- <tr>
3628
- <th>Version</th>
3629
- <th>Date of issue</th>
3630
- <th>Reason for version update</th>
3631
- </tr>
3632
- <tr>
3633
- <td>01</td>
3634
- <td>30-JUL-2020</td>
3635
- <td>First issue</td>
3636
- </tr>
3637
- </table>
3638
-
3639
-
3640
- <figure>
3641
-
3642
- <!-- PageFooter="RIC" -->
3643
-
3644
- </figure>
3645
-
3646
-
3647
- <!-- PageFooter="biologics" -->
3648
- <!-- PageNumber="33" -->
3649
- <!-- PageBreak -->
3650
-
3651
-
3652
- <figure>
3653
-
3654
- RIC
3655
-
3656
- biologics
3657
-
3658
- </figure>
3659
-
3660
-
3661
- YOUR MOLECULE. OUR ANALYTICS. NO SECRETS.
3662
-
3663
- <!-- PageFooter="www.RICbiologics.com" -->
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
logs/di_content/di_content_20250604_141118.txt DELETED
The diff for this file is too large to render. See raw diff
 
logs/di_content/di_content_20250604_141519.txt DELETED
@@ -1,2110 +0,0 @@
1
- # ARGX DISCOVERY: EVALUATION OF LIABILITIES IN VH AND VL REGION OF TWO CONSTRUCTS
2
-
3
- Argenx - P3016_R04_v01
4
-
5
-
6
- <figure>
7
-
8
- RIC
9
-
10
- biologics
11
-
12
- </figure>
13
-
14
-
15
- <!-- PageBreak -->
16
-
17
-
18
- <figure>
19
- </figure>
20
-
21
-
22
- <!-- PageHeader="Table of contents" -->
23
-
24
- l Project information
25
-
26
- Scope
27
-
28
- l Test samples
29
-
30
- l
31
- Method
32
-
33
- l
34
- Results
35
-
36
- · P052_OA-02A10-GLLiab4His1_0-hlgG1-CH2-CH3-LALAPG-ABDEG-FJB_2024-01-
37
- 26_002
38
-
39
- · P052_OA-02A10-GLLiab4+Liab11-His1_0-hlgG1-CH2-CH3-LALAPG-ABDEG-
40
- FJB_2024-01-26_001
41
-
42
- l
43
- Conclusions
44
-
45
-
46
- <figure>
47
-
48
- RIC
49
-
50
- </figure>
51
-
52
-
53
- <!-- PageFooter="biologics" -->
54
- <!-- PageNumber="2" -->
55
- <!-- PageBreak -->
56
-
57
-
58
- <figure>
59
- </figure>
60
-
61
-
62
- ## Project information
63
-
64
-
65
- <table>
66
- <tr>
67
- <td>Sales quote:</td>
68
- <td>SQ20202722</td>
69
- </tr>
70
- <tr>
71
- <td>l Project code:</td>
72
- <td>P3016</td>
73
- </tr>
74
- <tr>
75
- <td>l LNB number:</td>
76
- <td>2023.040</td>
77
- </tr>
78
- <tr>
79
- <td>l Project responsible:</td>
80
- <td>Nathan Cardon</td>
81
- </tr>
82
- <tr>
83
- <td>l Report name:</td>
84
- <td>P3016_R04_v01</td>
85
- </tr>
86
- </table>
87
-
88
-
89
- <figure>
90
-
91
- RIC
92
-
93
- </figure>
94
-
95
-
96
- <!-- PageFooter="biologics" -->
97
- <!-- PageNumber="3" -->
98
- <!-- PageBreak -->
99
-
100
-
101
- <figure>
102
- </figure>
103
-
104
-
105
- Scope
106
-
107
- l This report describes the results of a liability assessment for two Argenx
108
- discovery constructs. Non-stressed and temperature-stressed samples
109
- stored for four weeks at 37℃ were evaluated by reduced protein RPLC-UV-
110
- MS and peptide map analysis.
111
-
112
-
113
- <figure>
114
-
115
- RIC
116
-
117
- </figure>
118
-
119
-
120
- <!-- PageFooter="biologics" -->
121
- <!-- PageNumber="4" -->
122
- <!-- PageBreak -->
123
-
124
-
125
- <figure>
126
- </figure>
127
-
128
-
129
- ## Test samples
130
-
131
- The samples used in this study are listed below
132
-
133
-
134
- <table>
135
- <tr>
136
- <th>Construct</th>
137
- <th>Storage condition</th>
138
- <th>Concentration (mg/ml)</th>
139
- </tr>
140
- <tr>
141
- <td rowspan="2">P052_OA-02A10-GLLiab4His1_0-hIgG1-CH2- CH3-LALAPG-ABDEG-FJB_2024-01-26_002</td>
142
- <td>T0</td>
143
- <td>1.0</td>
144
- </tr>
145
- <tr>
146
- <td>T4w 37°℃</td>
147
- <td>1.0</td>
148
- </tr>
149
- <tr>
150
- <td rowspan="2">P052_OA-02A10-GLLiab4+Liab11-His1_0- hIgG1-CH2-CH3-LALAPG-ABDEG-FJB_2024- 01-26_001</td>
151
- <td>T0</td>
152
- <td>1.0</td>
153
- </tr>
154
- <tr>
155
- <td>T4w 37℃</td>
156
- <td>1.0</td>
157
- </tr>
158
- </table>
159
-
160
-
161
- Note: all antibodies are in an One-Armed (OA) format
162
-
163
-
164
- <figure>
165
-
166
- RIC
167
-
168
- </figure>
169
-
170
-
171
- <!-- PageFooter="biologics" -->
172
- <!-- PageNumber="5" -->
173
- <!-- PageBreak -->
174
-
175
-
176
- <figure>
177
- </figure>
178
-
179
-
180
- ## Method: Protein analysis by RPLC-(UV)-MS
181
-
182
- l The samples were reduced by incubation with DTT while in denaturing
183
- conditions. The samples were analyzed using a C8 RPLC column on a 1290
184
- Infinity UHPLC system coupled to a 6530 Q-TOF mass spectrometer (both
185
- from Agilent Technologies).
186
-
187
- l RPLC was performed with trifluoroacetic acid (TFA) as ion pairing additive,
188
- and with H2O and acetonitrile as mobile phases.
189
-
190
- l Data acquisition and processing were performed with BioConfirm
191
- MassHunter 7.0 (Agilent Technologies). UV 280 nm and MS data were
192
- acquired simultaneously.
193
-
194
-
195
- <figure>
196
-
197
- RIC
198
-
199
- </figure>
200
-
201
-
202
- <!-- PageFooter="biologics" -->
203
- <!-- PageNumber="6" -->
204
- <!-- PageBreak -->
205
-
206
-
207
- <figure>
208
- </figure>
209
-
210
-
211
- ## Method: Peptide map analysis in reducing conditions
212
-
213
- l
214
- Prior to digestion, the samples were reduced using dithiothreitol (DTT), and alkylated
215
- with iodoacetamide (IAA). The samples were digested using trypsin as protease.
216
-
217
- l The digests were analyzed on RPLC-MS using a C18 RPLC column. RPLC was performed
218
- with formic acid (FA) as additive, and with H2O and acetonitrile as mobile phases. The
219
- analyses were performed on a 1290 Infinity UHPLC system (Agilent Technologies) coupled
220
- to a 6540 Q-TOF Mass Spectrometer (Agilent Technologies) operated in MS and MS/MS
221
- mode.
222
-
223
- l Data processing was performed using BioConfirm 10.0 and MassHunter 7.0 (Agilent
224
- Technologies).
225
-
226
- l Measured signals were matched onto the sequence. Identification was based primarily
227
- on MS-only data. Enzyme specified was trypsin (C-terminal cleavage at lysine or arginine)
228
- and 0-2 missed cleavages were allowed. N-terminal cyclization (pyroglutamate from E/Q),
229
- D isomerization, N/Q deamidation, M/W oxidation and N-glycosylation were considered
230
- as variable modifications while cysteine carbamidomethylation (sample preparation
231
- related) was considered as fixed modification. Peak areas from extracted ion
232
- chromatograms (EICs) were used for quantifying modifications.
233
-
234
- l Note that peptide map data processing was focused on the variable regions of the
235
- constructs.
236
-
237
-
238
- <figure>
239
-
240
- RIC
241
-
242
- </figure>
243
-
244
-
245
- biologics
246
-
247
- <!-- PageNumber="7" -->
248
- <!-- PageBreak -->
249
-
250
-
251
- <figure>
252
- </figure>
253
-
254
-
255
- P052_OA-02A10-GLLIAB4HIS1_0-HIGG1-CH2-CH3-LALAPG-ABDEG-
256
- FJB_2024-01-26_002
257
-
258
- <!-- PageBreak -->
259
-
260
-
261
- <figure>
262
- </figure>
263
-
264
-
265
- ## Results: AA sequence
266
-
267
- l
268
-
269
- AA sequence of GLLiab4_Heavy_Knob_LALAPG_ABDEG (MW (G0F): 50740.4 Da)
270
-
271
- EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYVMSWVRQAPGKGLEWVSHIQGGGITSYADSVKGRFTISRDNSKNTLYLQ
272
- MNSLRAEDTAVYYCAKWLVDYGLGNRGSMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV
273
- SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPS
274
- VFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKC
275
- KVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF
276
- FLYSKLTVDKSRWQQGNVFSCSVMHEALKFHYTQKSLSLSPG
277
-
278
- l AA sequence of GLHis1_Light_CL1 (MW (pyroQ): 23646.43 Da)
279
-
280
- QAVLTQPPSLSASPGASARLTCSLSSGTIVHGYHINWYQQKAGSPPRYLLRFYSDSNKHQGSGVPSRFSGSKDASANAGILLIS
281
- GLQPEDEADYYCGTYHSNTGTYVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK
282
- AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
283
-
284
- l AA sequence of CH2_CH3_Hole_LALAPG_ABDEG (MW (G0F) 26719.1 Da)
285
-
286
- DKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRV
287
- VSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNG
288
- QPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALKFHYTQKSLSLS
289
-
290
-
291
- <figure>
292
-
293
- RIC
294
-
295
- <!-- PageFooter="biologics" -->
296
-
297
- </figure>
298
-
299
-
300
- <table>
301
- <tr>
302
- <td>Blue:</td>
303
- <td>VH and VL</td>
304
- </tr>
305
- <tr>
306
- <td>Green:</td>
307
- <td>N-glycosylation site</td>
308
- </tr>
309
- <tr>
310
- <td>Red:</td>
311
- <td>N-terminal cyclization</td>
312
- </tr>
313
- </table>
314
-
315
-
316
- <!-- PageNumber="9" -->
317
- <!-- PageBreak -->
318
-
319
-
320
- <figure>
321
- </figure>
322
-
323
-
324
- ## Results: reduced RPLC-UV-MS
325
-
326
-
327
- ### l
328
-
329
-
330
- #### Overlays of the UV214nm profiles
331
-
332
-
333
- <figure>
334
-
335
- x10 2
336
-
337
- DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P3016_Molecule1_W0_C8_19MAR2024.d
338
-
339
- HC_Knob
340
-
341
- 6.5
342
-
343
- T0
344
-
345
- 6
346
-
347
- T4w 37℃
348
-
349
- x: Unknown fragment (13463 Da)
350
-
351
- 0: GG clip (G144-G452)
352
-
353
- 6
354
-
355
- Hole
356
-
357
- y: Intact LC without pyroQ
358
-
359
- 1: GG clip (G55-G452)
360
-
361
- 5.5
362
-
363
- z: Intact LC (pyroQ) + LC fragments:
364
-
365
- 2: NS clip (73-452)
366
-
367
- 5
368
-
369
- b
370
-
371
- LC
372
-
373
- N terminal Q loss
374
-
375
- 3: - 17 Da (potentially HC +
376
- succinimide)
377
-
378
- C-terminal S loss
379
-
380
- 4.5
381
-
382
- a: M oxidation: Hydroxy-y-lactam
383
-
384
- z
385
-
386
- b: Intact Hole
387
-
388
- C-terminal CS loss
389
-
390
- 4: Traces oxidation (+32 Da)
391
-
392
- 5: Oxidation (+16Da)
393
-
394
- 4
395
-
396
- c: N-terminal DK loss
397
-
398
- 6: Intact HC_knob
399
-
400
- 3.5
401
-
402
- 7: PyroE
403
-
404
- 8: DP clip (E1-D276)
405
-
406
- 3
407
-
408
- 2.5
409
-
410
- 2
411
-
412
- Unknown fragment*
413
-
414
- 7
415
-
416
- 1.5
417
-
418
- 1
419
-
420
- c
421
-
422
- 0.5
423
-
424
- x
425
-
426
- 5
427
-
428
- a
429
-
430
- y
431
-
432
- 0
433
-
434
- 1
435
-
436
- 2
437
-
438
- 3
439
-
440
- 4
441
-
442
- 8
443
-
444
- 0
445
-
446
- 2
447
-
448
- 3
449
-
450
- 4
451
-
452
- 5
453
-
454
- 6
455
-
456
- 7
457
-
458
- 8
459
-
460
- 9
461
-
462
- 10
463
-
464
- Response Units vs. Acquisition Time (min)
465
-
466
- 11
467
-
468
- 12
469
-
470
- 13
471
-
472
- 14
473
-
474
- 15
475
-
476
- 16
477
-
478
- 17
479
-
480
- 18
481
-
482
- 19
483
-
484
- 20
485
-
486
- 21
487
-
488
- 22
489
-
490
- 23
491
-
492
- 24
493
-
494
- </figure>
495
-
496
- \* No MS data for this peak (falls outside the
497
- measurement window)
498
-
499
- Color legend:
500
-
501
- Black: clear identity on RPLC-UV-MS
502
-
503
- Blue: modification with clear trend visible on RPLC-UV-MS
504
- Blue: modification in variable region also confirmed in peptide
505
- mapping
506
-
507
-
508
- Grey: most likely method induced modification
509
-
510
-
511
- <figure>
512
- </figure>
513
-
514
-
515
- RIC
516
-
517
- <!-- PageFooter="biologics" -->
518
- <!-- PageNumber="10" -->
519
- <!-- PageBreak -->
520
-
521
-
522
- <figure>
523
- </figure>
524
-
525
-
526
- ## Results: reduced RPLC-UV-MS
527
-
528
-
529
- ### l Deconvoluted spectra of Hole, LC and HC_Knob (peak b, peak z and peak 6)
530
-
531
- ×10 6
532
-
533
- +ESI Scan (rt: 9.2-10.1 min, 89 scans) Frag=200.0V P3016_Molecule1_W0_C8_19MAR2024.d Deconvoluted (Isotope Width=10.0)
534
-
535
- 1.25
536
-
537
- 26717.06
538
-
539
- Theoretical mass Hole (G0F): 26719.1 Da
540
-
541
- 1
542
-
543
- 0.75
544
-
545
- 0.5
546
-
547
- 0.25
548
-
549
- 0
550
-
551
- 21343.69
552
-
553
- LL
554
-
555
- 32883.11
556
-
557
- +ESI Scan (rt: 12.9-13.5 min, 60 scans) Frag=200.0V P3016_Molecule1_W0_C8_19MAR2024.d Deconvoluted (Isotope Width=10.0)
558
-
559
- ×10 6
560
-
561
- 2.5
562
-
563
- 23644.69
564
-
565
- Theoretical mass LC (pyroQ): 23646.4 Da
566
-
567
- 2
568
-
569
- 1.5
570
-
571
- 1
572
-
573
- 0.5
574
-
575
- 15375.35
576
-
577
- 25932.56
578
-
579
- 30286.33
580
-
581
- 0
582
-
583
- x10 5
584
-
585
- +ESI Scan (rt: 16.4-21.6 min, 519 scans) Frag=200.0V P3016_Molecule1_W0_C8_19MAR2024.d Deconvoluted (Isotope Width=14.1)
586
-
587
-
588
- <figure>
589
-
590
- Theoretical mass HC_knob (G0F): 50740.4 Da
591
-
592
- 50736.55
593
-
594
- 0.8
595
-
596
- 0.6
597
-
598
- 0.4
599
-
600
- 0.2
601
-
602
- 0
603
-
604
- 43809.72
605
-
606
- 58410.62
607
-
608
- 10000
609
-
610
- 12500
611
-
612
- 15000
613
-
614
- 17500
615
-
616
- 20000
617
-
618
- 22500
619
-
620
- 25000
621
-
622
- 27500 30000
623
-
624
- 32500 35000 375
625
- 37500
626
-
627
- Counts vs. Deconvoluted Mass (amu)
628
-
629
- 40000
630
-
631
- 42500
632
-
633
- 45000
634
-
635
- 47500
636
-
637
- 50000
638
-
639
- 52500
640
-
641
- 55000
642
-
643
- 57500
644
-
645
- 60000
646
-
647
- </figure>
648
-
649
-
650
- <figure>
651
-
652
- RIC
653
-
654
- </figure>
655
-
656
-
657
- <!-- PageFooter="biologics" -->
658
- <!-- PageNumber="11" -->
659
- <!-- PageBreak -->
660
-
661
-
662
- <figure>
663
- </figure>
664
-
665
-
666
- ## Results: tryptic peptide map
667
-
668
-
669
- ### l N-terminal and C-terminal modifications for HC_Knob and LC
670
-
671
-
672
- <table>
673
- <tr>
674
- <th colspan="5">Relative quantification by EIC (%)</th>
675
- </tr>
676
- <tr>
677
- <th>AA Sequence</th>
678
- <th>Seq Loc</th>
679
- <th>Modification</th>
680
- <th>T0</th>
681
- <th>T4w37℃</th>
682
- </tr>
683
- <tr>
684
- <td rowspan="2">EVOLVESGGGLVQPGGSLR</td>
685
- <td rowspan="2">HC(1-19)</td>
686
- <td></td>
687
- <td>98.8</td>
688
- <td>89.1</td>
689
- </tr>
690
- <tr>
691
- <td>PyroE</td>
692
- <td>1.2</td>
693
- <td>10.9</td>
694
- </tr>
695
- <tr>
696
- <td rowspan="3">QAVLTQPPSLSASPGASAR</td>
697
- <td rowspan="3">LC(1-19)</td>
698
- <td></td>
699
- <td>3.3</td>
700
- <td>0.0</td>
701
- </tr>
702
- <tr>
703
- <td>PyroQ</td>
704
- <td>96.7</td>
705
- <td>99.7</td>
706
- </tr>
707
- <tr>
708
- <td>N terminal Q loss</td>
709
- <td>0.0</td>
710
- <td>0.3</td>
711
- </tr>
712
- <tr>
713
- <td rowspan="3">TVAPTECS</td>
714
- <td rowspan="3">LC(216-223)</td>
715
- <td></td>
716
- <td>100.0</td>
717
- <td>99.6</td>
718
- </tr>
719
- <tr>
720
- <td>S loss</td>
721
- <td>0.0</td>
722
- <td>0.2</td>
723
- </tr>
724
- <tr>
725
- <td>CS loss</td>
726
- <td>0.0</td>
727
- <td>0.2</td>
728
- </tr>
729
- </table>
730
-
731
-
732
- For information purposes the following color code is applied: Values showing an increase or decrease by
733
- between 1.0% to 10.0% compared to T0 sample are in blue and underlined, whereas values showing an
734
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
735
-
736
-
737
- <figure>
738
-
739
- RIC
740
-
741
- </figure>
742
-
743
-
744
- <!-- PageFooter="biologics" -->
745
- <!-- PageNumber="12" -->
746
- <!-- PageBreak -->
747
-
748
-
749
- <figure>
750
- </figure>
751
-
752
-
753
- ## Results: tryptic peptide map
754
-
755
-
756
- ### l M/W oxidations in variable parts of HC_Knob and LC
757
-
758
-
759
- <table>
760
- <tr>
761
- <th colspan="5">Relative quantification by EIC (%)</th>
762
- </tr>
763
- <tr>
764
- <th>AA Sequence</th>
765
- <th>Seq Loc</th>
766
- <th>Modification</th>
767
- <th>T0</th>
768
- <th>T4w37℃</th>
769
- </tr>
770
- <tr>
771
- <td rowspan="2">LSCAASGFTFSSYVMSWVR</td>
772
- <td rowspan="2">HC(20-38)</td>
773
- <td></td>
774
- <td>97.1</td>
775
- <td>96.1</td>
776
- </tr>
777
- <tr>
778
- <td>Oxidation</td>
779
- <td>2.9</td>
780
- <td>3.9</td>
781
- </tr>
782
- <tr>
783
- <td rowspan="2">NTLYLQMNSLR</td>
784
- <td rowspan="2">HC(76-86)</td>
785
- <td></td>
786
- <td>98.3</td>
787
- <td>97.8</td>
788
- </tr>
789
- <tr>
790
- <td>Oxidation</td>
791
- <td>1.7</td>
792
- <td>2.2</td>
793
- </tr>
794
- <tr>
795
- <td rowspan="4">WLVDYGLGNR</td>
796
- <td rowspan="4">HC (098-107)</td>
797
- <td></td>
798
- <td>100.0</td>
799
- <td>97.2</td>
800
- </tr>
801
- <tr>
802
- <td>Oxidation</td>
803
- <td>0.0</td>
804
- <td>0.8</td>
805
- </tr>
806
- <tr>
807
- <td>Double oxidation</td>
808
- <td>0.0</td>
809
- <td>0.5</td>
810
- </tr>
811
- <tr>
812
- <td>+ 4 (Kynurenine)</td>
813
- <td>0.0</td>
814
- <td>1.5</td>
815
- </tr>
816
- <tr>
817
- <td rowspan="2">GSMDYWGQGTTVTVSSASTK</td>
818
- <td rowspan="2">HC(108-127)</td>
819
- <td></td>
820
- <td>97.1</td>
821
- <td>96.2</td>
822
- </tr>
823
- <tr>
824
- <td>Oxidation</td>
825
- <td>3.1</td>
826
- <td>4.3</td>
827
- </tr>
828
- </table>
829
-
830
-
831
- For information purposes the following color code is applied: Values showing an increase or decrease by
832
- between 1.0% to 10.0% compared to T0 sample are in blue and underlined, whereas values showing an
833
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
834
-
835
-
836
- <figure>
837
-
838
- RIC
839
-
840
- biologics
841
-
842
- </figure>
843
-
844
-
845
- <!-- PageNumber="13" -->
846
- <!-- PageBreak -->
847
-
848
-
849
- <figure>
850
- </figure>
851
-
852
-
853
- ## Results: tryptic peptide map
854
-
855
-
856
- ### l N/Q deamidation in variable parts of HC_Knob and LC
857
-
858
-
859
- <table>
860
- <tr>
861
- <th colspan="5">Relative quantification by EIC (%)</th>
862
- </tr>
863
- <tr>
864
- <th>AA Sequence</th>
865
- <th>Seq Loc</th>
866
- <th>Modification</th>
867
- <th>T0</th>
868
- <th>T4w 37℃</th>
869
- </tr>
870
- <tr>
871
- <td rowspan="2">GLEWVSHIQGGGITSYADSVK</td>
872
- <td rowspan="2">HC(44-64)</td>
873
- <td></td>
874
- <td>99.4</td>
875
- <td>96.3</td>
876
- </tr>
877
- <tr>
878
- <td>deamidation</td>
879
- <td>0.6</td>
880
- <td>3.7</td>
881
- </tr>
882
- <tr>
883
- <td rowspan="2">DNSKNTLYLQMNSLR*</td>
884
- <td rowspan="2">HC(72-86)</td>
885
- <td></td>
886
- <td>98.6</td>
887
- <td>98.5</td>
888
- </tr>
889
- <tr>
890
- <td>deamidation</td>
891
- <td>1.4</td>
892
- <td>1.5</td>
893
- </tr>
894
- <tr>
895
- <td rowspan="2">NTLYLQMNSLR</td>
896
- <td rowspan="2">HC(76-86)</td>
897
- <td></td>
898
- <td>99.2</td>
899
- <td>99.1</td>
900
- </tr>
901
- <tr>
902
- <td>deamidation</td>
903
- <td>0.8</td>
904
- <td>0.9</td>
905
- </tr>
906
- <tr>
907
- <td rowspan="2">WLVDYGLGNR</td>
908
- <td rowspan="2">HC(98-107)</td>
909
- <td></td>
910
- <td>99.8</td>
911
- <td>98.6</td>
912
- </tr>
913
- <tr>
914
- <td>deamidation</td>
915
- <td>0.2</td>
916
- <td>1.4</td>
917
- </tr>
918
- <tr>
919
- <td rowspan="2">DASANAGILLISGLQPEDEADYYCGTYHSNT GTYVFGGGTK</td>
920
- <td rowspan="2">LC(73-113)</td>
921
- <td></td>
922
- <td>97.7</td>
923
- <td>95.9</td>
924
- </tr>
925
- <tr>
926
- <td>deamidation</td>
927
- <td>2.3</td>
928
- <td>4.1</td>
929
- </tr>
930
- </table>
931
-
932
- *The deamidation level on the misscleaved peptide was checked as the peptide DNSK has bad retention to have a reliable
933
- quantification. However, the misscleaved peptide has low abundance which can also lead to unreliable quantification of
934
- modifications.
935
-
936
-
937
- <figure>
938
-
939
- RIC
940
-
941
- </figure>
942
-
943
-
944
- biologics
945
-
946
- For information purposes the following color code is applied: Values showing an increase or decrease by
947
- between 1.0% to 10.0% compared to T0 sample are in blue and underlined, whereas values showing an
948
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
949
-
950
- <!-- PageNumber="14" -->
951
- <!-- PageBreak -->
952
-
953
-
954
- <figure>
955
- </figure>
956
-
957
-
958
- ## Results: tryptic peptide map
959
-
960
-
961
- ### l Isomerization events in variable parts of HC_Knob and LC
962
-
963
-
964
- <table>
965
- <tr>
966
- <th colspan="5">Relative quantification by EIC (%)</th>
967
- </tr>
968
- <tr>
969
- <th>AA Sequence</th>
970
- <th>Seq Loc</th>
971
- <th>Modification</th>
972
- <th>T0</th>
973
- <th>T4w 37℃</th>
974
- </tr>
975
- <tr>
976
- <td rowspan="2">WLVDYGLGNR</td>
977
- <td rowspan="2">HC(98-107)</td>
978
- <td></td>
979
- <td>99.7</td>
980
- <td>97.5</td>
981
- </tr>
982
- <tr>
983
- <td>isomerization</td>
984
- <td>0.3</td>
985
- <td>2.5</td>
986
- </tr>
987
- </table>
988
-
989
-
990
- For information purposes the following color code is applied: Values showing an increase or decrease by
991
- between 1.0% to 10.0% compared to T0 sample are in blue and underlined, whereas values showing an
992
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
993
-
994
-
995
- <figure>
996
-
997
- RIC
998
-
999
- </figure>
1000
-
1001
-
1002
- biologics
1003
-
1004
- <!-- PageNumber="15" -->
1005
- <!-- PageBreak -->
1006
-
1007
-
1008
- <figure>
1009
- </figure>
1010
-
1011
-
1012
- ## Results: tryptic peptide map
1013
-
1014
-
1015
- ### l Clipping events in variable parts of HC_Knob and LC
1016
-
1017
-
1018
- <table>
1019
- <tr>
1020
- <th colspan="5">Relative quantification by EIC (%)</th>
1021
- </tr>
1022
- <tr>
1023
- <th>AA Sequence</th>
1024
- <th>Seq Loc</th>
1025
- <th>Modification</th>
1026
- <th>T0</th>
1027
- <th>T4w 37℃</th>
1028
- </tr>
1029
- <tr>
1030
- <td>GLEWVSHIQGGGITSYADSVK</td>
1031
- <td>HC(44-64)</td>
1032
- <td></td>
1033
- <td>100.0</td>
1034
- <td>99.7</td>
1035
- </tr>
1036
- <tr>
1037
- <td>GLEWVSHIQGG</td>
1038
- <td>HC(44-54)</td>
1039
- <td rowspan="2">GG clip</td>
1040
- <td>0.0</td>
1041
- <td>0.3*</td>
1042
- </tr>
1043
- <tr>
1044
- <td>GITSYADSVK</td>
1045
- <td>HC(55-64)</td>
1046
- <td>0.0</td>
1047
- <td>0.8*</td>
1048
- </tr>
1049
- </table>
1050
-
1051
- *Due to differences in ionization efficiency between small and large peptides, the level of clipping reported here is most
1052
- likely an overestimation.
1053
-
1054
-
1055
- For information purposes the following color code is applied: Values showing an increase or decrease by
1056
- between 1.0% to 10.0% compared to T0 sample are in blue and underlined, whereas values showing an
1057
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
1058
-
1059
-
1060
- <figure>
1061
-
1062
- RIC
1063
-
1064
- </figure>
1065
-
1066
-
1067
- <!-- PageFooter="biologics" -->
1068
- <!-- PageNumber="16" -->
1069
- <!-- PageBreak -->
1070
-
1071
-
1072
- <figure>
1073
- </figure>
1074
-
1075
-
1076
- ## Conclusions
1077
-
1078
- l A potential unidentified clipping event may be present. Two peaks were present in the RPLC-UV-
1079
- MS profile for which no identity was found. One peak (RT around 12 min) had a clear mass of
1080
- 13463 Da, while no mass could be retrieved for the second peak (RT around 3 min). Further
1081
- experiments are required to find the origin of the unknown peaks.
1082
- A less abundant clipping was found between G143G14 which falls just outside the variable region of
1083
- HC_Knob but for sure may impact the functionality. Another clipping, this time in the variable
1084
- region, was found between G54G55 . This clipping was confirmed via peptide mapping in the
1085
- stressed sample in low amounts: < 1%.
1086
-
1087
- l Cyclization of the N-terminal glutamate on the HC_knob increased up to 10.9% during temperature
1088
- stress (both present in RPLC-UV-MS and peptide map). Cyclization of the N-terminus on the LC
1089
- reached completion after storage for four weeks at 37℃.
1090
-
1091
- l In addition, tryptic peptide peaks containing oxidation were found in the variable regions.
1092
- Especially for W98 located on the HC_knob where the oxidation levels increased up to 2.8% after
1093
- four weeks storage at 37℃. A second relevant increase in oxidation levels during the 4 weeks
1094
- storage was found for HC(108-127): from 3.1 to 4.3%.
1095
-
1096
- l Deamidation events on the HC_knob were limited, the largest increase was found for peptide
1097
- HC(44-64) from 0.5% up to 3.7% over the 4 weeks storage. Another relevant increase in
1098
- deamidation was found on LC(73-113) from 2.3 to 4.1%.
1099
-
1100
- l In only one peptide, associated with the variable region, isomerization was observed. This in
1101
- peptide HC(98-107): up to 2.5%.
1102
-
1103
-
1104
- <figure>
1105
-
1106
- RIC
1107
-
1108
- <!-- PageFooter="biologics" -->
1109
-
1110
- </figure>
1111
-
1112
-
1113
- <!-- PageNumber="17" -->
1114
- <!-- PageBreak -->
1115
-
1116
-
1117
- <figure>
1118
- </figure>
1119
-
1120
-
1121
- P052_OA-02A10-GLLIAB4+LIAB11-His1_0-HIGG1-CH2-CH3-LALAPG-
1122
- ABDEG-FJB_2024-01-26_001
1123
-
1124
- <!-- PageBreak -->
1125
-
1126
-
1127
- <figure>
1128
- </figure>
1129
-
1130
-
1131
- ### Results: AA sequence
1132
-
1133
- l AA sequence of GLLiab4+11_Heavy_Knob_LALAPG_ABDEG (MW (G0F): 50768.4
1134
- Da)
1135
-
1136
- EVOLVESGGGLVQPGGSLRLSCAASGFTFSSYVMSWVRQAPGKGLEWVSHIQGGGITSYADSVKGRATISRDNSKNTLYLQ
1137
- MNSLRAEDTAVYYCARWLVDYGLGNRGSMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV
1138
- SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPS
1139
- VFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKC
1140
- KVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF
1141
- FLYSKLTVDKSRWQQGNVFSCSVMHEALKFHYTQKSLSLSPG
1142
-
1143
- l AA sequence of GLHis1_Light_CL1 (MW (pyroQ): 23646.4Da)
1144
-
1145
- QAVLTQPPSLSASPGASARLTCSLSSGTIVHGYHINWYQQKAGSPPRYLLRFYSDSNKHQGSGVPSRFSGSKDASANAGILLIS
1146
- GLQPEDEADYYCGTYHSNTGTYVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK
1147
- AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
1148
-
1149
- l AA sequence of CH2_CH3_Hole_LALAPG_ABDEG (MW (G0F) 26719.1 Da)
1150
-
1151
- DKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRV
1152
- VSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNG
1153
- QPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALKFHYTQKSLSLSPG
1154
-
1155
-
1156
- <figure>
1157
- </figure>
1158
-
1159
-
1160
- RIC
1161
-
1162
- biologics
1163
-
1164
-
1165
- <table>
1166
- <tr>
1167
- <td>Blue:</td>
1168
- <td>VH and VL</td>
1169
- </tr>
1170
- <tr>
1171
- <td>Green:</td>
1172
- <td>N-glycosylation site 19</td>
1173
- </tr>
1174
- <tr>
1175
- <td>Red:</td>
1176
- <td>N-terminal cyclization</td>
1177
- </tr>
1178
- </table>
1179
-
1180
-
1181
- <!-- PageBreak -->
1182
-
1183
-
1184
- <figure>
1185
- </figure>
1186
-
1187
-
1188
- ### Results: reduced RPLC-UV-MS
1189
-
1190
- l Overlays of the UV214nm profiles P052_OA-02A10-GLLiab4+Liab11-His1_0-
1191
- hIgG1-CH2-CH3-LALAPG-ABDEG-FJB_2024-01-26_001
1192
-
1193
-
1194
- <figure>
1195
-
1196
- ×10 2
1197
-
1198
- DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P3016_Molecule2_W0_C8_19MAR2024.d
1199
-
1200
- HC_Knob
1201
-
1202
- 6.5
1203
-
1204
- T0
1205
-
1206
- 6
1207
-
1208
- T4w 37℃
1209
-
1210
- 6
1211
-
1212
- x: Unknown fragment (13463 Da)
1213
-
1214
- 0: GG clip (G144-G452)
1215
-
1216
- y: Intact LC without pyroQ
1217
-
1218
- 1: GG clip (G55-G452)
1219
-
1220
- 5.5
1221
-
1222
- Hole
1223
-
1224
- z: Intact LC (pyroQ) + LC fragments:
1225
-
1226
- 2: unknown
1227
-
1228
- 5
1229
-
1230
- b
1231
-
1232
- LC
1233
-
1234
- N terminal Q loss
1235
-
1236
- 3: - 17 Da (potentially HC +
1237
- succinimide)
1238
-
1239
- 4.5
1240
-
1241
- a: Hydroxy-y-lactam oxidation
1242
-
1243
- C-terminal S loss
1244
-
1245
- z
1246
-
1247
- b: Intact Hole
1248
-
1249
- C-terminal CS loss
1250
-
1251
- 4: Traces of Oxidation (+32 Da)
1252
-
1253
- 4
1254
-
1255
- c: N-terminal DK loss
1256
-
1257
- 5: Oxidation (+16Da)
1258
-
1259
- 6: Intact HC_knob
1260
-
1261
- 3.5
1262
-
1263
- 7: PyroE
1264
-
1265
- 3
1266
-
1267
- 8: DP clip (E1-D276)
1268
-
1269
- 2.5
1270
-
1271
- 2
1272
-
1273
- 1.5
1274
-
1275
- Unknown fragment*
1276
-
1277
- 7
1278
-
1279
- 1
1280
-
1281
- 5
1282
-
1283
- c
1284
-
1285
- 0.5
1286
-
1287
- x
1288
-
1289
- a
1290
-
1291
- y
1292
-
1293
- 0
1294
-
1295
- 3
1296
-
1297
- 4
1298
-
1299
- 1
1300
-
1301
- 2
1302
-
1303
- 8
1304
-
1305
- 0
1306
-
1307
- 2
1308
-
1309
- 3
1310
-
1311
- 4
1312
-
1313
- 5
1314
-
1315
- 6
1316
-
1317
- 7
1318
-
1319
- 8
1320
-
1321
- 9
1322
-
1323
- 10
1324
-
1325
- Response Units vs. Acquisition Time (min)
1326
-
1327
- 11
1328
-
1329
- 12
1330
-
1331
- 13
1332
-
1333
- 14
1334
-
1335
- 15
1336
-
1337
- 16
1338
-
1339
- 17
1340
-
1341
- 18
1342
-
1343
- 19
1344
-
1345
- 20
1346
-
1347
- 21
1348
-
1349
- 22
1350
-
1351
- 23
1352
-
1353
- 24
1354
-
1355
- Color legend:
1356
-
1357
- </figure>
1358
-
1359
- \* No MS data for this peak (falls outside the
1360
- measurement window)
1361
-
1362
- Black: clear identity on RPLC-UV-MS
1363
-
1364
- Blue: modification with clear trend visible on RPLC-UV-MS
1365
- Blue: modification in variable region also confirmed in peptide
1366
- mapping
1367
-
1368
- Grey: most likely method induced modification
1369
-
1370
-
1371
- <figure>
1372
- </figure>
1373
-
1374
-
1375
- RIC
1376
-
1377
- biologics
1378
-
1379
- <!-- PageNumber="20" -->
1380
- <!-- PageBreak -->
1381
-
1382
-
1383
- <figure>
1384
- </figure>
1385
-
1386
-
1387
- ## Results: reduced RPLC-UV-MS
1388
-
1389
-
1390
- ### l Deconvoluted spectra of Hole, LC and HC_Knob (peak b, peak z and peak 6)
1391
-
1392
- ×10 6
1393
-
1394
- +ESI Scan (rt: 9.2-10.2 min, 103 scans) Frag=200.0V P3016_Molecule2_W0_C8_19MAR2024.d Deconvoluted (Isotope Width=10.0)
1395
-
1396
- 26717.00
1397
-
1398
- Theoretical mass Hole (G0F): 26719.1 Da
1399
-
1400
- 1
1401
-
1402
- 0.8
1403
-
1404
- 0.6
1405
-
1406
- 0.4
1407
-
1408
- 0.2
1409
-
1410
- 0
1411
-
1412
- 21343.73
1413
-
1414
- 32956.97
1415
-
1416
- +ESI Scan (rt: 12.8-13.7 min, 91 scans) Frag=200.0V P3016_Molecule2_W0_C8_19MAR2024.d Deconvoluted (Isotope Width=10.0)
1417
-
1418
- x10 6
1419
-
1420
- 1.5
1421
-
1422
- 1.25
1423
-
1424
- 1
1425
-
1426
- 0.75
1427
-
1428
- 0.5
1429
-
1430
- 0.25
1431
-
1432
- 0
1433
-
1434
- x10 5
1435
-
1436
- 17938.20
1437
-
1438
- 25795.40
1439
-
1440
- 30285.87
1441
-
1442
- 23644.57
1443
-
1444
- Theoretical mass LC (pyroQ): 23646.43 Da
1445
-
1446
- +ESI Scan (rt: 16.5-21.2 min, 467 scans) Frag=200.0V P3016_Molecule2_W0_C8_19MAR2024.d Deconvoluted (Isotope Width=14.1)
1447
-
1448
-
1449
- <figure>
1450
-
1451
- 1
1452
-
1453
- Theoretical mass HC_knob (G0F): 50768.4 Da
1454
-
1455
- 50764.08
1456
-
1457
- 0.8
1458
-
1459
- 0.6
1460
-
1461
- 0.4
1462
-
1463
- 0.2
1464
-
1465
- 0
1466
-
1467
- 43849.21
1468
-
1469
- 53430.56
1470
-
1471
- 58466.31
1472
-
1473
- 10000
1474
-
1475
- 12500
1476
-
1477
- 15000
1478
-
1479
- 17500
1480
-
1481
- 20000
1482
-
1483
- 22500
1484
- 00 25000 2750
1485
-
1486
- 30000 32500 35
1487
- 35000 37500
1488
-
1489
- Counts vs. Deconvoluted Mass (amu)
1490
-
1491
- 42500
1492
-
1493
- 45000
1494
-
1495
- 47500
1496
- 50000
1497
-
1498
- 52500
1499
-
1500
- 55000
1501
-
1502
- 57500
1503
-
1504
- 60000
1505
-
1506
- </figure>
1507
-
1508
-
1509
- <figure>
1510
-
1511
- RIC
1512
-
1513
- </figure>
1514
-
1515
-
1516
- <!-- PageFooter="biologics" -->
1517
- <!-- PageNumber="21" -->
1518
- <!-- PageBreak -->
1519
-
1520
-
1521
- <figure>
1522
- </figure>
1523
-
1524
-
1525
- ## Results: tryptic peptide map
1526
-
1527
-
1528
- ### l N-terminal and C-terminal modifications for HC_Knob and LC
1529
-
1530
-
1531
- <table>
1532
- <tr>
1533
- <th colspan="5">Relative quantification by EIC (%)</th>
1534
- </tr>
1535
- <tr>
1536
- <th>AA Sequence</th>
1537
- <th>Seq Loc</th>
1538
- <th>Modification</th>
1539
- <th>T0</th>
1540
- <th>T4w37℃</th>
1541
- </tr>
1542
- <tr>
1543
- <td rowspan="2">EVOLVESGGGLVQPGGSLR</td>
1544
- <td rowspan="2">HC(1-19)</td>
1545
- <td></td>
1546
- <td>98.6</td>
1547
- <td>88.0</td>
1548
- </tr>
1549
- <tr>
1550
- <td>PyroE</td>
1551
- <td>1.4</td>
1552
- <td>12.0</td>
1553
- </tr>
1554
- <tr>
1555
- <td rowspan="3">QAVLTQPPSLSASPGASAR</td>
1556
- <td rowspan="3">LC(1-19)</td>
1557
- <td></td>
1558
- <td>3.5</td>
1559
- <td>0</td>
1560
- </tr>
1561
- <tr>
1562
- <td>PyroQ</td>
1563
- <td>96.5</td>
1564
- <td>99.8</td>
1565
- </tr>
1566
- <tr>
1567
- <td>N terminal Q loss</td>
1568
- <td>0.0</td>
1569
- <td>0.2</td>
1570
- </tr>
1571
- <tr>
1572
- <td rowspan="3">TVAPTECS</td>
1573
- <td rowspan="3">LC(216-223)</td>
1574
- <td></td>
1575
- <td>100.0</td>
1576
- <td>99.6</td>
1577
- </tr>
1578
- <tr>
1579
- <td>S loss</td>
1580
- <td>0.0</td>
1581
- <td>0.2</td>
1582
- </tr>
1583
- <tr>
1584
- <td>CS loss</td>
1585
- <td>0.0</td>
1586
- <td>0.2</td>
1587
- </tr>
1588
- </table>
1589
-
1590
-
1591
- For information purposes the following color code is applied: Values showing an increase or decrease by
1592
- between 1.0% to 10.0% compared to T0 sample are in blue and underlined, whereas values showing an
1593
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
1594
-
1595
-
1596
- <figure>
1597
-
1598
- RIC
1599
-
1600
- </figure>
1601
-
1602
-
1603
- <!-- PageFooter="biologics" -->
1604
- <!-- PageNumber="22" -->
1605
- <!-- PageBreak -->
1606
-
1607
-
1608
- <figure>
1609
- </figure>
1610
-
1611
-
1612
- ## Results: tryptic peptide map
1613
-
1614
-
1615
- ### l M/W oxidations in variable parts of HC_Knob and LC
1616
-
1617
-
1618
- <table>
1619
- <tr>
1620
- <th colspan="5">Relative quantification by EIC (%)</th>
1621
- </tr>
1622
- <tr>
1623
- <th>AA Sequence</th>
1624
- <th>Seq Loc</th>
1625
- <th>Modification</th>
1626
- <th>T0</th>
1627
- <th>T4w37℃</th>
1628
- </tr>
1629
- <tr>
1630
- <td rowspan="2">LSCAASGFTFSSYVMSWVR</td>
1631
- <td rowspan="2">HC(20-38)</td>
1632
- <td></td>
1633
- <td>97.1</td>
1634
- <td>95.9</td>
1635
- </tr>
1636
- <tr>
1637
- <td>Oxidation</td>
1638
- <td>2.9</td>
1639
- <td>4.1</td>
1640
- </tr>
1641
- <tr>
1642
- <td rowspan="2">NTLYLQMNSLR</td>
1643
- <td rowspan="2">HC(76-86)</td>
1644
- <td></td>
1645
- <td>98.4</td>
1646
- <td>97.8</td>
1647
- </tr>
1648
- <tr>
1649
- <td>Oxidation</td>
1650
- <td>1.6</td>
1651
- <td>2.2</td>
1652
- </tr>
1653
- <tr>
1654
- <td rowspan="4">WLVDYGLGNR</td>
1655
- <td rowspan="4">HC (098-107)</td>
1656
- <td></td>
1657
- <td>100.0</td>
1658
- <td>93.2</td>
1659
- </tr>
1660
- <tr>
1661
- <td>Oxidation</td>
1662
- <td>0.0</td>
1663
- <td>2.2</td>
1664
- </tr>
1665
- <tr>
1666
- <td>Double oxidation</td>
1667
- <td>0.0</td>
1668
- <td>2.0</td>
1669
- </tr>
1670
- <tr>
1671
- <td>+ 4 (Kynurenine)</td>
1672
- <td>0.0</td>
1673
- <td>2.7</td>
1674
- </tr>
1675
- <tr>
1676
- <td rowspan="2">GSMDYWGQGTTVTVSSASTK</td>
1677
- <td rowspan="2">HC(108-127)</td>
1678
- <td></td>
1679
- <td>97.1</td>
1680
- <td>96.2</td>
1681
- </tr>
1682
- <tr>
1683
- <td>Oxidation</td>
1684
- <td>2.9</td>
1685
- <td>3.8</td>
1686
- </tr>
1687
- </table>
1688
-
1689
-
1690
- For information purposes the following color code is applied: Values showing an increase or decrease by
1691
- between 1.0% to 10.0% compared to T0 sample are in blue and underlined, whereas values showing an
1692
