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ADNI_126_S_4507_MR_Accelerated_Sag_IR-FSPGR___br_raw_20140114155416501_56_S210193_I404763	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild atrophy of the right amygdala; the left amygdala is normal - putamen maintains a normal appearance with no observable atrophic features - no observable atrophic changes in the caudate - no clear atrophic alterations are visible in the thalamus - accumbens appears within normal limits without apparent atrophy - pallidum maintains a normal appearance with no observable atrophic features - mild atrophy of the left hippocampus, mild atrophy of the right hippocampus For the cerebral cortex: - insular cortex demonstrates a healthy morphology without signs of atrophy - occipital lobe maintains a normal appearance with no observable atrophic features - parietal lobe appears within normal limits without apparent atrophy - no observable atrophic changes in the temporal lobe - no observable atrophic changes in the frontal lobe - limbic cortex maintains a normal appearance with no observable atrophic features For the ventricles: - mild-to-moderate enlargement of the left lateral ventricle and mild enlargement of the right lateral ventricle - 3rd ventricle maintains a typical volume without observable enlargement - moderate enlargement of the left inf. lateral ventricle and mild-to-moderate enlargement of the right inf. lateral ventricle - mild enlargement of the 4th ventricle - no findings suggestive of enlargement are seen in the external csf For additional Regions of Interest: - the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) shows no notable changes suggestive of atrophy - no clear atrophic alterations are visible in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - no evident atrophy or tissue thinning seen in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - mild atrophy of the right medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus); the left medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) is normal	AD	We have the following subject's personal information: - The subject is a male of 80.1 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 25. In his MMSE test, he has an orientation to time score of 4. In his MMSE test, he has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - The subject has a Boston Naming Test (BNT) total score of 28. - On the semantic categorical fluency test, the subject named 15 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 1. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for preparing a balanced meal, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject requires assitance for shopping alone for clothes, household necessities, or groceries, for remembering appointments, family occasions, holidays, medications. - On the Trail Making Test Part A, his total number of seconds to complete is 48. On the Trail Making Test Part B, his total number of seconds to complete is 242. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_116_S_4483_MR_MPRAGE_br_raw_20120125125758694_69_S138478_I280672	On a T1-weighted brain MRI we observed: For the subcortical structures: - pallidum appears within normal limits without apparent atrophy - the hippocampus shows no notable changes suggestive of atrophy - putamen maintains a normal appearance with no observable atrophic features - amygdala appears within normal limits without apparent atrophy - caudate appears preserved, with no observable tissue loss - accumbens appears within normal limits without apparent atrophy - the thalamus shows no notable changes suggestive of atrophy For the ventricles: - no clear enlargement or abnormal growth seen in the 4th ventricle - 3rd ventricle maintains a typical volume without observable enlargement - external csf appears within normal size limits with no apparent enlargement - inf. lateral ventricle appears within normal size limits with no apparent enlargement - no observable enlargement of the lateral ventricle For the cerebral cortex: - frontal lobe demonstrates a healthy morphology without signs of atrophy - mild atrophy of the right limbic cortex; normal-to-mild atrophy of the left limbic cortex; focal volume loss observed in the following subregions: entorhinal area (mild atrophy both left and right), parahippocampal gyrus (mild atrophy both left and right), middle cingulate gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) and anterior cingulate gyrus (normal on the left and mild atrophy on the right) - parietal lobe appears preserved, with no observable tissue loss - insular cortex demonstrates a healthy morphology without signs of atrophy - occipital lobe appears within normal limits without apparent atrophy - temporal lobe appears within normal limits without apparent atrophy For additional Regions of Interest: - no evident atrophy or tissue thinning seen in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) shows no notable changes suggestive of atrophy - the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) shows no notable changes suggestive of atrophy - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) maintains a normal appearance with no observable atrophic features	CN	We have the following subject's personal information: - The subject is a female of 69.6 years old. - Subject's current marrietal status is: married. - She has 15.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 17. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
NIFD_1_S_0003_MR_t1_mprage_S3_DIS3D_br_raw_20110414102634247_37_S104274_I227698	On a T1-weighted brain MRI we observed: For the ventricles: - mild-to-moderate enlargement of the external csf - moderate enlargement of the 3rd ventricle - no observable enlargement of the 4th ventricle - severe bilateral enlargement of the inf. lateral ventricle - mild enlargement of the left lateral ventricle and moderate enlargement of the right lateral ventricle For the subcortical structures: - moderate atrophy of the right putamen; normal-to-mild atrophy of the left putamen - moderate atrophy of the right caudate; the left caudate is normal - mild atrophy of the right thalamus; normal-to-mild atrophy of the left thalamus - mild atrophy of the left accumbens and moderate-to-severe atrophy of the right accumbens - severe bilateral atrophy of the amygdala - mild-to-moderate atrophy of the left hippocampus, moderate atrophy of the right hippocampus - moderate atrophy of the right pallidum; the left pallidum is normal For the cerebral cortex: - moderate atrophy of the left temporal lobe and severe atrophy of the right temporal lobe; focal volume loss observed in the following subregions: temporal pole (moderate atrophy on the left and severe atrophy on the right), fusiform gyrus (mild-to-moderate atrophy on the left and moderate atrophy on the right), inf. temporal gyrus (mild-to-moderate atrophy on the left and moderate atrophy on the right), middle temporal gyrus (normal on the left and moderate-to-severe atrophy on the right), planum polare (normal on the left and moderate atrophy on the right) and sup. temporal gyrus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right) - no evident atrophy or tissue thinning seen in the frontal lobe - occipital lobe appears preserved, with no observable tissue loss - mild atrophy of the left limbic cortex and moderate atrophy of the right limbic cortex; focal volume loss observed in the following subregions: entorhinal area (mild-to-moderate atrophy on the left and moderate atrophy on the right), anterior cingulate gyrus (mild atrophy on the left and moderate atrophy on the right), parahippocampal gyrus (mild atrophy both left and right) and middle cingulate gyrus (mild atrophy on the right) - no findings suggestive of atrophy are seen in the parietal lobe - mild atrophy of the left insular cortex and moderate atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (moderate atrophy on the left and moderate-to-severe atrophy on the right), posterior insula (moderate atrophy on the left and moderate-to-severe atrophy on the right) and frontal operculum (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right) For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) maintains a normal appearance with no observable atrophic features - mild atrophy of the left salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) and moderate atrophy of the right salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - moderate-to-severe atrophy of the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) and severe atrophy of the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - no appreciable degenerative or atrophic changes observed in the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	SV	We have the following subject's personal information: - The subject is a male of 66.0 years old. - He has 12.0 years of education (equivalent to high school or GRE) We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal. The subject has difficulity, but does by himself, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in agitation or aggression, irritability or lability, a moderate (significant, but not dramatic) change in anxiety, apathy or indifference, a mild (noticeable, but not significant) change in elation or euphoria. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 5.0. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_127_S_5228_MR_Accelerated_Sag_IR-FSPGR_br_raw_20130624154135623_65_S193156_I377858	On a T1-weighted brain MRI we observed: For the cerebral cortex: - temporal lobe appears preserved, with no observable tissue loss - the parietal lobe shows no notable changes suggestive of atrophy - insular cortex demonstrates a healthy morphology without signs of atrophy - no evident atrophy or tissue thinning seen in the limbic cortex - no appreciable degenerative or atrophic changes observed in the frontal lobe - occipital lobe maintains a normal appearance with no observable atrophic features For the subcortical structures: - the pallidum shows no notable changes suggestive of atrophy - no evident atrophy or tissue thinning seen in the putamen - caudate appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the amygdala - no findings suggestive of atrophy are seen in the hippocampus - no clear atrophic alterations are visible in the thalamus - accumbens maintains a normal appearance with no observable atrophic features For the ventricles: - no evident size increase noted in the inf. lateral ventricle - lateral ventricle appears to be of normal dimensions, with no observable increase in size - no appreciable enlargement noted in the 3rd ventricle - external csf appears to be of normal dimensions, with no observable increase in size - 4th ventricle appears within normal size limits with no apparent enlargement For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) appears within normal limits without apparent atrophy - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) demonstrates a healthy morphology without signs of atrophy - no clear atrophic alterations are visible in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) shows no notable changes suggestive of atrophy	CN	We have the following subject's personal information: - The subject is a female of 77.9 years old. - Subject's current marrietal status is: married. - She has 15.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 27. In her MMSE test, she has an orientation to time score of 4. In her MMSE test, she has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 13. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_016_S_6708_MR_Accelerated_Sagittal_MPRAGE__br_raw_20190404142449518_88_S812850_I1151022	On a T1-weighted brain MRI we observed: For the ventricles: - mild enlargement of the 4th ventricle - mild enlargement of the left lateral ventricle; the right lateral ventricle is normal - moderate enlargement of the external csf - mild-to-moderate enlargement of the left inf. lateral ventricle; normal-to-mild enlargement of the right inf. lateral ventricle - 3rd ventricle maintains its expected proportions without signs of enlargement For the subcortical structures: - no clear atrophic alterations are visible in the putamen - no findings suggestive of atrophy are seen in the pallidum - accumbens appears preserved, with no observable tissue loss - mild bilateral atrophy of the caudate - thalamus appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the hippocampus - mild bilateral atrophy of the amygdala For the cerebral cortex: - mild atrophy of the left parietal lobe; the right parietal lobe is normal; focal volume loss observed in the following subregions: supramarginal gyrus (mild atrophy on the left and normal on the right) and angular gyrus (mild atrophy on the left and normal on the right) - mild-to-moderate atrophy of the left frontal lobe; normal-to-mild atrophy of the right frontal lobe; focal volume loss observed in the following subregions: sup. frontal gyrus (mild atrophy both left and right), precentral gyrus (normal on the left and mild atrophy on the right), sup. frontal gyrus medial segment (mild atrophy on the left and normal on the right), opercular inf. frontal gyrus (mild atrophy on the left), lateral orbital gyrus (mild atrophy on the left) and supplementary motor cortex (mild atrophy on the left) - mild atrophy of the right occipital lobe; the left occipital lobe is normal; focal volume loss observed in the following subregions: inf. occipital gyrus (mild atrophy both left and right) and