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
1693
-
1694
-
1695
- <figure>
1696
-
1697
- RIC
1698
-
1699
- biologics
1700
-
1701
- </figure>
1702
-
1703
-
1704
- <!-- PageNumber="23" -->
1705
- <!-- PageBreak -->
1706
-
1707
-
1708
- <figure>
1709
- </figure>
1710
-
1711
-
1712
- ## Results: tryptic peptide map
1713
-
1714
-
1715
- ### l
1716
-
1717
-
1718
- #### N/Q deamidation in variable parts of HC_Knob and LC
1719
-
1720
-
1721
- <table>
1722
- <tr>
1723
- <th colspan="5">Relative quantification by EIC (%)</th>
1724
- </tr>
1725
- <tr>
1726
- <th>AA Sequence</th>
1727
- <th>Seq Loc</th>
1728
- <th>Modification</th>
1729
- <th>T0</th>
1730
- <th>T4w 37℃</th>
1731
- </tr>
1732
- <tr>
1733
- <td rowspan="2">GLEWVSHIQGGGITSYADSVK</td>
1734
- <td rowspan="2">HC(44-64)</td>
1735
- <td></td>
1736
- <td>99.4</td>
1737
- <td>96.3</td>
1738
- </tr>
1739
- <tr>
1740
- <td>deamidation</td>
1741
- <td>0.6</td>
1742
- <td>3.7</td>
1743
- </tr>
1744
- <tr>
1745
- <td rowspan="2">DNSKNTLYLQMNSLR*</td>
1746
- <td rowspan="2">HC(72-86)</td>
1747
- <td></td>
1748
- <td>98.1</td>
1749
- <td>98.5</td>
1750
- </tr>
1751
- <tr>
1752
- <td>deamidation</td>
1753
- <td>1.9</td>
1754
- <td>1.5</td>
1755
- </tr>
1756
- <tr>
1757
- <td rowspan="2">NTLYLQMNSLR</td>
1758
- <td rowspan="2">HC(76-86)</td>
1759
- <td></td>
1760
- <td>99.7</td>
1761
- <td>99.0</td>
1762
- </tr>
1763
- <tr>
1764
- <td>deamidation</td>
1765
- <td>0.3</td>
1766
- <td>1.0</td>
1767
- </tr>
1768
- <tr>
1769
- <td rowspan="2">WLVDYGLGNR</td>
1770
- <td rowspan="2">HC(98-107)</td>
1771
- <td></td>
1772
- <td>99.8</td>
1773
- <td>99.0</td>
1774
- </tr>
1775
- <tr>
1776
- <td>deamidation</td>
1777
- <td>0.2</td>
1778
- <td>1.0</td>
1779
- </tr>
1780
- <tr>
1781
- <td rowspan="2">DASANAGILLISGLQPEDEADYYCGTYHSNT GTYVFGGGTK</td>
1782
- <td rowspan="2">LC(73-113)</td>
1783
- <td></td>
1784
- <td>97.5</td>
1785
- <td>95.4</td>
1786
- </tr>
1787
- <tr>
1788
- <td>deamidation</td>
1789
- <td>2.5</td>
1790
- <td>4.6</td>
1791
- </tr>
1792
- </table>
1793
-
1794
- *The deamidation level on the misscleaved peptide was checked as the peptide DNSK has bad retention to have a reliable
1795
- quantification. However, the misscleaved peptide has low abundance which can also lead to unreliable quantification of
1796
- modifications
1797
-
1798
-
1799
- <figure>
1800
-
1801
- RIC
1802
-
1803
- </figure>
1804
-
1805
-
1806
- biologics
1807
-
1808
- For information purposes the following color code is applied: Values showing an increase or decrease by
1809
- between 1.0% to 10.0% compared to T0 sample are in blue and underlined, whereas values showing an
1810
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
1811
-
1812
- <!-- PageNumber="24" -->
1813
- <!-- PageBreak -->
1814
-
1815
-
1816
- <figure>
1817
- </figure>
1818
-
1819
-
1820
- ## Results: tryptic peptide map
1821
-
1822
-
1823
- ### l Isomerization events in variable parts of HC_Knob and LC
1824
-
1825
-
1826
- <table>
1827
- <tr>
1828
- <th colspan="5">Relative quantification by EIC (%)</th>
1829
- </tr>
1830
- <tr>
1831
- <th>AA Sequence</th>
1832
- <th>Seq Loc</th>
1833
- <th>Modification</th>
1834
- <th>T0</th>
1835
- <th>T4w 37℃</th>
1836
- </tr>
1837
- <tr>
1838
- <td rowspan="2">WLVDYGLGNR</td>
1839
- <td rowspan="2">HC(98-107)</td>
1840
- <td></td>
1841
- <td>99.5</td>
1842
- <td>95.1</td>
1843
- </tr>
1844
- <tr>
1845
- <td>isomerization</td>
1846
- <td>0.5</td>
1847
- <td>4.9</td>
1848
- </tr>
1849
- </table>
1850
-
1851
-
1852
- For information purposes the following color code is applied: Values showing an increase or decrease by
1853
- between 1.0% to 10.0% compared to T0 sample are in blue and underlined, whereas values showing an
1854
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
1855
-
1856
-
1857
- <figure>
1858
-
1859
- RIC
1860
-
1861
- </figure>
1862
-
1863
-
1864
- biologics
1865
-
1866
- <!-- PageNumber="25" -->
1867
- <!-- PageBreak -->
1868
-
1869
-
1870
- <figure>
1871
- </figure>
1872
-
1873
-
1874
- ## Results: tryptic peptide map
1875
-
1876
-
1877
- ### l Clipping events in variable parts of HC_Knob and LC
1878
-
1879
-
1880
- <table>
1881
- <tr>
1882
- <th colspan="5">Relative quantification by EIC (%)</th>
1883
- </tr>
1884
- <tr>
1885
- <th>AA Sequence</th>
1886
- <th>Seq Loc</th>
1887
- <th>Modification</th>
1888
- <th>T0</th>
1889
- <th>T4w 37℃</th>
1890
- </tr>
1891
- <tr>
1892
- <td>GLEWVSHIQGGGITSYADSVK</td>
1893
- <td>HC(44-64)</td>
1894
- <td></td>
1895
- <td>100.0</td>
1896
- <td>99.7</td>
1897
- </tr>
1898
- <tr>
1899
- <td>GLEWVSHIQGG</td>
1900
- <td>HC(44-54)</td>
1901
- <td rowspan="2">GG clip</td>
1902
- <td>0.0</td>
1903
- <td>0.3*</td>
1904
- </tr>
1905
- <tr>
1906
- <td>GITSYADSVK</td>
1907
- <td>HC(55-64)</td>
1908
- <td>0.0</td>
1909
- <td>0.8*</td>
1910
- </tr>
1911
- </table>
1912
-
1913
- *Due to differences in ionization efficiency between small and large peptides, the level of clipping reported here is most
1914
- likely an overestimation.
1915
-
1916
-
1917
- For information purposes the following color code is applied: Values showing an increase or decrease by
1918
- between 1.0% to 10.0% compared to T0 sample are in blue and underlined, whereas values showing an
1919
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
1920
-
1921
-
1922
- <figure>
1923
-
1924
- RIC
1925
-
1926
- </figure>
1927
-
1928
-
1929
- <!-- PageFooter="biologics" -->
1930
- <!-- PageNumber="26" -->
1931
- <!-- PageBreak -->
1932
-
1933
-
1934
- <figure>
1935
- </figure>
1936
-
1937
-
1938
- ## Conclusions
1939
-
1940
- l A potential unidentified clipping event may be present. Two peaks were present in the RPLC-UV-
1941
- MS profile for which no identity was found. One peak (RT around 12 min) had a clear mass of
1942
- 13463 Da, while no mass could be retrieved for the second peak (RT around 3 min). Further
1943
- experiments are required to find the origin of the unknown peaks.
1944
- A less abundant clipping was found between G143G14 which falls just outside the variable region of
1945
- HC_Knob but for sure may impact the functionality. Another clipping, this time in the variable
1946
- region, was found between G54G55 . This clipping was confirmed via peptide mapping in the
1947
- stressed sample in low amounts: < 1%.
1948
-
1949
- l Cyclization of the N-terminal glutamate on the HC_knob increased up to 12.0% during temperature
1950
- stress (both present in RPLC-UV-MS and peptide map). Cyclization of the N-terminus on the LC
1951
- reached completion after storage for four weeks at 37℃.
1952
-
1953
- l In addition, tryptic peptide peaks containing oxidation were found in the variable regions.
1954
- Especially for Wgg located on the HC_knob where the oxidation levels increased up to 6.9% after
1955
- four weeks storage at 37℃. A second relevant increase in oxidation levels during the 4 weeks
1956
- storage was found for HC(20-38): from 2.9 to 4.1%.
1957
-
1958
- l Deamidation events on the HC_knob were limited, the largest increase was found for peptide
1959
- HC(44-64) from 0.6% up to 3.7% over the 4 weeks storage. Another relevant increase in
1960
- deamidation was found on LC(73-113) from 2.5 to 4.6%.
1961
-
1962
- l In only one peptide, associated with the variable region, isomerization was observed. This in
1963
- peptide HC(98-107): up to 4.9%.
1964
-
1965
-
1966
- <figure>
1967
-
1968
- RIC
1969
-
1970
- <!-- PageFooter="biologics" -->
1971
-
1972
- </figure>
1973
-
1974
-
1975
- <!-- PageNumber="27" -->
1976
- <!-- PageBreak -->
1977
-
1978
-
1979
- <figure>
1980
- </figure>
1981
-
1982
-
1983
- ### Signature section RIC
1984
-
1985
-
1986
- #### Author
1987
-
1988
-
1989
- <table>
1990
- <tr>
1991
- <th>Nathan Cardon</th>
1992
- <th>Date:</th>
1993
- <th>14-MAY-2024</th>
1994
- </tr>
1995
- <tr>
1996
- <td>Sr Research Associate | Project Responsible</td>
1997
- <td>Signature:</td>
1998
- <td></td>
1999
- </tr>
2000
- <tr>
2001
- <td colspan="3">Reviewer</td>
2002
- </tr>
2003
- <tr>
2004
- <td>Gianni Vandenborre Ph.D.</td>
2005
- <td>Date:</td>
2006
- <td>14-MAY-2024</td>
2007
- </tr>
2008
- <tr>
2009
- <td>Sr Scientist</td>
2010
- <td>Signature:</td>
2011
- <td></td>
2012
- </tr>
2013
- <tr>
2014
- <td>Mabelle Meersseman</td>
2015
- <td>Date:</td>
2016
- <td>15-MAY-2024</td>
2017
- </tr>
2018
- <tr>
2019
- <td>Group Leader</td>
2020
- <td>Signature:</td>
2021
- <td></td>
2022
- </tr>
2023
- <tr>
2024
- <td colspan="3">Approver</td>
2025
- </tr>
2026
- <tr>
2027
- <td>Koen Sandra Ph.D.</td>
2028
- <td>Date:</td>
2029
- <td>15-MAY-2024</td>
2030
- </tr>
2031
- <tr>
2032
- <td>CEO</td>
2033
- <td>Signature:</td>
2034
- <td>Koen Sandra</td>
2035
- </tr>
2036
- </table>
2037
-
2038
-
2039
- <figure>
2040
-
2041
- RIC
2042
-
2043
- </figure>
2044
-
2045
-
2046
- <!-- PageFooter="biologics" -->
2047
- <!-- PageNumber="28" -->
2048
- <!-- PageBreak -->
2049
-
2050
-
2051
- <figure>
2052
- </figure>
2053
-
2054
-
2055
- # Version control
2056
-
2057
-
2058
- <table>
2059
- <tr>
2060
- <th>Version</th>
2061
- <th>Date of issue</th>
2062
- <th>Reason for version update</th>
2063
- </tr>
2064
- <tr>
2065
- <td>01</td>
2066
- <td>15-MAY-2024</td>
2067
- <td>First issue</td>
2068
- </tr>
2069
- <tr>
2070
- <td></td>
2071
- <td></td>
2072
- <td></td>
2073
- </tr>
2074
- <tr>
2075
- <td></td>
2076
- <td></td>
2077
- <td></td>
2078
- </tr>
2079
- </table>
2080
-
2081
-
2082
- 15-MAY-2024
2083
-
2084
- Obo Jaussens
2085
-
2086
-
2087
- <figure>
2088
-
2089
- RIC
2090
-
2091
- </figure>
2092
-
2093
-
2094
- <!-- PageFooter="biologics" -->
2095
- <!-- PageNumber="29" -->
2096
- <!-- PageBreak -->
2097
-
2098
-
2099
- <figure>
2100
-
2101
- RIC
2102
-
2103
- biologics
2104
-
2105
- </figure>
2106
-
2107
-
2108
- YOUR MOLECULE. OUR ANALYTICS. NO SECRETS.
2109
-
2110
- <!-- PageFooter="www.RIC-biologics.com" -->
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
logs/di_content/di_content_20250605_114836.txt DELETED
@@ -1,1608 +0,0 @@
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- # ARGX DISCOVERY: EVALUATION OF LIABILITIES IN VH AND VL REGION OF ONE CONSTRUCT
2
-
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- Argenx - P3016_R010_v00
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-
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-
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- <figure>
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-
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- RIC
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-
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- biologics
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-
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- </figure>
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-
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-
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
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- <!-- PageHeader="Table of contents" -->
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-
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- l Project information
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-
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- Scope
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-
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- Test samples
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-
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- l
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- Method
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-
33
- l
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- Results
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-
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- · P018_3D6 VHO VL6 _hlgG1_LALAPG_F405L-FJB_2024-04-18_002
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-
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- l
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- Conclusions
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-
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-
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- <figure>
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-
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- RIC
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-
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- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="2" -->
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- <!-- PageBreak -->
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- <figure>
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- </figure>
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-
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-
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- ## Project information
59
-
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- l
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-
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- l
63
-
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- l
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-
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- l
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-
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-
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- <table>
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- <tr>
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- <td>Sales quote:</td>
72
- <td>SQ20202722</td>
73
- </tr>
74
- <tr>
75
- <td>Project code:</td>
76
- <td>P3016</td>
77
- </tr>
78
- <tr>
79
- <td>LNB number:</td>
80
- <td>2023.040</td>
81
- </tr>
82
- <tr>
83
- <td>Project responsible:</td>
84
- <td>Nathan Cardon</td>
85
- </tr>
86
- <tr>
87
- <td>Report name:</td>
88
- <td>P3016_R010_v01</td>
89
- </tr>
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- </table>
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-
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-
93
- <figure>
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-
95
- RIC
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-
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- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="3" -->
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
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- Scope
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-
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- l This report describes the results of a liability assessment of one argenx
112
- discovery construct. Non-stressed and temperature-stressed samples
113
- stored for multiple weeks at 37℃ were evaluated by reduced protein RPLC-
114
- UV-MS and peptide map analysis. The focus of both analyses was on the
115
- variable regions of the different constructs.
116
-
117
-
118
- <figure>
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-
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- RIC
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-
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- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="4" -->
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- <!-- PageBreak -->
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-
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-
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- <figure>
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- </figure>
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-
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-
134
- ### Test samples
135
-
136
- The samples used in this study are listed below
137
-
138
-
139
- <table>
140
- <tr>
141
- <th>Construct</th>
142
- <th>Stress condition</th>
143
- <th>Concentration (mg/mL)</th>
144
- </tr>
145
- <tr>
146
- <td rowspan="3">P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
147
- <td>T0W</td>
148
- <td>1.00</td>
149
- </tr>
150
- <tr>
151
- <td>T2W_37℃</td>
152
- <td>1.00</td>
153
- </tr>
154
- <tr>
155
- <td>T4W_37℃</td>
156
- <td>1.00</td>
157
- </tr>
158
- </table>
159
-
160
-
161
- <figure>
162
-
163
- RIC
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-
165
- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="5" -->
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- <!-- PageBreak -->
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-
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-
173
- <figure>
174
- </figure>
175
-
176
-
177
- ## Method: Reduced protein analysis by RPLC-UV-MS
178
-
179
- l The samples were reduced by incubation with DTT while in denaturing conditions. The
180
- samples were analyzed using a C8 RPLC column on a 1290 Infinity UHPLC system coupled
181
- to a 6540 Q-TOF mass spectrometer (both from Agilent Technologies).
182
-
183
- l RPLC was performed with trifluoroacetic acid (TFA) as ion pairing additive, and with H2O
184
- and acetonitrile as mobile phases.
185
-
186
- l Data acquisition and processing were performed with BioConfirm MassHunter 7.0
187
- (Agilent Technologies). UV 280 nm and MS data were acquired simultaneously.
188
-
189
-
190
- <figure>
191
-
192
- RIC
193
-
194
- </figure>
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-
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-
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- <!-- PageFooter="biologics" -->
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- <!-- PageNumber="6" -->
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- <!-- PageBreak -->
200
-
201
-
202
- <figure>
203
- </figure>
204
-
205
-
206
- ## Method: Peptide map analysis in reducing conditions
207
-
208
- l Prior to digestion, the samples were reduced using dithiothreitol (DTT) and alkylated with
209
- iodoacetamide (IAA). The samples were digested using trypsin as protease.
210
-
211
- l The digests were analyzed on RPLC-MS using a C18 RPLC column. RPLC was performed
212
- with formic acid (FA) as additive, and with H2O and acetonitrile as mobile phases. The
213
- analyses were performed on a 1290 Infinity UHPLC system (Agilent Technologies) coupled
214
- to a 6545 Q-TOF Mass Spectrometer (Agilent Technologies) operated in MS and MS/MS
215
- mode.
216
-
217
- l Data processing was performed using BioConfirm 10.0 and MassHunter 7.0 (Agilent
218
- Technologies).
219
-
220
- l Measured signals were matched onto the sequence. Identification was based primarily
221
- on MS-only data. Enzyme specified was trypsin (C-terminal cleavage at lysine or arginine)
222
- and 0-2 missed cleavages were allowed. N-terminal cyclization (pyroglutamate from E/Q),
223
- D isomerization, N/Q deamidation, M/W oxidation and N-glycosylation were considered
224
- as variable modifications while cysteine carbamidomethylation (sample preparation
225
- related) was considered as fixed modification. Peak areas from extracted ion
226
- chromatograms (EICs) were used for quantifying modifications.
227
-
228
- l Note that peptide map data processing was focused on the variable regions of the
229
- constructs.
230
-
231
-
232
- <figure>
233
-
234
- RIC
235
-
236
- </figure>
237
-
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-
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- <!-- PageFooter="biologics" -->
240
- <!-- PageNumber="7" -->
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- <!-- PageBreak -->
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-
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- P018_3D6 VHO VL6_HIGG1_LALAPG
244
-
245
- <!-- PageBreak -->
246
-
247
-
248
- <figure>
249
- </figure>
250
-
251
-
252
- ## AA sequence of P018_3D6 VHO VL6 _hIgG1_LALAPG
253
-
254
- l AA sequence of VH (MW (G0F): 50306.86Da):
255
-
256
- EVOLLESGGGLVQPGGSLRLSCAASGFTFSSYSLSWVRQAPGKGLEWVSTIKARRGTTLYADSVKDRIFTISR
257
- DNSKNTLYLQMNSLRAEDTAVYYCAKPLYSNLAGDFGSWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGT
258
- AALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKV
259
- DKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDG
260
- VEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLP
261
- PSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQQGNVF
262
- SCSVMHEALHNHYTQKSLSLSPGK
263
-
264
- AA sequence of VL (MW: 23376.19Da):
265
-
266
- DIQMTQSPSSLSASVGDRVTITCQASQSISSYLAWYQQKPGKAPKLLIYGGSRLQTGVPSRFSGSGSGTDFT
267
- LTISSLOPEDFATYYCQQDYSWPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAK
268
- VQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
269
-
270
-
271
- <figure>
272
-
273
- RIC
274
-
275
- <!-- PageFooter="biologics" -->
276
-
277
- </figure>
278
-
279
-
280
- <table>
281
- <tr>
282
- <td>Blue:</td>
283
- <td>VH and VL</td>
284
- </tr>
285
- <tr>
286
- <td>Blue:</td>
287
- <td>CDR</td>
288
- </tr>
289
- <tr>
290
- <td>Green:</td>
291
- <td>N-glycosylation site</td>
292
- </tr>
293
- </table>
294
-
295
-
296
- <!-- PageNumber="9" -->
297
- <!-- PageBreak -->
298
-
299
-
300
- <figure>
301
- </figure>
302
-
303
-
304
- ## Results: reduced protein RPLC-UV-MS
305
-
306
-
307
- ### l
308
-
309
-
310
- #### Overlays of the UV214nm profiles
311
-
312
-
313
- <figure>
314
-
315
- ×10 3
316
- DAD1 - A:Sig=214.0,8.0 Ref=360.0,100.0 P3016_10OCT24_rRPLC_UV_MS_P018_3D6_VHO_VL_T0.d
317
-
318
- 1\.
319
-
320
- HC
321
-
322
- T0W
323
-
324
- 0.95-
325
-
326
- 5
327
-
328
- 0.9
329
-
330
- T2W_37℃
331
-
332
- 0.85-
333
-
334
- T4W_37°℃
335
-
336
- 0.8
337
-
338
- LC
339
-
340
- 0.75-
341
-
342
- a: SG clip HC (E1-S140)
343
-
344
- 0.7-
345
-
346
- GG clip HC (E1-G141)
347
-
348
- g
349
-
350
- 1: LC + deamidation
351
-
352
- 2: RG clip HC (G51-G450)
353
-
354
- 0.65
355
-
356
- b: LC + deamidation
357
-
358
- NL clip HC (L104-G450)
359
-
360
- 0.6
361
-
362
- c: PK clip HC E1-P221
363
-
364
- 3: HC isomer
365
-
366
- 0.55-
367
-
368
- LC
369
-
370
- 4: unknown
371
-
372
- 0.5
373
-
374
- d & e: LC
375
-
376
- 5: HC
377
-
378
- 0.45
379
-
380
- LC + oxidation (1x, 2x)
381
-
382
- 6: HC + Deamidation
383
-
384
- 0.4
385
-
386
- f: LC + LC glycation (1x, 2x)
387
-
388
- 7: HC + PyroE
389
-
390
- 0.35-
391
-
392
- DR clip LC (R18-C224)
393
-
394
- DP clip HC (E1-D274)
395
-
396
- 0.3
397
-
398
- 0.25
399
-
400
- g: LC
401
-
402
- 8: CD clip HC (E1-C224)
403
-
404
- 9: Thioether HC+LC, (73651.6 Da)
405
- DG Clip HC: (E1-D284)
406
-
407
- 0.2
408
-
409
- 7
410
-
411
- 0.15
412
-
413
- 4
414
-
415
- 0.1
416
-
417
- 0.05
418
-
419
- f
420
-
421
- 2
422
-
423
- 3
424
-
425
- 6
426
-
427
- 9
428
-
429
- a
430
-
431
- b
432
-
433
- e
434
-
435
- 1
436
-
437
- 8
438
-
439
- c
440
-
441
- d
442
-
443
- 0
444
-
445
- 6
446
-
447
- 6.5
448
-
449
- 7
450
-
451
- 7.5
452
-
453
- 8
454
-
455
- 8.5
456
-
457
- 9
458
-
459
- 9.5
460
-
461
- 10
462
-
463
- 10.5
464
-
465
- 11
466
-
467
- 11.5
468
-
469
- 12
470
-
471
- 12.5
472
-
473
- 13
474
-
475
- 13.5
476
-
477
- 14
478
-
479
- 14.5
480
-
481
- 15
482
-
483
- 15.5
484
-
485
- 16
486
-
487
- 16.5
488
-
489
- 17
490
-
491
- 17.5
492
-
493
- 18
494
-
495
- 18.5
496
-
497
- 19
498
-
499
- 19.5
500
-
501
- 20
502
-
503
- 20.5
504
-
505
- 21
506
-
507
- 21.5
508
-
509
- 22
510
-
511
- Response Units vs. Acquisition Time (min)
512
-
513
- </figure>
514
-
515
- *T0 chromatogram aligned to facilitate data interpretation.
516
-
517
-
518
- <figure>
519
-
520
- RIC
521
-
522
- </figure>
523
-
524
-
525
- <!-- PageFooter="biologics" -->
526
-
527
- Color legend:
528
- Black: clear identity on RPLC-UV-MS
529
-
530
- Blue: modification with clear trend visible on RPLC-UV-MS
531
- Blue: modification in variable region also confirmed in
532
- peptide mapping
533
-
534
- Grey: most likely method induced modification
535
-
536
- <!-- PageNumber="10" -->
537
- <!-- PageBreak -->
538
-
539
-
540
- <figure>
541
- </figure>
542
-
543
-
544
- ## Results: reduced protein RPLC-UV-MS
545
-
546
-
547
- ### l Deconvoluted spectra of HC and LC
548
-
549
- +ESI Scan (rt: 13.0-13.7 min, 45 scans) Frag=200.0V P3016_10OCT24_rRPLC_UV_MS_P018_3D6_VHO_VL_TO.d Deconvoluted (Isotope Width=0.0)
550
-
551
- x10 6
552
-
553
- 2.5
554
-
555
- 23377.04
556
-
557
- Theoretical mass LC: 23376.2Da
558
-
559
- 2.25
560
-
561
- 2
562
-
563
- 1.75
564
-
565
- 1.5
566
-
567
- 1.25
568
-
569
- 1
570
-
571
- 0.75
572
-
573
- 0.5
574
-
575
- 0.25
576
-
577
- 0
578
-
579
- 15585.42 18295.12
580
-
581
- 11
582
-
583
- 28052.48
584
-
585
- 34559.61
586
-
587
- x10 5
588
-
589
- +ESI Scan (rt: 14.3-15.3 min, 58 scans) Frag=200.0V P3016_10OCT24_rRPLC_UV_MS_P018_3D6_VHO_VL_TO.d Deconvoluted (Isotope Width=0.0)
590
-
591
-
592
- <figure>
593
-
594
- Theoretical mass HC (G0F): 50306.9Da
595
-
596
- G0F
597
- 50308.16
598
-
599
- 7
600
-
601
- 6
602
-
603
- 5
604
-
605
- 4
606
-
607
- 3
608
-
609
- 2
610
-
611
- 1
612
-
613
- 0%
614
-
615
- 0
616
-
617
- 53210.42
618
-
619
- 57837.17
620
-
621
- 12000 14000 16000 18000 20000 22000 24000 26000 28000 30000 32000 34000 36000 38000 40000 42000 44000 46000 48000 50000 52000 54000 56000 58000
622
- Counts vs. Deconvoluted Mass (amu)
623
-
624
- </figure>
625
-
626
-
627
- <figure>
628
-
629
- RIC
630
-
631
- </figure>
632
-
633
-
634
- <!-- PageFooter="biologics" -->
635
- <!-- PageNumber="11" -->
636
- <!-- PageBreak -->
637
-
638
-
639
- <figure>
640
- </figure>
641
-
642
-
643
- ## Results: tryptic peptide map
644
-
645
-
646
- ### l N-terminal and C-terminal modifications for HC and LC
647
-
648
-
649
- <table>
650
- <tr>
651
- <th colspan="6">Relative quantification by EIC (%)</th>
652
- </tr>
653
- <tr>
654
- <th>AA Sequence</th>
655
- <th>Seq Loc</th>
656
- <th>Modification</th>
657
- <th>T0</th>
658
- <th>T2W_37℃</th>
659
- <th>T4W_37℃</th>
660
- </tr>
661
- <tr>
662
- <td rowspan="2">EVQLLESGGGLVQPGGSLR</td>
663
- <td rowspan="2">HC(1-19)</td>
664
- <td></td>
665
- <td>99.0</td>
666
- <td>96.1</td>
667
- <td>93.0</td>
668
- </tr>
669
- <tr>
670
- <td>PyroE</td>
671
- <td>1.0</td>
672
- <td>3.9</td>
673
- <td>7.0</td>
674
- </tr>
675
- </table>
676
-
677
-
678
- ### l Isomerization events in the variable parts of HC and LC
679
-
680
-
681
- <table>
682
- <tr>
683
- <th colspan="6">Relative quantification by EIC (%)</th>
684
- </tr>
685
- <tr>
686
- <th>AA Sequence</th>
687
- <th>Seq Loc</th>
688
- <th>Modification</th>
689
- <th>T0</th>
690
- <th>T2W_37℃</th>
691
- <th>T4W_37℃</th>
692
- </tr>
693
- <tr>
694
- <td rowspan="2">AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
695
- <td rowspan="2">HC(88-125)</td>
696
- <td></td>
697
- <td>99.9</td>
698
- <td>99.7</td>
699
- <td>99.5</td>
700
- </tr>
701
- <tr>
702
- <td>Isomerization</td>
703
- <td>0.1</td>
704
- <td>0.3</td>
705
- <td>0.5</td>
706
- </tr>
707
- </table>
708
-
709
-
710
- For information purposes the following color code is applied: Values showing an increase or decrease
711
- between 1.0% to 10.0% compared to the T0 sample are in blue and underlined, whereas values showing an
712
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
713
-
714
-
715
- <figure>
716
-
717
- RIC
718
-
719
- </figure>
720
-
721
-
722
- <!-- PageFooter="biologics" -->
723
- <!-- PageNumber="12" -->
724
- <!-- PageBreak -->
725
-
726
-
727
- <figure>
728
- </figure>
729
-
730
-
731
- ## Results: tryptic peptide map
732
-
733
-
734
- ### l M/W oxidations in variable parts of HC and LC
735
-
736
-
737
- <table>
738
- <tr>
739
- <th colspan="6">Relative quantification by EIC (%)</th>
740
- </tr>
741
- <tr>
742
- <th>AA Sequence</th>
743
- <th>Seq Loc</th>
744
- <th>Modification</th>
745
- <th>T0</th>
746
- <th>T2W_37℃</th>
747
- <th>T4W_37℃</th>
748
- </tr>
749
- <tr>
750
- <td rowspan="2">NTLYLQMNSLR</td>
751
- <td rowspan="2">HC(77-87)</td>
752
- <td></td>
753
- <td>99.5</td>
754
- <td>99.5</td>
755
- <td>99.5</td>
756
- </tr>
757
- <tr>
758
- <td>Oxidation</td>
759
- <td>0.5</td>
760
- <td>0.5</td>
761
- <td>0.5</td>
762
- </tr>
763
- <tr>
764
- <td rowspan="2">DIQMTQSPSSLSASVGDR</td>
765
- <td rowspan="2">LC(1-18)</td>
766
- <td></td>
767
- <td>99.5</td>
768
- <td>99.5</td>
769
- <td>99.5</td>
770
- </tr>
771
- <tr>
772
- <td>Oxidation</td>
773
- <td>0.5</td>
774
- <td>0.5</td>
775
- <td>0.5</td>
776
- </tr>
777
- </table>
778
-
779
-
780
- For information purposes the following color code is applied: Values showing an increase or decrease
781
- between 1.0% to 10.0% compared to the T0 sample are in blue and underlined, whereas values showing an
782
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
783
-
784
-
785
- <figure>
786
-
787
- RIC
788
-
789
- </figure>
790
-
791
-
792
- <!-- PageFooter="biologics" -->
793
- <!-- PageNumber="13" -->
794
- <!-- PageBreak -->
795
-
796
-
797
- <figure>
798
- </figure>
799
-
800
-
801
- ## Results: tryptic peptide map
802
-
803
-
804
- ### l N/Q deamidation in variable parts of HC and LC
805
-
806
-
807
- <table>
808
- <tr>
809
- <th colspan="6">Relative quantification by EIC (%)</th>
810
- </tr>
811
- <tr>
812
- <th>AA Sequence</th>
813
- <th>Seq Loc</th>
814
- <th>Modification</th>
815
- <th>T0</th>
816
- <th>T2W_37℃</th>
817
- <th>T4W_37℃</th>
818
- </tr>
819
- <tr>
820
- <td rowspan="2">EVQLLESGGGLVQPGGSLR</td>
821
- <td rowspan="2">HC(1-19)</td>
822
- <td></td>
823
- <td>99.6</td>
824
- <td>99.6</td>
825
- <td>99.5</td>
826
- </tr>
827
- <tr>
828
- <td>Deamidation</td>
829
- <td>0.4</td>
830
- <td>0.4</td>
831
- <td>0.5</td>
832
- </tr>
833
- <tr>
834
- <td rowspan="2">NTLYLQMNSLR*</td>
835
- <td rowspan="2">HC(77-87)</td>
836
- <td></td>
837
- <td>99.0</td>
838
- <td>98.8</td>
839
- <td>98.6</td>
840
- </tr>
841
- <tr>
842
- <td>Deamidation</td>
843
- <td>1.0</td>
844
- <td>1.2</td>
845
- <td>1.4</td>
846
- </tr>
847
- <tr>
848
- <td rowspan="2">AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
849
- <td rowspan="2">HC(88-125)</td>
850
- <td></td>
851
- <td>98.7</td>
852
- <td>96.1</td>
853
- <td>93.4</td>
854
- </tr>
855
- <tr>
856
- <td>Deamidation</td>
857
- <td>1.3</td>
858
- <td>3.9</td>
859
- <td>6.6</td>
860
- </tr>
861
- <tr>
862
- <td rowspan="2">VTITCQASQSISSYLAWYQQKPGK</td>
863
- <td rowspan="2">LC(19-42)</td>
864
- <td></td>
865
- <td>99.9</td>
866
- <td>99.8</td>
867
- <td>99.5</td>
868
- </tr>
869
- <tr>
870
- <td>Deamidation</td>
871
- <td>0.1</td>
872
- <td>0.2</td>
873
- <td>0.5</td>
874
- </tr>
875
- </table>
876
-
877
- *MS/MS confirmed the deamidation site as N84, see next slides.
878
-
879
-
880
- For information purposes the following color code is applied: Values showing an increase or decrease
881
- between 1.0% to 10.0% compared to the T0 sample are in blue and underlined, whereas values showing an
882
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
883
-
884
-
885
- <figure>
886
-
887
- RIC
888
-
889
- </figure>
890
-
891
-
892
- <!-- PageFooter="biologics" -->
893
- <!-- PageNumber="14" -->
894
- <!-- PageBreak -->
895
-
896
-
897
- <figure>
898
- </figure>
899
-
900
-
901
- ## Results: tryptic peptide map
902
-
903
- l
904
-
905
-
906
- ### HC(77-87) deamidation site confirmation via MS/MS
907
-
908
- N77:
909
-
910
-
911
- <table>
912
- <tr>
913
- <th rowspan="2">b --- 1</th>
914
- <th></th>
915
- <th></th>
916
- <th>y</th>
917
- </tr>
918
- <tr>
919
- <th>N(+0.984016)</th>
920
- <th>11</th>
921
- <th>---</th>
922
- </tr>
923
- <tr>
924
- <td>217.0819 2</td>
925
- <td>T</td>
926
- <td>10</td>
927
- <td>1238.6562</td>
928
- </tr>
929
- <tr>
930
- <td>330.1660 3</td>
931
- <td>L</td>
932
- <td>9</td>
933
- <td>1137.6085</td>
934
- </tr>
935
- <tr>
936
- <td>493.2293 4</td>
937
- <td>Y</td>
938
- <td>8</td>
939
- <td>1024.5244</td>
940
- </tr>
941
- <tr>
942
- <td>606.3134 5</td>
943
- <td>L</td>
944
- <td>7</td>
945
- <td>861.4611</td>
946
- </tr>
947
- <tr>
948
- <td>734.3719 6</td>
949
- <td>Q</td>
950
- <td>6</td>
951
- <td>748.3770</td>
952
- </tr>
953
- <tr>
954
- <td>865.4124 7</td>
955
- <td>M</td>
956
- <td>5</td>
957
- <td>620.3185</td>
958
- </tr>
959
- <tr>
960
- <td>979.4553 8</td>
961
- <td>N</td>
962
- <td>4</td>
963
- <td>489.2780</td>
964
- </tr>
965
- <tr>
966
- <td>066.4874 9</td>
967
- <td>S</td>
968
- <td>3</td>
969
- <td>375.2350</td>
970
- </tr>
971
- <tr>
972
- <td>179.5714 10</td>
973
- <td>L</td>
974
- <td>2</td>
975
- <td>288.2030</td>
976
- </tr>
977
- <tr>
978
- <td>--- 11</td>
979
- <td>R</td>
980
- <td>1</td>
981
- <td>175.1190</td>
982
- </tr>
983
- </table>
984
-
985
-
986
- <figure>
987
-
988
- N84:
989
-
990
- Visible
991
- when
992
- zooming
993
-
994
- </figure>
995
-
996
-
997
- <table>
998
- <tr>
999
- <th>b</th>
1000
- <th colspan="3">y</th>
1001
- </tr>
1002
- <tr>
1003
- <td>--- 1</td>
1004
- <td>N</td>
1005
- <td>11</td>
1006
- <td>---</td>
1007
- </tr>
1008
- <tr>
1009
- <td>216.0979 2</td>
1010
- <td>T</td>
1011
- <td>10</td>
1012
- <td>1239.6402</td>
1013
- </tr>
1014
- <tr>
1015
- <td>329.1819 3</td>
1016
- <td>L</td>
1017
- <td>9</td>
1018
- <td>1138.5925</td>
1019
- </tr>
1020
- <tr>
1021
- <td>492.2453 4</td>
1022
- <td>Y</td>
1023
- <td>8</td>
1024
- <td>1025.5084</td>
1025
- </tr>
1026
- <tr>
1027
- <td>605.3293 5</td>
1028
- <td>L</td>
1029
- <td>7</td>
1030
- <td>862.4451</td>
1031
- </tr>
1032
- <tr>
1033
- <td>733.3879 6</td>
1034
- <td>Q</td>
1035
- <td>6</td>
1036
- <td>749.3611</td>
1037
- </tr>
1038
- <tr>
1039
- <td>864.4284 7</td>
1040
- <td>M</td>
1041
- <td>5</td>
1042
- <td>621.3025</td>
1043
- </tr>
1044
- <tr>
1045
- <td>979.4553 8</td>
1046
- <td>N(+0.984016)</td>
1047
- <td>4</td>
1048
- <td>490.2620</td>
1049
- </tr>
1050
- <tr>
1051
- <td>1066.4874 9</td>
1052
- <td>S</td>
1053
- <td>3</td>
1054
- <td>375.2350</td>
1055
- </tr>
1056
- <tr>
1057
- <td>1179.5714 10</td>
1058
- <td>L</td>
1059
- <td>2</td>
1060
- <td>288.2030</td>
1061
- </tr>
1062
- <tr>
1063
- <td>--- 11</td>
1064
- <td>R</td>
1065
- <td>1</td>
1066
- <td>175.1190</td>
1067
- </tr>
1068
- </table>
1069
-
1070
-
1071
- +ESI Product lon (rt: 20.9 min) Frag=175.0V [email protected] (677.3463[z=2] -> ** ) P3016_PM_09OCT2024_R_MS2_P018_3D6_2024-04-18_002_T4w-2.d
1072
-
1073
-
1074
- <figure>
1075
-
1076
- x10 3
1077
-
1078
- 216.0979
1079
-
1080
- 4
1081
-
1082
- 3
1083
-
1084
- 862.4438
1085
-
1086
- 329.1827
1087
-
1088
- 1025.5063
1089
-
1090
- 2
1091
-
1092
- 492.2425
1093
-
1094
- 749.3614
1095
-
1096
- 621.3030
1097
-
1098
- 1138.5930
1099
-
1100
- 1
1101
-
1102
- 375.2330
1103
-
1104
- 447.2224
1105
-
1106
- 813.6398
1107
-
1108
- 0
1109
-
1110
- 150
1111
-
1112
- 200
1113
-
1114
- 250
1115
-
1116
- 300
1117
-
1118
- 350
1119
-
1120
- 400
1121
-
1122
- 450
1123
-
1124
- 500
1125
-
1126
- 550
1127
-
1128
- 600
1129
-
1130
- 650
1131
-
1132
- 700
1133
-
1134
- 750
1135
-
1136
- Counts vs. Mass-to-Charge (m/z)
1137
-
1138
- 800
1139
-
1140
- 850
1141
-
1142
- 900
1143
-
1144
- 950
1145
-
1146
- 1000
1147
-
1148
- 1050
1149
-
1150
- 1100
1151
-
1152
- 1150
1153
-
1154
- </figure>
1155
-
1156
-
1157
- <figure>
1158
-
1159
- RIC
1160
-
1161
- biologics
1162
-
1163
- </figure>
1164
-
1165
-
1166
- <!-- PageFooter="MS/MS data confirms N84 as the deamidation site." -->
1167
- <!-- PageNumber="15" -->
1168
- <!-- PageBreak -->
1169
-
1170
-
1171
- <figure>
1172
- </figure>
1173
-
1174
-
1175
- ## Results: tryptic peptide map
1176
-
1177
-
1178
- ### Thioether bond
1179
-
1180
-
1181
- <table>
1182
- <tr>
1183
- <th colspan="6">Relative quantification by EIC (%)</th>
1184
- </tr>
1185
- <tr>
1186
- <th>AA Sequence</th>
1187
- <th>Seq Loc</th>
1188
- <th>Modification</th>
1189
- <th>T0</th>
1190
- <th>T2W_37℃</th>
1191
- <th>T4W_37℃</th>
1192
- </tr>
1193
- <tr>
1194
- <td>SCDK</td>
1195
- <td>HC(223-226)</td>
1196
- <td></td>
1197
- <td rowspan="2">99.8</td>
1198
- <td rowspan="2">99.5</td>
1199
- <td rowspan="2">98.8</td>
1200
- </tr>
1201
- <tr>
1202
- <td>SFNRGEC</td>
1203
- <td>LC(208-214)</td>
1204
- <td></td>
1205
- </tr>
1206
- <tr>
1207
- <td>SFNRGEC - SCDK</td>
1208
- <td>HC(223-226) + LC(208-214)</td>
1209
- <td>Thioether</td>
1210
- <td>0.2</td>
1211
- <td>0.5</td>
1212
- <td>1.2</td>
1213
- </tr>
1214
- </table>
1215
-
1216
-
1217
- For information purposes the following color code is applied: Values showing an increase or decrease
1218
- between 1.0% to 10.0% compared to the T0 sample are in blue and underlined, whereas values showing an
1219
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
1220
-
1221
-
1222
- <figure>
1223
-
1224
- RIC
1225
-
1226
- </figure>
1227
-
1228
-
1229
- <!-- PageFooter="biologics" -->
1230
- <!-- PageNumber="16" -->
1231
- <!-- PageBreak -->
1232
-
1233
-
1234
- <figure>
1235
- </figure>
1236
-
1237
-
1238
- ## Results: tryptic peptide map
1239
-
1240
-
1241
- ### l Confirmation of clipping events via peptide mapping
1242
-
1243
-
1244
- <table>
1245
- <tr>
1246
- <th colspan="6">Relative quantification by EIC (%)*</th>
1247
- </tr>
1248
- <tr>
1249
- <th>AA Sequence</th>
1250
- <th>Seq Loc</th>
1251
- <th>Modification</th>
1252
- <th>T0</th>
1253
- <th>T2W_37℃</th>
1254
- <th>T4W_37℃</th>
1255
- </tr>
1256
- <tr>
1257
- <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
1258
- <td rowspan="3">HC(88-125)</td>
1259
- <td></td>
1260
- <td>98.6</td>
1261
- <td>98.1</td>
1262
- <td>96.8</td>
1263
- </tr>
1264
- <tr>
1265
- <td>AEDTAVYYCAKPLYSN</td>
1266
- <td>Clipping</td>
1267
- <td>0.3</td>
1268
- <td>0.4</td>
1269
- <td>0.6</td>
1270
- </tr>
1271
- <tr>
1272
- <td>LAGDFGSWGQGTTVTVSSASTK</td>
1273
- <td>Clipping</td>
1274
- <td>1.1</td>
1275
- <td>1.5</td>
1276
- <td>2.6</td>
1277
- </tr>
1278
- <tr>
1279
- <td>STSGGTAALGCLVK</td>
1280
- <td rowspan="3">HC(138-151)</td>
1281
- <td></td>
1282
- <td>99.9</td>
1283
- <td>99.3</td>
1284
- <td>98.7</td>
1285
- </tr>
1286
- <tr>
1287
- <td>GGTAALGCLVK</td>
1288
- <td>Clipping</td>
1289
- <td>0.0</td>
1290
- <td>0.2</td>
1291
- <td>0.3</td>
1292
- </tr>
1293
- <tr>
1294
- <td>GTAALGCLVK</td>
1295
- <td>Clipping_2</td>
1296
- <td>0.1</td>
1297
- <td>0.5</td>
1298
- <td>0.9</td>
1299
- </tr>
1300
- <tr>
1301
- <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
1302
- <td rowspan="2">HC(223-252)</td>
1303
- <td></td>
1304
- <td>99.6</td>
1305
- <td>99.4</td>
1306
- <td>99.0</td>
1307
- </tr>
1308
- <tr>
1309
- <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
1310
- <td>Clipping</td>
1311
- <td>0.4</td>
1312
- <td>0.6</td>
1313
- <td>1.0</td>
1314
- </tr>
1315
- </table>
1316
-
1317
- *Note that due to the differences in ionization efficiency between large and small peptides, the quantification of clipping
1318
- events via peptide mapping is most likely an overestimation. Nevertheless, peptide mapping allows for the confirmation of
1319
- clipping events and discern possible trends.
1320
-
1321
-
1322
- For information purposes the following color code is applied: Values showing an increase or decrease
1323
- between 1.0% to 10.0% compared to the T0 sample are in blue and underlined, whereas values showing an
1324
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
1325
-
1326
-
1327
- <figure>
1328
-
1329
- RIC
1330
-
1331
- </figure>
1332
-
1333
-
1334
- <!-- PageFooter="biologics" -->
1335
- <!-- PageNumber="17" -->
1336
- <!-- PageBreak -->
1337
-
1338
-
1339
- <figure>
1340
- </figure>
1341
-
1342
-
1343
- ## P018_3D6 VHO VL6 _hIgG1_LALAPG: Conclusions
1344
-
1345
- l Some minor liabilities were found in the variable parts of the
1346
- P018_3D6 VHO VL6 _hIgG1_LALAPG construct
1347
-
1348
- · On RPLC-UV-MS, some minor clipping events, that increased during the temperature stress, were
1349
- observed. These clippings were further confirmed via peptide mapping. The most apparent clipping is the
1350
- clipping between N103 and LL104 in CDR3 of the HC. This clipping slightly increased during temperature
1351
- stress from 1.4 to 3.2%.
1352
-
1353
- · A clear deamidation that increased during stress was found on peptide HC(88-125),
1354
- AEDTAVYYCAKPLYSN 103 LAGDFGSWGQGTTVTVSSASTK where deamidation increased from 1.3% to 6.6%
1355
- after 4 weeks at 37℃. This asparagine is part of the HC CDR3 domain. Some other minor deamidation
1356
- events were also observed.
1357
-
1358
- · Cyclization of the N-terminal glutamate on the HC increased up to 7.0% during temperature stress (both
1359
- present in RPLC-UV-MS and peptide map).
1360
-
1361
- · Only minor oxidation events were identified in the variable regions of both the heavy and light chain.
1362
-
1363
- · Both RPLC-UV-MS and peptide mapping confirmed the presence of a thioether bound HC+LC.
1364
-
1365
- · Light chain glycation was clearly observed on RPLC-UV-MS (1x and 2x).
1366
-
1367
-
1368
- <figure>
1369
-
1370
- RIC
1371
-
1372
- </figure>
1373
-
1374
-
1375
- <!-- PageFooter="biologics" -->
1376
- <!-- PageNumber="18" -->
1377
- <!-- PageBreak -->
1378
-
1379
-
1380
- <figure>
1381
- </figure>
1382
-
1383
-
1384
- ## P018_3D6 VHO VL6 _hIgG1_LALAPG: Conclusions
1385
-
1386
-
1387
- ### Graphical summary (T0->T4W)
1388
-
1389
- Oxidation: 0.5%
1390
-
1391
- Deamidation: 1.0 -> 1.4%
1392
-
1393
- Deamidation: 1.3 -> 6.6%
1394
-
1395
- PyroE: 1.0 -> 7.0%
1396
-
1397
- l
1398
- VH
1399
-
1400
- EVOLLESGGGLVQPGGSLRLSCAASGFTFSSYSLSWVRQAPGKGLEWVSTIKARRGTTLY
1401
- ADSVKDRFTISRDNSKNTLYLQMg3N34SLRAEDTAVYYCAKPLYSN103L104AGDFGSWGQ
1402
- GTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTF
1403
- PAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPA,
1404
- PEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKT
1405
- KPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVY
1406
- TLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLT
1407
- VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
1408
-
1409
- Clipping: 1.4 -> 3.2%
1410
-
1411
- G0F most abundant
1412
-
1413
- l
1414
- VL
1415
-
1416
- Oxidation: 0.5%
1417
- DIQMATQSPSSLSASVGDRVTITCQASQSISSYLAWYQQKPGKAPKLLIYGGSRLQTGVPS
1418
- RFSGSGSGTDFTLTISSLOPEDFATYYCQQDYSWPLTFGQGTKVEIKRTVAAPSVFIFPPSD
1419
- EQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLS
1420
- KADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
1421
-
1422
-
1423
- <table>
1424
- <tr>
1425
- <td>Blue:</td>
1426
- <td>VH and VL</td>
1427
- </tr>
1428
- <tr>
1429
- <td>Blue:</td>
1430
- <td>CDR</td>
1431
- </tr>
1432
- <tr>
1433
- <td>Green:</td>
1434
- <td>N-glycosylation site</td>
1435
- </tr>
1436
- </table>
1437
-
1438
-
1439
- <figure>
1440
-
1441
- RIC
1442
-
1443
- </figure>
1444
-
1445
-
1446
- <!-- PageFooter="biologics" -->
1447
-
1448
- For information purposes the following color code is applied: Values showing an increase or decrease
1449
- between 1.0% to 10.0% compared to the T0 sample are in blue and underlined, whereas values showing an
1450
- increase of more than 10.0% compared to T0 are in red, bold and underlined.
1451
-
1452
- <!-- PageNumber="19" -->
1453
- <!-- PageBreak -->
1454
-
1455
-
1456
- <figure>
1457
- </figure>
1458
-
1459
-
1460
- ### Author section RIC
1461
-
1462
-
1463
- #### Author
1464
-
1465
- Nathan Cardon
1466
- Senior research associate | Project Responsible
1467
-
1468
-
1469
- <figure>
1470
-
1471
- RIC
1472
-
1473
- </figure>
1474
-
1475
-
1476
- <!-- PageFooter="biologics" -->
1477
- <!-- PageNumber="20" -->
1478
- <!-- PageBreak -->
1479
-
1480
-
1481
- <figure>
1482
- </figure>
1483
-
1484
-
1485
- ### Signature section RIC
1486
-
1487
-
1488
- #### Reviewer
1489
-
1490
-
1491
- <table>
1492
- <tr>
1493
- <td>Mabelle Meersseman</td>
1494
- <td>Date:</td>
1495
- </tr>
1496
- <tr>
1497
- <td>Group Leader</td>
1498
- <td>Signature:</td>
1499
- </tr>
1500
- <tr>
1501
- <td>Approver</td>
1502
- <td></td>
1503
- </tr>
1504
- <tr>
1505
- <td>Koen Sandra Ph.D.</td>
1506
- <td>Date:</td>
1507
- </tr>
1508
- <tr>
1509
- <td>CEO</td>
1510
- <td>Signature:</td>
1511
- </tr>
1512
- </table>
1513
-
1514
-
1515
- <figure>
1516
-
1517
- RIC
1518
-
1519
- </figure>
1520
-
1521
-
1522
- <!-- PageFooter="biologics" -->
1523
- <!-- PageNumber="21" -->
1524
- <!-- PageBreak -->
1525
-
1526
-
1527
- <figure>
1528
- </figure>
1529
-
1530
-
1531
- ### Signature section client
1532
-
1533
- Approver
1534
-
1535
- Name:
1536
-
1537
- Date:
1538
-
1539
- Signature:
1540
-
1541
-
1542
- <figure>
1543
-
1544
- RIC
1545
-
1546
- </figure>
1547
-
1548
-
1549
- <!-- PageFooter="biologics" -->
1550
- <!-- PageNumber="22" -->
1551
- <!-- PageBreak -->
1552
-
1553
-
1554
- <figure>
1555
- </figure>
1556
-
1557
-
1558
- ### Version control
1559
-
1560
-
1561
- <table>
1562
- <tr>
1563
- <th>Version</th>
1564
- <th>Date of issue</th>
1565
- <th>Reason for version update</th>
1566
- </tr>
1567
- <tr>
1568
- <td>00</td>
1569
- <td>20 November 2024</td>
1570
- <td>Draft</td>
1571
- </tr>
1572
- <tr>
1573
- <td></td>
1574
- <td></td>
1575
- <td></td>
1576
- </tr>
1577
- <tr>
1578
- <td></td>
1579
- <td></td>
1580
- <td></td>
1581
- </tr>
1582
- </table>
1583
-
1584
-
1585
- <figure>
1586
-
1587
- RIC
1588
-
1589
- </figure>
1590
-
1591
-
1592
- <!-- PageFooter="biologics" -->
1593
- <!-- PageNumber="23" -->
1594
- <!-- PageBreak -->
1595
-
1596
-
1597
- <figure>
1598
-
1599
- RIC
1600
-
1601
- biologics
1602
-
1603
- </figure>
1604
-
1605
-
1606
- YOUR MOLECULE. OUR ANALYTICS. NO SECRETS.
1607
-
1608
- <!-- PageFooter="www.RIC-biologics.com" -->
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
logs/di_content/di_content_20250605_134434_tables.json ADDED
@@ -0,0 +1,72 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ [
2
+ {
3
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Sales quote:</td>\n<td>SQ20202722</td>\n</tr>\n<tr>\n<td>Project code:</td>\n<td>P3016</td>\n</tr>\n<tr>\n<td>LNB number:</td>\n<td>2023.040</td>\n</tr>\n<tr>\n<td>Project responsible:</td>\n<td>Nathan Cardon</td>\n</tr>\n<tr>\n<td>Report name:</td>\n<td>P3016_R010_v01</td>\n</tr>\n</table>",
4
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Sales quote:</th>\n<th>SQ20202722</th>\n</tr>\n<tr>\n<td>Project code:</td>\n<td>P3016</td>\n</tr>\n<tr>\n<td>LNB number:</td>\n<td>2023.040</td>\n</tr>\n<tr>\n<td>Project responsible:</td>\n<td>Nathan Cardon</td>\n</tr>\n<tr>\n<td>Report name:</td>\n<td>P3016_R010_v01</td>\n</tr>\n</table>",
5
+ "markdown": "| Sales quote: | SQ20202722 |\n| --- | --- |\n| Project code: | P3016 |\n| LNB number: | 2023.040 |\n| Project responsible: | Nathan Cardon |\n| Report name: | P3016_R010_v01 |"
6
+ },
7
+ {
8
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Construct</td>\n<td>Stress condition</td>\n<td>Concentration (mg/mL)</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T0W</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T2W_37\u2103</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T4W_37\u2103</td>\n<td>1.00</td>\n</tr>\n</table>",
9
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Construct</th>\n<th>Stress condition</th>\n<th>Concentration (mg/mL)</th>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T0W</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T2W_37\u2103</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T4W_37\u2103</td>\n<td>1.00</td>\n</tr>\n</table>",
10
+ "markdown": "| Construct | Stress condition | Concentration (mg/mL) |\n| --- | --- | --- |\n| P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T0W | 1.00 |\n| P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T2W_37\u2103 | 1.00 |\n| P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T4W_37\u2103 | 1.00 |"
11
+ },
12
+ {
13
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Blue:</td>\n<td>VH and VL</td>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
14
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Blue:</th>\n<th>VH and VL</th>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
15
+ "markdown": "| Blue: | VH and VL |\n| --- | --- |\n| Blue: | CDR |\n| Green: | N-glycosylation site |"
16
+ },
17
+ {
18
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.0</td>\n<td>96.1</td>\n<td>93.0</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>PyroE</td>\n<td>1.0</td>\n<td>3.9</td>\n<td>7.0</td>\n</tr>\n</table>",
19
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.0</td>\n<td>96.1</td>\n<td>93.0</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>PyroE</td>\n<td>1.0</td>\n<td>3.9</td>\n<td>7.0</td>\n</tr>\n</table>",
20
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.0 | 96.1 | 93.0 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | PyroE | 1.0 | 3.9 | 7.0 |"
21
+ },
22
+ {
23
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>99.9</td>\n<td>99.7</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Isomerization</td>\n<td>0.1</td>\n<td>0.3</td>\n<td>0.5</td>\n</tr>\n</table>",
24
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>99.9</td>\n<td>99.7</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Isomerization</td>\n<td>0.1</td>\n<td>0.3</td>\n<td>0.5</td>\n</tr>\n</table>",
25
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 99.9 | 99.7 | 99.5 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Isomerization | 0.1 | 0.3 | 0.5 |"
26
+ },
27
+ {
28
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n</table>",
29
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n</table>",
30
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| NTLYLQMNSLR | HC(77-87) | | 99.5 | 99.5 | 99.5 |\n| NTLYLQMNSLR | HC(77-87) | Oxidation | 0.5 | 0.5 | 0.5 |\n| DIQMTQSPSSLSASVGDR | LC(1-18) | | 99.5 | 99.5 | 99.5 |\n| DIQMTQSPSSLSASVGDR | LC(1-18) | Oxidation | 0.5 | 0.5 | 0.5 |"
31
+ },
32
+ {
33
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.6</td>\n<td>99.6</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>Deamidation</td>\n<td>0.4</td>\n<td>0.4</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.0</td>\n<td>98.8</td>\n<td>98.6</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td>Deamidation</td>\n<td>1.0</td>\n<td>1.2</td>\n<td>1.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.7</td>\n<td>96.1</td>\n<td>93.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Deamidation</td>\n<td>1.3</td>\n<td>3.9</td>\n<td>6.6</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td></td>\n<td>99.9</td>\n<td>99.8</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td>Deamidation</td>\n<td>0.1</td>\n<td>0.2</td>\n<td>0.5</td>\n</tr>\n</table>",
34
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.6</td>\n<td>99.6</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>Deamidation</td>\n<td>0.4</td>\n<td>0.4</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.0</td>\n<td>98.8</td>\n<td>98.6</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td>Deamidation</td>\n<td>1.0</td>\n<td>1.2</td>\n<td>1.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.7</td>\n<td>96.1</td>\n<td>93.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Deamidation</td>\n<td>1.3</td>\n<td>3.9</td>\n<td>6.6</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td></td>\n<td>99.9</td>\n<td>99.8</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td>Deamidation</td>\n<td>0.1</td>\n<td>0.2</td>\n<td>0.5</td>\n</tr>\n</table>",
35
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.6 | 99.6 | 99.5 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | Deamidation | 0.4 | 0.4 | 0.5 |\n| NTLYLQMNSLR* | HC(77-87) | | 99.0 | 98.8 | 98.6 |\n| NTLYLQMNSLR* | HC(77-87) | Deamidation | 1.0 | 1.2 | 1.4 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.7 | 96.1 | 93.4 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Deamidation | 1.3 | 3.9 | 6.6 |\n| VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | | 99.9 | 99.8 | 99.5 |\n| VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | Deamidation | 0.1 | 0.2 | 0.5 |"
36
+ },
37
+ {
38
+ "original_html": "<table border=\"1\">\n<tr>\n<td>b --- 1</td>\n<td></td>\n<td></td>\n<td>y</td>\n</tr>\n<tr>\n<td>b --- 1</td>\n<td>N(+0.984016)</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>217.0819 2</td>\n<td>T</td>\n<td>10</td>\n<td>1238.6562</td>\n</tr>\n<tr>\n<td>330.1660 3</td>\n<td>L</td>\n<td>9</td>\n<td>1137.6085</td>\n</tr>\n<tr>\n<td>493.2293 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1024.5244</td>\n</tr>\n<tr>\n<td>606.3134 5</td>\n<td>L</td>\n<td>7</td>\n<td>861.4611</td>\n</tr>\n<tr>\n<td>734.3719 6</td>\n<td>Q</td>\n<td>6</td>\n<td>748.3770</td>\n</tr>\n<tr>\n<td>865.4124 7</td>\n<td>M</td>\n<td>5</td>\n<td>620.3185</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N</td>\n<td>4</td>\n<td>489.2780</td>\n</tr>\n<tr>\n<td>066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
39
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>b --- 1</th>\n<th></th>\n<th></th>\n<th>y</th>\n</tr>\n<tr>\n<td>b --- 1</td>\n<td>N(+0.984016)</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>217.0819 2</td>\n<td>T</td>\n<td>10</td>\n<td>1238.6562</td>\n</tr>\n<tr>\n<td>330.1660 3</td>\n<td>L</td>\n<td>9</td>\n<td>1137.6085</td>\n</tr>\n<tr>\n<td>493.2293 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1024.5244</td>\n</tr>\n<tr>\n<td>606.3134 5</td>\n<td>L</td>\n<td>7</td>\n<td>861.4611</td>\n</tr>\n<tr>\n<td>734.3719 6</td>\n<td>Q</td>\n<td>6</td>\n<td>748.3770</td>\n</tr>\n<tr>\n<td>865.4124 7</td>\n<td>M</td>\n<td>5</td>\n<td>620.3185</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N</td>\n<td>4</td>\n<td>489.2780</td>\n</tr>\n<tr>\n<td>066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
40
+ "markdown": "| b --- 1 | | | y |\n| --- | --- | --- | --- |\n| b --- 1 | N(+0.984016) | 11 | --- |\n| 217.0819 2 | T | 10 | 1238.6562 |\n| 330.1660 3 | L | 9 | 1137.6085 |\n| 493.2293 4 | Y | 8 | 1024.5244 |\n| 606.3134 5 | L | 7 | 861.4611 |\n| 734.3719 6 | Q | 6 | 748.3770 |\n| 865.4124 7 | M | 5 | 620.3185 |\n| 979.4553 8 | N | 4 | 489.2780 |\n| 066.4874 9 | S | 3 | 375.2350 |\n| 179.5714 10 | L | 2 | 288.2030 |\n| --- 11 | R | 1 | 175.1190 |"
41
+ },
42
+ {
43
+ "original_html": "<table border=\"1\">\n<tr>\n<td>b</td>\n<td>y</td>\n<td>y</td>\n<td>y</td>\n</tr>\n<tr>\n<td>--- 1</td>\n<td>N</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>216.0979 2</td>\n<td>T</td>\n<td>10</td>\n<td>1239.6402</td>\n</tr>\n<tr>\n<td>329.1819 3</td>\n<td>L</td>\n<td>9</td>\n<td>1138.5925</td>\n</tr>\n<tr>\n<td>492.2453 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1025.5084</td>\n</tr>\n<tr>\n<td>605.3293 5</td>\n<td>L</td>\n<td>7</td>\n<td>862.4451</td>\n</tr>\n<tr>\n<td>733.3879 6</td>\n<td>Q</td>\n<td>6</td>\n<td>749.3611</td>\n</tr>\n<tr>\n<td>864.4284 7</td>\n<td>M</td>\n<td>5</td>\n<td>621.3025</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N(+0.984016)</td>\n<td>4</td>\n<td>490.2620</td>\n</tr>\n<tr>\n<td>1066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>1179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
44
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>b</th>\n<th>y</th>\n<th>y</th>\n<th>y</th>\n</tr>\n<tr>\n<td>--- 1</td>\n<td>N</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>216.0979 2</td>\n<td>T</td>\n<td>10</td>\n<td>1239.6402</td>\n</tr>\n<tr>\n<td>329.1819 3</td>\n<td>L</td>\n<td>9</td>\n<td>1138.5925</td>\n</tr>\n<tr>\n<td>492.2453 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1025.5084</td>\n</tr>\n<tr>\n<td>605.3293 5</td>\n<td>L</td>\n<td>7</td>\n<td>862.4451</td>\n</tr>\n<tr>\n<td>733.3879 6</td>\n<td>Q</td>\n<td>6</td>\n<td>749.3611</td>\n</tr>\n<tr>\n<td>864.4284 7</td>\n<td>M</td>\n<td>5</td>\n<td>621.3025</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N(+0.984016)</td>\n<td>4</td>\n<td>490.2620</td>\n</tr>\n<tr>\n<td>1066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>1179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
45
+ "markdown": "| b | y | y | y |\n| --- | --- | --- | --- |\n| --- 1 | N | 11 | --- |\n| 216.0979 2 | T | 10 | 1239.6402 |\n| 329.1819 3 | L | 9 | 1138.5925 |\n| 492.2453 4 | Y | 8 | 1025.5084 |\n| 605.3293 5 | L | 7 | 862.4451 |\n| 733.3879 6 | Q | 6 | 749.3611 |\n| 864.4284 7 | M | 5 | 621.3025 |\n| 979.4553 8 | N(+0.984016) | 4 | 490.2620 |\n| 1066.4874 9 | S | 3 | 375.2350 |\n| 1179.5714 10 | L | 2 | 288.2030 |\n| --- 11 | R | 1 | 175.1190 |"
46
+ },
47
+ {
48
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>SCDK</td>\n<td>HC(223-226)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC</td>\n<td>LC(208-214)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC - SCDK</td>\n<td>HC(223-226) + LC(208-214)</td>\n<td>Thioether</td>\n<td>0.2</td>\n<td>0.5</td>\n<td>1.2</td>\n</tr>\n</table>",
49
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>SCDK</td>\n<td>HC(223-226)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC</td>\n<td>LC(208-214)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC - SCDK</td>\n<td>HC(223-226) + LC(208-214)</td>\n<td>Thioether</td>\n<td>0.2</td>\n<td>0.5</td>\n<td>1.2</td>\n</tr>\n</table>",
50
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| SCDK | HC(223-226) | | 99.8 | 99.5 | 98.8 |\n| SFNRGEC | LC(208-214) | | 99.8 | 99.5 | 98.8 |\n| SFNRGEC - SCDK | HC(223-226) + LC(208-214) | Thioether | 0.2 | 0.5 | 1.2 |"
51
+ },
52
+ {
53
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.6</td>\n<td>98.1</td>\n<td>96.8</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSN</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>0.3</td>\n<td>0.4</td>\n<td>0.6</td>\n</tr>\n<tr>\n<td>LAGDFGSWGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>1.1</td>\n<td>1.5</td>\n<td>2.6</td>\n</tr>\n<tr>\n<td>STSGGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td></td>\n<td>99.9</td>\n<td>99.3</td>\n<td>98.7</td>\n</tr>\n<tr>\n<td>GGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping</td>\n<td>0.0</td>\n<td>0.2</td>\n<td>0.3</td>\n</tr>\n<tr>\n<td>GTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping_2</td>\n<td>0.1</td>\n<td>0.5</td>\n<td>0.9</td>\n</tr>\n<tr>\n<td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>\n<td>HC(223-252)</td>\n<td></td>\n<td>99.6</td>\n<td>99.4</td>\n<td>99.0</td>\n</tr>\n<tr>\n<td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>\n<td>HC(223-252)</td>\n<td>Clipping</td>\n<td>0.4</td>\n<td>0.6</td>\n<td>1.0</td>\n</tr>\n</table>",
54
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.6</td>\n<td>98.1</td>\n<td>96.8</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSN</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>0.3</td>\n<td>0.4</td>\n<td>0.6</td>\n</tr>\n<tr>\n<td>LAGDFGSWGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>1.1</td>\n<td>1.5</td>\n<td>2.6</td>\n</tr>\n<tr>\n<td>STSGGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td></td>\n<td>99.9</td>\n<td>99.3</td>\n<td>98.7</td>\n</tr>\n<tr>\n<td>GGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping</td>\n<td>0.0</td>\n<td>0.2</td>\n<td>0.3</td>\n</tr>\n<tr>\n<td>GTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping_2</td>\n<td>0.1</td>\n<td>0.5</td>\n<td>0.9</td>\n</tr>\n<tr>\n<td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>\n<td>HC(223-252)</td>\n<td></td>\n<td>99.6</td>\n<td>99.4</td>\n<td>99.0</td>\n</tr>\n<tr>\n<td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>\n<td>HC(223-252)</td>\n<td>Clipping</td>\n<td>0.4</td>\n<td>0.6</td>\n<td>1.0</td>\n</tr>\n</table>",
55
+ "markdown": "| Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.6 | 98.1 | 96.8 |\n| AEDTAVYYCAKPLYSN | HC(88-125) | Clipping | 0.3 | 0.4 | 0.6 |\n| LAGDFGSWGQGTTVTVSSASTK | HC(88-125) | Clipping | 1.1 | 1.5 | 2.6 |\n| STSGGTAALGCLVK | HC(138-151) | | 99.9 | 99.3 | 98.7 |\n| GGTAALGCLVK | HC(138-151) | Clipping | 0.0 | 0.2 | 0.3 |\n| GTAALGCLVK | HC(138-151) | Clipping_2 | 0.1 | 0.5 | 0.9 |\n| SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK | HC(223-252) | | 99.6 | 99.4 | 99.0 |\n| DKTHTCPPCPAPEAAGGPSVFLFP PKPK | HC(223-252) | Clipping | 0.4 | 0.6 | 1.0 |"
56
+ },
57
+ {
58
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Blue:</td>\n<td>VH and VL</td>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
59
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Blue:</th>\n<th>VH and VL</th>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
60
+ "markdown": "| Blue: | VH and VL |\n| --- | --- |\n| Blue: | CDR |\n| Green: | N-glycosylation site |"
61
+ },
62
+ {
63
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Mabelle Meersseman</td>\n<td>Date:</td>\n</tr>\n<tr>\n<td>Group Leader</td>\n<td>Signature:</td>\n</tr>\n<tr>\n<td>Approver</td>\n<td></td>\n</tr>\n<tr>\n<td>Koen Sandra Ph.D.</td>\n<td>Date:</td>\n</tr>\n<tr>\n<td>CEO</td>\n<td>Signature:</td>\n</tr>\n</table>",
64
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Mabelle Meersseman</th>\n<th>Date:</th>\n</tr>\n<tr>\n<td>Group Leader</td>\n<td>Signature:</td>\n</tr>\n<tr>\n<td>Approver</td>\n<td></td>\n</tr>\n<tr>\n<td>Koen Sandra Ph.D.</td>\n<td>Date:</td>\n</tr>\n<tr>\n<td>CEO</td>\n<td>Signature:</td>\n</tr>\n</table>",
65
+ "markdown": "| Mabelle Meersseman | Date: |\n| --- | --- |\n| Group Leader | Signature: |\n| Approver | |\n| Koen Sandra Ph.D. | Date: |\n| CEO | Signature: |"
66
+ },
67
+ {
68
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Version</td>\n<td>Date of issue</td>\n<td>Reason for version update</td>\n</tr>\n<tr>\n<td>00</td>\n<td>20 November 2024</td>\n<td>Draft</td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n</table>",
69
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Version</th>\n<th>Date of issue</th>\n<th>Reason for version update</th>\n</tr>\n<tr>\n<td>00</td>\n<td>20 November 2024</td>\n<td>Draft</td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n</table>",
70
+ "markdown": "| Version | Date of issue | Reason for version update |\n| --- | --- | --- |\n| 00 | 20 November 2024 | Draft |\n| | | |\n| | | |"
71
+ }
72
+ ]
logs/di_content/di_content_20250605_134434_tables.md ADDED
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1
+ # Azure Document Intelligence Tables
2
+
3
+ ## Table 1
4
+
5
+ | Sales quote: | SQ20202722 |
6
+ | --- | --- |
7
+ | Project code: | P3016 |
8
+ | LNB number: | 2023.040 |
9
+ | Project responsible: | Nathan Cardon |
10
+ | Report name: | P3016_R010_v01 |
11
+
12
+ ## Table 2
13
+
14
+ | Construct | Stress condition | Concentration (mg/mL) |
15
+ | --- | --- | --- |
16
+ | P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T0W | 1.00 |
17
+ | P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T2W_37℃ | 1.00 |
18
+ | P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T4W_37℃ | 1.00 |
19
+
20
+ ## Table 3
21
+
22
+ | Blue: | VH and VL |
23
+ | --- | --- |
24
+ | Blue: | CDR |
25
+ | Green: | N-glycosylation site |
26
+
27
+ ## Table 4
28
+
29
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
30
+ | --- | --- | --- | --- | --- | --- |
31
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
32
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.0 | 96.1 | 93.0 |
33
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | PyroE | 1.0 | 3.9 | 7.0 |
34
+
35
+ ## Table 5
36
+
37
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
38
+ | --- | --- | --- | --- | --- | --- |
39
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
40
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 99.9 | 99.7 | 99.5 |
41
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Isomerization | 0.1 | 0.3 | 0.5 |
42
+
43
+ ## Table 6
44
+
45
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
46
+ | --- | --- | --- | --- | --- | --- |
47
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
48
+ | NTLYLQMNSLR | HC(77-87) | | 99.5 | 99.5 | 99.5 |
49
+ | NTLYLQMNSLR | HC(77-87) | Oxidation | 0.5 | 0.5 | 0.5 |
50
+ | DIQMTQSPSSLSASVGDR | LC(1-18) | | 99.5 | 99.5 | 99.5 |
51
+ | DIQMTQSPSSLSASVGDR | LC(1-18) | Oxidation | 0.5 | 0.5 | 0.5 |
52
+
53
+ ## Table 7
54
+
55
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
56
+ | --- | --- | --- | --- | --- | --- |
57
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
58
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.6 | 99.6 | 99.5 |
59
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | Deamidation | 0.4 | 0.4 | 0.5 |
60
+ | NTLYLQMNSLR* | HC(77-87) | | 99.0 | 98.8 | 98.6 |
61
+ | NTLYLQMNSLR* | HC(77-87) | Deamidation | 1.0 | 1.2 | 1.4 |
62
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.7 | 96.1 | 93.4 |
63
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Deamidation | 1.3 | 3.9 | 6.6 |
64
+ | VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | | 99.9 | 99.8 | 99.5 |
65
+ | VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | Deamidation | 0.1 | 0.2 | 0.5 |
66
+
67
+ ## Table 8
68
+
69
+ | b --- 1 | | | y |
70
+ | --- | --- | --- | --- |
71
+ | b --- 1 | N(+0.984016) | 11 | --- |
72
+ | 217.0819 2 | T | 10 | 1238.6562 |
73
+ | 330.1660 3 | L | 9 | 1137.6085 |
74
+ | 493.2293 4 | Y | 8 | 1024.5244 |
75
+ | 606.3134 5 | L | 7 | 861.4611 |
76
+ | 734.3719 6 | Q | 6 | 748.3770 |
77
+ | 865.4124 7 | M | 5 | 620.3185 |
78
+ | 979.4553 8 | N | 4 | 489.2780 |
79
+ | 066.4874 9 | S | 3 | 375.2350 |
80
+ | 179.5714 10 | L | 2 | 288.2030 |
81
+ | --- 11 | R | 1 | 175.1190 |
82
+
83
+ ## Table 9
84
+
85
+ | b | y | y | y |
86
+ | --- | --- | --- | --- |
87
+ | --- 1 | N | 11 | --- |
88
+ | 216.0979 2 | T | 10 | 1239.6402 |
89
+ | 329.1819 3 | L | 9 | 1138.5925 |
90
+ | 492.2453 4 | Y | 8 | 1025.5084 |
91
+ | 605.3293 5 | L | 7 | 862.4451 |
92
+ | 733.3879 6 | Q | 6 | 749.3611 |
93
+ | 864.4284 7 | M | 5 | 621.3025 |
94
+ | 979.4553 8 | N(+0.984016) | 4 | 490.2620 |
95
+ | 1066.4874 9 | S | 3 | 375.2350 |
96
+ | 1179.5714 10 | L | 2 | 288.2030 |
97
+ | --- 11 | R | 1 | 175.1190 |
98
+
99
+ ## Table 10
100
+
101
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
102
+ | --- | --- | --- | --- | --- | --- |
103
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
104
+ | SCDK | HC(223-226) | | 99.8 | 99.5 | 98.8 |
105
+ | SFNRGEC | LC(208-214) | | 99.8 | 99.5 | 98.8 |
106
+ | SFNRGEC - SCDK | HC(223-226) + LC(208-214) | Thioether | 0.2 | 0.5 | 1.2 |
107
+
108
+ ## Table 11
109
+
110
+ | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* |
111
+ | --- | --- | --- | --- | --- | --- |
112
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
113
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.6 | 98.1 | 96.8 |
114
+ | AEDTAVYYCAKPLYSN | HC(88-125) | Clipping | 0.3 | 0.4 | 0.6 |
115
+ | LAGDFGSWGQGTTVTVSSASTK | HC(88-125) | Clipping | 1.1 | 1.5 | 2.6 |
116
+ | STSGGTAALGCLVK | HC(138-151) | | 99.9 | 99.3 | 98.7 |
117
+ | GGTAALGCLVK | HC(138-151) | Clipping | 0.0 | 0.2 | 0.3 |
118
+ | GTAALGCLVK | HC(138-151) | Clipping_2 | 0.1 | 0.5 | 0.9 |
119
+ | SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK | HC(223-252) | | 99.6 | 99.4 | 99.0 |
120
+ | DKTHTCPPCPAPEAAGGPSVFLFP PKPK | HC(223-252) | Clipping | 0.4 | 0.6 | 1.0 |
121
+
122
+ ## Table 12
123
+
124
+ | Blue: | VH and VL |
125
+ | --- | --- |
126
+ | Blue: | CDR |
127
+ | Green: | N-glycosylation site |
128
+
129
+ ## Table 13
130
+
131
+ | Mabelle Meersseman | Date: |
132
+ | --- | --- |
133
+ | Group Leader | Signature: |
134
+ | Approver | |
135
+ | Koen Sandra Ph.D. | Date: |
136
+ | CEO | Signature: |
137
+
138
+ ## Table 14
139
+
140
+ | Version | Date of issue | Reason for version update |
141
+ | --- | --- | --- |
142
+ | 00 | 20 November 2024 | Draft |
143
+ | | | |
144
+ | | | |
145
+
logs/di_content/di_content_20250605_134434_tables_comparison.html ADDED
@@ -0,0 +1,1380 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Table Comparison</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ .table-pair { display: flex; gap: 20px; margin-bottom: 20px; }
9
+ .table-wrapper { flex: 1; }
10
+ h2 { color: #333; }
11
+ h3 { color: #666; margin: 10px 0; }
12
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
13
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
14
+ th { background-color: #f5f5f5; }
15
+ .original { background-color: #f0f7ff; }
16
+ .expanded { background-color: #f0fff0; }
17
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
18
+ </style>
19
+ </head>
20
+ <body>
21
+ <h1>Table Comparison - Original vs Expanded</h1>
22
+
23
+ <div class="table-container">
24
+ <h2>Table 1</h2>
25
+ <div class="table-pair">
26
+ <div class="table-wrapper">
27
+ <h3>Original Table (with rowspans)</h3>
28
+ <table border="1">
29
+ <tr>
30
+ <td>Sales quote:</td>
31
+ <td>SQ20202722</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project code:</td>
35
+ <td>P3016</td>
36
+ </tr>
37
+ <tr>
38
+ <td>LNB number:</td>
39
+ <td>2023.040</td>
40
+ </tr>
41
+ <tr>
42
+ <td>Project responsible:</td>
43
+ <td>Nathan Cardon</td>
44
+ </tr>
45
+ <tr>
46
+ <td>Report name:</td>
47
+ <td>P3016_R010_v01</td>
48
+ </tr>
49
+ </table>
50
+ </div>
51
+ <div class="table-wrapper">
52
+ <h3>Expanded Table (rowspans resolved)</h3>
53
+ <table border="1">
54
+ <tr>
55
+ <th>Sales quote:</th>
56
+ <th>SQ20202722</th>
57
+ </tr>
58
+ <tr>
59
+ <td>Project code:</td>
60
+ <td>P3016</td>
61
+ </tr>
62
+ <tr>
63
+ <td>LNB number:</td>
64
+ <td>2023.040</td>
65
+ </tr>
66
+ <tr>
67
+ <td>Project responsible:</td>
68
+ <td>Nathan Cardon</td>
69
+ </tr>
70
+ <tr>
71
+ <td>Report name:</td>
72
+ <td>P3016_R010_v01</td>
73
+ </tr>
74
+ </table>
75
+ </div>
76
+ </div>
77
+ <hr>
78
+ </div>
79
+
80
+ <div class="table-container">
81
+ <h2>Table 2</h2>
82
+ <div class="table-pair">
83
+ <div class="table-wrapper">
84
+ <h3>Original Table (with rowspans)</h3>
85
+ <table border="1">
86
+ <tr>
87
+ <td>Construct</td>
88
+ <td>Stress condition</td>
89
+ <td>Concentration (mg/mL)</td>
90
+ </tr>
91
+ <tr>
92
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
93
+ <td>T0W</td>
94
+ <td>1.00</td>
95
+ </tr>
96
+ <tr>
97
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
98
+ <td>T2W_37℃</td>
99
+ <td>1.00</td>
100
+ </tr>
101
+ <tr>
102
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
103
+ <td>T4W_37℃</td>
104
+ <td>1.00</td>
105
+ </tr>
106
+ </table>
107
+ </div>
108
+ <div class="table-wrapper">
109
+ <h3>Expanded Table (rowspans resolved)</h3>
110
+ <table border="1">
111
+ <tr>
112
+ <th>Construct</th>
113
+ <th>Stress condition</th>
114
+ <th>Concentration (mg/mL)</th>
115
+ </tr>
116
+ <tr>
117
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
118
+ <td>T0W</td>
119
+ <td>1.00</td>
120
+ </tr>
121
+ <tr>
122
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
123
+ <td>T2W_37℃</td>
124
+ <td>1.00</td>
125
+ </tr>
126
+ <tr>
127
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
128
+ <td>T4W_37℃</td>
129
+ <td>1.00</td>
130
+ </tr>
131
+ </table>
132
+ </div>
133
+ </div>
134
+ <hr>
135
+ </div>
136
+
137
+ <div class="table-container">
138
+ <h2>Table 3</h2>
139
+ <div class="table-pair">
140
+ <div class="table-wrapper">
141
+ <h3>Original Table (with rowspans)</h3>
142
+ <table border="1">
143
+ <tr>
144
+ <td>Blue:</td>
145
+ <td>VH and VL</td>
146
+ </tr>
147
+ <tr>
148
+ <td>Blue:</td>
149
+ <td>CDR</td>
150
+ </tr>
151
+ <tr>
152
+ <td>Green:</td>
153
+ <td>N-glycosylation site</td>
154
+ </tr>
155
+ </table>
156
+ </div>
157
+ <div class="table-wrapper">
158
+ <h3>Expanded Table (rowspans resolved)</h3>
159
+ <table border="1">
160
+ <tr>
161
+ <th>Blue:</th>
162
+ <th>VH and VL</th>
163
+ </tr>
164
+ <tr>
165
+ <td>Blue:</td>
166
+ <td>CDR</td>
167
+ </tr>
168
+ <tr>
169
+ <td>Green:</td>
170
+ <td>N-glycosylation site</td>
171
+ </tr>
172
+ </table>
173
+ </div>
174
+ </div>
175
+ <hr>
176
+ </div>
177
+
178
+ <div class="table-container">
179
+ <h2>Table 4</h2>
180
+ <div class="table-pair">
181
+ <div class="table-wrapper">
182
+ <h3>Original Table (with rowspans)</h3>
183
+ <table border="1">
184
+ <tr>
185
+ <td>Relative quantification by EIC (%)</td>
186
+ <td>Relative quantification by EIC (%)</td>
187
+ <td>Relative quantification by EIC (%)</td>
188
+ <td>Relative quantification by EIC (%)</td>
189
+ <td>Relative quantification by EIC (%)</td>
190
+ <td>Relative quantification by EIC (%)</td>
191
+ </tr>
192
+ <tr>
193
+ <td>AA Sequence</td>
194
+ <td>Seq Loc</td>
195
+ <td>Modification</td>
196
+ <td>T0</td>
197
+ <td>T2W_37℃</td>
198
+ <td>T4W_37℃</td>
199
+ </tr>
200
+ <tr>
201
+ <td>EVQLLESGGGLVQPGGSLR</td>
202
+ <td>HC(1-19)</td>
203
+ <td></td>
204
+ <td>99.0</td>
205
+ <td>96.1</td>
206
+ <td>93.0</td>
207
+ </tr>
208
+ <tr>
209
+ <td>EVQLLESGGGLVQPGGSLR</td>
210
+ <td>HC(1-19)</td>
211
+ <td>PyroE</td>
212
+ <td>1.0</td>
213
+ <td>3.9</td>
214
+ <td>7.0</td>
215
+ </tr>
216
+ </table>
217
+ </div>
218
+ <div class="table-wrapper">
219
+ <h3>Expanded Table (rowspans resolved)</h3>
220
+ <table border="1">
221
+ <tr>
222
+ <th>Relative quantification by EIC (%)</th>
223
+ <th>Relative quantification by EIC (%)</th>
224
+ <th>Relative quantification by EIC (%)</th>
225
+ <th>Relative quantification by EIC (%)</th>
226
+ <th>Relative quantification by EIC (%)</th>
227
+ <th>Relative quantification by EIC (%)</th>
228
+ </tr>
229
+ <tr>
230
+ <td>AA Sequence</td>
231
+ <td>Seq Loc</td>
232
+ <td>Modification</td>
233
+ <td>T0</td>
234
+ <td>T2W_37℃</td>
235
+ <td>T4W_37℃</td>
236
+ </tr>
237
+ <tr>
238
+ <td>EVQLLESGGGLVQPGGSLR</td>
239
+ <td>HC(1-19)</td>
240
+ <td></td>
241
+ <td>99.0</td>
242
+ <td>96.1</td>
243
+ <td>93.0</td>
244
+ </tr>
245
+ <tr>
246
+ <td>EVQLLESGGGLVQPGGSLR</td>
247
+ <td>HC(1-19)</td>
248
+ <td>PyroE</td>
249
+ <td>1.0</td>
250
+ <td>3.9</td>
251
+ <td>7.0</td>
252
+ </tr>
253
+ </table>
254
+ </div>
255
+ </div>
256
+ <hr>
257
+ </div>
258
+
259
+ <div class="table-container">
260
+ <h2>Table 5</h2>
261
+ <div class="table-pair">
262
+ <div class="table-wrapper">
263
+ <h3>Original Table (with rowspans)</h3>
264
+ <table border="1">
265
+ <tr>
266
+ <td>Relative quantification by EIC (%)</td>
267
+ <td>Relative quantification by EIC (%)</td>
268
+ <td>Relative quantification by EIC (%)</td>
269
+ <td>Relative quantification by EIC (%)</td>
270
+ <td>Relative quantification by EIC (%)</td>
271
+ <td>Relative quantification by EIC (%)</td>
272
+ </tr>
273
+ <tr>
274
+ <td>AA Sequence</td>
275
+ <td>Seq Loc</td>
276
+ <td>Modification</td>
277
+ <td>T0</td>
278
+ <td>T2W_37℃</td>
279
+ <td>T4W_37℃</td>
280
+ </tr>
281
+ <tr>
282
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
283
+ <td>HC(88-125)</td>
284
+ <td></td>
285
+ <td>99.9</td>
286
+ <td>99.7</td>
287
+ <td>99.5</td>
288
+ </tr>
289
+ <tr>
290
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
291
+ <td>HC(88-125)</td>
292
+ <td>Isomerization</td>
293
+ <td>0.1</td>
294
+ <td>0.3</td>
295
+ <td>0.5</td>
296
+ </tr>
297
+ </table>
298
+ </div>
299
+ <div class="table-wrapper">
300
+ <h3>Expanded Table (rowspans resolved)</h3>
301
+ <table border="1">
302
+ <tr>
303
+ <th>Relative quantification by EIC (%)</th>
304
+ <th>Relative quantification by EIC (%)</th>
305
+ <th>Relative quantification by EIC (%)</th>
306
+ <th>Relative quantification by EIC (%)</th>
307
+ <th>Relative quantification by EIC (%)</th>
308
+ <th>Relative quantification by EIC (%)</th>
309
+ </tr>
310
+ <tr>
311
+ <td>AA Sequence</td>
312
+ <td>Seq Loc</td>
313
+ <td>Modification</td>
314
+ <td>T0</td>
315
+ <td>T2W_37℃</td>
316
+ <td>T4W_37℃</td>
317
+ </tr>
318
+ <tr>
319
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
320
+ <td>HC(88-125)</td>
321
+ <td></td>
322
+ <td>99.9</td>
323
+ <td>99.7</td>
324
+ <td>99.5</td>
325
+ </tr>
326
+ <tr>
327
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
328
+ <td>HC(88-125)</td>
329
+ <td>Isomerization</td>
330
+ <td>0.1</td>
331
+ <td>0.3</td>
332
+ <td>0.5</td>
333
+ </tr>
334
+ </table>
335
+ </div>
336
+ </div>
337
+ <hr>
338
+ </div>
339
+
340
+ <div class="table-container">
341
+ <h2>Table 6</h2>
342
+ <div class="table-pair">
343
+ <div class="table-wrapper">
344
+ <h3>Original Table (with rowspans)</h3>
345
+ <table border="1">
346
+ <tr>
347
+ <td>Relative quantification by EIC (%)</td>
348
+ <td>Relative quantification by EIC (%)</td>
349
+ <td>Relative quantification by EIC (%)</td>
350
+ <td>Relative quantification by EIC (%)</td>
351
+ <td>Relative quantification by EIC (%)</td>
352
+ <td>Relative quantification by EIC (%)</td>
353
+ </tr>
354
+ <tr>
355
+ <td>AA Sequence</td>
356
+ <td>Seq Loc</td>
357
+ <td>Modification</td>
358
+ <td>T0</td>
359
+ <td>T2W_37℃</td>
360
+ <td>T4W_37℃</td>
361
+ </tr>
362
+ <tr>
363
+ <td>NTLYLQMNSLR</td>
364
+ <td>HC(77-87)</td>
365
+ <td></td>
366
+ <td>99.5</td>
367
+ <td>99.5</td>
368
+ <td>99.5</td>
369
+ </tr>
370
+ <tr>
371
+ <td>NTLYLQMNSLR</td>
372
+ <td>HC(77-87)</td>
373
+ <td>Oxidation</td>
374
+ <td>0.5</td>
375
+ <td>0.5</td>
376
+ <td>0.5</td>
377
+ </tr>
378
+ <tr>
379
+ <td>DIQMTQSPSSLSASVGDR</td>
380
+ <td>LC(1-18)</td>
381
+ <td></td>
382
+ <td>99.5</td>
383
+ <td>99.5</td>
384
+ <td>99.5</td>
385
+ </tr>
386
+ <tr>
387
+ <td>DIQMTQSPSSLSASVGDR</td>
388
+ <td>LC(1-18)</td>
389
+ <td>Oxidation</td>
390
+ <td>0.5</td>
391
+ <td>0.5</td>
392
+ <td>0.5</td>
393
+ </tr>
394
+ </table>
395
+ </div>
396
+ <div class="table-wrapper">
397
+ <h3>Expanded Table (rowspans resolved)</h3>
398
+ <table border="1">
399
+ <tr>
400
+ <th>Relative quantification by EIC (%)</th>
401
+ <th>Relative quantification by EIC (%)</th>
402
+ <th>Relative quantification by EIC (%)</th>
403
+ <th>Relative quantification by EIC (%)</th>
404
+ <th>Relative quantification by EIC (%)</th>
405
+ <th>Relative quantification by EIC (%)</th>
406
+ </tr>
407
+ <tr>
408
+ <td>AA Sequence</td>
409
+ <td>Seq Loc</td>
410
+ <td>Modification</td>
411
+ <td>T0</td>
412
+ <td>T2W_37℃</td>
413
+ <td>T4W_37℃</td>
414
+ </tr>
415
+ <tr>
416
+ <td>NTLYLQMNSLR</td>
417
+ <td>HC(77-87)</td>
418
+ <td></td>
419
+ <td>99.5</td>
420
+ <td>99.5</td>
421
+ <td>99.5</td>
422
+ </tr>
423
+ <tr>
424
+ <td>NTLYLQMNSLR</td>
425
+ <td>HC(77-87)</td>
426
+ <td>Oxidation</td>
427
+ <td>0.5</td>
428
+ <td>0.5</td>
429
+ <td>0.5</td>
430
+ </tr>
431
+ <tr>
432
+ <td>DIQMTQSPSSLSASVGDR</td>
433
+ <td>LC(1-18)</td>
434
+ <td></td>
435
+ <td>99.5</td>
436
+ <td>99.5</td>
437
+ <td>99.5</td>
438
+ </tr>
439
+ <tr>
440
+ <td>DIQMTQSPSSLSASVGDR</td>
441
+ <td>LC(1-18)</td>
442
+ <td>Oxidation</td>
443
+ <td>0.5</td>
444
+ <td>0.5</td>
445
+ <td>0.5</td>
446
+ </tr>
447
+ </table>
448
+ </div>
449
+ </div>
450
+ <hr>
451
+ </div>
452
+
453
+ <div class="table-container">
454
+ <h2>Table 7</h2>
455
+ <div class="table-pair">
456
+ <div class="table-wrapper">
457
+ <h3>Original Table (with rowspans)</h3>
458
+ <table border="1">
459
+ <tr>
460
+ <td>Relative quantification by EIC (%)</td>
461
+ <td>Relative quantification by EIC (%)</td>
462
+ <td>Relative quantification by EIC (%)</td>
463
+ <td>Relative quantification by EIC (%)</td>
464
+ <td>Relative quantification by EIC (%)</td>
465
+ <td>Relative quantification by EIC (%)</td>
466
+ </tr>
467
+ <tr>
468
+ <td>AA Sequence</td>
469
+ <td>Seq Loc</td>
470
+ <td>Modification</td>
471
+ <td>T0</td>
472
+ <td>T2W_37℃</td>
473
+ <td>T4W_37℃</td>
474
+ </tr>
475
+ <tr>
476
+ <td>EVQLLESGGGLVQPGGSLR</td>
477
+ <td>HC(1-19)</td>
478
+ <td></td>
479
+ <td>99.6</td>
480
+ <td>99.6</td>
481
+ <td>99.5</td>
482
+ </tr>
483
+ <tr>
484
+ <td>EVQLLESGGGLVQPGGSLR</td>
485
+ <td>HC(1-19)</td>
486
+ <td>Deamidation</td>
487
+ <td>0.4</td>
488
+ <td>0.4</td>
489
+ <td>0.5</td>
490
+ </tr>
491
+ <tr>
492
+ <td>NTLYLQMNSLR*</td>
493
+ <td>HC(77-87)</td>
494
+ <td></td>
495
+ <td>99.0</td>
496
+ <td>98.8</td>
497
+ <td>98.6</td>
498
+ </tr>
499
+ <tr>
500
+ <td>NTLYLQMNSLR*</td>
501
+ <td>HC(77-87)</td>
502
+ <td>Deamidation</td>
503
+ <td>1.0</td>
504
+ <td>1.2</td>
505
+ <td>1.4</td>
506
+ </tr>
507
+ <tr>
508
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
509
+ <td>HC(88-125)</td>
510
+ <td></td>
511
+ <td>98.7</td>
512
+ <td>96.1</td>
513
+ <td>93.4</td>
514
+ </tr>
515
+ <tr>
516
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
517
+ <td>HC(88-125)</td>
518
+ <td>Deamidation</td>
519
+ <td>1.3</td>
520
+ <td>3.9</td>
521
+ <td>6.6</td>
522
+ </tr>
523
+ <tr>
524
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
525
+ <td>LC(19-42)</td>
526
+ <td></td>
527
+ <td>99.9</td>
528
+ <td>99.8</td>
529
+ <td>99.5</td>
530
+ </tr>
531
+ <tr>
532
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
533
+ <td>LC(19-42)</td>
534
+ <td>Deamidation</td>
535
+ <td>0.1</td>
536
+ <td>0.2</td>
537
+ <td>0.5</td>
538
+ </tr>
539
+ </table>
540
+ </div>
541
+ <div class="table-wrapper">
542
+ <h3>Expanded Table (rowspans resolved)</h3>
543
+ <table border="1">
544
+ <tr>
545
+ <th>Relative quantification by EIC (%)</th>
546
+ <th>Relative quantification by EIC (%)</th>
547
+ <th>Relative quantification by EIC (%)</th>
548
+ <th>Relative quantification by EIC (%)</th>
549
+ <th>Relative quantification by EIC (%)</th>
550
+ <th>Relative quantification by EIC (%)</th>
551
+ </tr>
552
+ <tr>
553
+ <td>AA Sequence</td>
554
+ <td>Seq Loc</td>
555
+ <td>Modification</td>
556
+ <td>T0</td>
557
+ <td>T2W_37℃</td>
558
+ <td>T4W_37℃</td>
559
+ </tr>
560
+ <tr>
561
+ <td>EVQLLESGGGLVQPGGSLR</td>
562
+ <td>HC(1-19)</td>
563
+ <td></td>
564
+ <td>99.6</td>
565
+ <td>99.6</td>
566
+ <td>99.5</td>
567
+ </tr>
568
+ <tr>
569
+ <td>EVQLLESGGGLVQPGGSLR</td>
570
+ <td>HC(1-19)</td>
571
+ <td>Deamidation</td>
572
+ <td>0.4</td>
573
+ <td>0.4</td>
574
+ <td>0.5</td>
575
+ </tr>
576
+ <tr>
577
+ <td>NTLYLQMNSLR*</td>
578
+ <td>HC(77-87)</td>
579
+ <td></td>
580
+ <td>99.0</td>
581
+ <td>98.8</td>
582
+ <td>98.6</td>
583
+ </tr>
584
+ <tr>
585
+ <td>NTLYLQMNSLR*</td>
586
+ <td>HC(77-87)</td>
587
+ <td>Deamidation</td>
588
+ <td>1.0</td>
589
+ <td>1.2</td>
590
+ <td>1.4</td>
591
+ </tr>
592
+ <tr>
593
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
594
+ <td>HC(88-125)</td>
595
+ <td></td>
596
+ <td>98.7</td>
597
+ <td>96.1</td>
598
+ <td>93.4</td>
599
+ </tr>
600
+ <tr>
601
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
602
+ <td>HC(88-125)</td>
603
+ <td>Deamidation</td>
604
+ <td>1.3</td>
605
+ <td>3.9</td>
606
+ <td>6.6</td>
607
+ </tr>
608
+ <tr>
609
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
610
+ <td>LC(19-42)</td>
611
+ <td></td>
612
+ <td>99.9</td>
613
+ <td>99.8</td>
614
+ <td>99.5</td>
615
+ </tr>
616
+ <tr>
617
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
618
+ <td>LC(19-42)</td>
619
+ <td>Deamidation</td>
620
+ <td>0.1</td>
621
+ <td>0.2</td>
622
+ <td>0.5</td>
623
+ </tr>
624
+ </table>
625
+ </div>
626
+ </div>
627
+ <hr>
628
+ </div>
629
+
630
+ <div class="table-container">
631
+ <h2>Table 8</h2>
632
+ <div class="table-pair">
633
+ <div class="table-wrapper">
634
+ <h3>Original Table (with rowspans)</h3>
635
+ <table border="1">
636
+ <tr>
637
+ <td>b --- 1</td>
638
+ <td></td>
639
+ <td></td>
640
+ <td>y</td>
641
+ </tr>
642
+ <tr>
643
+ <td>b --- 1</td>
644
+ <td>N(+0.984016)</td>
645
+ <td>11</td>
646
+ <td>---</td>
647
+ </tr>
648
+ <tr>
649
+ <td>217.0819 2</td>
650
+ <td>T</td>
651
+ <td>10</td>
652
+ <td>1238.6562</td>
653
+ </tr>
654
+ <tr>
655
+ <td>330.1660 3</td>
656
+ <td>L</td>
657
+ <td>9</td>
658
+ <td>1137.6085</td>
659
+ </tr>
660
+ <tr>
661
+ <td>493.2293 4</td>
662
+ <td>Y</td>
663
+ <td>8</td>
664
+ <td>1024.5244</td>
665
+ </tr>
666
+ <tr>
667
+ <td>606.3134 5</td>
668
+ <td>L</td>
669
+ <td>7</td>
670
+ <td>861.4611</td>
671
+ </tr>
672
+ <tr>
673
+ <td>734.3719 6</td>
674
+ <td>Q</td>
675
+ <td>6</td>
676
+ <td>748.3770</td>
677
+ </tr>
678
+ <tr>
679
+ <td>865.4124 7</td>
680
+ <td>M</td>
681
+ <td>5</td>
682
+ <td>620.3185</td>
683
+ </tr>
684
+ <tr>
685
+ <td>979.4553 8</td>
686
+ <td>N</td>
687
+ <td>4</td>
688
+ <td>489.2780</td>
689
+ </tr>
690
+ <tr>
691
+ <td>066.4874 9</td>
692
+ <td>S</td>
693
+ <td>3</td>
694
+ <td>375.2350</td>
695
+ </tr>
696
+ <tr>
697
+ <td>179.5714 10</td>
698
+ <td>L</td>
699
+ <td>2</td>
700
+ <td>288.2030</td>
701
+ </tr>
702
+ <tr>
703
+ <td>--- 11</td>
704
+ <td>R</td>
705
+ <td>1</td>
706
+ <td>175.1190</td>
707
+ </tr>
708
+ </table>
709
+ </div>
710
+ <div class="table-wrapper">
711
+ <h3>Expanded Table (rowspans resolved)</h3>
712
+ <table border="1">
713
+ <tr>
714
+ <th>b --- 1</th>
715
+ <th></th>
716
+ <th></th>
717
+ <th>y</th>
718
+ </tr>
719
+ <tr>
720
+ <td>b --- 1</td>
721
+ <td>N(+0.984016)</td>
722
+ <td>11</td>
723
+ <td>---</td>
724
+ </tr>
725
+ <tr>
726
+ <td>217.0819 2</td>
727
+ <td>T</td>
728
+ <td>10</td>
729
+ <td>1238.6562</td>
730
+ </tr>
731
+ <tr>
732
+ <td>330.1660 3</td>
733
+ <td>L</td>
734
+ <td>9</td>
735
+ <td>1137.6085</td>
736
+ </tr>
737
+ <tr>
738
+ <td>493.2293 4</td>
739
+ <td>Y</td>
740
+ <td>8</td>
741
+ <td>1024.5244</td>
742
+ </tr>
743
+ <tr>
744
+ <td>606.3134 5</td>
745
+ <td>L</td>
746
+ <td>7</td>
747
+ <td>861.4611</td>
748
+ </tr>
749
+ <tr>
750
+ <td>734.3719 6</td>
751
+ <td>Q</td>
752
+ <td>6</td>
753
+ <td>748.3770</td>
754
+ </tr>
755
+ <tr>
756
+ <td>865.4124 7</td>
757
+ <td>M</td>
758
+ <td>5</td>
759
+ <td>620.3185</td>
760
+ </tr>
761
+ <tr>
762
+ <td>979.4553 8</td>
763
+ <td>N</td>
764
+ <td>4</td>
765
+ <td>489.2780</td>
766
+ </tr>
767
+ <tr>
768
+ <td>066.4874 9</td>
769
+ <td>S</td>
770
+ <td>3</td>
771
+ <td>375.2350</td>
772
+ </tr>
773
+ <tr>
774
+ <td>179.5714 10</td>
775
+ <td>L</td>
776
+ <td>2</td>
777
+ <td>288.2030</td>
778
+ </tr>
779
+ <tr>
780
+ <td>--- 11</td>
781
+ <td>R</td>
782
+ <td>1</td>
783
+ <td>175.1190</td>
784
+ </tr>
785
+ </table>
786
+ </div>
787
+ </div>
788
+ <hr>
789
+ </div>
790
+
791
+ <div class="table-container">
792
+ <h2>Table 9</h2>
793
+ <div class="table-pair">
794
+ <div class="table-wrapper">
795
+ <h3>Original Table (with rowspans)</h3>
796
+ <table border="1">
797
+ <tr>
798
+ <td>b</td>
799
+ <td>y</td>
800
+ <td>y</td>
801
+ <td>y</td>
802
+ </tr>
803
+ <tr>
804
+ <td>--- 1</td>
805
+ <td>N</td>
806
+ <td>11</td>
807
+ <td>---</td>
808
+ </tr>
809
+ <tr>
810
+ <td>216.0979 2</td>
811
+ <td>T</td>
812
+ <td>10</td>
813
+ <td>1239.6402</td>
814
+ </tr>
815
+ <tr>
816
+ <td>329.1819 3</td>
817
+ <td>L</td>
818
+ <td>9</td>
819
+ <td>1138.5925</td>
820
+ </tr>
821
+ <tr>
822
+ <td>492.2453 4</td>
823
+ <td>Y</td>
824
+ <td>8</td>
825
+ <td>1025.5084</td>
826
+ </tr>
827
+ <tr>
828
+ <td>605.3293 5</td>
829
+ <td>L</td>
830
+ <td>7</td>
831
+ <td>862.4451</td>
832
+ </tr>
833
+ <tr>
834
+ <td>733.3879 6</td>
835
+ <td>Q</td>
836
+ <td>6</td>
837
+ <td>749.3611</td>
838
+ </tr>
839
+ <tr>
840
+ <td>864.4284 7</td>
841
+ <td>M</td>
842
+ <td>5</td>
843
+ <td>621.3025</td>
844
+ </tr>
845
+ <tr>
846
+ <td>979.4553 8</td>
847
+ <td>N(+0.984016)</td>
848
+ <td>4</td>
849
+ <td>490.2620</td>
850
+ </tr>
851
+ <tr>
852
+ <td>1066.4874 9</td>
853
+ <td>S</td>
854
+ <td>3</td>
855
+ <td>375.2350</td>
856
+ </tr>
857
+ <tr>
858
+ <td>1179.5714 10</td>
859
+ <td>L</td>
860
+ <td>2</td>
861
+ <td>288.2030</td>
862
+ </tr>
863
+ <tr>
864
+ <td>--- 11</td>
865
+ <td>R</td>
866
+ <td>1</td>
867
+ <td>175.1190</td>
868
+ </tr>
869
+ </table>
870
+ </div>
871
+ <div class="table-wrapper">
872
+ <h3>Expanded Table (rowspans resolved)</h3>
873
+ <table border="1">
874
+ <tr>
875
+ <th>b</th>
876
+ <th>y</th>
877
+ <th>y</th>
878
+ <th>y</th>
879
+ </tr>
880
+ <tr>
881
+ <td>--- 1</td>
882
+ <td>N</td>
883
+ <td>11</td>
884
+ <td>---</td>
885
+ </tr>
886
+ <tr>
887
+ <td>216.0979 2</td>
888
+ <td>T</td>
889
+ <td>10</td>
890
+ <td>1239.6402</td>
891
+ </tr>
892
+ <tr>
893
+ <td>329.1819 3</td>
894
+ <td>L</td>
895
+ <td>9</td>
896
+ <td>1138.5925</td>
897
+ </tr>
898
+ <tr>
899
+ <td>492.2453 4</td>
900
+ <td>Y</td>
901
+ <td>8</td>
902
+ <td>1025.5084</td>
903
+ </tr>
904
+ <tr>
905
+ <td>605.3293 5</td>
906
+ <td>L</td>
907
+ <td>7</td>
908
+ <td>862.4451</td>
909
+ </tr>
910
+ <tr>
911
+ <td>733.3879 6</td>
912
+ <td>Q</td>
913
+ <td>6</td>
914
+ <td>749.3611</td>
915
+ </tr>
916
+ <tr>
917
+ <td>864.4284 7</td>
918
+ <td>M</td>
919
+ <td>5</td>
920
+ <td>621.3025</td>
921
+ </tr>
922
+ <tr>
923
+ <td>979.4553 8</td>
924
+ <td>N(+0.984016)</td>
925
+ <td>4</td>
926
+ <td>490.2620</td>
927
+ </tr>
928
+ <tr>
929
+ <td>1066.4874 9</td>
930
+ <td>S</td>
931
+ <td>3</td>
932
+ <td>375.2350</td>
933
+ </tr>
934
+ <tr>
935
+ <td>1179.5714 10</td>
936
+ <td>L</td>
937
+ <td>2</td>
938
+ <td>288.2030</td>
939
+ </tr>
940
+ <tr>
941
+ <td>--- 11</td>
942
+ <td>R</td>
943
+ <td>1</td>
944
+ <td>175.1190</td>
945
+ </tr>
946
+ </table>
947
+ </div>
948
+ </div>
949
+ <hr>
950
+ </div>
951
+
952
+ <div class="table-container">
953
+ <h2>Table 10</h2>
954
+ <div class="table-pair">
955
+ <div class="table-wrapper">
956
+ <h3>Original Table (with rowspans)</h3>
957
+ <table border="1">
958
+ <tr>
959
+ <td>Relative quantification by EIC (%)</td>
960
+ <td>Relative quantification by EIC (%)</td>
961
+ <td>Relative quantification by EIC (%)</td>
962
+ <td>Relative quantification by EIC (%)</td>
963
+ <td>Relative quantification by EIC (%)</td>
964
+ <td>Relative quantification by EIC (%)</td>
965
+ </tr>
966
+ <tr>
967
+ <td>AA Sequence</td>
968
+ <td>Seq Loc</td>
969
+ <td>Modification</td>
970
+ <td>T0</td>
971
+ <td>T2W_37℃</td>
972
+ <td>T4W_37℃</td>
973
+ </tr>
974
+ <tr>
975
+ <td>SCDK</td>
976
+ <td>HC(223-226)</td>
977
+ <td></td>
978
+ <td>99.8</td>
979
+ <td>99.5</td>
980
+ <td>98.8</td>
981
+ </tr>
982
+ <tr>
983
+ <td>SFNRGEC</td>
984
+ <td>LC(208-214)</td>
985
+ <td></td>
986
+ <td>99.8</td>
987
+ <td>99.5</td>
988
+ <td>98.8</td>
989
+ </tr>
990
+ <tr>
991
+ <td>SFNRGEC - SCDK</td>
992
+ <td>HC(223-226) + LC(208-214)</td>
993
+ <td>Thioether</td>
994
+ <td>0.2</td>
995
+ <td>0.5</td>
996
+ <td>1.2</td>
997
+ </tr>
998
+ </table>
999
+ </div>
1000
+ <div class="table-wrapper">
1001
+ <h3>Expanded Table (rowspans resolved)</h3>
1002
+ <table border="1">
1003
+ <tr>
1004
+ <th>Relative quantification by EIC (%)</th>
1005
+ <th>Relative quantification by EIC (%)</th>
1006
+ <th>Relative quantification by EIC (%)</th>
1007
+ <th>Relative quantification by EIC (%)</th>
1008
+ <th>Relative quantification by EIC (%)</th>
1009
+ <th>Relative quantification by EIC (%)</th>
1010
+ </tr>
1011
+ <tr>
1012
+ <td>AA Sequence</td>
1013
+ <td>Seq Loc</td>
1014
+ <td>Modification</td>
1015
+ <td>T0</td>
1016
+ <td>T2W_37℃</td>
1017
+ <td>T4W_37℃</td>
1018
+ </tr>
1019
+ <tr>
1020
+ <td>SCDK</td>
1021
+ <td>HC(223-226)</td>
1022
+ <td></td>
1023
+ <td>99.8</td>
1024
+ <td>99.5</td>
1025
+ <td>98.8</td>
1026
+ </tr>
1027
+ <tr>
1028
+ <td>SFNRGEC</td>
1029
+ <td>LC(208-214)</td>
1030
+ <td></td>
1031
+ <td>99.8</td>
1032
+ <td>99.5</td>
1033
+ <td>98.8</td>
1034
+ </tr>
1035
+ <tr>
1036
+ <td>SFNRGEC - SCDK</td>
1037
+ <td>HC(223-226) + LC(208-214)</td>
1038
+ <td>Thioether</td>
1039
+ <td>0.2</td>
1040
+ <td>0.5</td>
1041
+ <td>1.2</td>
1042
+ </tr>
1043
+ </table>
1044
+ </div>
1045
+ </div>
1046
+ <hr>
1047
+ </div>
1048
+
1049
+ <div class="table-container">
1050
+ <h2>Table 11</h2>
1051
+ <div class="table-pair">
1052
+ <div class="table-wrapper">
1053
+ <h3>Original Table (with rowspans)</h3>
1054
+ <table border="1">
1055
+ <tr>
1056
+ <td>Relative quantification by EIC (%)*</td>
1057
+ <td>Relative quantification by EIC (%)*</td>
1058
+ <td>Relative quantification by EIC (%)*</td>
1059
+ <td>Relative quantification by EIC (%)*</td>
1060
+ <td>Relative quantification by EIC (%)*</td>
1061
+ <td>Relative quantification by EIC (%)*</td>
1062
+ </tr>
1063
+ <tr>
1064
+ <td>AA Sequence</td>
1065
+ <td>Seq Loc</td>
1066
+ <td>Modification</td>
1067
+ <td>T0</td>
1068
+ <td>T2W_37℃</td>
1069
+ <td>T4W_37℃</td>
1070
+ </tr>
1071
+ <tr>
1072
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
1073
+ <td>HC(88-125)</td>
1074
+ <td></td>
1075
+ <td>98.6</td>
1076
+ <td>98.1</td>
1077
+ <td>96.8</td>
1078
+ </tr>
1079
+ <tr>
1080
+ <td>AEDTAVYYCAKPLYSN</td>
1081
+ <td>HC(88-125)</td>
1082
+ <td>Clipping</td>
1083
+ <td>0.3</td>
1084
+ <td>0.4</td>
1085
+ <td>0.6</td>
1086
+ </tr>
1087
+ <tr>
1088
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
1089
+ <td>HC(88-125)</td>
1090
+ <td>Clipping</td>
1091
+ <td>1.1</td>
1092
+ <td>1.5</td>
1093
+ <td>2.6</td>
1094
+ </tr>
1095
+ <tr>
1096
+ <td>STSGGTAALGCLVK</td>
1097
+ <td>HC(138-151)</td>
1098
+ <td></td>
1099
+ <td>99.9</td>
1100
+ <td>99.3</td>
1101
+ <td>98.7</td>
1102
+ </tr>
1103
+ <tr>
1104
+ <td>GGTAALGCLVK</td>
1105
+ <td>HC(138-151)</td>
1106
+ <td>Clipping</td>
1107
+ <td>0.0</td>
1108
+ <td>0.2</td>
1109
+ <td>0.3</td>
1110
+ </tr>
1111
+ <tr>
1112
+ <td>GTAALGCLVK</td>
1113
+ <td>HC(138-151)</td>
1114
+ <td>Clipping_2</td>
1115
+ <td>0.1</td>
1116
+ <td>0.5</td>
1117
+ <td>0.9</td>
1118
+ </tr>
1119
+ <tr>
1120
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
1121
+ <td>HC(223-252)</td>
1122
+ <td></td>
1123
+ <td>99.6</td>
1124
+ <td>99.4</td>
1125
+ <td>99.0</td>
1126
+ </tr>
1127
+ <tr>
1128
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
1129
+ <td>HC(223-252)</td>
1130
+ <td>Clipping</td>
1131
+ <td>0.4</td>
1132
+ <td>0.6</td>
1133
+ <td>1.0</td>
1134
+ </tr>
1135
+ </table>
1136
+ </div>
1137
+ <div class="table-wrapper">
1138
+ <h3>Expanded Table (rowspans resolved)</h3>
1139
+ <table border="1">
1140
+ <tr>
1141
+ <th>Relative quantification by EIC (%)*</th>
1142
+ <th>Relative quantification by EIC (%)*</th>
1143
+ <th>Relative quantification by EIC (%)*</th>
1144
+ <th>Relative quantification by EIC (%)*</th>
1145
+ <th>Relative quantification by EIC (%)*</th>
1146
+ <th>Relative quantification by EIC (%)*</th>
1147
+ </tr>
1148
+ <tr>
1149
+ <td>AA Sequence</td>
1150
+ <td>Seq Loc</td>
1151
+ <td>Modification</td>
1152
+ <td>T0</td>
1153
+ <td>T2W_37℃</td>
1154
+ <td>T4W_37℃</td>
1155
+ </tr>
1156
+ <tr>
1157
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
1158
+ <td>HC(88-125)</td>
1159
+ <td></td>
1160
+ <td>98.6</td>
1161
+ <td>98.1</td>
1162
+ <td>96.8</td>
1163
+ </tr>
1164
+ <tr>
1165
+ <td>AEDTAVYYCAKPLYSN</td>
1166
+ <td>HC(88-125)</td>
1167
+ <td>Clipping</td>
1168
+ <td>0.3</td>
1169
+ <td>0.4</td>
1170
+ <td>0.6</td>
1171
+ </tr>
1172
+ <tr>
1173
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
1174
+ <td>HC(88-125)</td>
1175
+ <td>Clipping</td>
1176
+ <td>1.1</td>
1177
+ <td>1.5</td>
1178
+ <td>2.6</td>
1179
+ </tr>
1180
+ <tr>
1181
+ <td>STSGGTAALGCLVK</td>
1182
+ <td>HC(138-151)</td>
1183
+ <td></td>
1184
+ <td>99.9</td>
1185
+ <td>99.3</td>
1186
+ <td>98.7</td>
1187
+ </tr>
1188
+ <tr>
1189
+ <td>GGTAALGCLVK</td>
1190
+ <td>HC(138-151)</td>
1191
+ <td>Clipping</td>
1192
+ <td>0.0</td>
1193
+ <td>0.2</td>
1194
+ <td>0.3</td>
1195
+ </tr>
1196
+ <tr>
1197
+ <td>GTAALGCLVK</td>
1198
+ <td>HC(138-151)</td>
1199
+ <td>Clipping_2</td>
1200
+ <td>0.1</td>
1201
+ <td>0.5</td>
1202
+ <td>0.9</td>
1203
+ </tr>
1204
+ <tr>
1205
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
1206
+ <td>HC(223-252)</td>
1207
+ <td></td>
1208
+ <td>99.6</td>
1209
+ <td>99.4</td>
1210
+ <td>99.0</td>
1211
+ </tr>
1212
+ <tr>
1213
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
1214
+ <td>HC(223-252)</td>
1215
+ <td>Clipping</td>
1216
+ <td>0.4</td>
1217
+ <td>0.6</td>
1218
+ <td>1.0</td>
1219
+ </tr>
1220
+ </table>
1221
+ </div>
1222
+ </div>
1223
+ <hr>
1224
+ </div>
1225
+
1226
+ <div class="table-container">
1227
+ <h2>Table 12</h2>
1228
+ <div class="table-pair">
1229
+ <div class="table-wrapper">
1230
+ <h3>Original Table (with rowspans)</h3>
1231
+ <table border="1">
1232
+ <tr>
1233
+ <td>Blue:</td>
1234
+ <td>VH and VL</td>
1235
+ </tr>
1236
+ <tr>
1237
+ <td>Blue:</td>
1238
+ <td>CDR</td>
1239
+ </tr>
1240
+ <tr>
1241
+ <td>Green:</td>
1242
+ <td>N-glycosylation site</td>
1243
+ </tr>
1244
+ </table>
1245
+ </div>
1246
+ <div class="table-wrapper">
1247
+ <h3>Expanded Table (rowspans resolved)</h3>
1248
+ <table border="1">
1249
+ <tr>
1250
+ <th>Blue:</th>
1251
+ <th>VH and VL</th>
1252
+ </tr>
1253
+ <tr>
1254
+ <td>Blue:</td>
1255
+ <td>CDR</td>
1256
+ </tr>
1257
+ <tr>
1258
+ <td>Green:</td>
1259
+ <td>N-glycosylation site</td>
1260
+ </tr>
1261
+ </table>
1262
+ </div>
1263
+ </div>
1264
+ <hr>
1265
+ </div>
1266
+
1267
+ <div class="table-container">
1268
+ <h2>Table 13</h2>
1269
+ <div class="table-pair">
1270
+ <div class="table-wrapper">
1271
+ <h3>Original Table (with rowspans)</h3>
1272
+ <table border="1">
1273
+ <tr>
1274
+ <td>Mabelle Meersseman</td>
1275
+ <td>Date:</td>
1276
+ </tr>
1277
+ <tr>
1278
+ <td>Group Leader</td>
1279
+ <td>Signature:</td>
1280
+ </tr>
1281
+ <tr>
1282
+ <td>Approver</td>
1283
+ <td></td>
1284
+ </tr>
1285
+ <tr>
1286
+ <td>Koen Sandra Ph.D.</td>
1287
+ <td>Date:</td>
1288
+ </tr>
1289
+ <tr>
1290
+ <td>CEO</td>
1291
+ <td>Signature:</td>
1292
+ </tr>
1293
+ </table>
1294
+ </div>
1295
+ <div class="table-wrapper">
1296
+ <h3>Expanded Table (rowspans resolved)</h3>
1297
+ <table border="1">
1298
+ <tr>
1299
+ <th>Mabelle Meersseman</th>
1300
+ <th>Date:</th>
1301
+ </tr>
1302
+ <tr>
1303
+ <td>Group Leader</td>
1304
+ <td>Signature:</td>
1305
+ </tr>
1306
+ <tr>
1307
+ <td>Approver</td>
1308
+ <td></td>
1309
+ </tr>
1310
+ <tr>
1311
+ <td>Koen Sandra Ph.D.</td>
1312
+ <td>Date:</td>
1313
+ </tr>
1314
+ <tr>
1315
+ <td>CEO</td>
1316
+ <td>Signature:</td>
1317
+ </tr>
1318
+ </table>
1319
+ </div>
1320
+ </div>
1321
+ <hr>
1322
+ </div>
1323
+
1324
+ <div class="table-container">
1325
+ <h2>Table 14</h2>
1326
+ <div class="table-pair">
1327
+ <div class="table-wrapper">
1328
+ <h3>Original Table (with rowspans)</h3>
1329
+ <table border="1">
1330
+ <tr>
1331
+ <td>Version</td>
1332
+ <td>Date of issue</td>
1333
+ <td>Reason for version update</td>
1334
+ </tr>
1335
+ <tr>
1336
+ <td>00</td>
1337
+ <td>20 November 2024</td>
1338
+ <td>Draft</td>
1339
+ </tr>
1340
+ <tr>
1341
+ <td></td>
1342
+ <td></td>
1343
+ <td></td>
1344
+ </tr>
1345
+ <tr>
1346
+ <td></td>
1347
+ <td></td>
1348
+ <td></td>
1349
+ </tr>
1350
+ </table>
1351
+ </div>
1352
+ <div class="table-wrapper">
1353
+ <h3>Expanded Table (rowspans resolved)</h3>
1354
+ <table border="1">
1355
+ <tr>
1356
+ <th>Version</th>
1357
+ <th>Date of issue</th>
1358
+ <th>Reason for version update</th>
1359
+ </tr>
1360
+ <tr>
1361
+ <td>00</td>
1362
+ <td>20 November 2024</td>
1363
+ <td>Draft</td>
1364
+ </tr>
1365
+ <tr>
1366
+ <td></td>
1367
+ <td></td>
1368
+ <td></td>
1369
+ </tr>
1370
+ <tr>
1371
+ <td></td>
1372
+ <td></td>
1373
+ <td></td>
1374
+ </tr>
1375
+ </table>
1376
+ </div>
1377
+ </div>
1378
+ <hr>
1379
+ </div>
1380
+ </body></html>
logs/di_content/di_content_20250605_135925_tables.json ADDED
@@ -0,0 +1,86 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ [
2
+ {
3
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Sales quote:</td>\n<td>SQ20202722</td>\n</tr>\n<tr>\n<td>Project code:</td>\n<td>P3016</td>\n</tr>\n<tr>\n<td>LNB number:</td>\n<td>2023.040</td>\n</tr>\n<tr>\n<td>Project responsible:</td>\n<td>Nathan Cardon</td>\n</tr>\n<tr>\n<td>Report name:</td>\n<td>P3016_R010_v01</td>\n</tr>\n</table>",
4
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Sales quote:</th>\n<th>SQ20202722</th>\n</tr>\n<tr>\n<td>Project code:</td>\n<td>P3016</td>\n</tr>\n<tr>\n<td>LNB number:</td>\n<td>2023.040</td>\n</tr>\n<tr>\n<td>Project responsible:</td>\n<td>Nathan Cardon</td>\n</tr>\n<tr>\n<td>Report name:</td>\n<td>P3016_R010_v01</td>\n</tr>\n</table>",
5
+ "exploded_html": "<table border=\"1\"><tr><th>Project code:</th><th>Variable</th><th>SQ20202722</th></tr><tr><td>LNB number:</td><td>P3016</td><td>2023.040</td></tr><tr><td>Project responsible:</td><td>P3016</td><td>Nathan Cardon</td></tr><tr><td>Report name:</td><td>P3016</td><td>P3016_R010_v01</td></tr></table>",
6
+ "markdown": "| Sales quote: | SQ20202722 |\n| --- | --- |\n| Project code: | P3016 |\n| LNB number: | 2023.040 |\n| Project responsible: | Nathan Cardon |\n| Report name: | P3016_R010_v01 |"
7
+ },
8
+ {
9
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Construct</td>\n<td>Stress condition</td>\n<td>Concentration (mg/mL)</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T0W</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T2W_37\u2103</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T4W_37\u2103</td>\n<td>1.00</td>\n</tr>\n</table>",
10
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Construct</th>\n<th>Stress condition</th>\n<th>Concentration (mg/mL)</th>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T0W</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T2W_37\u2103</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T4W_37\u2103</td>\n<td>1.00</td>\n</tr>\n</table>",
11
+ "exploded_html": "<table border=\"1\"><tr><th>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</th><th>Variable</th><th>Stress condition</th></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>T0W</td><td>T2W_37\u2103</td></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>1.00</td><td>1.00</td></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>T0W</td><td>T4W_37\u2103</td></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>1.00</td><td>1.00</td></tr></table>",
12
+ "markdown": "| Construct | Stress condition | Concentration (mg/mL) |\n| --- | --- | --- |\n| P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T0W | 1.00 |\n| P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T2W_37\u2103 | 1.00 |\n| P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T4W_37\u2103 | 1.00 |"
13
+ },
14
+ {
15
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Blue:</td>\n<td>VH and VL</td>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
16
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Blue:</th>\n<th>VH and VL</th>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
17
+ "exploded_html": "<table border=\"1\"><tr><th>Blue:</th><th>Variable</th><th>VH and VL</th></tr><tr><td>Green:</td><td>CDR</td><td>N-glycosylation site</td></tr></table>",
18
+ "markdown": "| Blue: | VH and VL |\n| --- | --- |\n| Blue: | CDR |\n| Green: | N-glycosylation site |"
19
+ },
20
+ {
21
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.0</td>\n<td>96.1</td>\n<td>93.0</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>PyroE</td>\n<td>1.0</td>\n<td>3.9</td>\n<td>7.0</td>\n</tr>\n</table>",
22
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.0</td>\n<td>96.1</td>\n<td>93.0</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>PyroE</td>\n<td>1.0</td>\n<td>3.9</td>\n<td>7.0</td>\n</tr>\n</table>",
23
+ "exploded_html": "",
24
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.0 | 96.1 | 93.0 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | PyroE | 1.0 | 3.9 | 7.0 |"
25
+ },
26
+ {
27
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>99.9</td>\n<td>99.7</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Isomerization</td>\n<td>0.1</td>\n<td>0.3</td>\n<td>0.5</td>\n</tr>\n</table>",
28
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>99.9</td>\n<td>99.7</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Isomerization</td>\n<td>0.1</td>\n<td>0.3</td>\n<td>0.5</td>\n</tr>\n</table>",
29
+ "exploded_html": "",
30
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 99.9 | 99.7 | 99.5 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Isomerization | 0.1 | 0.3 | 0.5 |"
31
+ },
32
+ {
33
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n</table>",
34
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n</table>",
35
+ "exploded_html": "",
36
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| NTLYLQMNSLR | HC(77-87) | | 99.5 | 99.5 | 99.5 |\n| NTLYLQMNSLR | HC(77-87) | Oxidation | 0.5 | 0.5 | 0.5 |\n| DIQMTQSPSSLSASVGDR | LC(1-18) | | 99.5 | 99.5 | 99.5 |\n| DIQMTQSPSSLSASVGDR | LC(1-18) | Oxidation | 0.5 | 0.5 | 0.5 |"
37
+ },
38
+ {
39
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.6</td>\n<td>99.6</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>Deamidation</td>\n<td>0.4</td>\n<td>0.4</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.0</td>\n<td>98.8</td>\n<td>98.6</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td>Deamidation</td>\n<td>1.0</td>\n<td>1.2</td>\n<td>1.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.7</td>\n<td>96.1</td>\n<td>93.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Deamidation</td>\n<td>1.3</td>\n<td>3.9</td>\n<td>6.6</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td></td>\n<td>99.9</td>\n<td>99.8</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td>Deamidation</td>\n<td>0.1</td>\n<td>0.2</td>\n<td>0.5</td>\n</tr>\n</table>",
40
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.6</td>\n<td>99.6</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>Deamidation</td>\n<td>0.4</td>\n<td>0.4</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.0</td>\n<td>98.8</td>\n<td>98.6</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td>Deamidation</td>\n<td>1.0</td>\n<td>1.2</td>\n<td>1.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.7</td>\n<td>96.1</td>\n<td>93.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Deamidation</td>\n<td>1.3</td>\n<td>3.9</td>\n<td>6.6</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td></td>\n<td>99.9</td>\n<td>99.8</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td>Deamidation</td>\n<td>0.1</td>\n<td>0.2</td>\n<td>0.5</td>\n</tr>\n</table>",
41
+ "exploded_html": "",
42
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.6 | 99.6 | 99.5 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | Deamidation | 0.4 | 0.4 | 0.5 |\n| NTLYLQMNSLR* | HC(77-87) | | 99.0 | 98.8 | 98.6 |\n| NTLYLQMNSLR* | HC(77-87) | Deamidation | 1.0 | 1.2 | 1.4 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.7 | 96.1 | 93.4 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Deamidation | 1.3 | 3.9 | 6.6 |\n| VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | | 99.9 | 99.8 | 99.5 |\n| VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | Deamidation | 0.1 | 0.2 | 0.5 |"
43
+ },
44
+ {
45
+ "original_html": "<table border=\"1\">\n<tr>\n<td>b --- 1</td>\n<td></td>\n<td></td>\n<td>y</td>\n</tr>\n<tr>\n<td>b --- 1</td>\n<td>N(+0.984016)</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>217.0819 2</td>\n<td>T</td>\n<td>10</td>\n<td>1238.6562</td>\n</tr>\n<tr>\n<td>330.1660 3</td>\n<td>L</td>\n<td>9</td>\n<td>1137.6085</td>\n</tr>\n<tr>\n<td>493.2293 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1024.5244</td>\n</tr>\n<tr>\n<td>606.3134 5</td>\n<td>L</td>\n<td>7</td>\n<td>861.4611</td>\n</tr>\n<tr>\n<td>734.3719 6</td>\n<td>Q</td>\n<td>6</td>\n<td>748.3770</td>\n</tr>\n<tr>\n<td>865.4124 7</td>\n<td>M</td>\n<td>5</td>\n<td>620.3185</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N</td>\n<td>4</td>\n<td>489.2780</td>\n</tr>\n<tr>\n<td>066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
46
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>b --- 1</th>\n<th></th>\n<th></th>\n<th>y</th>\n</tr>\n<tr>\n<td>b --- 1</td>\n<td>N(+0.984016)</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>217.0819 2</td>\n<td>T</td>\n<td>10</td>\n<td>1238.6562</td>\n</tr>\n<tr>\n<td>330.1660 3</td>\n<td>L</td>\n<td>9</td>\n<td>1137.6085</td>\n</tr>\n<tr>\n<td>493.2293 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1024.5244</td>\n</tr>\n<tr>\n<td>606.3134 5</td>\n<td>L</td>\n<td>7</td>\n<td>861.4611</td>\n</tr>\n<tr>\n<td>734.3719 6</td>\n<td>Q</td>\n<td>6</td>\n<td>748.3770</td>\n</tr>\n<tr>\n<td>865.4124 7</td>\n<td>M</td>\n<td>5</td>\n<td>620.3185</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N</td>\n<td>4</td>\n<td>489.2780</td>\n</tr>\n<tr>\n<td>066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
47
+ "exploded_html": "<table border=\"1\"><tr><th>b --- 1</th><th>N(+0.984016)</th><th>11</th><th>Variable</th><th>y</th></tr><tr><td>217.0819 2</td><td>T</td><td>10</td><td>---</td><td>1238.6562</td></tr><tr><td>330.1660 3</td><td>L</td><td>9</td><td>---</td><td>1137.6085</td></tr><tr><td>493.2293 4</td><td>Y</td><td>8</td><td>---</td><td>1024.5244</td></tr><tr><td>606.3134 5</td><td>L</td><td>7</td><td>---</td><td>861.4611</td></tr><tr><td>734.3719 6</td><td>Q</td><td>6</td><td>---</td><td>748.3770</td></tr><tr><td>865.4124 7</td><td>M</td><td>5</td><td>---</td><td>620.3185</td></tr><tr><td>979.4553 8</td><td>N</td><td>4</td><td>---</td><td>489.2780</td></tr><tr><td>066.4874 9</td><td>S</td><td>3</td><td>---</td><td>375.2350</td></tr><tr><td>179.5714 10</td><td>L</td><td>2</td><td>---</td><td>288.2030</td></tr><tr><td>--- 11</td><td>R</td><td>1</td><td>---</td><td>175.1190</td></tr></table>",
48
+ "markdown": "| b --- 1 | | | y |\n| --- | --- | --- | --- |\n| b --- 1 | N(+0.984016) | 11 | --- |\n| 217.0819 2 | T | 10 | 1238.6562 |\n| 330.1660 3 | L | 9 | 1137.6085 |\n| 493.2293 4 | Y | 8 | 1024.5244 |\n| 606.3134 5 | L | 7 | 861.4611 |\n| 734.3719 6 | Q | 6 | 748.3770 |\n| 865.4124 7 | M | 5 | 620.3185 |\n| 979.4553 8 | N | 4 | 489.2780 |\n| 066.4874 9 | S | 3 | 375.2350 |\n| 179.5714 10 | L | 2 | 288.2030 |\n| --- 11 | R | 1 | 175.1190 |"
49
+ },
50
+ {
51
+ "original_html": "<table border=\"1\">\n<tr>\n<td>b</td>\n<td>y</td>\n<td>y</td>\n<td>y</td>\n</tr>\n<tr>\n<td>--- 1</td>\n<td>N</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>216.0979 2</td>\n<td>T</td>\n<td>10</td>\n<td>1239.6402</td>\n</tr>\n<tr>\n<td>329.1819 3</td>\n<td>L</td>\n<td>9</td>\n<td>1138.5925</td>\n</tr>\n<tr>\n<td>492.2453 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1025.5084</td>\n</tr>\n<tr>\n<td>605.3293 5</td>\n<td>L</td>\n<td>7</td>\n<td>862.4451</td>\n</tr>\n<tr>\n<td>733.3879 6</td>\n<td>Q</td>\n<td>6</td>\n<td>749.3611</td>\n</tr>\n<tr>\n<td>864.4284 7</td>\n<td>M</td>\n<td>5</td>\n<td>621.3025</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N(+0.984016)</td>\n<td>4</td>\n<td>490.2620</td>\n</tr>\n<tr>\n<td>1066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>1179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
52
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>b</th>\n<th>y</th>\n<th>y</th>\n<th>y</th>\n</tr>\n<tr>\n<td>--- 1</td>\n<td>N</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>216.0979 2</td>\n<td>T</td>\n<td>10</td>\n<td>1239.6402</td>\n</tr>\n<tr>\n<td>329.1819 3</td>\n<td>L</td>\n<td>9</td>\n<td>1138.5925</td>\n</tr>\n<tr>\n<td>492.2453 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1025.5084</td>\n</tr>\n<tr>\n<td>605.3293 5</td>\n<td>L</td>\n<td>7</td>\n<td>862.4451</td>\n</tr>\n<tr>\n<td>733.3879 6</td>\n<td>Q</td>\n<td>6</td>\n<td>749.3611</td>\n</tr>\n<tr>\n<td>864.4284 7</td>\n<td>M</td>\n<td>5</td>\n<td>621.3025</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N(+0.984016)</td>\n<td>4</td>\n<td>490.2620</td>\n</tr>\n<tr>\n<td>1066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>1179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
53
+ "exploded_html": "<table border=\"1\"><tr><th>--- 1</th><th>Variable</th><th>y</th></tr><tr><td>216.0979 2</td><td>N</td><td>T</td></tr><tr><td>216.0979 2</td><td>11</td><td>10</td></tr><tr><td>216.0979 2</td><td>---</td><td>1239.6402</td></tr><tr><td>329.1819 3</td><td>N</td><td>L</td></tr><tr><td>329.1819 3</td><td>11</td><td>9</td></tr><tr><td>329.1819 3</td><td>---</td><td>1138.5925</td></tr><tr><td>492.2453 4</td><td>N</td><td>Y</td></tr><tr><td>492.2453 4</td><td>11</td><td>8</td></tr><tr><td>492.2453 4</td><td>---</td><td>1025.5084</td></tr><tr><td>605.3293 5</td><td>N</td><td>L</td></tr><tr><td>605.3293 5</td><td>11</td><td>7</td></tr><tr><td>605.3293 5</td><td>---</td><td>862.4451</td></tr><tr><td>733.3879 6</td><td>N</td><td>Q</td></tr><tr><td>733.3879 6</td><td>11</td><td>6</td></tr><tr><td>733.3879 6</td><td>---</td><td>749.3611</td></tr><tr><td>864.4284 7</td><td>N</td><td>M</td></tr><tr><td>864.4284 7</td><td>11</td><td>5</td></tr><tr><td>864.4284 7</td><td>---</td><td>621.3025</td></tr><tr><td>979.4553 8</td><td>N</td><td>N(+0.984016)</td></tr><tr><td>979.4553 8</td><td>11</td><td>4</td></tr><tr><td>979.4553 8</td><td>---</td><td>490.2620</td></tr><tr><td>1066.4874 9</td><td>N</td><td>S</td></tr><tr><td>1066.4874 9</td><td>11</td><td>3</td></tr><tr><td>1066.4874 9</td><td>---</td><td>375.2350</td></tr><tr><td>1179.5714 10</td><td>N</td><td>L</td></tr><tr><td>1179.5714 10</td><td>11</td><td>2</td></tr><tr><td>1179.5714 10</td><td>---</td><td>288.2030</td></tr><tr><td>--- 11</td><td>N</td><td>R</td></tr><tr><td>--- 11</td><td>11</td><td>1</td></tr><tr><td>--- 11</td><td>---</td><td>175.1190</td></tr></table>",
54
+ "markdown": "| b | y | y | y |\n| --- | --- | --- | --- |\n| --- 1 | N | 11 | --- |\n| 216.0979 2 | T | 10 | 1239.6402 |\n| 329.1819 3 | L | 9 | 1138.5925 |\n| 492.2453 4 | Y | 8 | 1025.5084 |\n| 605.3293 5 | L | 7 | 862.4451 |\n| 733.3879 6 | Q | 6 | 749.3611 |\n| 864.4284 7 | M | 5 | 621.3025 |\n| 979.4553 8 | N(+0.984016) | 4 | 490.2620 |\n| 1066.4874 9 | S | 3 | 375.2350 |\n| 1179.5714 10 | L | 2 | 288.2030 |\n| --- 11 | R | 1 | 175.1190 |"
55
+ },
56
+ {
57
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>SCDK</td>\n<td>HC(223-226)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC</td>\n<td>LC(208-214)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC - SCDK</td>\n<td>HC(223-226) + LC(208-214)</td>\n<td>Thioether</td>\n<td>0.2</td>\n<td>0.5</td>\n<td>1.2</td>\n</tr>\n</table>",
58
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>SCDK</td>\n<td>HC(223-226)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC</td>\n<td>LC(208-214)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC - SCDK</td>\n<td>HC(223-226) + LC(208-214)</td>\n<td>Thioether</td>\n<td>0.2</td>\n<td>0.5</td>\n<td>1.2</td>\n</tr>\n</table>",
59
+ "exploded_html": "",
60
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| SCDK | HC(223-226) | | 99.8 | 99.5 | 98.8 |\n| SFNRGEC | LC(208-214) | | 99.8 | 99.5 | 98.8 |\n| SFNRGEC - SCDK | HC(223-226) + LC(208-214) | Thioether | 0.2 | 0.5 | 1.2 |"
61
+ },
62
+ {
63
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.6</td>\n<td>98.1</td>\n<td>96.8</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSN</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>0.3</td>\n<td>0.4</td>\n<td>0.6</td>\n</tr>\n<tr>\n<td>LAGDFGSWGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>1.1</td>\n<td>1.5</td>\n<td>2.6</td>\n</tr>\n<tr>\n<td>STSGGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td></td>\n<td>99.9</td>\n<td>99.3</td>\n<td>98.7</td>\n</tr>\n<tr>\n<td>GGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping</td>\n<td>0.0</td>\n<td>0.2</td>\n<td>0.3</td>\n</tr>\n<tr>\n<td>GTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping_2</td>\n<td>0.1</td>\n<td>0.5</td>\n<td>0.9</td>\n</tr>\n<tr>\n<td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>\n<td>HC(223-252)</td>\n<td></td>\n<td>99.6</td>\n<td>99.4</td>\n<td>99.0</td>\n</tr>\n<tr>\n<td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>\n<td>HC(223-252)</td>\n<td>Clipping</td>\n<td>0.4</td>\n<td>0.6</td>\n<td>1.0</td>\n</tr>\n</table>",
64
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.6</td>\n<td>98.1</td>\n<td>96.8</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSN</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>0.3</td>\n<td>0.4</td>\n<td>0.6</td>\n</tr>\n<tr>\n<td>LAGDFGSWGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>1.1</td>\n<td>1.5</td>\n<td>2.6</td>\n</tr>\n<tr>\n<td>STSGGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td></td>\n<td>99.9</td>\n<td>99.3</td>\n<td>98.7</td>\n</tr>\n<tr>\n<td>GGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping</td>\n<td>0.0</td>\n<td>0.2</td>\n<td>0.3</td>\n</tr>\n<tr>\n<td>GTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping_2</td>\n<td>0.1</td>\n<td>0.5</td>\n<td>0.9</td>\n</tr>\n<tr>\n<td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>\n<td>HC(223-252)</td>\n<td></td>\n<td>99.6</td>\n<td>99.4</td>\n<td>99.0</td>\n</tr>\n<tr>\n<td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>\n<td>HC(223-252)</td>\n<td>Clipping</td>\n<td>0.4</td>\n<td>0.6</td>\n<td>1.0</td>\n</tr>\n</table>",
65
+ "exploded_html": "",
66
+ "markdown": "| Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.6 | 98.1 | 96.8 |\n| AEDTAVYYCAKPLYSN | HC(88-125) | Clipping | 0.3 | 0.4 | 0.6 |\n| LAGDFGSWGQGTTVTVSSASTK | HC(88-125) | Clipping | 1.1 | 1.5 | 2.6 |\n| STSGGTAALGCLVK | HC(138-151) | | 99.9 | 99.3 | 98.7 |\n| GGTAALGCLVK | HC(138-151) | Clipping | 0.0 | 0.2 | 0.3 |\n| GTAALGCLVK | HC(138-151) | Clipping_2 | 0.1 | 0.5 | 0.9 |\n| SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK | HC(223-252) | | 99.6 | 99.4 | 99.0 |\n| DKTHTCPPCPAPEAAGGPSVFLFP PKPK | HC(223-252) | Clipping | 0.4 | 0.6 | 1.0 |"
67
+ },
68
+ {
69
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Blue:</td>\n<td>VH and VL</td>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
70
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Blue:</th>\n<th>VH and VL</th>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
71
+ "exploded_html": "<table border=\"1\"><tr><th>Blue:</th><th>Variable</th><th>VH and VL</th></tr><tr><td>Green:</td><td>CDR</td><td>N-glycosylation site</td></tr></table>",
72
+ "markdown": "| Blue: | VH and VL |\n| --- | --- |\n| Blue: | CDR |\n| Green: | N-glycosylation site |"
73
+ },
74
+ {
75
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Mabelle Meersseman</td>\n<td>Date:</td>\n</tr>\n<tr>\n<td>Group Leader</td>\n<td>Signature:</td>\n</tr>\n<tr>\n<td>Approver</td>\n<td></td>\n</tr>\n<tr>\n<td>Koen Sandra Ph.D.</td>\n<td>Date:</td>\n</tr>\n<tr>\n<td>CEO</td>\n<td>Signature:</td>\n</tr>\n</table>",
76
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Mabelle Meersseman</th>\n<th>Date:</th>\n</tr>\n<tr>\n<td>Group Leader</td>\n<td>Signature:</td>\n</tr>\n<tr>\n<td>Approver</td>\n<td></td>\n</tr>\n<tr>\n<td>Koen Sandra Ph.D.</td>\n<td>Date:</td>\n</tr>\n<tr>\n<td>CEO</td>\n<td>Signature:</td>\n</tr>\n</table>",
77
+ "exploded_html": "<table border=\"1\"><tr><th>Group Leader</th><th>Variable</th><th>Date:</th></tr><tr><td>Approver</td><td>Signature:</td><td></td></tr><tr><td>Koen Sandra Ph.D.</td><td>Signature:</td><td>Date:</td></tr><tr><td>CEO</td><td>Signature:</td><td>Signature:</td></tr></table>",
78
+ "markdown": "| Mabelle Meersseman | Date: |\n| --- | --- |\n| Group Leader | Signature: |\n| Approver | |\n| Koen Sandra Ph.D. | Date: |\n| CEO | Signature: |"
79
+ },
80
+ {
81
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Version</td>\n<td>Date of issue</td>\n<td>Reason for version update</td>\n</tr>\n<tr>\n<td>00</td>\n<td>20 November 2024</td>\n<td>Draft</td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n</table>",
82
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Version</th>\n<th>Date of issue</th>\n<th>Reason for version update</th>\n</tr>\n<tr>\n<td>00</td>\n<td>20 November 2024</td>\n<td>Draft</td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n</table>",
83
+ "exploded_html": "<table border=\"1\"><tr><th>00</th><th>Variable</th><th>Date of issue</th></tr><tr><td></td><td>20 November 2024</td><td></td></tr><tr><td></td><td>Draft</td><td></td></tr><tr><td></td><td>20 November 2024</td><td></td></tr><tr><td></td><td>Draft</td><td></td></tr></table>",
84
+ "markdown": "| Version | Date of issue | Reason for version update |\n| --- | --- | --- |\n| 00 | 20 November 2024 | Draft |\n| | | |\n| | | |"
85
+ }
86
+ ]
logs/di_content/di_content_20250605_135925_tables.md ADDED
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1
+ # Azure Document Intelligence Tables
2
+
3
+ ## Table 1
4
+
5
+ | Sales quote: | SQ20202722 |
6
+ | --- | --- |
7
+ | Project code: | P3016 |
8
+ | LNB number: | 2023.040 |
9
+ | Project responsible: | Nathan Cardon |
10
+ | Report name: | P3016_R010_v01 |
11
+
12
+ ## Table 2
13
+
14
+ | Construct | Stress condition | Concentration (mg/mL) |
15
+ | --- | --- | --- |
16
+ | P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T0W | 1.00 |
17
+ | P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T2W_37℃ | 1.00 |
18
+ | P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T4W_37℃ | 1.00 |
19
+
20
+ ## Table 3
21
+
22
+ | Blue: | VH and VL |
23
+ | --- | --- |
24
+ | Blue: | CDR |
25
+ | Green: | N-glycosylation site |
26
+
27
+ ## Table 4
28
+
29
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
30
+ | --- | --- | --- | --- | --- | --- |
31
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
32
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.0 | 96.1 | 93.0 |
33
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | PyroE | 1.0 | 3.9 | 7.0 |
34
+
35
+ ## Table 5
36
+
37
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
38
+ | --- | --- | --- | --- | --- | --- |
39
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
40
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 99.9 | 99.7 | 99.5 |
41
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Isomerization | 0.1 | 0.3 | 0.5 |
42
+
43
+ ## Table 6
44
+
45
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
46
+ | --- | --- | --- | --- | --- | --- |
47
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
48
+ | NTLYLQMNSLR | HC(77-87) | | 99.5 | 99.5 | 99.5 |
49
+ | NTLYLQMNSLR | HC(77-87) | Oxidation | 0.5 | 0.5 | 0.5 |
50
+ | DIQMTQSPSSLSASVGDR | LC(1-18) | | 99.5 | 99.5 | 99.5 |
51
+ | DIQMTQSPSSLSASVGDR | LC(1-18) | Oxidation | 0.5 | 0.5 | 0.5 |
52
+
53
+ ## Table 7
54
+
55
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
56
+ | --- | --- | --- | --- | --- | --- |
57
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
58
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.6 | 99.6 | 99.5 |
59
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | Deamidation | 0.4 | 0.4 | 0.5 |
60
+ | NTLYLQMNSLR* | HC(77-87) | | 99.0 | 98.8 | 98.6 |
61
+ | NTLYLQMNSLR* | HC(77-87) | Deamidation | 1.0 | 1.2 | 1.4 |
62
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.7 | 96.1 | 93.4 |
63
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Deamidation | 1.3 | 3.9 | 6.6 |
64
+ | VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | | 99.9 | 99.8 | 99.5 |
65
+ | VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | Deamidation | 0.1 | 0.2 | 0.5 |
66
+
67
+ ## Table 8
68
+
69
+ | b --- 1 | | | y |
70
+ | --- | --- | --- | --- |
71
+ | b --- 1 | N(+0.984016) | 11 | --- |
72
+ | 217.0819 2 | T | 10 | 1238.6562 |
73
+ | 330.1660 3 | L | 9 | 1137.6085 |
74
+ | 493.2293 4 | Y | 8 | 1024.5244 |
75
+ | 606.3134 5 | L | 7 | 861.4611 |
76
+ | 734.3719 6 | Q | 6 | 748.3770 |
77
+ | 865.4124 7 | M | 5 | 620.3185 |
78
+ | 979.4553 8 | N | 4 | 489.2780 |
79
+ | 066.4874 9 | S | 3 | 375.2350 |
80
+ | 179.5714 10 | L | 2 | 288.2030 |
81
+ | --- 11 | R | 1 | 175.1190 |
82
+
83
+ ## Table 9
84
+
85
+ | b | y | y | y |
86
+ | --- | --- | --- | --- |
87
+ | --- 1 | N | 11 | --- |
88
+ | 216.0979 2 | T | 10 | 1239.6402 |
89
+ | 329.1819 3 | L | 9 | 1138.5925 |
90
+ | 492.2453 4 | Y | 8 | 1025.5084 |
91
+ | 605.3293 5 | L | 7 | 862.4451 |
92
+ | 733.3879 6 | Q | 6 | 749.3611 |
93
+ | 864.4284 7 | M | 5 | 621.3025 |
94
+ | 979.4553 8 | N(+0.984016) | 4 | 490.2620 |
95
+ | 1066.4874 9 | S | 3 | 375.2350 |
96
+ | 1179.5714 10 | L | 2 | 288.2030 |
97
+ | --- 11 | R | 1 | 175.1190 |
98
+
99
+ ## Table 10
100
+
101
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
102
+ | --- | --- | --- | --- | --- | --- |
103
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
104
+ | SCDK | HC(223-226) | | 99.8 | 99.5 | 98.8 |
105
+ | SFNRGEC | LC(208-214) | | 99.8 | 99.5 | 98.8 |
106
+ | SFNRGEC - SCDK | HC(223-226) + LC(208-214) | Thioether | 0.2 | 0.5 | 1.2 |
107
+
108
+ ## Table 11
109
+
110
+ | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* |
111
+ | --- | --- | --- | --- | --- | --- |
112
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
113
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.6 | 98.1 | 96.8 |
114
+ | AEDTAVYYCAKPLYSN | HC(88-125) | Clipping | 0.3 | 0.4 | 0.6 |
115
+ | LAGDFGSWGQGTTVTVSSASTK | HC(88-125) | Clipping | 1.1 | 1.5 | 2.6 |
116
+ | STSGGTAALGCLVK | HC(138-151) | | 99.9 | 99.3 | 98.7 |
117
+ | GGTAALGCLVK | HC(138-151) | Clipping | 0.0 | 0.2 | 0.3 |
118
+ | GTAALGCLVK | HC(138-151) | Clipping_2 | 0.1 | 0.5 | 0.9 |
119
+ | SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK | HC(223-252) | | 99.6 | 99.4 | 99.0 |
120
+ | DKTHTCPPCPAPEAAGGPSVFLFP PKPK | HC(223-252) | Clipping | 0.4 | 0.6 | 1.0 |
121
+
122
+ ## Table 12
123
+
124
+ | Blue: | VH and VL |
125
+ | --- | --- |
126
+ | Blue: | CDR |
127
+ | Green: | N-glycosylation site |
128
+
129
+ ## Table 13
130
+
131
+ | Mabelle Meersseman | Date: |
132
+ | --- | --- |
133
+ | Group Leader | Signature: |
134
+ | Approver | |
135
+ | Koen Sandra Ph.D. | Date: |
136
+ | CEO | Signature: |
137
+
138
+ ## Table 14
139
+
140
+ | Version | Date of issue | Reason for version update |
141
+ | --- | --- | --- |
142
+ | 00 | 20 November 2024 | Draft |
143
+ | | | |
144
+ | | | |
145
+
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+ <body>
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+ <h1>Table Comparison - Original vs Expanded</h1>
22
+
logs/di_content/di_content_20250605_140153_tables.json ADDED
@@ -0,0 +1,86 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ [
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+ {
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+ "original_html": "<table border=\"1\">\n<tr>\n<td>Sales quote:</td>\n<td>SQ20202722</td>\n</tr>\n<tr>\n<td>Project code:</td>\n<td>P3016</td>\n</tr>\n<tr>\n<td>LNB number:</td>\n<td>2023.040</td>\n</tr>\n<tr>\n<td>Project responsible:</td>\n<td>Nathan Cardon</td>\n</tr>\n<tr>\n<td>Report name:</td>\n<td>P3016_R010_v01</td>\n</tr>\n</table>",
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+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Sales quote:</th>\n<th>SQ20202722</th>\n</tr>\n<tr>\n<td>Project code:</td>\n<td>P3016</td>\n</tr>\n<tr>\n<td>LNB number:</td>\n<td>2023.040</td>\n</tr>\n<tr>\n<td>Project responsible:</td>\n<td>Nathan Cardon</td>\n</tr>\n<tr>\n<td>Report name:</td>\n<td>P3016_R010_v01</td>\n</tr>\n</table>",
5
+ "exploded_html": "<table border=\"1\"><tr><th>Project code:</th><th>Variable</th><th>SQ20202722</th></tr><tr><td>LNB number:</td><td>P3016</td><td>2023.040</td></tr><tr><td>Project responsible:</td><td>P3016</td><td>Nathan Cardon</td></tr><tr><td>Report name:</td><td>P3016</td><td>P3016_R010_v01</td></tr></table>",
6
+ "markdown": "| Sales quote: | SQ20202722 |\n| --- | --- |\n| Project code: | P3016 |\n| LNB number: | 2023.040 |\n| Project responsible: | Nathan Cardon |\n| Report name: | P3016_R010_v01 |"
7
+ },
8
+ {
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+ "original_html": "<table border=\"1\">\n<tr>\n<td>Construct</td>\n<td>Stress condition</td>\n<td>Concentration (mg/mL)</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T0W</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T2W_37\u2103</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T4W_37\u2103</td>\n<td>1.00</td>\n</tr>\n</table>",
10
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Construct</th>\n<th>Stress condition</th>\n<th>Concentration (mg/mL)</th>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T0W</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T2W_37\u2103</td>\n<td>1.00</td>\n</tr>\n<tr>\n<td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>\n<td>T4W_37\u2103</td>\n<td>1.00</td>\n</tr>\n</table>",
11
+ "exploded_html": "<table border=\"1\"><tr><th>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</th><th>Variable</th><th>Stress condition</th></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>T0W</td><td>T2W_37\u2103</td></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>1.00</td><td>1.00</td></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>T0W</td><td>T4W_37\u2103</td></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>1.00</td><td>1.00</td></tr></table>",
12
+ "markdown": "| Construct | Stress condition | Concentration (mg/mL) |\n| --- | --- | --- |\n| P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T0W | 1.00 |\n| P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T2W_37\u2103 | 1.00 |\n| P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T4W_37\u2103 | 1.00 |"
13
+ },
14
+ {
15
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Blue:</td>\n<td>VH and VL</td>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
16
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Blue:</th>\n<th>VH and VL</th>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
17
+ "exploded_html": "<table border=\"1\"><tr><th>Blue:</th><th>Variable</th><th>VH and VL</th></tr><tr><td>Green:</td><td>CDR</td><td>N-glycosylation site</td></tr></table>",
18
+ "markdown": "| Blue: | VH and VL |\n| --- | --- |\n| Blue: | CDR |\n| Green: | N-glycosylation site |"
19
+ },
20
+ {
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+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.0</td>\n<td>96.1</td>\n<td>93.0</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>PyroE</td>\n<td>1.0</td>\n<td>3.9</td>\n<td>7.0</td>\n</tr>\n</table>",
22
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.0</td>\n<td>96.1</td>\n<td>93.0</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>PyroE</td>\n<td>1.0</td>\n<td>3.9</td>\n<td>7.0</td>\n</tr>\n</table>",
23
+ "exploded_html": "",
24
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.0 | 96.1 | 93.0 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | PyroE | 1.0 | 3.9 | 7.0 |"
25
+ },
26
+ {
27
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>99.9</td>\n<td>99.7</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Isomerization</td>\n<td>0.1</td>\n<td>0.3</td>\n<td>0.5</td>\n</tr>\n</table>",
28
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>99.9</td>\n<td>99.7</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Isomerization</td>\n<td>0.1</td>\n<td>0.3</td>\n<td>0.5</td>\n</tr>\n</table>",
29
+ "exploded_html": "",
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+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 99.9 | 99.7 | 99.5 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Isomerization | 0.1 | 0.3 | 0.5 |"
31
+ },
32
+ {
33
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n</table>",
34
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR</td>\n<td>HC(77-87)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td></td>\n<td>99.5</td>\n<td>99.5</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>DIQMTQSPSSLSASVGDR</td>\n<td>LC(1-18)</td>\n<td>Oxidation</td>\n<td>0.5</td>\n<td>0.5</td>\n<td>0.5</td>\n</tr>\n</table>",
35
+ "exploded_html": "",
36
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| NTLYLQMNSLR | HC(77-87) | | 99.5 | 99.5 | 99.5 |\n| NTLYLQMNSLR | HC(77-87) | Oxidation | 0.5 | 0.5 | 0.5 |\n| DIQMTQSPSSLSASVGDR | LC(1-18) | | 99.5 | 99.5 | 99.5 |\n| DIQMTQSPSSLSASVGDR | LC(1-18) | Oxidation | 0.5 | 0.5 | 0.5 |"
37
+ },
38
+ {
39
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.6</td>\n<td>99.6</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>Deamidation</td>\n<td>0.4</td>\n<td>0.4</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.0</td>\n<td>98.8</td>\n<td>98.6</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td>Deamidation</td>\n<td>1.0</td>\n<td>1.2</td>\n<td>1.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.7</td>\n<td>96.1</td>\n<td>93.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Deamidation</td>\n<td>1.3</td>\n<td>3.9</td>\n<td>6.6</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td></td>\n<td>99.9</td>\n<td>99.8</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td>Deamidation</td>\n<td>0.1</td>\n<td>0.2</td>\n<td>0.5</td>\n</tr>\n</table>",
40
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td></td>\n<td>99.6</td>\n<td>99.6</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>EVQLLESGGGLVQPGGSLR</td>\n<td>HC(1-19)</td>\n<td>Deamidation</td>\n<td>0.4</td>\n<td>0.4</td>\n<td>0.5</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td></td>\n<td>99.0</td>\n<td>98.8</td>\n<td>98.6</td>\n</tr>\n<tr>\n<td>NTLYLQMNSLR*</td>\n<td>HC(77-87)</td>\n<td>Deamidation</td>\n<td>1.0</td>\n<td>1.2</td>\n<td>1.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.7</td>\n<td>96.1</td>\n<td>93.4</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Deamidation</td>\n<td>1.3</td>\n<td>3.9</td>\n<td>6.6</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td></td>\n<td>99.9</td>\n<td>99.8</td>\n<td>99.5</td>\n</tr>\n<tr>\n<td>VTITCQASQSISSYLAWYQQKPGK</td>\n<td>LC(19-42)</td>\n<td>Deamidation</td>\n<td>0.1</td>\n<td>0.2</td>\n<td>0.5</td>\n</tr>\n</table>",
41
+ "exploded_html": "",
42
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.6 | 99.6 | 99.5 |\n| EVQLLESGGGLVQPGGSLR | HC(1-19) | Deamidation | 0.4 | 0.4 | 0.5 |\n| NTLYLQMNSLR* | HC(77-87) | | 99.0 | 98.8 | 98.6 |\n| NTLYLQMNSLR* | HC(77-87) | Deamidation | 1.0 | 1.2 | 1.4 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.7 | 96.1 | 93.4 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Deamidation | 1.3 | 3.9 | 6.6 |\n| VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | | 99.9 | 99.8 | 99.5 |\n| VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | Deamidation | 0.1 | 0.2 | 0.5 |"
43
+ },
44
+ {
45
+ "original_html": "<table border=\"1\">\n<tr>\n<td>b --- 1</td>\n<td></td>\n<td></td>\n<td>y</td>\n</tr>\n<tr>\n<td>b --- 1</td>\n<td>N(+0.984016)</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>217.0819 2</td>\n<td>T</td>\n<td>10</td>\n<td>1238.6562</td>\n</tr>\n<tr>\n<td>330.1660 3</td>\n<td>L</td>\n<td>9</td>\n<td>1137.6085</td>\n</tr>\n<tr>\n<td>493.2293 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1024.5244</td>\n</tr>\n<tr>\n<td>606.3134 5</td>\n<td>L</td>\n<td>7</td>\n<td>861.4611</td>\n</tr>\n<tr>\n<td>734.3719 6</td>\n<td>Q</td>\n<td>6</td>\n<td>748.3770</td>\n</tr>\n<tr>\n<td>865.4124 7</td>\n<td>M</td>\n<td>5</td>\n<td>620.3185</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N</td>\n<td>4</td>\n<td>489.2780</td>\n</tr>\n<tr>\n<td>066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
46
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>b --- 1</th>\n<th></th>\n<th></th>\n<th>y</th>\n</tr>\n<tr>\n<td>b --- 1</td>\n<td>N(+0.984016)</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>217.0819 2</td>\n<td>T</td>\n<td>10</td>\n<td>1238.6562</td>\n</tr>\n<tr>\n<td>330.1660 3</td>\n<td>L</td>\n<td>9</td>\n<td>1137.6085</td>\n</tr>\n<tr>\n<td>493.2293 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1024.5244</td>\n</tr>\n<tr>\n<td>606.3134 5</td>\n<td>L</td>\n<td>7</td>\n<td>861.4611</td>\n</tr>\n<tr>\n<td>734.3719 6</td>\n<td>Q</td>\n<td>6</td>\n<td>748.3770</td>\n</tr>\n<tr>\n<td>865.4124 7</td>\n<td>M</td>\n<td>5</td>\n<td>620.3185</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N</td>\n<td>4</td>\n<td>489.2780</td>\n</tr>\n<tr>\n<td>066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
47
+ "exploded_html": "<table border=\"1\"><tr><th>b --- 1</th><th>N(+0.984016)</th><th>11</th><th>Variable</th><th>y</th></tr><tr><td>217.0819 2</td><td>T</td><td>10</td><td>---</td><td>1238.6562</td></tr><tr><td>330.1660 3</td><td>L</td><td>9</td><td>---</td><td>1137.6085</td></tr><tr><td>493.2293 4</td><td>Y</td><td>8</td><td>---</td><td>1024.5244</td></tr><tr><td>606.3134 5</td><td>L</td><td>7</td><td>---</td><td>861.4611</td></tr><tr><td>734.3719 6</td><td>Q</td><td>6</td><td>---</td><td>748.3770</td></tr><tr><td>865.4124 7</td><td>M</td><td>5</td><td>---</td><td>620.3185</td></tr><tr><td>979.4553 8</td><td>N</td><td>4</td><td>---</td><td>489.2780</td></tr><tr><td>066.4874 9</td><td>S</td><td>3</td><td>---</td><td>375.2350</td></tr><tr><td>179.5714 10</td><td>L</td><td>2</td><td>---</td><td>288.2030</td></tr><tr><td>--- 11</td><td>R</td><td>1</td><td>---</td><td>175.1190</td></tr></table>",
48
+ "markdown": "| b --- 1 | | | y |\n| --- | --- | --- | --- |\n| b --- 1 | N(+0.984016) | 11 | --- |\n| 217.0819 2 | T | 10 | 1238.6562 |\n| 330.1660 3 | L | 9 | 1137.6085 |\n| 493.2293 4 | Y | 8 | 1024.5244 |\n| 606.3134 5 | L | 7 | 861.4611 |\n| 734.3719 6 | Q | 6 | 748.3770 |\n| 865.4124 7 | M | 5 | 620.3185 |\n| 979.4553 8 | N | 4 | 489.2780 |\n| 066.4874 9 | S | 3 | 375.2350 |\n| 179.5714 10 | L | 2 | 288.2030 |\n| --- 11 | R | 1 | 175.1190 |"
49
+ },
50
+ {
51
+ "original_html": "<table border=\"1\">\n<tr>\n<td>b</td>\n<td>y</td>\n<td>y</td>\n<td>y</td>\n</tr>\n<tr>\n<td>--- 1</td>\n<td>N</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>216.0979 2</td>\n<td>T</td>\n<td>10</td>\n<td>1239.6402</td>\n</tr>\n<tr>\n<td>329.1819 3</td>\n<td>L</td>\n<td>9</td>\n<td>1138.5925</td>\n</tr>\n<tr>\n<td>492.2453 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1025.5084</td>\n</tr>\n<tr>\n<td>605.3293 5</td>\n<td>L</td>\n<td>7</td>\n<td>862.4451</td>\n</tr>\n<tr>\n<td>733.3879 6</td>\n<td>Q</td>\n<td>6</td>\n<td>749.3611</td>\n</tr>\n<tr>\n<td>864.4284 7</td>\n<td>M</td>\n<td>5</td>\n<td>621.3025</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N(+0.984016)</td>\n<td>4</td>\n<td>490.2620</td>\n</tr>\n<tr>\n<td>1066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>1179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
52
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>b</th>\n<th>y</th>\n<th>y</th>\n<th>y</th>\n</tr>\n<tr>\n<td>--- 1</td>\n<td>N</td>\n<td>11</td>\n<td>---</td>\n</tr>\n<tr>\n<td>216.0979 2</td>\n<td>T</td>\n<td>10</td>\n<td>1239.6402</td>\n</tr>\n<tr>\n<td>329.1819 3</td>\n<td>L</td>\n<td>9</td>\n<td>1138.5925</td>\n</tr>\n<tr>\n<td>492.2453 4</td>\n<td>Y</td>\n<td>8</td>\n<td>1025.5084</td>\n</tr>\n<tr>\n<td>605.3293 5</td>\n<td>L</td>\n<td>7</td>\n<td>862.4451</td>\n</tr>\n<tr>\n<td>733.3879 6</td>\n<td>Q</td>\n<td>6</td>\n<td>749.3611</td>\n</tr>\n<tr>\n<td>864.4284 7</td>\n<td>M</td>\n<td>5</td>\n<td>621.3025</td>\n</tr>\n<tr>\n<td>979.4553 8</td>\n<td>N(+0.984016)</td>\n<td>4</td>\n<td>490.2620</td>\n</tr>\n<tr>\n<td>1066.4874 9</td>\n<td>S</td>\n<td>3</td>\n<td>375.2350</td>\n</tr>\n<tr>\n<td>1179.5714 10</td>\n<td>L</td>\n<td>2</td>\n<td>288.2030</td>\n</tr>\n<tr>\n<td>--- 11</td>\n<td>R</td>\n<td>1</td>\n<td>175.1190</td>\n</tr>\n</table>",
53
+ "exploded_html": "<table border=\"1\"><tr><th>--- 1</th><th>Variable</th><th>y</th></tr><tr><td>216.0979 2</td><td>N</td><td>T</td></tr><tr><td>216.0979 2</td><td>11</td><td>10</td></tr><tr><td>216.0979 2</td><td>---</td><td>1239.6402</td></tr><tr><td>329.1819 3</td><td>N</td><td>L</td></tr><tr><td>329.1819 3</td><td>11</td><td>9</td></tr><tr><td>329.1819 3</td><td>---</td><td>1138.5925</td></tr><tr><td>492.2453 4</td><td>N</td><td>Y</td></tr><tr><td>492.2453 4</td><td>11</td><td>8</td></tr><tr><td>492.2453 4</td><td>---</td><td>1025.5084</td></tr><tr><td>605.3293 5</td><td>N</td><td>L</td></tr><tr><td>605.3293 5</td><td>11</td><td>7</td></tr><tr><td>605.3293 5</td><td>---</td><td>862.4451</td></tr><tr><td>733.3879 6</td><td>N</td><td>Q</td></tr><tr><td>733.3879 6</td><td>11</td><td>6</td></tr><tr><td>733.3879 6</td><td>---</td><td>749.3611</td></tr><tr><td>864.4284 7</td><td>N</td><td>M</td></tr><tr><td>864.4284 7</td><td>11</td><td>5</td></tr><tr><td>864.4284 7</td><td>---</td><td>621.3025</td></tr><tr><td>979.4553 8</td><td>N</td><td>N(+0.984016)</td></tr><tr><td>979.4553 8</td><td>11</td><td>4</td></tr><tr><td>979.4553 8</td><td>---</td><td>490.2620</td></tr><tr><td>1066.4874 9</td><td>N</td><td>S</td></tr><tr><td>1066.4874 9</td><td>11</td><td>3</td></tr><tr><td>1066.4874 9</td><td>---</td><td>375.2350</td></tr><tr><td>1179.5714 10</td><td>N</td><td>L</td></tr><tr><td>1179.5714 10</td><td>11</td><td>2</td></tr><tr><td>1179.5714 10</td><td>---</td><td>288.2030</td></tr><tr><td>--- 11</td><td>N</td><td>R</td></tr><tr><td>--- 11</td><td>11</td><td>1</td></tr><tr><td>--- 11</td><td>---</td><td>175.1190</td></tr></table>",
54
+ "markdown": "| b | y | y | y |\n| --- | --- | --- | --- |\n| --- 1 | N | 11 | --- |\n| 216.0979 2 | T | 10 | 1239.6402 |\n| 329.1819 3 | L | 9 | 1138.5925 |\n| 492.2453 4 | Y | 8 | 1025.5084 |\n| 605.3293 5 | L | 7 | 862.4451 |\n| 733.3879 6 | Q | 6 | 749.3611 |\n| 864.4284 7 | M | 5 | 621.3025 |\n| 979.4553 8 | N(+0.984016) | 4 | 490.2620 |\n| 1066.4874 9 | S | 3 | 375.2350 |\n| 1179.5714 10 | L | 2 | 288.2030 |\n| --- 11 | R | 1 | 175.1190 |"
55
+ },
56
+ {
57
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n<td>Relative quantification by EIC (%)</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>SCDK</td>\n<td>HC(223-226)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC</td>\n<td>LC(208-214)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC - SCDK</td>\n<td>HC(223-226) + LC(208-214)</td>\n<td>Thioether</td>\n<td>0.2</td>\n<td>0.5</td>\n<td>1.2</td>\n</tr>\n</table>",
58
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n<th>Relative quantification by EIC (%)</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>SCDK</td>\n<td>HC(223-226)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC</td>\n<td>LC(208-214)</td>\n<td></td>\n<td>99.8</td>\n<td>99.5</td>\n<td>98.8</td>\n</tr>\n<tr>\n<td>SFNRGEC - SCDK</td>\n<td>HC(223-226) + LC(208-214)</td>\n<td>Thioether</td>\n<td>0.2</td>\n<td>0.5</td>\n<td>1.2</td>\n</tr>\n</table>",
59
+ "exploded_html": "",
60
+ "markdown": "| Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| SCDK | HC(223-226) | | 99.8 | 99.5 | 98.8 |\n| SFNRGEC | LC(208-214) | | 99.8 | 99.5 | 98.8 |\n| SFNRGEC - SCDK | HC(223-226) + LC(208-214) | Thioether | 0.2 | 0.5 | 1.2 |"
61
+ },
62
+ {
63
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n<td>Relative quantification by EIC (%)*</td>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.6</td>\n<td>98.1</td>\n<td>96.8</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSN</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>0.3</td>\n<td>0.4</td>\n<td>0.6</td>\n</tr>\n<tr>\n<td>LAGDFGSWGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>1.1</td>\n<td>1.5</td>\n<td>2.6</td>\n</tr>\n<tr>\n<td>STSGGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td></td>\n<td>99.9</td>\n<td>99.3</td>\n<td>98.7</td>\n</tr>\n<tr>\n<td>GGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping</td>\n<td>0.0</td>\n<td>0.2</td>\n<td>0.3</td>\n</tr>\n<tr>\n<td>GTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping_2</td>\n<td>0.1</td>\n<td>0.5</td>\n<td>0.9</td>\n</tr>\n<tr>\n<td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>\n<td>HC(223-252)</td>\n<td></td>\n<td>99.6</td>\n<td>99.4</td>\n<td>99.0</td>\n</tr>\n<tr>\n<td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>\n<td>HC(223-252)</td>\n<td>Clipping</td>\n<td>0.4</td>\n<td>0.6</td>\n<td>1.0</td>\n</tr>\n</table>",
64
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n<th>Relative quantification by EIC (%)*</th>\n</tr>\n<tr>\n<td>AA Sequence</td>\n<td>Seq Loc</td>\n<td>Modification</td>\n<td>T0</td>\n<td>T2W_37\u2103</td>\n<td>T4W_37\u2103</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td></td>\n<td>98.6</td>\n<td>98.1</td>\n<td>96.8</td>\n</tr>\n<tr>\n<td>AEDTAVYYCAKPLYSN</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>0.3</td>\n<td>0.4</td>\n<td>0.6</td>\n</tr>\n<tr>\n<td>LAGDFGSWGQGTTVTVSSASTK</td>\n<td>HC(88-125)</td>\n<td>Clipping</td>\n<td>1.1</td>\n<td>1.5</td>\n<td>2.6</td>\n</tr>\n<tr>\n<td>STSGGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td></td>\n<td>99.9</td>\n<td>99.3</td>\n<td>98.7</td>\n</tr>\n<tr>\n<td>GGTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping</td>\n<td>0.0</td>\n<td>0.2</td>\n<td>0.3</td>\n</tr>\n<tr>\n<td>GTAALGCLVK</td>\n<td>HC(138-151)</td>\n<td>Clipping_2</td>\n<td>0.1</td>\n<td>0.5</td>\n<td>0.9</td>\n</tr>\n<tr>\n<td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>\n<td>HC(223-252)</td>\n<td></td>\n<td>99.6</td>\n<td>99.4</td>\n<td>99.0</td>\n</tr>\n<tr>\n<td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>\n<td>HC(223-252)</td>\n<td>Clipping</td>\n<td>0.4</td>\n<td>0.6</td>\n<td>1.0</td>\n</tr>\n</table>",
65
+ "exploded_html": "",
66
+ "markdown": "| Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* |\n| --- | --- | --- | --- | --- | --- |\n| AA Sequence | Seq Loc | Modification | T0 | T2W_37\u2103 | T4W_37\u2103 |\n| AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.6 | 98.1 | 96.8 |\n| AEDTAVYYCAKPLYSN | HC(88-125) | Clipping | 0.3 | 0.4 | 0.6 |\n| LAGDFGSWGQGTTVTVSSASTK | HC(88-125) | Clipping | 1.1 | 1.5 | 2.6 |\n| STSGGTAALGCLVK | HC(138-151) | | 99.9 | 99.3 | 98.7 |\n| GGTAALGCLVK | HC(138-151) | Clipping | 0.0 | 0.2 | 0.3 |\n| GTAALGCLVK | HC(138-151) | Clipping_2 | 0.1 | 0.5 | 0.9 |\n| SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK | HC(223-252) | | 99.6 | 99.4 | 99.0 |\n| DKTHTCPPCPAPEAAGGPSVFLFP PKPK | HC(223-252) | Clipping | 0.4 | 0.6 | 1.0 |"
67
+ },
68
+ {
69
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Blue:</td>\n<td>VH and VL</td>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
70
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Blue:</th>\n<th>VH and VL</th>\n</tr>\n<tr>\n<td>Blue:</td>\n<td>CDR</td>\n</tr>\n<tr>\n<td>Green:</td>\n<td>N-glycosylation site</td>\n</tr>\n</table>",
71
+ "exploded_html": "<table border=\"1\"><tr><th>Blue:</th><th>Variable</th><th>VH and VL</th></tr><tr><td>Green:</td><td>CDR</td><td>N-glycosylation site</td></tr></table>",
72
+ "markdown": "| Blue: | VH and VL |\n| --- | --- |\n| Blue: | CDR |\n| Green: | N-glycosylation site |"
73
+ },
74
+ {
75
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Mabelle Meersseman</td>\n<td>Date:</td>\n</tr>\n<tr>\n<td>Group Leader</td>\n<td>Signature:</td>\n</tr>\n<tr>\n<td>Approver</td>\n<td></td>\n</tr>\n<tr>\n<td>Koen Sandra Ph.D.</td>\n<td>Date:</td>\n</tr>\n<tr>\n<td>CEO</td>\n<td>Signature:</td>\n</tr>\n</table>",
76
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Mabelle Meersseman</th>\n<th>Date:</th>\n</tr>\n<tr>\n<td>Group Leader</td>\n<td>Signature:</td>\n</tr>\n<tr>\n<td>Approver</td>\n<td></td>\n</tr>\n<tr>\n<td>Koen Sandra Ph.D.</td>\n<td>Date:</td>\n</tr>\n<tr>\n<td>CEO</td>\n<td>Signature:</td>\n</tr>\n</table>",
77
+ "exploded_html": "<table border=\"1\"><tr><th>Group Leader</th><th>Variable</th><th>Date:</th></tr><tr><td>Approver</td><td>Signature:</td><td></td></tr><tr><td>Koen Sandra Ph.D.</td><td>Signature:</td><td>Date:</td></tr><tr><td>CEO</td><td>Signature:</td><td>Signature:</td></tr></table>",
78
+ "markdown": "| Mabelle Meersseman | Date: |\n| --- | --- |\n| Group Leader | Signature: |\n| Approver | |\n| Koen Sandra Ph.D. | Date: |\n| CEO | Signature: |"
79
+ },
80
+ {
81
+ "original_html": "<table border=\"1\">\n<tr>\n<td>Version</td>\n<td>Date of issue</td>\n<td>Reason for version update</td>\n</tr>\n<tr>\n<td>00</td>\n<td>20 November 2024</td>\n<td>Draft</td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n</table>",
82
+ "expanded_html": "<table border=\"1\">\n<tr>\n<th>Version</th>\n<th>Date of issue</th>\n<th>Reason for version update</th>\n</tr>\n<tr>\n<td>00</td>\n<td>20 November 2024</td>\n<td>Draft</td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n<tr>\n<td></td>\n<td></td>\n<td></td>\n</tr>\n</table>",
83
+ "exploded_html": "<table border=\"1\"><tr><th>00</th><th>Variable</th><th>Date of issue</th></tr><tr><td></td><td>20 November 2024</td><td></td></tr><tr><td></td><td>Draft</td><td></td></tr><tr><td></td><td>20 November 2024</td><td></td></tr><tr><td></td><td>Draft</td><td></td></tr></table>",
84
+ "markdown": "| Version | Date of issue | Reason for version update |\n| --- | --- | --- |\n| 00 | 20 November 2024 | Draft |\n| | | |\n| | | |"
85
+ }
86
+ ]
logs/di_content/di_content_20250605_140153_tables.md ADDED
@@ -0,0 +1,145 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ # Azure Document Intelligence Tables
2
+
3
+ ## Table 1
4
+
5
+ | Sales quote: | SQ20202722 |
6
+ | --- | --- |
7
+ | Project code: | P3016 |
8
+ | LNB number: | 2023.040 |
9
+ | Project responsible: | Nathan Cardon |
10
+ | Report name: | P3016_R010_v01 |
11
+
12
+ ## Table 2
13
+
14
+ | Construct | Stress condition | Concentration (mg/mL) |
15
+ | --- | --- | --- |
16
+ | P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T0W | 1.00 |
17
+ | P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T2W_37℃ | 1.00 |
18
+ | P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002 | T4W_37℃ | 1.00 |
19
+
20
+ ## Table 3
21
+
22
+ | Blue: | VH and VL |
23
+ | --- | --- |
24
+ | Blue: | CDR |
25
+ | Green: | N-glycosylation site |
26
+
27
+ ## Table 4
28
+
29
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
30
+ | --- | --- | --- | --- | --- | --- |
31
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
32
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.0 | 96.1 | 93.0 |
33
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | PyroE | 1.0 | 3.9 | 7.0 |
34
+
35
+ ## Table 5
36
+
37
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
38
+ | --- | --- | --- | --- | --- | --- |
39
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
40
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 99.9 | 99.7 | 99.5 |
41
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Isomerization | 0.1 | 0.3 | 0.5 |
42
+
43
+ ## Table 6
44
+
45
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
46
+ | --- | --- | --- | --- | --- | --- |
47
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
48
+ | NTLYLQMNSLR | HC(77-87) | | 99.5 | 99.5 | 99.5 |
49
+ | NTLYLQMNSLR | HC(77-87) | Oxidation | 0.5 | 0.5 | 0.5 |
50
+ | DIQMTQSPSSLSASVGDR | LC(1-18) | | 99.5 | 99.5 | 99.5 |
51
+ | DIQMTQSPSSLSASVGDR | LC(1-18) | Oxidation | 0.5 | 0.5 | 0.5 |
52
+
53
+ ## Table 7
54
+
55
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
56
+ | --- | --- | --- | --- | --- | --- |
57
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
58
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | | 99.6 | 99.6 | 99.5 |
59
+ | EVQLLESGGGLVQPGGSLR | HC(1-19) | Deamidation | 0.4 | 0.4 | 0.5 |
60
+ | NTLYLQMNSLR* | HC(77-87) | | 99.0 | 98.8 | 98.6 |
61
+ | NTLYLQMNSLR* | HC(77-87) | Deamidation | 1.0 | 1.2 | 1.4 |
62
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.7 | 96.1 | 93.4 |
63
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | Deamidation | 1.3 | 3.9 | 6.6 |
64
+ | VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | | 99.9 | 99.8 | 99.5 |
65
+ | VTITCQASQSISSYLAWYQQKPGK | LC(19-42) | Deamidation | 0.1 | 0.2 | 0.5 |
66
+
67
+ ## Table 8
68
+
69
+ | b --- 1 | | | y |
70
+ | --- | --- | --- | --- |
71
+ | b --- 1 | N(+0.984016) | 11 | --- |
72
+ | 217.0819 2 | T | 10 | 1238.6562 |
73
+ | 330.1660 3 | L | 9 | 1137.6085 |
74
+ | 493.2293 4 | Y | 8 | 1024.5244 |
75
+ | 606.3134 5 | L | 7 | 861.4611 |
76
+ | 734.3719 6 | Q | 6 | 748.3770 |
77
+ | 865.4124 7 | M | 5 | 620.3185 |
78
+ | 979.4553 8 | N | 4 | 489.2780 |
79
+ | 066.4874 9 | S | 3 | 375.2350 |
80
+ | 179.5714 10 | L | 2 | 288.2030 |
81
+ | --- 11 | R | 1 | 175.1190 |
82
+
83
+ ## Table 9
84
+
85
+ | b | y | y | y |
86
+ | --- | --- | --- | --- |
87
+ | --- 1 | N | 11 | --- |
88
+ | 216.0979 2 | T | 10 | 1239.6402 |
89
+ | 329.1819 3 | L | 9 | 1138.5925 |
90
+ | 492.2453 4 | Y | 8 | 1025.5084 |
91
+ | 605.3293 5 | L | 7 | 862.4451 |
92
+ | 733.3879 6 | Q | 6 | 749.3611 |
93
+ | 864.4284 7 | M | 5 | 621.3025 |
94
+ | 979.4553 8 | N(+0.984016) | 4 | 490.2620 |
95
+ | 1066.4874 9 | S | 3 | 375.2350 |
96
+ | 1179.5714 10 | L | 2 | 288.2030 |
97
+ | --- 11 | R | 1 | 175.1190 |
98
+
99
+ ## Table 10
100
+
101
+ | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) | Relative quantification by EIC (%) |
102
+ | --- | --- | --- | --- | --- | --- |
103
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
104
+ | SCDK | HC(223-226) | | 99.8 | 99.5 | 98.8 |
105
+ | SFNRGEC | LC(208-214) | | 99.8 | 99.5 | 98.8 |
106
+ | SFNRGEC - SCDK | HC(223-226) + LC(208-214) | Thioether | 0.2 | 0.5 | 1.2 |
107
+
108
+ ## Table 11
109
+
110
+ | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* | Relative quantification by EIC (%)* |
111
+ | --- | --- | --- | --- | --- | --- |
112
+ | AA Sequence | Seq Loc | Modification | T0 | T2W_37℃ | T4W_37℃ |
113
+ | AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK | HC(88-125) | | 98.6 | 98.1 | 96.8 |
114
+ | AEDTAVYYCAKPLYSN | HC(88-125) | Clipping | 0.3 | 0.4 | 0.6 |
115
+ | LAGDFGSWGQGTTVTVSSASTK | HC(88-125) | Clipping | 1.1 | 1.5 | 2.6 |
116
+ | STSGGTAALGCLVK | HC(138-151) | | 99.9 | 99.3 | 98.7 |
117
+ | GGTAALGCLVK | HC(138-151) | Clipping | 0.0 | 0.2 | 0.3 |
118
+ | GTAALGCLVK | HC(138-151) | Clipping_2 | 0.1 | 0.5 | 0.9 |
119
+ | SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK | HC(223-252) | | 99.6 | 99.4 | 99.0 |
120
+ | DKTHTCPPCPAPEAAGGPSVFLFP PKPK | HC(223-252) | Clipping | 0.4 | 0.6 | 1.0 |
121
+
122
+ ## Table 12
123
+
124
+ | Blue: | VH and VL |
125
+ | --- | --- |
126
+ | Blue: | CDR |
127
+ | Green: | N-glycosylation site |
128
+
129
+ ## Table 13
130
+
131
+ | Mabelle Meersseman | Date: |
132
+ | --- | --- |
133
+ | Group Leader | Signature: |
134
+ | Approver | |
135
+ | Koen Sandra Ph.D. | Date: |
136
+ | CEO | Signature: |
137
+
138
+ ## Table 14
139
+
140
+ | Version | Date of issue | Reason for version update |
141
+ | --- | --- | --- |
142
+ | 00 | 20 November 2024 | Draft |
143
+ | | | |
144
+ | | | |
145
+
logs/di_content/di_content_20250605_140153_tables_comparison.html ADDED
@@ -0,0 +1,1436 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Table Comparison</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ .table-pair { display: flex; gap: 20px; margin-bottom: 20px; }
9
+ .table-wrapper { flex: 1; }
10
+ h2 { color: #333; }
11
+ h3 { color: #666; margin: 10px 0; }
12
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
13
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
14
+ th { background-color: #f5f5f5; }
15
+ .original { background-color: #f0f7ff; }
16
+ .expanded { background-color: #f0fff0; }
17
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
18
+ </style>
19
+ </head>
20
+ <body>
21
+ <h1>Table Comparison - Original vs Expanded</h1>
22
+
23
+ <div class="table-container">
24
+ <h2>Table 1</h2>
25
+ <div class="table-pair">
26
+ <div class="table-wrapper">
27
+ <h3>Original Table (with rowspans)</h3>
28
+ <table border="1">
29
+ <tr>
30
+ <td>Sales quote:</td>
31
+ <td>SQ20202722</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project code:</td>
35
+ <td>P3016</td>
36
+ </tr>
37
+ <tr>
38
+ <td>LNB number:</td>
39
+ <td>2023.040</td>
40
+ </tr>
41
+ <tr>
42
+ <td>Project responsible:</td>
43
+ <td>Nathan Cardon</td>
44
+ </tr>
45
+ <tr>
46
+ <td>Report name:</td>
47
+ <td>P3016_R010_v01</td>
48
+ </tr>
49
+ </table>
50
+ </div>
51
+ <div class="table-wrapper">
52
+ <h3>Expanded Table (rowspans resolved)</h3>
53
+ <table border="1">
54
+ <tr>
55
+ <th>Sales quote:</th>
56
+ <th>SQ20202722</th>
57
+ </tr>
58
+ <tr>
59
+ <td>Project code:</td>
60
+ <td>P3016</td>
61
+ </tr>
62
+ <tr>
63
+ <td>LNB number:</td>
64
+ <td>2023.040</td>
65
+ </tr>
66
+ <tr>
67
+ <td>Project responsible:</td>
68
+ <td>Nathan Cardon</td>
69
+ </tr>
70
+ <tr>
71
+ <td>Report name:</td>
72
+ <td>P3016_R010_v01</td>
73
+ </tr>
74
+ </table>
75
+ </div>
76
+ </div>
77
+ <div>
78
+ <h3>Exploded (long/normalized) Table</h3>
79
+ <table border="1"><tr><th>Project code:</th><th>Variable</th><th>SQ20202722</th></tr><tr><td>LNB number:</td><td>P3016</td><td>2023.040</td></tr><tr><td>Project responsible:</td><td>P3016</td><td>Nathan Cardon</td></tr><tr><td>Report name:</td><td>P3016</td><td>P3016_R010_v01</td></tr></table>
80
+ </div>
81
+ <hr>
82
+ </div>
83
+ </body></html>
84
+ <div class="table-container">
85
+ <h2>Table 2</h2>
86
+ <div class="table-pair">
87
+ <div class="table-wrapper">
88
+ <h3>Original Table (with rowspans)</h3>
89
+ <table border="1">
90
+ <tr>
91
+ <td>Construct</td>
92
+ <td>Stress condition</td>
93
+ <td>Concentration (mg/mL)</td>
94
+ </tr>
95
+ <tr>
96
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
97
+ <td>T0W</td>
98
+ <td>1.00</td>
99
+ </tr>
100
+ <tr>
101
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
102
+ <td>T2W_37℃</td>
103
+ <td>1.00</td>
104
+ </tr>
105
+ <tr>
106
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
107
+ <td>T4W_37℃</td>
108
+ <td>1.00</td>
109
+ </tr>
110
+ </table>
111
+ </div>
112
+ <div class="table-wrapper">
113
+ <h3>Expanded Table (rowspans resolved)</h3>
114
+ <table border="1">
115
+ <tr>
116
+ <th>Construct</th>
117
+ <th>Stress condition</th>
118
+ <th>Concentration (mg/mL)</th>
119
+ </tr>
120
+ <tr>
121
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
122
+ <td>T0W</td>
123
+ <td>1.00</td>
124
+ </tr>
125
+ <tr>
126
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
127
+ <td>T2W_37℃</td>
128
+ <td>1.00</td>
129
+ </tr>
130
+ <tr>
131
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
132
+ <td>T4W_37℃</td>
133
+ <td>1.00</td>
134
+ </tr>
135
+ </table>
136
+ </div>
137
+ </div>
138
+ <div>
139
+ <h3>Exploded (long/normalized) Table</h3>
140
+ <table border="1"><tr><th>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</th><th>Variable</th><th>Stress condition</th></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>T0W</td><td>T2W_37℃</td></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>1.00</td><td>1.00</td></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>T0W</td><td>T4W_37℃</td></tr><tr><td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td><td>1.00</td><td>1.00</td></tr></table>
141
+ </div>
142
+ <hr>
143
+ </div>
144
+ </body></html>
145
+ <div class="table-container">
146
+ <h2>Table 3</h2>
147
+ <div class="table-pair">
148
+ <div class="table-wrapper">
149
+ <h3>Original Table (with rowspans)</h3>
150
+ <table border="1">
151
+ <tr>
152
+ <td>Blue:</td>
153
+ <td>VH and VL</td>
154
+ </tr>
155
+ <tr>
156
+ <td>Blue:</td>
157
+ <td>CDR</td>
158
+ </tr>
159
+ <tr>
160
+ <td>Green:</td>
161
+ <td>N-glycosylation site</td>
162
+ </tr>
163
+ </table>
164
+ </div>
165
+ <div class="table-wrapper">
166
+ <h3>Expanded Table (rowspans resolved)</h3>
167
+ <table border="1">
168
+ <tr>
169
+ <th>Blue:</th>
170
+ <th>VH and VL</th>
171
+ </tr>
172
+ <tr>
173
+ <td>Blue:</td>
174
+ <td>CDR</td>
175
+ </tr>
176
+ <tr>
177
+ <td>Green:</td>
178
+ <td>N-glycosylation site</td>
179
+ </tr>
180
+ </table>
181
+ </div>
182
+ </div>
183
+ <div>
184
+ <h3>Exploded (long/normalized) Table</h3>
185
+ <table border="1"><tr><th>Blue:</th><th>Variable</th><th>VH and VL</th></tr><tr><td>Green:</td><td>CDR</td><td>N-glycosylation site</td></tr></table>
186
+ </div>
187
+ <hr>
188
+ </div>
189
+ </body></html>
190
+ <div class="table-container">
191
+ <h2>Table 4</h2>
192
+ <div class="table-pair">
193
+ <div class="table-wrapper">
194
+ <h3>Original Table (with rowspans)</h3>
195
+ <table border="1">
196
+ <tr>
197
+ <td>Relative quantification by EIC (%)</td>
198
+ <td>Relative quantification by EIC (%)</td>
199
+ <td>Relative quantification by EIC (%)</td>
200
+ <td>Relative quantification by EIC (%)</td>
201
+ <td>Relative quantification by EIC (%)</td>
202
+ <td>Relative quantification by EIC (%)</td>
203
+ </tr>
204
+ <tr>
205
+ <td>AA Sequence</td>
206
+ <td>Seq Loc</td>
207
+ <td>Modification</td>
208
+ <td>T0</td>
209
+ <td>T2W_37℃</td>
210
+ <td>T4W_37℃</td>
211
+ </tr>
212
+ <tr>
213
+ <td>EVQLLESGGGLVQPGGSLR</td>
214
+ <td>HC(1-19)</td>
215
+ <td></td>
216
+ <td>99.0</td>
217
+ <td>96.1</td>
218
+ <td>93.0</td>
219
+ </tr>
220
+ <tr>
221
+ <td>EVQLLESGGGLVQPGGSLR</td>
222
+ <td>HC(1-19)</td>
223
+ <td>PyroE</td>
224
+ <td>1.0</td>
225
+ <td>3.9</td>
226
+ <td>7.0</td>
227
+ </tr>
228
+ </table>
229
+ </div>
230
+ <div class="table-wrapper">
231
+ <h3>Expanded Table (rowspans resolved)</h3>
232
+ <table border="1">
233
+ <tr>
234
+ <th>Relative quantification by EIC (%)</th>
235
+ <th>Relative quantification by EIC (%)</th>
236
+ <th>Relative quantification by EIC (%)</th>
237
+ <th>Relative quantification by EIC (%)</th>
238
+ <th>Relative quantification by EIC (%)</th>
239
+ <th>Relative quantification by EIC (%)</th>
240
+ </tr>
241
+ <tr>
242
+ <td>AA Sequence</td>
243
+ <td>Seq Loc</td>
244
+ <td>Modification</td>
245
+ <td>T0</td>
246
+ <td>T2W_37℃</td>
247
+ <td>T4W_37℃</td>
248
+ </tr>
249
+ <tr>
250
+ <td>EVQLLESGGGLVQPGGSLR</td>
251
+ <td>HC(1-19)</td>
252
+ <td></td>
253
+ <td>99.0</td>
254
+ <td>96.1</td>
255
+ <td>93.0</td>
256
+ </tr>
257
+ <tr>
258
+ <td>EVQLLESGGGLVQPGGSLR</td>
259
+ <td>HC(1-19)</td>
260
+ <td>PyroE</td>
261
+ <td>1.0</td>
262
+ <td>3.9</td>
263
+ <td>7.0</td>
264
+ </tr>
265
+ </table>
266
+ </div>
267
+ </div>
268
+ <div>
269
+ <h3>Exploded (long/normalized) Table</h3>
270
+
271
+ </div>
272
+ <hr>
273
+ </div>
274
+ </body></html>
275
+ <div class="table-container">
276
+ <h2>Table 5</h2>
277
+ <div class="table-pair">
278
+ <div class="table-wrapper">
279
+ <h3>Original Table (with rowspans)</h3>
280
+ <table border="1">
281
+ <tr>
282
+ <td>Relative quantification by EIC (%)</td>
283
+ <td>Relative quantification by EIC (%)</td>
284
+ <td>Relative quantification by EIC (%)</td>
285
+ <td>Relative quantification by EIC (%)</td>
286
+ <td>Relative quantification by EIC (%)</td>
287
+ <td>Relative quantification by EIC (%)</td>
288
+ </tr>
289
+ <tr>
290
+ <td>AA Sequence</td>
291
+ <td>Seq Loc</td>
292
+ <td>Modification</td>
293
+ <td>T0</td>
294
+ <td>T2W_37℃</td>
295
+ <td>T4W_37℃</td>
296
+ </tr>
297
+ <tr>
298
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
299
+ <td>HC(88-125)</td>
300
+ <td></td>
301
+ <td>99.9</td>
302
+ <td>99.7</td>
303
+ <td>99.5</td>
304
+ </tr>
305
+ <tr>
306
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
307
+ <td>HC(88-125)</td>
308
+ <td>Isomerization</td>
309
+ <td>0.1</td>
310
+ <td>0.3</td>
311
+ <td>0.5</td>
312
+ </tr>
313
+ </table>
314
+ </div>
315
+ <div class="table-wrapper">
316
+ <h3>Expanded Table (rowspans resolved)</h3>
317
+ <table border="1">
318
+ <tr>
319
+ <th>Relative quantification by EIC (%)</th>
320
+ <th>Relative quantification by EIC (%)</th>
321
+ <th>Relative quantification by EIC (%)</th>
322
+ <th>Relative quantification by EIC (%)</th>
323
+ <th>Relative quantification by EIC (%)</th>
324
+ <th>Relative quantification by EIC (%)</th>
325
+ </tr>
326
+ <tr>
327
+ <td>AA Sequence</td>
328
+ <td>Seq Loc</td>
329
+ <td>Modification</td>
330
+ <td>T0</td>
331
+ <td>T2W_37℃</td>
332
+ <td>T4W_37℃</td>
333
+ </tr>
334
+ <tr>
335
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
336
+ <td>HC(88-125)</td>
337
+ <td></td>
338
+ <td>99.9</td>
339
+ <td>99.7</td>
340
+ <td>99.5</td>
341
+ </tr>
342
+ <tr>
343
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
344
+ <td>HC(88-125)</td>
345
+ <td>Isomerization</td>
346
+ <td>0.1</td>
347
+ <td>0.3</td>
348
+ <td>0.5</td>
349
+ </tr>
350
+ </table>
351
+ </div>
352
+ </div>
353
+ <div>
354
+ <h3>Exploded (long/normalized) Table</h3>
355
+
356
+ </div>
357
+ <hr>
358
+ </div>
359
+ </body></html>
360
+ <div class="table-container">
361
+ <h2>Table 6</h2>
362
+ <div class="table-pair">
363
+ <div class="table-wrapper">
364
+ <h3>Original Table (with rowspans)</h3>
365
+ <table border="1">
366
+ <tr>
367
+ <td>Relative quantification by EIC (%)</td>
368
+ <td>Relative quantification by EIC (%)</td>
369
+ <td>Relative quantification by EIC (%)</td>
370
+ <td>Relative quantification by EIC (%)</td>
371
+ <td>Relative quantification by EIC (%)</td>
372
+ <td>Relative quantification by EIC (%)</td>
373
+ </tr>
374
+ <tr>
375
+ <td>AA Sequence</td>
376
+ <td>Seq Loc</td>
377
+ <td>Modification</td>
378
+ <td>T0</td>
379
+ <td>T2W_37℃</td>
380
+ <td>T4W_37℃</td>
381
+ </tr>
382
+ <tr>
383
+ <td>NTLYLQMNSLR</td>
384
+ <td>HC(77-87)</td>
385
+ <td></td>
386
+ <td>99.5</td>
387
+ <td>99.5</td>
388
+ <td>99.5</td>
389
+ </tr>
390
+ <tr>
391
+ <td>NTLYLQMNSLR</td>
392
+ <td>HC(77-87)</td>
393
+ <td>Oxidation</td>
394
+ <td>0.5</td>
395
+ <td>0.5</td>
396
+ <td>0.5</td>
397
+ </tr>
398
+ <tr>
399
+ <td>DIQMTQSPSSLSASVGDR</td>
400
+ <td>LC(1-18)</td>
401
+ <td></td>
402
+ <td>99.5</td>
403
+ <td>99.5</td>
404
+ <td>99.5</td>
405
+ </tr>
406
+ <tr>
407
+ <td>DIQMTQSPSSLSASVGDR</td>
408
+ <td>LC(1-18)</td>
409
+ <td>Oxidation</td>
410
+ <td>0.5</td>
411
+ <td>0.5</td>
412
+ <td>0.5</td>
413
+ </tr>
414
+ </table>
415
+ </div>
416
+ <div class="table-wrapper">
417
+ <h3>Expanded Table (rowspans resolved)</h3>
418
+ <table border="1">
419
+ <tr>
420
+ <th>Relative quantification by EIC (%)</th>
421
+ <th>Relative quantification by EIC (%)</th>
422
+ <th>Relative quantification by EIC (%)</th>
423
+ <th>Relative quantification by EIC (%)</th>
424
+ <th>Relative quantification by EIC (%)</th>
425
+ <th>Relative quantification by EIC (%)</th>
426
+ </tr>
427
+ <tr>
428
+ <td>AA Sequence</td>
429
+ <td>Seq Loc</td>
430
+ <td>Modification</td>
431
+ <td>T0</td>
432
+ <td>T2W_37℃</td>
433
+ <td>T4W_37℃</td>
434
+ </tr>
435
+ <tr>
436
+ <td>NTLYLQMNSLR</td>
437
+ <td>HC(77-87)</td>
438
+ <td></td>
439
+ <td>99.5</td>
440
+ <td>99.5</td>
441
+ <td>99.5</td>
442
+ </tr>
443
+ <tr>
444
+ <td>NTLYLQMNSLR</td>
445
+ <td>HC(77-87)</td>
446
+ <td>Oxidation</td>
447
+ <td>0.5</td>
448
+ <td>0.5</td>
449
+ <td>0.5</td>
450
+ </tr>
451
+ <tr>
452
+ <td>DIQMTQSPSSLSASVGDR</td>
453
+ <td>LC(1-18)</td>
454
+ <td></td>
455
+ <td>99.5</td>
456
+ <td>99.5</td>
457
+ <td>99.5</td>
458
+ </tr>
459
+ <tr>
460
+ <td>DIQMTQSPSSLSASVGDR</td>
461
+ <td>LC(1-18)</td>
462
+ <td>Oxidation</td>
463
+ <td>0.5</td>
464
+ <td>0.5</td>
465
+ <td>0.5</td>
466
+ </tr>
467
+ </table>
468
+ </div>
469
+ </div>
470
+ <div>
471
+ <h3>Exploded (long/normalized) Table</h3>
472
+
473
+ </div>
474
+ <hr>
475
+ </div>
476
+ </body></html>
477
+ <div class="table-container">
478
+ <h2>Table 7</h2>
479
+ <div class="table-pair">
480
+ <div class="table-wrapper">
481
+ <h3>Original Table (with rowspans)</h3>
482
+ <table border="1">
483
+ <tr>
484
+ <td>Relative quantification by EIC (%)</td>
485
+ <td>Relative quantification by EIC (%)</td>
486
+ <td>Relative quantification by EIC (%)</td>
487
+ <td>Relative quantification by EIC (%)</td>
488
+ <td>Relative quantification by EIC (%)</td>
489
+ <td>Relative quantification by EIC (%)</td>
490
+ </tr>
491
+ <tr>
492
+ <td>AA Sequence</td>
493
+ <td>Seq Loc</td>
494
+ <td>Modification</td>
495
+ <td>T0</td>
496
+ <td>T2W_37℃</td>
497
+ <td>T4W_37℃</td>
498
+ </tr>
499
+ <tr>
500
+ <td>EVQLLESGGGLVQPGGSLR</td>
501
+ <td>HC(1-19)</td>
502
+ <td></td>
503
+ <td>99.6</td>
504
+ <td>99.6</td>
505
+ <td>99.5</td>
506
+ </tr>
507
+ <tr>
508
+ <td>EVQLLESGGGLVQPGGSLR</td>
509
+ <td>HC(1-19)</td>
510
+ <td>Deamidation</td>
511
+ <td>0.4</td>
512
+ <td>0.4</td>
513
+ <td>0.5</td>
514
+ </tr>
515
+ <tr>
516
+ <td>NTLYLQMNSLR*</td>
517
+ <td>HC(77-87)</td>
518
+ <td></td>
519
+ <td>99.0</td>
520
+ <td>98.8</td>
521
+ <td>98.6</td>
522
+ </tr>
523
+ <tr>
524
+ <td>NTLYLQMNSLR*</td>
525
+ <td>HC(77-87)</td>
526
+ <td>Deamidation</td>
527
+ <td>1.0</td>
528
+ <td>1.2</td>
529
+ <td>1.4</td>
530
+ </tr>
531
+ <tr>
532
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
533
+ <td>HC(88-125)</td>
534
+ <td></td>
535
+ <td>98.7</td>
536
+ <td>96.1</td>
537
+ <td>93.4</td>
538
+ </tr>
539
+ <tr>
540
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
541
+ <td>HC(88-125)</td>
542
+ <td>Deamidation</td>
543
+ <td>1.3</td>
544
+ <td>3.9</td>
545
+ <td>6.6</td>
546
+ </tr>
547
+ <tr>
548
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
549
+ <td>LC(19-42)</td>
550
+ <td></td>
551
+ <td>99.9</td>
552
+ <td>99.8</td>
553
+ <td>99.5</td>
554
+ </tr>
555
+ <tr>
556
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
557
+ <td>LC(19-42)</td>
558
+ <td>Deamidation</td>
559
+ <td>0.1</td>
560
+ <td>0.2</td>
561
+ <td>0.5</td>
562
+ </tr>
563
+ </table>
564
+ </div>
565
+ <div class="table-wrapper">
566
+ <h3>Expanded Table (rowspans resolved)</h3>
567
+ <table border="1">
568
+ <tr>
569
+ <th>Relative quantification by EIC (%)</th>
570
+ <th>Relative quantification by EIC (%)</th>
571
+ <th>Relative quantification by EIC (%)</th>
572
+ <th>Relative quantification by EIC (%)</th>
573
+ <th>Relative quantification by EIC (%)</th>
574
+ <th>Relative quantification by EIC (%)</th>
575
+ </tr>
576
+ <tr>
577
+ <td>AA Sequence</td>
578
+ <td>Seq Loc</td>
579
+ <td>Modification</td>
580
+ <td>T0</td>
581
+ <td>T2W_37℃</td>
582
+ <td>T4W_37℃</td>
583
+ </tr>
584
+ <tr>
585
+ <td>EVQLLESGGGLVQPGGSLR</td>
586
+ <td>HC(1-19)</td>
587
+ <td></td>
588
+ <td>99.6</td>
589
+ <td>99.6</td>
590
+ <td>99.5</td>
591
+ </tr>
592
+ <tr>
593
+ <td>EVQLLESGGGLVQPGGSLR</td>
594
+ <td>HC(1-19)</td>
595
+ <td>Deamidation</td>
596
+ <td>0.4</td>
597
+ <td>0.4</td>
598
+ <td>0.5</td>
599
+ </tr>
600
+ <tr>
601
+ <td>NTLYLQMNSLR*</td>
602
+ <td>HC(77-87)</td>
603
+ <td></td>
604
+ <td>99.0</td>
605
+ <td>98.8</td>
606
+ <td>98.6</td>
607
+ </tr>
608
+ <tr>
609
+ <td>NTLYLQMNSLR*</td>
610
+ <td>HC(77-87)</td>
611
+ <td>Deamidation</td>
612
+ <td>1.0</td>
613
+ <td>1.2</td>
614
+ <td>1.4</td>
615
+ </tr>
616
+ <tr>
617
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
618
+ <td>HC(88-125)</td>
619
+ <td></td>
620
+ <td>98.7</td>
621
+ <td>96.1</td>
622
+ <td>93.4</td>
623
+ </tr>
624
+ <tr>
625
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
626
+ <td>HC(88-125)</td>
627
+ <td>Deamidation</td>
628
+ <td>1.3</td>
629
+ <td>3.9</td>
630
+ <td>6.6</td>
631
+ </tr>
632
+ <tr>
633
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
634
+ <td>LC(19-42)</td>
635
+ <td></td>
636
+ <td>99.9</td>
637
+ <td>99.8</td>
638
+ <td>99.5</td>
639
+ </tr>
640
+ <tr>
641
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
642
+ <td>LC(19-42)</td>
643
+ <td>Deamidation</td>
644
+ <td>0.1</td>
645
+ <td>0.2</td>
646
+ <td>0.5</td>
647
+ </tr>
648
+ </table>
649
+ </div>
650
+ </div>
651
+ <div>
652
+ <h3>Exploded (long/normalized) Table</h3>
653
+
654
+ </div>
655
+ <hr>
656
+ </div>
657
+ </body></html>
658
+ <div class="table-container">
659
+ <h2>Table 8</h2>
660
+ <div class="table-pair">
661
+ <div class="table-wrapper">
662
+ <h3>Original Table (with rowspans)</h3>
663
+ <table border="1">
664
+ <tr>
665
+ <td>b --- 1</td>
666
+ <td></td>
667
+ <td></td>
668
+ <td>y</td>
669
+ </tr>
670
+ <tr>
671
+ <td>b --- 1</td>
672
+ <td>N(+0.984016)</td>
673
+ <td>11</td>
674
+ <td>---</td>
675
+ </tr>
676
+ <tr>
677
+ <td>217.0819 2</td>
678
+ <td>T</td>
679
+ <td>10</td>
680
+ <td>1238.6562</td>
681
+ </tr>
682
+ <tr>
683
+ <td>330.1660 3</td>
684
+ <td>L</td>
685
+ <td>9</td>
686
+ <td>1137.6085</td>
687
+ </tr>
688
+ <tr>
689
+ <td>493.2293 4</td>
690
+ <td>Y</td>
691
+ <td>8</td>
692
+ <td>1024.5244</td>
693
+ </tr>
694
+ <tr>
695
+ <td>606.3134 5</td>
696
+ <td>L</td>
697
+ <td>7</td>
698
+ <td>861.4611</td>
699
+ </tr>
700
+ <tr>
701
+ <td>734.3719 6</td>
702
+ <td>Q</td>
703
+ <td>6</td>
704
+ <td>748.3770</td>
705
+ </tr>
706
+ <tr>
707
+ <td>865.4124 7</td>
708
+ <td>M</td>
709
+ <td>5</td>
710
+ <td>620.3185</td>
711
+ </tr>
712
+ <tr>
713
+ <td>979.4553 8</td>
714
+ <td>N</td>
715
+ <td>4</td>
716
+ <td>489.2780</td>
717
+ </tr>
718
+ <tr>
719
+ <td>066.4874 9</td>
720
+ <td>S</td>
721
+ <td>3</td>
722
+ <td>375.2350</td>
723
+ </tr>
724
+ <tr>
725
+ <td>179.5714 10</td>
726
+ <td>L</td>
727
+ <td>2</td>
728
+ <td>288.2030</td>
729
+ </tr>
730
+ <tr>
731
+ <td>--- 11</td>
732
+ <td>R</td>
733
+ <td>1</td>
734
+ <td>175.1190</td>
735
+ </tr>
736
+ </table>
737
+ </div>
738
+ <div class="table-wrapper">
739
+ <h3>Expanded Table (rowspans resolved)</h3>
740
+ <table border="1">
741
+ <tr>
742
+ <th>b --- 1</th>
743
+ <th></th>
744
+ <th></th>
745
+ <th>y</th>
746
+ </tr>
747
+ <tr>
748
+ <td>b --- 1</td>
749
+ <td>N(+0.984016)</td>
750
+ <td>11</td>
751
+ <td>---</td>
752
+ </tr>
753
+ <tr>
754
+ <td>217.0819 2</td>
755
+ <td>T</td>
756
+ <td>10</td>
757
+ <td>1238.6562</td>
758
+ </tr>
759
+ <tr>
760
+ <td>330.1660 3</td>
761
+ <td>L</td>
762
+ <td>9</td>
763
+ <td>1137.6085</td>
764
+ </tr>
765
+ <tr>
766
+ <td>493.2293 4</td>
767
+ <td>Y</td>
768
+ <td>8</td>
769
+ <td>1024.5244</td>
770
+ </tr>
771
+ <tr>
772
+ <td>606.3134 5</td>
773
+ <td>L</td>
774
+ <td>7</td>
775
+ <td>861.4611</td>
776
+ </tr>
777
+ <tr>
778
+ <td>734.3719 6</td>
779
+ <td>Q</td>
780
+ <td>6</td>
781
+ <td>748.3770</td>
782
+ </tr>
783
+ <tr>
784
+ <td>865.4124 7</td>
785
+ <td>M</td>
786
+ <td>5</td>
787
+ <td>620.3185</td>
788
+ </tr>
789
+ <tr>
790
+ <td>979.4553 8</td>
791
+ <td>N</td>
792
+ <td>4</td>
793
+ <td>489.2780</td>
794
+ </tr>
795
+ <tr>
796
+ <td>066.4874 9</td>
797
+ <td>S</td>
798
+ <td>3</td>
799
+ <td>375.2350</td>
800
+ </tr>
801
+ <tr>
802
+ <td>179.5714 10</td>
803
+ <td>L</td>
804
+ <td>2</td>
805
+ <td>288.2030</td>
806
+ </tr>
807
+ <tr>
808
+ <td>--- 11</td>
809
+ <td>R</td>
810
+ <td>1</td>
811
+ <td>175.1190</td>
812
+ </tr>
813
+ </table>
814
+ </div>
815
+ </div>
816
+ <div>
817
+ <h3>Exploded (long/normalized) Table</h3>
818
+ <table border="1"><tr><th>b --- 1</th><th>N(+0.984016)</th><th>11</th><th>Variable</th><th>y</th></tr><tr><td>217.0819 2</td><td>T</td><td>10</td><td>---</td><td>1238.6562</td></tr><tr><td>330.1660 3</td><td>L</td><td>9</td><td>---</td><td>1137.6085</td></tr><tr><td>493.2293 4</td><td>Y</td><td>8</td><td>---</td><td>1024.5244</td></tr><tr><td>606.3134 5</td><td>L</td><td>7</td><td>---</td><td>861.4611</td></tr><tr><td>734.3719 6</td><td>Q</td><td>6</td><td>---</td><td>748.3770</td></tr><tr><td>865.4124 7</td><td>M</td><td>5</td><td>---</td><td>620.3185</td></tr><tr><td>979.4553 8</td><td>N</td><td>4</td><td>---</td><td>489.2780</td></tr><tr><td>066.4874 9</td><td>S</td><td>3</td><td>---</td><td>375.2350</td></tr><tr><td>179.5714 10</td><td>L</td><td>2</td><td>---</td><td>288.2030</td></tr><tr><td>--- 11</td><td>R</td><td>1</td><td>---</td><td>175.1190</td></tr></table>
819
+ </div>
820
+ <hr>
821
+ </div>
822
+ </body></html>
823
+ <div class="table-container">
824
+ <h2>Table 9</h2>
825
+ <div class="table-pair">
826
+ <div class="table-wrapper">
827
+ <h3>Original Table (with rowspans)</h3>
828
+ <table border="1">
829
+ <tr>
830
+ <td>b</td>
831
+ <td>y</td>
832
+ <td>y</td>
833
+ <td>y</td>
834
+ </tr>
835
+ <tr>
836
+ <td>--- 1</td>
837
+ <td>N</td>
838
+ <td>11</td>
839
+ <td>---</td>
840
+ </tr>
841
+ <tr>
842
+ <td>216.0979 2</td>
843
+ <td>T</td>
844
+ <td>10</td>
845
+ <td>1239.6402</td>
846
+ </tr>
847
+ <tr>
848
+ <td>329.1819 3</td>
849
+ <td>L</td>
850
+ <td>9</td>
851
+ <td>1138.5925</td>
852
+ </tr>
853
+ <tr>
854
+ <td>492.2453 4</td>
855
+ <td>Y</td>
856
+ <td>8</td>
857
+ <td>1025.5084</td>
858
+ </tr>
859
+ <tr>
860
+ <td>605.3293 5</td>
861
+ <td>L</td>
862
+ <td>7</td>
863
+ <td>862.4451</td>
864
+ </tr>
865
+ <tr>
866
+ <td>733.3879 6</td>
867
+ <td>Q</td>
868
+ <td>6</td>
869
+ <td>749.3611</td>
870
+ </tr>
871
+ <tr>
872
+ <td>864.4284 7</td>
873
+ <td>M</td>
874
+ <td>5</td>
875
+ <td>621.3025</td>
876
+ </tr>
877
+ <tr>
878
+ <td>979.4553 8</td>
879
+ <td>N(+0.984016)</td>
880
+ <td>4</td>
881
+ <td>490.2620</td>
882
+ </tr>
883
+ <tr>
884
+ <td>1066.4874 9</td>
885
+ <td>S</td>
886
+ <td>3</td>
887
+ <td>375.2350</td>
888
+ </tr>
889
+ <tr>
890
+ <td>1179.5714 10</td>
891
+ <td>L</td>
892
+ <td>2</td>
893
+ <td>288.2030</td>
894
+ </tr>
895
+ <tr>
896
+ <td>--- 11</td>
897
+ <td>R</td>
898
+ <td>1</td>
899
+ <td>175.1190</td>
900
+ </tr>
901
+ </table>
902
+ </div>
903
+ <div class="table-wrapper">
904
+ <h3>Expanded Table (rowspans resolved)</h3>
905
+ <table border="1">
906
+ <tr>
907
+ <th>b</th>
908
+ <th>y</th>
909
+ <th>y</th>
910
+ <th>y</th>
911
+ </tr>
912
+ <tr>
913
+ <td>--- 1</td>
914
+ <td>N</td>
915
+ <td>11</td>
916
+ <td>---</td>
917
+ </tr>
918
+ <tr>
919
+ <td>216.0979 2</td>
920
+ <td>T</td>
921
+ <td>10</td>
922
+ <td>1239.6402</td>
923
+ </tr>
924
+ <tr>
925
+ <td>329.1819 3</td>
926
+ <td>L</td>
927
+ <td>9</td>
928
+ <td>1138.5925</td>
929
+ </tr>
930
+ <tr>
931
+ <td>492.2453 4</td>
932
+ <td>Y</td>
933
+ <td>8</td>
934
+ <td>1025.5084</td>
935
+ </tr>
936
+ <tr>
937
+ <td>605.3293 5</td>
938
+ <td>L</td>
939
+ <td>7</td>
940
+ <td>862.4451</td>
941
+ </tr>
942
+ <tr>
943
+ <td>733.3879 6</td>
944
+ <td>Q</td>
945
+ <td>6</td>
946
+ <td>749.3611</td>
947
+ </tr>
948
+ <tr>
949
+ <td>864.4284 7</td>
950
+ <td>M</td>
951
+ <td>5</td>
952
+ <td>621.3025</td>
953
+ </tr>
954
+ <tr>
955
+ <td>979.4553 8</td>
956
+ <td>N(+0.984016)</td>
957
+ <td>4</td>
958
+ <td>490.2620</td>
959
+ </tr>
960
+ <tr>
961
+ <td>1066.4874 9</td>
962
+ <td>S</td>
963
+ <td>3</td>
964
+ <td>375.2350</td>
965
+ </tr>
966
+ <tr>
967
+ <td>1179.5714 10</td>
968
+ <td>L</td>
969
+ <td>2</td>
970
+ <td>288.2030</td>
971
+ </tr>
972
+ <tr>
973
+ <td>--- 11</td>
974
+ <td>R</td>
975
+ <td>1</td>
976
+ <td>175.1190</td>
977
+ </tr>
978
+ </table>
979
+ </div>
980
+ </div>
981
+ <div>
982
+ <h3>Exploded (long/normalized) Table</h3>
983
+ <table border="1"><tr><th>--- 1</th><th>Variable</th><th>y</th></tr><tr><td>216.0979 2</td><td>N</td><td>T</td></tr><tr><td>216.0979 2</td><td>11</td><td>10</td></tr><tr><td>216.0979 2</td><td>---</td><td>1239.6402</td></tr><tr><td>329.1819 3</td><td>N</td><td>L</td></tr><tr><td>329.1819 3</td><td>11</td><td>9</td></tr><tr><td>329.1819 3</td><td>---</td><td>1138.5925</td></tr><tr><td>492.2453 4</td><td>N</td><td>Y</td></tr><tr><td>492.2453 4</td><td>11</td><td>8</td></tr><tr><td>492.2453 4</td><td>---</td><td>1025.5084</td></tr><tr><td>605.3293 5</td><td>N</td><td>L</td></tr><tr><td>605.3293 5</td><td>11</td><td>7</td></tr><tr><td>605.3293 5</td><td>---</td><td>862.4451</td></tr><tr><td>733.3879 6</td><td>N</td><td>Q</td></tr><tr><td>733.3879 6</td><td>11</td><td>6</td></tr><tr><td>733.3879 6</td><td>---</td><td>749.3611</td></tr><tr><td>864.4284 7</td><td>N</td><td>M</td></tr><tr><td>864.4284 7</td><td>11</td><td>5</td></tr><tr><td>864.4284 7</td><td>---</td><td>621.3025</td></tr><tr><td>979.4553 8</td><td>N</td><td>N(+0.984016)</td></tr><tr><td>979.4553 8</td><td>11</td><td>4</td></tr><tr><td>979.4553 8</td><td>---</td><td>490.2620</td></tr><tr><td>1066.4874 9</td><td>N</td><td>S</td></tr><tr><td>1066.4874 9</td><td>11</td><td>3</td></tr><tr><td>1066.4874 9</td><td>---</td><td>375.2350</td></tr><tr><td>1179.5714 10</td><td>N</td><td>L</td></tr><tr><td>1179.5714 10</td><td>11</td><td>2</td></tr><tr><td>1179.5714 10</td><td>---</td><td>288.2030</td></tr><tr><td>--- 11</td><td>N</td><td>R</td></tr><tr><td>--- 11</td><td>11</td><td>1</td></tr><tr><td>--- 11</td><td>---</td><td>175.1190</td></tr></table>
984
+ </div>
985
+ <hr>
986
+ </div>
987
+ </body></html>
988
+ <div class="table-container">
989
+ <h2>Table 10</h2>
990
+ <div class="table-pair">
991
+ <div class="table-wrapper">
992
+ <h3>Original Table (with rowspans)</h3>
993
+ <table border="1">
994
+ <tr>
995
+ <td>Relative quantification by EIC (%)</td>
996
+ <td>Relative quantification by EIC (%)</td>
997
+ <td>Relative quantification by EIC (%)</td>
998
+ <td>Relative quantification by EIC (%)</td>
999
+ <td>Relative quantification by EIC (%)</td>
1000
+ <td>Relative quantification by EIC (%)</td>
1001
+ </tr>
1002
+ <tr>
1003
+ <td>AA Sequence</td>
1004
+ <td>Seq Loc</td>
1005
+ <td>Modification</td>
1006
+ <td>T0</td>
1007
+ <td>T2W_37℃</td>
1008
+ <td>T4W_37℃</td>
1009
+ </tr>
1010
+ <tr>
1011
+ <td>SCDK</td>
1012
+ <td>HC(223-226)</td>
1013
+ <td></td>
1014
+ <td>99.8</td>
1015
+ <td>99.5</td>
1016
+ <td>98.8</td>
1017
+ </tr>
1018
+ <tr>
1019
+ <td>SFNRGEC</td>
1020
+ <td>LC(208-214)</td>
1021
+ <td></td>
1022
+ <td>99.8</td>
1023
+ <td>99.5</td>
1024
+ <td>98.8</td>
1025
+ </tr>
1026
+ <tr>
1027
+ <td>SFNRGEC - SCDK</td>
1028
+ <td>HC(223-226) + LC(208-214)</td>
1029
+ <td>Thioether</td>
1030
+ <td>0.2</td>
1031
+ <td>0.5</td>
1032
+ <td>1.2</td>
1033
+ </tr>
1034
+ </table>
1035
+ </div>
1036
+ <div class="table-wrapper">
1037
+ <h3>Expanded Table (rowspans resolved)</h3>
1038
+ <table border="1">
1039
+ <tr>
1040
+ <th>Relative quantification by EIC (%)</th>
1041
+ <th>Relative quantification by EIC (%)</th>
1042
+ <th>Relative quantification by EIC (%)</th>
1043
+ <th>Relative quantification by EIC (%)</th>
1044
+ <th>Relative quantification by EIC (%)</th>
1045
+ <th>Relative quantification by EIC (%)</th>
1046
+ </tr>
1047
+ <tr>
1048
+ <td>AA Sequence</td>
1049
+ <td>Seq Loc</td>
1050
+ <td>Modification</td>
1051
+ <td>T0</td>
1052
+ <td>T2W_37℃</td>
1053
+ <td>T4W_37℃</td>
1054
+ </tr>
1055
+ <tr>
1056
+ <td>SCDK</td>
1057
+ <td>HC(223-226)</td>
1058
+ <td></td>
1059
+ <td>99.8</td>
1060
+ <td>99.5</td>
1061
+ <td>98.8</td>
1062
+ </tr>
1063
+ <tr>
1064
+ <td>SFNRGEC</td>
1065
+ <td>LC(208-214)</td>
1066
+ <td></td>
1067
+ <td>99.8</td>
1068
+ <td>99.5</td>
1069
+ <td>98.8</td>
1070
+ </tr>
1071
+ <tr>
1072
+ <td>SFNRGEC - SCDK</td>
1073
+ <td>HC(223-226) + LC(208-214)</td>
1074
+ <td>Thioether</td>
1075
+ <td>0.2</td>
1076
+ <td>0.5</td>
1077
+ <td>1.2</td>
1078
+ </tr>
1079
+ </table>
1080
+ </div>
1081
+ </div>
1082
+ <div>
1083
+ <h3>Exploded (long/normalized) Table</h3>
1084
+
1085
+ </div>
1086
+ <hr>
1087
+ </div>
1088
+ </body></html>
1089
+ <div class="table-container">
1090
+ <h2>Table 11</h2>
1091
+ <div class="table-pair">
1092
+ <div class="table-wrapper">
1093
+ <h3>Original Table (with rowspans)</h3>
1094
+ <table border="1">
1095
+ <tr>
1096
+ <td>Relative quantification by EIC (%)*</td>
1097
+ <td>Relative quantification by EIC (%)*</td>
1098
+ <td>Relative quantification by EIC (%)*</td>
1099
+ <td>Relative quantification by EIC (%)*</td>
1100
+ <td>Relative quantification by EIC (%)*</td>
1101
+ <td>Relative quantification by EIC (%)*</td>
1102
+ </tr>
1103
+ <tr>
1104
+ <td>AA Sequence</td>
1105
+ <td>Seq Loc</td>
1106
+ <td>Modification</td>
1107
+ <td>T0</td>
1108
+ <td>T2W_37℃</td>
1109
+ <td>T4W_37℃</td>
1110
+ </tr>
1111
+ <tr>
1112
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
1113
+ <td>HC(88-125)</td>
1114
+ <td></td>
1115
+ <td>98.6</td>
1116
+ <td>98.1</td>
1117
+ <td>96.8</td>
1118
+ </tr>
1119
+ <tr>
1120
+ <td>AEDTAVYYCAKPLYSN</td>
1121
+ <td>HC(88-125)</td>
1122
+ <td>Clipping</td>
1123
+ <td>0.3</td>
1124
+ <td>0.4</td>
1125
+ <td>0.6</td>
1126
+ </tr>
1127
+ <tr>
1128
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
1129
+ <td>HC(88-125)</td>
1130
+ <td>Clipping</td>
1131
+ <td>1.1</td>
1132
+ <td>1.5</td>
1133
+ <td>2.6</td>
1134
+ </tr>
1135
+ <tr>
1136
+ <td>STSGGTAALGCLVK</td>
1137
+ <td>HC(138-151)</td>
1138
+ <td></td>
1139
+ <td>99.9</td>
1140
+ <td>99.3</td>
1141
+ <td>98.7</td>
1142
+ </tr>
1143
+ <tr>
1144
+ <td>GGTAALGCLVK</td>
1145
+ <td>HC(138-151)</td>
1146
+ <td>Clipping</td>
1147
+ <td>0.0</td>
1148
+ <td>0.2</td>
1149
+ <td>0.3</td>
1150
+ </tr>
1151
+ <tr>
1152
+ <td>GTAALGCLVK</td>
1153
+ <td>HC(138-151)</td>
1154
+ <td>Clipping_2</td>
1155
+ <td>0.1</td>
1156
+ <td>0.5</td>
1157
+ <td>0.9</td>
1158
+ </tr>
1159
+ <tr>
1160
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
1161
+ <td>HC(223-252)</td>
1162
+ <td></td>
1163
+ <td>99.6</td>
1164
+ <td>99.4</td>
1165
+ <td>99.0</td>
1166
+ </tr>
1167
+ <tr>
1168
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
1169
+ <td>HC(223-252)</td>
1170
+ <td>Clipping</td>
1171
+ <td>0.4</td>
1172
+ <td>0.6</td>
1173
+ <td>1.0</td>
1174
+ </tr>
1175
+ </table>
1176
+ </div>
1177
+ <div class="table-wrapper">
1178
+ <h3>Expanded Table (rowspans resolved)</h3>
1179
+ <table border="1">
1180
+ <tr>
1181
+ <th>Relative quantification by EIC (%)*</th>
1182
+ <th>Relative quantification by EIC (%)*</th>
1183
+ <th>Relative quantification by EIC (%)*</th>
1184
+ <th>Relative quantification by EIC (%)*</th>
1185
+ <th>Relative quantification by EIC (%)*</th>
1186
+ <th>Relative quantification by EIC (%)*</th>
1187
+ </tr>
1188
+ <tr>
1189
+ <td>AA Sequence</td>
1190
+ <td>Seq Loc</td>
1191
+ <td>Modification</td>
1192
+ <td>T0</td>
1193
+ <td>T2W_37℃</td>
1194
+ <td>T4W_37℃</td>
1195
+ </tr>
1196
+ <tr>
1197
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
1198
+ <td>HC(88-125)</td>
1199
+ <td></td>
1200
+ <td>98.6</td>
1201
+ <td>98.1</td>
1202
+ <td>96.8</td>
1203
+ </tr>
1204
+ <tr>
1205
+ <td>AEDTAVYYCAKPLYSN</td>
1206
+ <td>HC(88-125)</td>
1207
+ <td>Clipping</td>
1208
+ <td>0.3</td>
1209
+ <td>0.4</td>
1210
+ <td>0.6</td>
1211
+ </tr>
1212
+ <tr>
1213
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
1214
+ <td>HC(88-125)</td>
1215
+ <td>Clipping</td>
1216
+ <td>1.1</td>
1217
+ <td>1.5</td>
1218
+ <td>2.6</td>
1219
+ </tr>
1220
+ <tr>
1221
+ <td>STSGGTAALGCLVK</td>
1222
+ <td>HC(138-151)</td>
1223
+ <td></td>
1224
+ <td>99.9</td>
1225
+ <td>99.3</td>
1226
+ <td>98.7</td>
1227
+ </tr>
1228
+ <tr>
1229
+ <td>GGTAALGCLVK</td>
1230
+ <td>HC(138-151)</td>
1231
+ <td>Clipping</td>
1232
+ <td>0.0</td>
1233
+ <td>0.2</td>
1234
+ <td>0.3</td>
1235
+ </tr>
1236
+ <tr>
1237
+ <td>GTAALGCLVK</td>
1238
+ <td>HC(138-151)</td>
1239
+ <td>Clipping_2</td>
1240
+ <td>0.1</td>
1241
+ <td>0.5</td>
1242
+ <td>0.9</td>
1243
+ </tr>
1244
+ <tr>
1245
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
1246
+ <td>HC(223-252)</td>
1247
+ <td></td>
1248
+ <td>99.6</td>
1249
+ <td>99.4</td>
1250
+ <td>99.0</td>
1251
+ </tr>
1252
+ <tr>
1253
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
1254
+ <td>HC(223-252)</td>
1255
+ <td>Clipping</td>
1256
+ <td>0.4</td>
1257
+ <td>0.6</td>
1258
+ <td>1.0</td>
1259
+ </tr>
1260
+ </table>
1261
+ </div>
1262
+ </div>
1263
+ <div>
1264
+ <h3>Exploded (long/normalized) Table</h3>
1265
+
1266
+ </div>
1267
+ <hr>
1268
+ </div>
1269
+ </body></html>
1270
+ <div class="table-container">
1271
+ <h2>Table 12</h2>
1272
+ <div class="table-pair">
1273
+ <div class="table-wrapper">
1274
+ <h3>Original Table (with rowspans)</h3>
1275
+ <table border="1">
1276
+ <tr>
1277
+ <td>Blue:</td>
1278
+ <td>VH and VL</td>
1279
+ </tr>
1280
+ <tr>
1281
+ <td>Blue:</td>
1282
+ <td>CDR</td>
1283
+ </tr>
1284
+ <tr>
1285
+ <td>Green:</td>
1286
+ <td>N-glycosylation site</td>
1287
+ </tr>
1288
+ </table>
1289
+ </div>
1290
+ <div class="table-wrapper">
1291
+ <h3>Expanded Table (rowspans resolved)</h3>
1292
+ <table border="1">
1293
+ <tr>
1294
+ <th>Blue:</th>
1295
+ <th>VH and VL</th>
1296
+ </tr>
1297
+ <tr>
1298
+ <td>Blue:</td>
1299
+ <td>CDR</td>
1300
+ </tr>
1301
+ <tr>
1302
+ <td>Green:</td>
1303
+ <td>N-glycosylation site</td>
1304
+ </tr>
1305
+ </table>
1306
+ </div>
1307
+ </div>
1308
+ <div>
1309
+ <h3>Exploded (long/normalized) Table</h3>
1310
+ <table border="1"><tr><th>Blue:</th><th>Variable</th><th>VH and VL</th></tr><tr><td>Green:</td><td>CDR</td><td>N-glycosylation site</td></tr></table>
1311
+ </div>
1312
+ <hr>
1313
+ </div>
1314
+ </body></html>
1315
+ <div class="table-container">
1316
+ <h2>Table 13</h2>
1317
+ <div class="table-pair">
1318
+ <div class="table-wrapper">
1319
+ <h3>Original Table (with rowspans)</h3>
1320
+ <table border="1">
1321
+ <tr>
1322
+ <td>Mabelle Meersseman</td>
1323
+ <td>Date:</td>
1324
+ </tr>
1325
+ <tr>
1326
+ <td>Group Leader</td>
1327
+ <td>Signature:</td>
1328
+ </tr>
1329
+ <tr>
1330
+ <td>Approver</td>
1331
+ <td></td>
1332
+ </tr>
1333
+ <tr>
1334
+ <td>Koen Sandra Ph.D.</td>
1335
+ <td>Date:</td>
1336
+ </tr>
1337
+ <tr>
1338
+ <td>CEO</td>
1339
+ <td>Signature:</td>
1340
+ </tr>
1341
+ </table>
1342
+ </div>
1343
+ <div class="table-wrapper">
1344
+ <h3>Expanded Table (rowspans resolved)</h3>
1345
+ <table border="1">
1346
+ <tr>
1347
+ <th>Mabelle Meersseman</th>
1348
+ <th>Date:</th>
1349
+ </tr>
1350
+ <tr>
1351
+ <td>Group Leader</td>
1352
+ <td>Signature:</td>
1353
+ </tr>
1354
+ <tr>
1355
+ <td>Approver</td>
1356
+ <td></td>
1357
+ </tr>
1358
+ <tr>
1359
+ <td>Koen Sandra Ph.D.</td>
1360
+ <td>Date:</td>
1361
+ </tr>
1362
+ <tr>
1363
+ <td>CEO</td>
1364
+ <td>Signature:</td>
1365
+ </tr>
1366
+ </table>
1367
+ </div>
1368
+ </div>
1369
+ <div>
1370
+ <h3>Exploded (long/normalized) Table</h3>
1371
+ <table border="1"><tr><th>Group Leader</th><th>Variable</th><th>Date:</th></tr><tr><td>Approver</td><td>Signature:</td><td></td></tr><tr><td>Koen Sandra Ph.D.</td><td>Signature:</td><td>Date:</td></tr><tr><td>CEO</td><td>Signature:</td><td>Signature:</td></tr></table>
1372
+ </div>
1373
+ <hr>
1374
+ </div>
1375
+ </body></html>
1376
+ <div class="table-container">
1377
+ <h2>Table 14</h2>
1378
+ <div class="table-pair">
1379
+ <div class="table-wrapper">
1380
+ <h3>Original Table (with rowspans)</h3>
1381
+ <table border="1">
1382
+ <tr>
1383
+ <td>Version</td>
1384
+ <td>Date of issue</td>
1385
+ <td>Reason for version update</td>
1386
+ </tr>
1387
+ <tr>
1388
+ <td>00</td>
1389
+ <td>20 November 2024</td>
1390
+ <td>Draft</td>
1391
+ </tr>
1392
+ <tr>
1393
+ <td></td>
1394
+ <td></td>
1395
+ <td></td>
1396
+ </tr>
1397
+ <tr>
1398
+ <td></td>
1399
+ <td></td>
1400
+ <td></td>
1401
+ </tr>
1402
+ </table>
1403
+ </div>
1404
+ <div class="table-wrapper">
1405
+ <h3>Expanded Table (rowspans resolved)</h3>
1406
+ <table border="1">
1407
+ <tr>
1408
+ <th>Version</th>
1409
+ <th>Date of issue</th>
1410
+ <th>Reason for version update</th>
1411
+ </tr>
1412
+ <tr>
1413
+ <td>00</td>
1414
+ <td>20 November 2024</td>
1415
+ <td>Draft</td>
1416
+ </tr>
1417
+ <tr>
1418
+ <td></td>
1419
+ <td></td>
1420
+ <td></td>
1421
+ </tr>
1422
+ <tr>
1423
+ <td></td>
1424
+ <td></td>
1425
+ <td></td>
1426
+ </tr>
1427
+ </table>
1428
+ </div>
1429
+ </div>
1430
+ <div>
1431
+ <h3>Exploded (long/normalized) Table</h3>
1432
+ <table border="1"><tr><th>00</th><th>Variable</th><th>Date of issue</th></tr><tr><td></td><td>20 November 2024</td><td></td></tr><tr><td></td><td>Draft</td><td></td></tr><tr><td></td><td>20 November 2024</td><td></td></tr><tr><td></td><td>Draft</td><td></td></tr></table>
1433
+ </div>
1434
+ <hr>
1435
+ </div>
1436
+ </body></html>
logs/di_content/di_content_20250605_144418_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250605_144756_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_095045_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
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1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_100010_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_100428_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_100907_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_101256_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
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@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_102049_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_102457_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_105724_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_110120_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_110301_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_110430_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
logs/di_content/di_content_20250606_110628_tables.html ADDED
@@ -0,0 +1,675 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ <!DOCTYPE html>
2
+ <html>
3
+ <head>
4
+ <title>Azure DI Tables</title>
5
+ <style>
6
+ body { font-family: Arial, sans-serif; margin: 20px; }
7
+ .table-container { margin-bottom: 40px; }
8
+ h2 { color: #333; }
9
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
10
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
11
+ th { background-color: #f5f5f5; }
12
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
13
+ </style>
14
+ </head>
15
+ <body>
16
+ <h1>Azure Document Intelligence Tables</h1>
17
+
18
+ <div class="table-container">
19
+ <h2>Table 1</h2>
20
+ <table border="1">
21
+ <tr>
22
+ <td>Sales quote:</td>
23
+ <td>SQ20202722</td>
24
+ </tr>
25
+ <tr>
26
+ <td>Project code:</td>
27
+ <td>P3016</td>
28
+ </tr>
29
+ <tr>
30
+ <td>LNB number:</td>
31
+ <td>2023.040</td>
32
+ </tr>
33
+ <tr>
34
+ <td>Project responsible:</td>
35
+ <td>Nathan Cardon</td>
36
+ </tr>
37
+ <tr>
38
+ <td>Report name:</td>
39
+ <td>P3016_R010_v01</td>
40
+ </tr>
41
+ </table>
42
+ <hr>
43
+ </div>
44
+
45
+ <div class="table-container">
46
+ <h2>Table 2</h2>
47
+ <table border="1">
48
+ <tr>
49
+ <td>Construct</td>
50
+ <td>Stress condition</td>
51
+ <td>Concentration (mg/mL)</td>
52
+ </tr>
53
+ <tr>
54
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
55
+ <td>T0W</td>
56
+ <td>1.00</td>
57
+ </tr>
58
+ <tr>
59
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
60
+ <td>T2W_37℃</td>
61
+ <td>1.00</td>
62
+ </tr>
63
+ <tr>
64
+ <td>P018_3D6 VHO VL6 _hIgG1_LALAPG_F405L- FJB_2024-04-18_002</td>
65
+ <td>T4W_37℃</td>
66
+ <td>1.00</td>
67
+ </tr>
68
+ </table>
69
+ <hr>
70
+ </div>
71
+
72
+ <div class="table-container">
73
+ <h2>Table 3</h2>
74
+ <table border="1">
75
+ <tr>
76
+ <td>Blue:</td>
77
+ <td>VH and VL</td>
78
+ </tr>
79
+ <tr>
80
+ <td>Blue:</td>
81
+ <td>CDR</td>
82
+ </tr>
83
+ <tr>
84
+ <td>Green:</td>
85
+ <td>N-glycosylation site</td>
86
+ </tr>
87
+ </table>
88
+ <hr>
89
+ </div>
90
+
91
+ <div class="table-container">
92
+ <h2>Table 4</h2>
93
+ <table border="1">
94
+ <tr>
95
+ <td>Relative quantification by EIC (%)</td>
96
+ <td>Relative quantification by EIC (%)</td>
97
+ <td>Relative quantification by EIC (%)</td>
98
+ <td>Relative quantification by EIC (%)</td>
99
+ <td>Relative quantification by EIC (%)</td>
100
+ <td>Relative quantification by EIC (%)</td>
101
+ </tr>
102
+ <tr>
103
+ <td>AA Sequence</td>
104
+ <td>Seq Loc</td>
105
+ <td>Modification</td>
106
+ <td>T0</td>
107
+ <td>T2W_37℃</td>
108
+ <td>T4W_37℃</td>
109
+ </tr>
110
+ <tr>
111
+ <td>EVQLLESGGGLVQPGGSLR</td>
112
+ <td>HC(1-19)</td>
113
+ <td></td>
114
+ <td>99.0</td>
115
+ <td>96.1</td>
116
+ <td>93.0</td>
117
+ </tr>
118
+ <tr>
119
+ <td>EVQLLESGGGLVQPGGSLR</td>
120
+ <td>HC(1-19)</td>
121
+ <td>PyroE</td>
122
+ <td>1.0</td>
123
+ <td>3.9</td>
124
+ <td>7.0</td>
125
+ </tr>
126
+ </table>
127
+ <hr>
128
+ </div>
129
+
130
+ <div class="table-container">
131
+ <h2>Table 5</h2>
132
+ <table border="1">
133
+ <tr>
134
+ <td>Relative quantification by EIC (%)</td>
135
+ <td>Relative quantification by EIC (%)</td>
136
+ <td>Relative quantification by EIC (%)</td>
137
+ <td>Relative quantification by EIC (%)</td>
138
+ <td>Relative quantification by EIC (%)</td>
139
+ <td>Relative quantification by EIC (%)</td>
140
+ </tr>
141
+ <tr>
142
+ <td>AA Sequence</td>
143
+ <td>Seq Loc</td>
144
+ <td>Modification</td>
145
+ <td>T0</td>
146
+ <td>T2W_37℃</td>
147
+ <td>T4W_37℃</td>
148
+ </tr>
149
+ <tr>
150
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
151
+ <td>HC(88-125)</td>
152
+ <td></td>
153
+ <td>99.9</td>
154
+ <td>99.7</td>
155
+ <td>99.5</td>
156
+ </tr>
157
+ <tr>
158
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
159
+ <td>HC(88-125)</td>
160
+ <td>Isomerization</td>
161
+ <td>0.1</td>
162
+ <td>0.3</td>
163
+ <td>0.5</td>
164
+ </tr>
165
+ </table>
166
+ <hr>
167
+ </div>
168
+
169
+ <div class="table-container">
170
+ <h2>Table 6</h2>
171
+ <table border="1">
172
+ <tr>
173
+ <td>Relative quantification by EIC (%)</td>
174
+ <td>Relative quantification by EIC (%)</td>
175
+ <td>Relative quantification by EIC (%)</td>
176
+ <td>Relative quantification by EIC (%)</td>
177
+ <td>Relative quantification by EIC (%)</td>
178
+ <td>Relative quantification by EIC (%)</td>
179
+ </tr>
180
+ <tr>
181
+ <td>AA Sequence</td>
182
+ <td>Seq Loc</td>
183
+ <td>Modification</td>
184
+ <td>T0</td>
185
+ <td>T2W_37℃</td>
186
+ <td>T4W_37℃</td>
187
+ </tr>
188
+ <tr>
189
+ <td>NTLYLQMNSLR</td>
190
+ <td>HC(77-87)</td>
191
+ <td></td>
192
+ <td>99.5</td>
193
+ <td>99.5</td>
194
+ <td>99.5</td>
195
+ </tr>
196
+ <tr>
197
+ <td>NTLYLQMNSLR</td>
198
+ <td>HC(77-87)</td>
199
+ <td>Oxidation</td>
200
+ <td>0.5</td>
201
+ <td>0.5</td>
202
+ <td>0.5</td>
203
+ </tr>
204
+ <tr>
205
+ <td>DIQMTQSPSSLSASVGDR</td>
206
+ <td>LC(1-18)</td>
207
+ <td></td>
208
+ <td>99.5</td>
209
+ <td>99.5</td>
210
+ <td>99.5</td>
211
+ </tr>
212
+ <tr>
213
+ <td>DIQMTQSPSSLSASVGDR</td>
214
+ <td>LC(1-18)</td>
215
+ <td>Oxidation</td>
216
+ <td>0.5</td>
217
+ <td>0.5</td>
218
+ <td>0.5</td>
219
+ </tr>
220
+ </table>
221
+ <hr>
222
+ </div>
223
+
224
+ <div class="table-container">
225
+ <h2>Table 7</h2>
226
+ <table border="1">
227
+ <tr>
228
+ <td>Relative quantification by EIC (%)</td>
229
+ <td>Relative quantification by EIC (%)</td>
230
+ <td>Relative quantification by EIC (%)</td>
231
+ <td>Relative quantification by EIC (%)</td>
232
+ <td>Relative quantification by EIC (%)</td>
233
+ <td>Relative quantification by EIC (%)</td>
234
+ </tr>
235
+ <tr>
236
+ <td>AA Sequence</td>
237
+ <td>Seq Loc</td>
238
+ <td>Modification</td>
239
+ <td>T0</td>
240
+ <td>T2W_37℃</td>
241
+ <td>T4W_37℃</td>
242
+ </tr>
243
+ <tr>
244
+ <td>EVQLLESGGGLVQPGGSLR</td>
245
+ <td>HC(1-19)</td>
246
+ <td></td>
247
+ <td>99.6</td>
248
+ <td>99.6</td>
249
+ <td>99.5</td>
250
+ </tr>
251
+ <tr>
252
+ <td>EVQLLESGGGLVQPGGSLR</td>
253
+ <td>HC(1-19)</td>
254
+ <td>Deamidation</td>
255
+ <td>0.4</td>
256
+ <td>0.4</td>
257
+ <td>0.5</td>
258
+ </tr>
259
+ <tr>
260
+ <td>NTLYLQMNSLR*</td>
261
+ <td>HC(77-87)</td>
262
+ <td></td>
263
+ <td>99.0</td>
264
+ <td>98.8</td>
265
+ <td>98.6</td>
266
+ </tr>
267
+ <tr>
268
+ <td>NTLYLQMNSLR*</td>
269
+ <td>HC(77-87)</td>
270
+ <td>Deamidation</td>
271
+ <td>1.0</td>
272
+ <td>1.2</td>
273
+ <td>1.4</td>
274
+ </tr>
275
+ <tr>
276
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
277
+ <td>HC(88-125)</td>
278
+ <td></td>
279
+ <td>98.7</td>
280
+ <td>96.1</td>
281
+ <td>93.4</td>
282
+ </tr>
283
+ <tr>
284
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
285
+ <td>HC(88-125)</td>
286
+ <td>Deamidation</td>
287
+ <td>1.3</td>
288
+ <td>3.9</td>
289
+ <td>6.6</td>
290
+ </tr>
291
+ <tr>
292
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
293
+ <td>LC(19-42)</td>
294
+ <td></td>
295
+ <td>99.9</td>
296
+ <td>99.8</td>
297
+ <td>99.5</td>
298
+ </tr>
299
+ <tr>
300
+ <td>VTITCQASQSISSYLAWYQQKPGK</td>
301
+ <td>LC(19-42)</td>
302
+ <td>Deamidation</td>
303
+ <td>0.1</td>
304
+ <td>0.2</td>
305
+ <td>0.5</td>
306
+ </tr>
307
+ </table>
308
+ <hr>
309
+ </div>
310
+
311
+ <div class="table-container">
312
+ <h2>Table 8</h2>
313
+ <table border="1">
314
+ <tr>
315
+ <td>b --- 1</td>
316
+ <td></td>
317
+ <td></td>
318
+ <td>y</td>
319
+ </tr>
320
+ <tr>
321
+ <td>b --- 1</td>
322
+ <td>N(+0.984016)</td>
323
+ <td>11</td>
324
+ <td>---</td>
325
+ </tr>
326
+ <tr>
327
+ <td>217.0819 2</td>
328
+ <td>T</td>
329
+ <td>10</td>
330
+ <td>1238.6562</td>
331
+ </tr>
332
+ <tr>
333
+ <td>330.1660 3</td>
334
+ <td>L</td>
335
+ <td>9</td>
336
+ <td>1137.6085</td>
337
+ </tr>
338
+ <tr>
339
+ <td>493.2293 4</td>
340
+ <td>Y</td>
341
+ <td>8</td>
342
+ <td>1024.5244</td>
343
+ </tr>
344
+ <tr>
345
+ <td>606.3134 5</td>
346
+ <td>L</td>
347
+ <td>7</td>
348
+ <td>861.4611</td>
349
+ </tr>
350
+ <tr>
351
+ <td>734.3719 6</td>
352
+ <td>Q</td>
353
+ <td>6</td>
354
+ <td>748.3770</td>
355
+ </tr>
356
+ <tr>
357
+ <td>865.4124 7</td>
358
+ <td>M</td>
359
+ <td>5</td>
360
+ <td>620.3185</td>
361
+ </tr>
362
+ <tr>
363
+ <td>979.4553 8</td>
364
+ <td>N</td>
365
+ <td>4</td>
366
+ <td>489.2780</td>
367
+ </tr>
368
+ <tr>
369
+ <td>066.4874 9</td>
370
+ <td>S</td>
371
+ <td>3</td>
372
+ <td>375.2350</td>
373
+ </tr>
374
+ <tr>
375
+ <td>179.5714 10</td>
376
+ <td>L</td>
377
+ <td>2</td>
378
+ <td>288.2030</td>
379
+ </tr>
380
+ <tr>
381
+ <td>--- 11</td>
382
+ <td>R</td>
383
+ <td>1</td>
384
+ <td>175.1190</td>
385
+ </tr>
386
+ </table>
387
+ <hr>
388
+ </div>
389
+
390
+ <div class="table-container">
391
+ <h2>Table 9</h2>
392
+ <table border="1">
393
+ <tr>
394
+ <td>b</td>
395
+ <td>y</td>
396
+ <td>y</td>
397
+ <td>y</td>
398
+ </tr>
399
+ <tr>
400
+ <td>--- 1</td>
401
+ <td>N</td>
402
+ <td>11</td>
403
+ <td>---</td>
404
+ </tr>
405
+ <tr>
406
+ <td>216.0979 2</td>
407
+ <td>T</td>
408
+ <td>10</td>
409
+ <td>1239.6402</td>
410
+ </tr>
411
+ <tr>
412
+ <td>329.1819 3</td>
413
+ <td>L</td>
414
+ <td>9</td>
415
+ <td>1138.5925</td>
416
+ </tr>
417
+ <tr>
418
+ <td>492.2453 4</td>
419
+ <td>Y</td>
420
+ <td>8</td>
421
+ <td>1025.5084</td>
422
+ </tr>
423
+ <tr>
424
+ <td>605.3293 5</td>
425
+ <td>L</td>
426
+ <td>7</td>
427
+ <td>862.4451</td>
428
+ </tr>
429
+ <tr>
430
+ <td>733.3879 6</td>
431
+ <td>Q</td>
432
+ <td>6</td>
433
+ <td>749.3611</td>
434
+ </tr>
435
+ <tr>
436
+ <td>864.4284 7</td>
437
+ <td>M</td>
438
+ <td>5</td>
439
+ <td>621.3025</td>
440
+ </tr>
441
+ <tr>
442
+ <td>979.4553 8</td>
443
+ <td>N(+0.984016)</td>
444
+ <td>4</td>
445
+ <td>490.2620</td>
446
+ </tr>
447
+ <tr>
448
+ <td>1066.4874 9</td>
449
+ <td>S</td>
450
+ <td>3</td>
451
+ <td>375.2350</td>
452
+ </tr>
453
+ <tr>
454
+ <td>1179.5714 10</td>
455
+ <td>L</td>
456
+ <td>2</td>
457
+ <td>288.2030</td>
458
+ </tr>
459
+ <tr>
460
+ <td>--- 11</td>
461
+ <td>R</td>
462
+ <td>1</td>
463
+ <td>175.1190</td>
464
+ </tr>
465
+ </table>
466
+ <hr>
467
+ </div>
468
+
469
+ <div class="table-container">
470
+ <h2>Table 10</h2>
471
+ <table border="1">
472
+ <tr>
473
+ <td>Relative quantification by EIC (%)</td>
474
+ <td>Relative quantification by EIC (%)</td>
475
+ <td>Relative quantification by EIC (%)</td>
476
+ <td>Relative quantification by EIC (%)</td>
477
+ <td>Relative quantification by EIC (%)</td>
478
+ <td>Relative quantification by EIC (%)</td>
479
+ </tr>
480
+ <tr>
481
+ <td>AA Sequence</td>
482
+ <td>Seq Loc</td>
483
+ <td>Modification</td>
484
+ <td>T0</td>
485
+ <td>T2W_37℃</td>
486
+ <td>T4W_37℃</td>
487
+ </tr>
488
+ <tr>
489
+ <td>SCDK</td>
490
+ <td>HC(223-226)</td>
491
+ <td></td>
492
+ <td>99.8</td>
493
+ <td>99.5</td>
494
+ <td>98.8</td>
495
+ </tr>
496
+ <tr>
497
+ <td>SFNRGEC</td>
498
+ <td>LC(208-214)</td>
499
+ <td></td>
500
+ <td>99.8</td>
501
+ <td>99.5</td>
502
+ <td>98.8</td>
503
+ </tr>
504
+ <tr>
505
+ <td>SFNRGEC - SCDK</td>
506
+ <td>HC(223-226) + LC(208-214)</td>
507
+ <td>Thioether</td>
508
+ <td>0.2</td>
509
+ <td>0.5</td>
510
+ <td>1.2</td>
511
+ </tr>
512
+ </table>
513
+ <hr>
514
+ </div>
515
+
516
+ <div class="table-container">
517
+ <h2>Table 11</h2>
518
+ <table border="1">
519
+ <tr>
520
+ <td>Relative quantification by EIC (%)*</td>
521
+ <td>Relative quantification by EIC (%)*</td>
522
+ <td>Relative quantification by EIC (%)*</td>
523
+ <td>Relative quantification by EIC (%)*</td>
524
+ <td>Relative quantification by EIC (%)*</td>
525
+ <td>Relative quantification by EIC (%)*</td>
526
+ </tr>
527
+ <tr>
528
+ <td>AA Sequence</td>
529
+ <td>Seq Loc</td>
530
+ <td>Modification</td>
531
+ <td>T0</td>
532
+ <td>T2W_37℃</td>
533
+ <td>T4W_37℃</td>
534
+ </tr>
535
+ <tr>
536
+ <td>AEDTAVYYCAKPLYSNLAGDFGS WGQGTTVTVSSASTK</td>
537
+ <td>HC(88-125)</td>
538
+ <td></td>
539
+ <td>98.6</td>
540
+ <td>98.1</td>
541
+ <td>96.8</td>
542
+ </tr>
543
+ <tr>
544
+ <td>AEDTAVYYCAKPLYSN</td>
545
+ <td>HC(88-125)</td>
546
+ <td>Clipping</td>
547
+ <td>0.3</td>
548
+ <td>0.4</td>
549
+ <td>0.6</td>
550
+ </tr>
551
+ <tr>
552
+ <td>LAGDFGSWGQGTTVTVSSASTK</td>
553
+ <td>HC(88-125)</td>
554
+ <td>Clipping</td>
555
+ <td>1.1</td>
556
+ <td>1.5</td>
557
+ <td>2.6</td>
558
+ </tr>
559
+ <tr>
560
+ <td>STSGGTAALGCLVK</td>
561
+ <td>HC(138-151)</td>
562
+ <td></td>
563
+ <td>99.9</td>
564
+ <td>99.3</td>
565
+ <td>98.7</td>
566
+ </tr>
567
+ <tr>
568
+ <td>GGTAALGCLVK</td>
569
+ <td>HC(138-151)</td>
570
+ <td>Clipping</td>
571
+ <td>0.0</td>
572
+ <td>0.2</td>
573
+ <td>0.3</td>
574
+ </tr>
575
+ <tr>
576
+ <td>GTAALGCLVK</td>
577
+ <td>HC(138-151)</td>
578
+ <td>Clipping_2</td>
579
+ <td>0.1</td>
580
+ <td>0.5</td>
581
+ <td>0.9</td>
582
+ </tr>
583
+ <tr>
584
+ <td>SCDKTHTCPPCPAPEAAGGPSVFL FPPKPK</td>
585
+ <td>HC(223-252)</td>
586
+ <td></td>
587
+ <td>99.6</td>
588
+ <td>99.4</td>
589
+ <td>99.0</td>
590
+ </tr>
591
+ <tr>
592
+ <td>DKTHTCPPCPAPEAAGGPSVFLFP PKPK</td>
593
+ <td>HC(223-252)</td>
594
+ <td>Clipping</td>
595
+ <td>0.4</td>
596
+ <td>0.6</td>
597
+ <td>1.0</td>
598
+ </tr>
599
+ </table>
600
+ <hr>
601
+ </div>
602
+
603
+ <div class="table-container">
604
+ <h2>Table 12</h2>
605
+ <table border="1">
606
+ <tr>
607
+ <td>Blue:</td>
608
+ <td>VH and VL</td>
609
+ </tr>
610
+ <tr>
611
+ <td>Blue:</td>
612
+ <td>CDR</td>
613
+ </tr>
614
+ <tr>
615
+ <td>Green:</td>
616
+ <td>N-glycosylation site</td>
617
+ </tr>
618
+ </table>
619
+ <hr>
620
+ </div>
621
+
622
+ <div class="table-container">
623
+ <h2>Table 13</h2>
624
+ <table border="1">
625
+ <tr>
626
+ <td>Mabelle Meersseman</td>
627
+ <td>Date:</td>
628
+ </tr>
629
+ <tr>
630
+ <td>Group Leader</td>
631
+ <td>Signature:</td>
632
+ </tr>
633
+ <tr>
634
+ <td>Approver</td>
635
+ <td></td>
636
+ </tr>
637
+ <tr>
638
+ <td>Koen Sandra Ph.D.</td>
639
+ <td>Date:</td>
640
+ </tr>
641
+ <tr>
642
+ <td>CEO</td>
643
+ <td>Signature:</td>
644
+ </tr>
645
+ </table>
646
+ <hr>
647
+ </div>
648
+
649
+ <div class="table-container">
650
+ <h2>Table 14</h2>
651
+ <table border="1">
652
+ <tr>
653
+ <td>Version</td>
654
+ <td>Date of issue</td>
655
+ <td>Reason for version update</td>
656
+ </tr>
657
+ <tr>
658
+ <td>00</td>
659
+ <td>20 November 2024</td>
660
+ <td>Draft</td>
661
+ </tr>
662
+ <tr>
663
+ <td></td>
664
+ <td></td>
665
+ <td></td>
666
+ </tr>
667
+ <tr>
668
+ <td></td>
669
+ <td></td>
670
+ <td></td>
671
+ </tr>
672
+ </table>
673
+ <hr>
674
+ </div>
675
+ </body></html>
src/.DS_Store CHANGED
Binary files a/src/.DS_Store and b/src/.DS_Store differ
 
src/agents/__pycache__/field_mapper_agent.cpython-312.pyc CHANGED
Binary files a/src/agents/__pycache__/field_mapper_agent.cpython-312.pyc and b/src/agents/__pycache__/field_mapper_agent.cpython-312.pyc differ
 
src/agents/field_mapper_agent.py CHANGED
@@ -286,14 +286,14 @@ class FieldMapperAgent(BaseAgent):
286
  {text}
287
 
288
  Instructions:
289
- 1. First, identify all unique combinations of the specified indices in the document
290
- 2. For each unique combination found, extract the values for all specified fields
291
  3. Return the data in a tabular format where:
292
  - Each row represents a unique combination
293
  - Each column represents a field value
294
  4. Return ONLY the JSON value, no explanations
295
- 5. Format the response as a valid JSON object with arrays for each field
296
- 6. Keep the structure flat - do not nest values
297
 
298
  Example response format:
299
  {{
@@ -303,6 +303,9 @@ class FieldMapperAgent(BaseAgent):
303
  "field2": ["value10", "value11", "value12"]
304
  }}
305
 
 
 
 
306
  Field values:"""
307
 
308
  try:
@@ -322,14 +325,19 @@ class FieldMapperAgent(BaseAgent):
322
  self.logger.info(f"Unique indices extraction costs - Input tokens: {cost_tracker.llm_input_tokens}, Output tokens: {cost_tracker.llm_output_tokens}")
323
  self.logger.info(f"Unique indices extraction cost: ${cost_tracker.calculate_current_file_costs()['openai']['total_cost']:.4f}")
324
 
 
 
325
  if value and value.lower() not in ["none", "null", "n/a"]:
 
326
  try:
327
  json_value = json.loads(value)
328
  self.logger.info(f"Successfully extracted values: {json.dumps(json_value, indent=2)}")
329
  return json.dumps(json_value, indent=2)
330
  except json.JSONDecodeError:
331
- self.logger.error("Failed to parse LLM response as JSON")
332
- return None
 
 
333
  else:
334
  self.logger.warning("LLM returned no valid value")
335
  return None
 
286
  {text}
287
 
288
  Instructions:
289
+ 1. First, identify all unique combinations of the specified indices ({', '.join(unique_indices)}) in the document
290
+ 2. For each unique combination found, extract the values for all specified fields ({', '.join(fields_to_extract)})
291
  3. Return the data in a tabular format where:
292
  - Each row represents a unique combination
293
  - Each column represents a field value
294
  4. Return ONLY the JSON value, no explanations
295
+ 5. Format the response as a valid JSON object with field names as keys
296
+ 6. Keep the structure flat - do not nest values under 'details' or other keys
297
 
298
  Example response format:
299
  {{
 
303
  "field2": ["value10", "value11", "value12"]
304
  }}
305
 
306
+ Note: Each array in the response must have the same length, representing aligned rows of data.
307
+ For example, if there are 3 unique combinations found, each array should have 3 values.
308
+
309
  Field values:"""
310
 
311
  try:
 
325
  self.logger.info(f"Unique indices extraction costs - Input tokens: {cost_tracker.llm_input_tokens}, Output tokens: {cost_tracker.llm_output_tokens}")
326
  self.logger.info(f"Unique indices extraction cost: ${cost_tracker.calculate_current_file_costs()['openai']['total_cost']:.4f}")
327
 
328
+ self.logger.debug(f"Raw LLM response: {value}")
329
+
330
  if value and value.lower() not in ["none", "null", "n/a"]:
331
+ # Try to parse as JSON to ensure it's valid
332
  try:
333
  json_value = json.loads(value)
334
  self.logger.info(f"Successfully extracted values: {json.dumps(json_value, indent=2)}")
335
  return json.dumps(json_value, indent=2)
336
  except json.JSONDecodeError:
337
+ # If not valid JSON, wrap it in a JSON object
338
+ json_value = {", ".join(unique_indices + fields_to_extract): value.strip()}
339
+ self.logger.info(f"Wrapped non-JSON value in JSON object: {json.dumps(json_value, indent=2)}")
340
+ return json.dumps(json_value, indent=2)
341
  else:
342
  self.logger.warning("LLM returned no valid value")
343
  return None
src/agents/unique_indices_combinator.py ADDED
@@ -0,0 +1,145 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ """Agent to combine unique indices from tables and text using LLM-based extraction."""
2
+ from typing import Dict, Any, Optional, List
3
+ import logging
4
+ import json
5
+ from .base_agent import BaseAgent
6
+ from services.llm_client import LLMClient
7
+ from config.settings import settings
8
+
9
+ class UniqueIndicesCombinator(BaseAgent):
10
+ def __init__(self):
11
+ self.logger = logging.getLogger(__name__)
12
+ self.llm = LLMClient(settings)
13
+ self.logger.info("UniqueIndicesCombinator initialized")
14
+
15
+ def execute(self, ctx: Dict[str, Any]) -> Optional[str]:
16
+ """Execute the unique indices combination extraction."""
17
+ self.logger.info("Starting UniqueIndicesCombinator execution")
18
+ self.logger.info(f"Context keys available: {list(ctx.keys())}")
19
+
20
+ # Get text content
21
+ text = ""
22
+ if "text" in ctx:
23
+ text = ctx["text"]
24
+ self.logger.info(f"Found text in context (length: {len(text)})")
25
+ else:
26
+ self.logger.warning("No text found in context")
27
+ return None
28
+
29
+ # Get unique indices and descriptions
30
+ unique_indices = ctx.get("unique_indices", [])
31
+ unique_indices_descriptions = ctx.get("unique_indices_descriptions", {})
32
+
33
+ self.logger.info(f"Unique indices: {unique_indices}")
34
+ self.logger.info(f"Unique indices descriptions: {unique_indices_descriptions}")
35
+
36
+ if not unique_indices:
37
+ self.logger.warning("No unique indices provided in context")
38
+ return None
39
+
40
+ if not unique_indices_descriptions:
41
+ self.logger.warning("No unique indices descriptions provided in context")
42
+ return None
43
+
44
+ # Get document context
45
+ document_context = ctx.get("document_context", "Generic document")
46
+ self.logger.info(f"Using document context: {document_context}")
47
+
48
+ # Extract unique combinations
49
+ self.logger.info("Calling _extract_unique_combinations")
50
+ result = self._extract_unique_combinations(text, document_context, unique_indices, unique_indices_descriptions)
51
+
52
+ if result:
53
+ self.logger.info(f"Successfully extracted unique combinations: {result[:200]}...")
54
+ else:
55
+ self.logger.warning("No unique combinations extracted")
56
+
57
+ return result
58
+
59
+ def _extract_unique_combinations(self, text: str, context: str, unique_indices: List[str], unique_indices_descriptions: Dict[str, str]) -> Optional[str]:
60
+ """Use LLM to extract unique combinations of indices from the document."""
61
+ self.logger.info("Starting _extract_unique_combinations")
62
+ self.logger.info(f"Processing {len(unique_indices)} unique indices")
63
+
64
+ # Format the descriptions for the prompt
65
+ descriptions_text = "\n".join([f" {index}: {desc}" for index, desc in unique_indices_descriptions.items()])
66
+
67
+ prompt = f"""You are an AI assistant tasked with helping out argenx employees in the context of biotech, drug discovery, and drug development.
68
+ Your task is to assist the argenx team in retrieving all the unique combinations of indices from a given PDF.
69
+
70
+ <procedure>
71
+ - To start, you will be given a Document that contains a detailed scientific report on the evaluation of liabilities in a specific argenx discovery construct.
72
+ - Second step, you will analyze the source and all its intricacies
73
+ - Third step, is to manually extract unique {unique_indices} from the Document. The description of these concepts can be found below:
74
+ {descriptions_text}
75
+ - After that, compare the elements extracted and check the document to see if you have missed any.
76
+ - Only after you are 100% sure no elements were missed proceed to formulating the answer, if you are not sure check again.
77
+ - Finally, You will formulate an answer by stating list this information in table
78
+ </procedure>
79
+
80
+ <formatting rules>
81
+ - You must return ONLY a valid JSON array of objects, with no additional text or explanations
82
+ - Each object in the array should have the following structure:
83
+ {{
84
+ "{unique_indices[0]}": "value1",
85
+ "{unique_indices[1]}": "value2",
86
+ ...
87
+ }}
88
+ - Each object represents one unique combination of values
89
+ - Each key must be one of the unique indices: {unique_indices}
90
+ - Each value must be a string containing the value found in the document
91
+ - Do not include any explanatory text, notes, or markdown formatting
92
+ </formatting rules>
93
+
94
+ Consider the following document:
95
+ {text}
96
+
97
+ Return ONLY the JSON array with the unique combinations:"""
98
+
99
+ self.logger.info("Calling LLM for extraction")
100
+ self.logger.info(f"Using prompt: {prompt}") # Log first 500 chars of prompt
101
+
102
+ try:
103
+ # Get cost tracker from context
104
+ cost_tracker = self.ctx.get("cost_tracker") if hasattr(self, 'ctx') else None
105
+ if cost_tracker:
106
+ self.logger.info("Cost tracker found in context")
107
+ else:
108
+ self.logger.warning("No cost tracker found in context")
109
+
110
+ # Call LLM
111
+ result = self.llm.responses(
112
+ prompt, temperature=0.0,
113
+ ctx={"cost_tracker": cost_tracker} if cost_tracker else None,
114
+ description="Unique Indices Combination Extraction"
115
+ )
116
+
117
+ # Log cost tracking results if available
118
+ if cost_tracker:
119
+ self.logger.info(f"Extraction costs - Input tokens: {cost_tracker.llm_input_tokens}, Output tokens: {cost_tracker.llm_output_tokens}")
120
+ self.logger.info(f"Extraction cost: ${cost_tracker.calculate_current_file_costs()['openai']['total_cost']:.4f}")
121
+
122
+ self.logger.debug(f"Raw LLM response: {result}")
123
+
124
+ if result and result.lower() not in ["none", "null", "n/a"]:
125
+ try:
126
+ json_value = json.loads(result)
127
+ self.logger.info(f"Successfully parsed JSON response with {len(json_value)} unique combinations")
128
+
129
+ # Log the first combination as an example
130
+ if json_value and len(json_value) > 0:
131
+ self.logger.info(f"Example combination: {json.dumps(json_value[0], indent=2)}")
132
+
133
+ self.logger.debug(f"All combinations: {json.dumps(json_value, indent=2)}")
134
+ return json.dumps(json_value, indent=2)
135
+ except json.JSONDecodeError as e:
136
+ self.logger.error(f"Failed to parse LLM response as JSON: {str(e)}")
137
+ self.logger.error(f"Invalid JSON response: {result}")
138
+ return None
139
+ else:
140
+ self.logger.warning("LLM returned no valid value")
141
+ return None
142
+
143
+ except Exception as e:
144
+ self.logger.error(f"Error in unique indices extraction: {str(e)}", exc_info=True)
145
+ return None
src/app.py CHANGED
@@ -10,9 +10,6 @@ from config.settings import settings
10
  import fitz # PyMuPDF local import to avoid heavy load on startup
11
  import pandas as pd
12
  from datetime import datetime
13
- import io
14
- import sys
15
- from io import StringIO
16
  from services.cost_tracker import CostTracker
17
 
18
  # Create a custom stream handler to capture logs
@@ -247,6 +244,7 @@ else: # page == "Execution"
247
 
248
  # Add unique indices input if Unique Indices Strategy is selected
249
  unique_indices = None
 
250
  if strategy == "Unique Indices Strategy":
251
  unique_indices_str = st.text_input(
252
  "Unique Fields (comma-separated)",
@@ -254,6 +252,32 @@ else: # page == "Execution"
254
  )
255
  if unique_indices_str:
256
  unique_indices = [idx.strip() for idx in unique_indices_str.split(",") if idx.strip()]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
257
 
258
  def flatten_json_response(json_data, fields):
259
  """Flatten the nested JSON response into a tabular structure with dynamic columns."""
@@ -345,7 +369,8 @@ else: # page == "Execution"
345
  fields=field_list,
346
  field_descs=field_descs,
347
  strategy=strategy,
348
- unique_indices=unique_indices
 
349
  )
350
 
351
  # Add a visual separator
 
10
  import fitz # PyMuPDF local import to avoid heavy load on startup
11
  import pandas as pd
12
  from datetime import datetime
 
 
 
13
  from services.cost_tracker import CostTracker
14
 
15
  # Create a custom stream handler to capture logs
 
244
 
245
  # Add unique indices input if Unique Indices Strategy is selected
246
  unique_indices = None
247
+ unique_indices_descriptions = None
248
  if strategy == "Unique Indices Strategy":
249
  unique_indices_str = st.text_input(
250
  "Unique Fields (comma-separated)",
 
252
  )
253
  if unique_indices_str:
254
  unique_indices = [idx.strip() for idx in unique_indices_str.split(",") if idx.strip()]
255
+
256
+ # Add descriptions for each unique index
257
+ st.subheader("Unique Fields Descriptions")
258
+ st.markdown("""
259
+ Please provide a description for each unique field. This helps the system better understand what to look for.
260
+ Example:
261
+ ```
262
+ Protein Lot: Batch number of the Proteins
263
+ Timepoint: Time at which modification was measured (e.g., 0w, 2w, 4w)
264
+ Modification: Type of post-translational modification
265
+ Peptide: Peptide sequence containing the modification
266
+ ```
267
+ """)
268
+ unique_indices_descriptions_str = st.text_area(
269
+ "Unique Fields Descriptions (YAML format)",
270
+ help="Enter descriptions for each unique field in YAML format"
271
+ )
272
+ if unique_indices_descriptions_str:
273
+ try:
274
+ unique_indices_descriptions = yaml.safe_load(unique_indices_descriptions_str)
275
+ if not isinstance(unique_indices_descriptions, dict):
276
+ st.error("Descriptions must be in YAML format with field names as keys")
277
+ unique_indices_descriptions = None
278
+ except yaml.YAMLError as e:
279
+ st.error(f"Invalid YAML format: {e}")
280
+ unique_indices_descriptions = None
281
 
282
  def flatten_json_response(json_data, fields):
283
  """Flatten the nested JSON response into a tabular structure with dynamic columns."""
 
369
  fields=field_list,
370
  field_descs=field_descs,
371
  strategy=strategy,
372
+ unique_indices=unique_indices,
373
+ unique_indices_descriptions=unique_indices_descriptions
374
  )
375
 
376
  # Add a visual separator
src/config/prompts.yaml CHANGED
@@ -7,11 +7,14 @@ planner: |
7
  – doc_preview: a few kB of raw text from the uploaded document (may include table HTML).
8
  – fields: the list of field names the user wants extracted.
9
  – pdf_meta / field_descriptions for extra context.
 
 
10
 
11
  Available tools (use exactly these names in the JSON):
12
  PDFAgent → extracts raw text from the full PDF.
13
  TableAgent → calls Azure Document Intelligence to get HTML tables.
14
  FieldMapper → maps one field name to a candidate value.
 
15
 
16
  Control-flow helper:
17
  ForEachField – loops over every requested field and executes the nested "loop" array.
@@ -29,7 +32,17 @@ planner: |
29
  ]
30
  }
31
 
32
- Always include PDFAgent and TableAgent first, then the ForEachField loop. Keep plans short and deterministic.
 
 
 
 
 
 
 
 
 
 
33
 
34
  field_mapper: |
35
  You are "FieldMapper v1" – a precision extractor.
 
7
  – doc_preview: a few kB of raw text from the uploaded document (may include table HTML).
8
  – fields: the list of field names the user wants extracted.
9
  – pdf_meta / field_descriptions for extra context.
10
+ – strategy: the extraction strategy to use (e.g., "Original Strategy" or "Unique Indices").
11
+ – unique indices: list of indices to extract when using "Unique Indices" strategy.
12
 
13
  Available tools (use exactly these names in the JSON):
14
  PDFAgent → extracts raw text from the full PDF.
15
  TableAgent → calls Azure Document Intelligence to get HTML tables.
16
  FieldMapper → maps one field name to a candidate value.
17
+ UniqueIndicesCombinator → extracts unique combinations of indices from tables and text.
18
 
19
  Control-flow helper:
20
  ForEachField – loops over every requested field and executes the nested "loop" array.
 
32
  ]
33
  }
34
 
35
+ For "Unique Indices" strategy, use this schema instead:
36
+ {
37
+ "fields": [<same list you received>],
38
+ "steps": [
39
+ {"tool": "PDFAgent", "args": {}},
40
+ {"tool": "TableAgent", "args": {}},
41
+ {"tool": "UniqueIndicesCombinator", "args": {}}
42
+ ]
43
+ }
44
+
45
+ Always include PDFAgent and TableAgent first. Keep plans short and deterministic.
46
 
47
  field_mapper: |
48
  You are "FieldMapper v1" – a precision extractor.
src/orchestrator/__pycache__/executor.cpython-312.pyc CHANGED
Binary files a/src/orchestrator/__pycache__/executor.cpython-312.pyc and b/src/orchestrator/__pycache__/executor.cpython-312.pyc differ
 
src/orchestrator/__pycache__/planner.cpython-312.pyc CHANGED
Binary files a/src/orchestrator/__pycache__/planner.cpython-312.pyc and b/src/orchestrator/__pycache__/planner.cpython-312.pyc differ
 
src/orchestrator/executor.py CHANGED
@@ -15,6 +15,7 @@ from agents.field_mapper_agent import FieldMapperAgent
15
  from agents.semantic_reasoner import SemanticReasonerAgent
16
  from agents.confidence_scorer import ConfidenceScorer
17
  from agents.query_generator import QueryGenerator
 
18
 
19
  # Add import for CostTracker
20
  from services.cost_tracker import CostTracker
@@ -31,6 +32,7 @@ class Executor:
31
  "SemanticReasoner": SemanticReasonerAgent(),
32
  "ConfidenceScorer": ConfidenceScorer(),
33
  "QueryGenerator": QueryGenerator(),
 
34
  }
35
 
36
  self.logs: List[Dict[str, Any]] = []
@@ -39,8 +41,23 @@ class Executor:
39
 
40
  # ---------------------------------------------------------
41
  def run(self, plan: Dict[str, Any], pdf_file) -> tuple[pd.DataFrame, List[Dict[str, Any]]]: # noqa: D401
42
- # Validate fields are strings
 
 
 
 
43
  fields = plan.get("fields", [])
 
 
 
 
 
 
 
 
 
 
 
44
  if not all(isinstance(f, str) for f in fields):
45
  self.logger.error(f"Invalid fields format. Expected strings, got: {fields}")
46
  fields = [str(f) for f in fields] # Convert to strings as fallback
@@ -52,10 +69,20 @@ class Executor:
52
  "conf": 1.0,
53
  "pdf_meta": plan.get("pdf_meta", {}), # Include the plan's metadata
54
  "cost_tracker": self.cost_tracker,
 
 
 
55
  }
56
 
 
 
 
 
 
 
57
  try:
58
  for step in plan["steps"]:
 
59
  self._execute_step(step, ctx, depth=0)
60
  except Exception as e:
61
  self.logger.error(f"Error during execution: {str(e)}")
@@ -131,6 +158,15 @@ class Executor:
131
  if "tool" not in step:
132
  return
133
  tool_name = step["tool"]
 
 
 
 
 
 
 
 
 
134
 
135
  if tool_name == "ForEachField":
136
  for field in ctx["fields"]:
@@ -144,8 +180,12 @@ class Executor:
144
  # classic tool run
145
  tool = self.tools[tool_name]
146
  try:
 
147
  result = tool.execute(ctx)
148
  error = None
 
 
 
149
  except Exception as e:
150
  self.logger.error(f"Error in {tool_name}: {str(e)}")
151
  self.logger.error(traceback.format_exc())
@@ -167,6 +207,9 @@ class Executor:
167
  num_chunks = len(result.get("chunks", []))
168
  num_embeddings = len(result.get("embeddings", []))
169
  log_entry["result"] = f"Created index with {num_chunks} chunks and {num_embeddings} embeddings"
 
 
 
170
 
171
  self.logs.append(log_entry)
172
 
@@ -182,6 +225,19 @@ class Executor:
182
  ctx["results"] = {}
183
  else:
184
  ctx["results"] = result
 
 
 
 
 
 
 
 
 
 
 
 
 
185
  elif tool_name == "SemanticReasoner":
186
  ctx["results"][ctx["current_field"]] = result
187
  elif tool_name == "ConfidenceScorer":
 
15
  from agents.semantic_reasoner import SemanticReasonerAgent
16
  from agents.confidence_scorer import ConfidenceScorer
17
  from agents.query_generator import QueryGenerator
18
+ from agents.unique_indices_combinator import UniqueIndicesCombinator
19
 
20
  # Add import for CostTracker
21
  from services.cost_tracker import CostTracker
 
32
  "SemanticReasoner": SemanticReasonerAgent(),
33
  "ConfidenceScorer": ConfidenceScorer(),
34
  "QueryGenerator": QueryGenerator(),
35
+ "UniqueIndicesCombinator": UniqueIndicesCombinator(),
36
  }
37
 
38
  self.logs: List[Dict[str, Any]] = []
 
41
 
42
  # ---------------------------------------------------------
43
  def run(self, plan: Dict[str, Any], pdf_file) -> tuple[pd.DataFrame, List[Dict[str, Any]]]: # noqa: D401
44
+ self.logger.info("Starting plan execution")
45
+ self.logger.info(f"Plan strategy: {plan.get('strategy')}")
46
+ self.logger.info(f"Plan steps: {json.dumps(plan.get('steps', []), indent=2)}")
47
+
48
+ # Validate fields are strings and flatten nested lists
49
  fields = plan.get("fields", [])
50
+ if isinstance(fields, list):
51
+ # Flatten nested lists
52
+ flattened_fields = []
53
+ for field in fields:
54
+ if isinstance(field, list):
55
+ flattened_fields.extend(field)
56
+ else:
57
+ flattened_fields.append(field)
58
+ fields = flattened_fields
59
+
60
+ # Convert all fields to strings
61
  if not all(isinstance(f, str) for f in fields):
62
  self.logger.error(f"Invalid fields format. Expected strings, got: {fields}")
63
  fields = [str(f) for f in fields] # Convert to strings as fallback
 
69
  "conf": 1.0,
70
  "pdf_meta": plan.get("pdf_meta", {}), # Include the plan's metadata
71
  "cost_tracker": self.cost_tracker,
72
+ "strategy": plan.get("strategy", "Original Strategy"), # Include the strategy
73
+ "unique_indices": plan.get("unique_indices", []), # Include unique indices
74
+ "unique_indices_descriptions": plan.get("unique_indices_descriptions", {}) # Include descriptions
75
  }
76
 
77
+ self.logger.info("Initial context:")
78
+ self.logger.info(f"Strategy: {ctx['strategy']}")
79
+ self.logger.info(f"Fields: {ctx['fields']}")
80
+ self.logger.info(f"Unique indices: {ctx['unique_indices']}")
81
+ self.logger.info(f"Unique indices descriptions: {ctx['unique_indices_descriptions']}")
82
+
83
  try:
84
  for step in plan["steps"]:
85
+ self.logger.info(f"Executing step: {json.dumps(step, indent=2)}")
86
  self._execute_step(step, ctx, depth=0)
87
  except Exception as e:
88
  self.logger.error(f"Error during execution: {str(e)}")
 
158
  if "tool" not in step:
159
  return
160
  tool_name = step["tool"]
161
+
162
+ self.logger.info(f"Executing step: {tool_name} with args: {step.get('args', {})}")
163
+ self.logger.info(f"Current strategy: {ctx.get('strategy')}")
164
+ self.logger.info(f"Context keys: {list(ctx.keys())}")
165
+
166
+ # Skip ForEachField if using Unique Indices Strategy
167
+ if tool_name == "ForEachField" and ctx.get("strategy") == "Unique Indices Strategy":
168
+ self.logger.info("Skipping ForEachField for Unique Indices Strategy")
169
+ return
170
 
171
  if tool_name == "ForEachField":
172
  for field in ctx["fields"]:
 
180
  # classic tool run
181
  tool = self.tools[tool_name]
182
  try:
183
+ self.logger.info(f"Calling {tool_name}.execute()")
184
  result = tool.execute(ctx)
185
  error = None
186
+ self.logger.info(f"{tool_name} execution completed with result type: {type(result)}")
187
+ if result:
188
+ self.logger.info(f"{tool_name} result preview: {str(result)[:10]}...")
189
  except Exception as e:
190
  self.logger.error(f"Error in {tool_name}: {str(e)}")
191
  self.logger.error(traceback.format_exc())
 
207
  num_chunks = len(result.get("chunks", []))
208
  num_embeddings = len(result.get("embeddings", []))
209
  log_entry["result"] = f"Created index with {num_chunks} chunks and {num_embeddings} embeddings"
210
+ elif tool_name == "UniqueIndicesCombinator":
211
+ if result:
212
+ log_entry["result"] = f"Extracted unique combinations: {str(result)[:200]}..."
213
 
214
  self.logs.append(log_entry)
215
 
 
225
  ctx["results"] = {}
226
  else:
227
  ctx["results"] = result
228
+ elif tool_name == "UniqueIndicesCombinator":
229
+ # Store the results from UniqueIndicesCombinator
230
+ if isinstance(result, str):
231
+ try:
232
+ result_dict = json.loads(result)
233
+ ctx["results"] = result_dict # Store the entire dictionary
234
+ self.logger.info(f"Stored UniqueIndicesCombinator results: {json.dumps(result_dict, indent=2)}")
235
+ except json.JSONDecodeError:
236
+ self.logger.error(f"Failed to parse UniqueIndicesCombinator result as JSON: {result}")
237
+ ctx["results"] = {}
238
+ else:
239
+ ctx["results"] = result
240
+ self.logger.info(f"Stored UniqueIndicesCombinator results: {result}")
241
  elif tool_name == "SemanticReasoner":
242
  ctx["results"][ctx["current_field"]] = result
243
  elif tool_name == "ConfidenceScorer":
src/orchestrator/planner.py CHANGED
@@ -39,9 +39,20 @@ class Planner:
39
  field_descs: Dict | None = None,
40
  strategy: str = "Original Strategy",
41
  unique_indices: List[str] | None = None,
 
42
  ) -> Dict[str, Any]:
43
  """Return a JSON dict representing the execution plan."""
 
 
 
 
44
 
 
 
 
 
 
 
45
  user_context = {
46
  "pdf_meta": pdf_meta,
47
  "doc_preview": doc_preview or "",
@@ -49,12 +60,14 @@ class Planner:
49
  "field_descriptions": field_descs or {},
50
  "strategy": strategy,
51
  "unique_indices": unique_indices or [],
 
52
  }
53
 
54
  logger.info(f"Building plan for fields: {fields}")
55
  logger.info(f"Using strategy: {strategy}")
56
  if unique_indices:
57
  logger.info(f"Unique indices: {unique_indices}")
 
58
  logger.debug(f"User context: {user_context}")
59
 
60
  prompt = self.prompt_template.format_json(**user_context)
@@ -83,6 +96,8 @@ class Planner:
83
  plan["strategy"] = strategy
84
  if unique_indices:
85
  plan["unique_indices"] = unique_indices
 
 
86
  return plan
87
  else:
88
  missing_keys = []
@@ -103,7 +118,7 @@ class Planner:
103
 
104
  # ---------- fallback static plan ----------
105
  logger.info("Falling back to static plan")
106
- return self._static_plan(fields, strategy, unique_indices)
107
 
108
  # --------------------------------------------------
109
  @staticmethod
@@ -127,6 +142,7 @@ class Planner:
127
  pdf_meta = kwargs.get("pdf_meta", {})
128
  strategy = kwargs.get("strategy", "Original Strategy")
129
  unique_indices = kwargs.get("unique_indices", [])
 
130
 
131
  # Create a formatted string with the actual values
132
  formatted = self.s
@@ -144,6 +160,8 @@ class Planner:
144
  formatted = formatted.replace("strategy for extraction", f"extraction strategy: {strategy}")
145
  if unique_indices:
146
  formatted = formatted.replace("unique indices for extraction", f"unique indices: {json.dumps(unique_indices)}")
 
 
147
 
148
  return formatted
149
 
@@ -151,19 +169,36 @@ class Planner:
151
 
152
  # --------------------------------------------------
153
  @staticmethod
154
- def _static_plan(fields: List[str], strategy: str = "Original Strategy", unique_indices: List[str] | None = None) -> Dict[str, Any]:
155
  """Return a hard-coded plan to guarantee offline functionality."""
156
  logger.info("Generating static fallback plan")
157
- steps = [
158
- {"tool": "PDFAgent", "args": {}},
159
- {"tool": "TableAgent", "args": {}},
160
- {
161
- "tool": "ForEachField",
162
- "loop": [
163
- {"tool": "FieldMapper", "args": {"field": "$field"}},
164
- ],
165
- },
166
- ]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
167
  plan = {
168
  "steps": steps,
169
  "fields": fields,
@@ -172,4 +207,8 @@ class Planner:
172
  }
173
  if unique_indices:
174
  plan["unique_indices"] = unique_indices
 
 
 
 
175
  return plan
 
39
  field_descs: Dict | None = None,
40
  strategy: str = "Original Strategy",
41
  unique_indices: List[str] | None = None,
42
+ unique_indices_descriptions: Dict[str, str] | None = None,
43
  ) -> Dict[str, Any]:
44
  """Return a JSON dict representing the execution plan."""
45
+ logger.info(f"Building plan for strategy: {strategy}")
46
+ logger.info(f"Fields: {fields}")
47
+ logger.info(f"Unique indices: {unique_indices}")
48
+ logger.info(f"Unique indices descriptions: {unique_indices_descriptions}")
49
 
50
+ # For Unique Indices Strategy, use static plan directly
51
+ if strategy == "Unique Indices Strategy":
52
+ logger.info("Using static plan for Unique Indices Strategy")
53
+ return self._static_plan(fields, strategy, unique_indices, unique_indices_descriptions)
54
+
55
+ # For Original Strategy, try LLM first
56
  user_context = {
57
  "pdf_meta": pdf_meta,
58
  "doc_preview": doc_preview or "",
 
60
  "field_descriptions": field_descs or {},
61
  "strategy": strategy,
62
  "unique_indices": unique_indices or [],
63
+ "unique_indices_descriptions": unique_indices_descriptions or {},
64
  }
65
 
66
  logger.info(f"Building plan for fields: {fields}")
67
  logger.info(f"Using strategy: {strategy}")
68
  if unique_indices:
69
  logger.info(f"Unique indices: {unique_indices}")
70
+ logger.info(f"Unique indices descriptions: {unique_indices_descriptions}")
71
  logger.debug(f"User context: {user_context}")
72
 
73
  prompt = self.prompt_template.format_json(**user_context)
 
96
  plan["strategy"] = strategy
97
  if unique_indices:
98
  plan["unique_indices"] = unique_indices
99
+ if unique_indices_descriptions:
100
+ plan["unique_indices_descriptions"] = unique_indices_descriptions
101
  return plan
102
  else:
103
  missing_keys = []
 
118
 
119
  # ---------- fallback static plan ----------
120
  logger.info("Falling back to static plan")
121
+ return self._static_plan(fields, strategy, unique_indices, unique_indices_descriptions)
122
 
123
  # --------------------------------------------------
124
  @staticmethod
 
142
  pdf_meta = kwargs.get("pdf_meta", {})
143
  strategy = kwargs.get("strategy", "Original Strategy")
144
  unique_indices = kwargs.get("unique_indices", [])
145
+ unique_indices_descriptions = kwargs.get("unique_indices_descriptions", {})
146
 
147
  # Create a formatted string with the actual values
148
  formatted = self.s
 
160
  formatted = formatted.replace("strategy for extraction", f"extraction strategy: {strategy}")
161
  if unique_indices:
162
  formatted = formatted.replace("unique indices for extraction", f"unique indices: {json.dumps(unique_indices)}")
163
+ if unique_indices_descriptions:
164
+ formatted = formatted.replace("unique indices descriptions for extra context", f"unique indices descriptions: {json.dumps(unique_indices_descriptions)}")
165
 
166
  return formatted
167
 
 
169
 
170
  # --------------------------------------------------
171
  @staticmethod
172
+ def _static_plan(fields: List[str], strategy: str = "Original Strategy", unique_indices: List[str] | None = None, unique_indices_descriptions: Dict[str, str] | None = None) -> Dict[str, Any]:
173
  """Return a hard-coded plan to guarantee offline functionality."""
174
  logger.info("Generating static fallback plan")
175
+ logger.info(f"Strategy: {strategy}")
176
+ logger.info(f"Fields: {fields}")
177
+ logger.info(f"Unique indices: {unique_indices}")
178
+ logger.info(f"Unique indices descriptions: {unique_indices_descriptions}")
179
+
180
+ if strategy == "Unique Indices Strategy":
181
+ steps = [
182
+ {"tool": "PDFAgent", "args": {}},
183
+ {"tool": "TableAgent", "args": {}},
184
+ {"tool": "UniqueIndicesCombinator", "args": {}},
185
+ ]
186
+ logger.info("Generated plan for Unique Indices Strategy")
187
+ logger.info(f"Steps: {steps}")
188
+ else:
189
+ steps = [
190
+ {"tool": "PDFAgent", "args": {}},
191
+ {"tool": "TableAgent", "args": {}},
192
+ {
193
+ "tool": "ForEachField",
194
+ "loop": [
195
+ {"tool": "FieldMapper", "args": {"field": "$field"}},
196
+ ],
197
+ },
198
+ ]
199
+ logger.info("Generated plan for Original Strategy")
200
+ logger.info(f"Steps: {steps}")
201
+
202
  plan = {
203
  "steps": steps,
204
  "fields": fields,
 
207
  }
208
  if unique_indices:
209
  plan["unique_indices"] = unique_indices
210
+ if unique_indices_descriptions:
211
+ plan["unique_indices_descriptions"] = unique_indices_descriptions
212
+
213
+ logger.info(f"Final plan: {json.dumps(plan, indent=2)}")
214
  return plan
src/services/__pycache__/azure_di_service.cpython-312.pyc CHANGED
Binary files a/src/services/__pycache__/azure_di_service.cpython-312.pyc and b/src/services/__pycache__/azure_di_service.cpython-312.pyc differ
 
src/services/azure_di_service.py CHANGED
@@ -6,118 +6,131 @@ from pathlib import Path
6
  from azure.ai.documentintelligence import DocumentIntelligenceClient
7
  from azure.ai.documentintelligence.models import DocumentContentFormat
8
  from azure.core.credentials import AzureKeyCredential
9
- from azure.core.exceptions import HttpResponseError
10
 
11
  class AzureDIService:
12
  def __init__(self, endpoint: str, key: str):
13
  self.client = DocumentIntelligenceClient(endpoint=endpoint, credential=AzureKeyCredential(key))
14
  self.logger = logging.getLogger(__name__)
15
- self.log_dir = Path("logs/di_content")
16
  self.log_dir.mkdir(parents=True, exist_ok=True)
 
 
17
 
18
- def _process_table(self, table):
19
- """Process a table to properly handle rowspans and return expanded rows."""
20
  if not hasattr(table, 'cells'):
21
- return []
22
 
23
- # Get table dimensions
24
- rows = max(cell.row_index for cell in table.cells) + 1
25
- cols = max(cell.column_index for cell in table.cells) + 1
26
 
27
- # Initialize the expanded table
28
- expanded_table = []
29
- for _ in range(rows):
30
- expanded_table.append([None] * cols)
31
-
32
- # First pass: fill in all cells
33
- for cell in table.cells:
34
- expanded_table[cell.row_index][cell.column_index] = cell.content
35
-
36
- # Second pass: handle rowspans
37
  for cell in table.cells:
38
- if hasattr(cell, 'row_span') and cell.row_span > 1:
39
- # Copy the content to all spanned rows
40
- for i in range(1, cell.row_span):
41
- if cell.row_index + i < rows:
42
- expanded_table[cell.row_index + i][cell.column_index] = cell.content
43
-
44
- # Convert to list of dictionaries
45
- headers = expanded_table[0]
46
- result = []
47
- for row in expanded_table[1:]:
48
- row_dict = {}
49
- for i, value in enumerate(row):
50
- if i < len(headers):
51
- row_dict[headers[i]] = value
52
- result.append(row_dict)
53
-
54
- return result
 
 
 
55
 
56
  def extract_tables(self, pdf_bytes: bytes):
57
  try:
58
  self.logger.info("Starting document analysis with Azure Document Intelligence")
59
 
60
- # First call: Get markdown format for document context
61
- markdown_poller = self.client.begin_analyze_document(
62
  "prebuilt-layout",
63
  body=pdf_bytes,
64
  content_type="application/octet-stream",
65
  output_content_format=DocumentContentFormat.MARKDOWN
66
  )
67
- markdown_result = markdown_poller.result()
68
 
69
- # Second call: Get JSON format for table processing
70
- json_poller = self.client.begin_analyze_document(
71
- "prebuilt-layout",
72
- body=pdf_bytes,
73
- content_type="application/octet-stream",
74
- output_content_format=DocumentContentFormat.JSON
75
- )
76
- json_result = json_poller.result()
77
 
78
- # Process tables from JSON result
79
- tables_data = []
80
- if hasattr(json_result, "tables"):
81
- self.logger.info(f"Number of tables: {len(json_result.tables)}")
82
- for table in json_result.tables:
83
- processed_table = self._process_table(table)
84
- tables_data.extend(processed_table)
85
- self.logger.info(f"Processed table with {len(processed_table)} rows")
86
-
87
- # Save both markdown and JSON content for debugging
88
  timestamp = datetime.now().strftime("%Y%m%d_%H%M%S")
89
 
90
- # Save markdown content
91
- markdown_log = self.log_dir / f"di_content_{timestamp}_markdown.txt"
92
- with open(markdown_log, "w", encoding="utf-8") as f:
93
- if hasattr(markdown_result, "content"):
94
- f.write(markdown_result.content)
95
- self.logger.info(f"Saved markdown content to {markdown_log}")
96
-
97
- # Save JSON content
98
- json_log = self.log_dir / f"di_content_{timestamp}_json.txt"
99
- with open(json_log, "w", encoding="utf-8") as f:
100
- if hasattr(json_result, "content"):
101
- f.write(json_result.content)
102
- else:
103
- f.write(json.dumps(json_result.to_dict(), indent=2))
104
- self.logger.info(f"Saved JSON content to {json_log}")
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
105
 
106
  return {
107
- "text": markdown_result.content if hasattr(markdown_result, "content") else "",
108
- "tables": tables_data
109
  }
110
 
111
- except HttpResponseError as e:
112
- self.logger.error(f"Azure Document Intelligence API error: {str(e)}")
113
- if hasattr(e, 'response') and hasattr(e.response, 'json'):
114
- try:
115
- error_details = e.response.json()
116
- self.logger.error(f"Error details: {error_details}")
117
- except:
118
- pass
119
- raise
120
  except Exception as e:
121
- self.logger.error(f"Unexpected error during document analysis: {str(e)}")
122
- self.logger.exception("Full traceback:")
123
- raise
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
6
  from azure.ai.documentintelligence import DocumentIntelligenceClient
7
  from azure.ai.documentintelligence.models import DocumentContentFormat
8
  from azure.core.credentials import AzureKeyCredential
 
9
 
10
  class AzureDIService:
11
  def __init__(self, endpoint: str, key: str):
12
  self.client = DocumentIntelligenceClient(endpoint=endpoint, credential=AzureKeyCredential(key))
13
  self.logger = logging.getLogger(__name__)
14
+ self.log_dir = Path("logs/di_content").absolute()
15
  self.log_dir.mkdir(parents=True, exist_ok=True)
16
+ self.logger.info(f"Log directory created at: {self.log_dir}")
17
+ self.logger.info(f"Absolute path: {self.log_dir.absolute()}")
18
 
19
+ def _get_original_html_table(self, table):
20
+ """Generate HTML for the original table structure."""
21
  if not hasattr(table, 'cells'):
22
+ return ""
23
 
24
+ # Get dimensions
25
+ rows = max(cell.row_index + (getattr(cell, 'row_span', 1) or 1) - 1 for cell in table.cells) + 1
26
+ cols = max(cell.column_index + (getattr(cell, 'column_span', 1) or 1) - 1 for cell in table.cells) + 1
27
 
28
+ # Create matrix
29
+ matrix = [[None for _ in range(cols)] for _ in range(rows)]
 
 
 
 
 
 
 
 
30
  for cell in table.cells:
31
+ r0 = cell.row_index
32
+ c0 = cell.column_index
33
+ r_span = getattr(cell, 'row_span', 1) or 1
34
+ c_span = getattr(cell, 'column_span', 1) or 1
35
+ for dr in range(r_span):
36
+ for dc in range(c_span):
37
+ matrix[r0 + dr][c0 + dc] = cell.content
38
+
39
+ # Generate HTML
40
+ html = ['<table border="1">']
41
+ for row in matrix:
42
+ html.append('<tr>')
43
+ for cell in row:
44
+ if cell is not None:
45
+ html.append(f'<td>{cell}</td>')
46
+ else:
47
+ html.append('<td></td>')
48
+ html.append('</tr>')
49
+ html.append('</table>')
50
+ return '\n'.join(html)
51
 
52
  def extract_tables(self, pdf_bytes: bytes):
53
  try:
54
  self.logger.info("Starting document analysis with Azure Document Intelligence")
55
 
56
+ # Get document analysis
57
+ poller = self.client.begin_analyze_document(
58
  "prebuilt-layout",
59
  body=pdf_bytes,
60
  content_type="application/octet-stream",
61
  output_content_format=DocumentContentFormat.MARKDOWN
62
  )
63
+ result = poller.result()
64
 
65
+ # Extract tables
66
+ tables = []
67
+ for table in getattr(result, "tables", []):
68
+ table_data = {
69
+ "original_html": self._get_original_html_table(table)
70
+ }
71
+ tables.append(table_data)
 
72
 
73
+ # Save tables for debugging
 
 
 
 
 
 
 
 
 
74
  timestamp = datetime.now().strftime("%Y%m%d_%H%M%S")
75
 
76
+ # Save HTML version
77
+ html_path = self.log_dir / f"di_content_{timestamp}_tables.html"
78
+ with open(html_path, "w", encoding="utf-8") as f:
79
+ f.write("""<!DOCTYPE html>
80
+ <html>
81
+ <head>
82
+ <title>Azure DI Tables</title>
83
+ <style>
84
+ body { font-family: Arial, sans-serif; margin: 20px; }
85
+ .table-container { margin-bottom: 40px; }
86
+ h2 { color: #333; }
87
+ table { border-collapse: collapse; width: 100%; margin-bottom: 10px; }
88
+ th, td { border: 1px solid #ddd; padding: 8px; text-align: left; }
89
+ th { background-color: #f5f5f5; }
90
+ hr { border: none; border-top: 2px solid #ccc; margin: 20px 0; }
91
+ </style>
92
+ </head>
93
+ <body>
94
+ <h1>Azure Document Intelligence Tables</h1>
95
+ """)
96
+
97
+ for i, table in enumerate(tables, 1):
98
+ f.write(f"""
99
+ <div class="table-container">
100
+ <h2>Table {i}</h2>
101
+ {table['original_html']}
102
+ <hr>
103
+ </div>
104
+ """)
105
+
106
+ f.write("</body></html>")
107
+ self.logger.info(f"Saved HTML tables to: {html_path.absolute()}")
108
 
109
  return {
110
+ "text": result.content if hasattr(result, "content") else "",
111
+ "tables": tables
112
  }
113
 
 
 
 
 
 
 
 
 
 
114
  except Exception as e:
115
+ self.logger.error(f"Error extracting tables: {str(e)}")
116
+ raise
117
+
118
+ def _table_to_markdown(self, table) -> str:
119
+ """Convert a table to markdown format."""
120
+ expanded = self._expand_table(table)
121
+ if not expanded:
122
+ return ""
123
+
124
+ # Convert to markdown
125
+ md_rows = []
126
+ for row in expanded:
127
+ md_row = "| " + " | ".join(str(cell if cell is not None else "") for cell in row) + " |"
128
+ md_rows.append(md_row)
129
+
130
+ # Add header separator
131
+ if md_rows:
132
+ header = md_rows[0]
133
+ separator = "| " + " | ".join(["---"] * len(expanded[0])) + " |"
134
+ md_rows.insert(1, separator)
135
+
136
+ return "\n".join(md_rows)
src/ui/strategy_selector.py CHANGED
@@ -1,6 +1,6 @@
1
  """Strategy selection UI components for Streamlit."""
2
  import streamlit as st
3
- from typing import Dict, Any, List, Tuple
4
 
5
  def render_strategy_selector() -> Tuple[str, Dict[str, Any]]:
6
  """Render strategy selection UI and return selected strategy and parameters."""
 
1
  """Strategy selection UI components for Streamlit."""
2
  import streamlit as st
3
+ from typing import Dict, Any, Tuple
4
 
5
  def render_strategy_selector() -> Tuple[str, Dict[str, Any]]:
6
  """Render strategy selection UI and return selected strategy and parameters."""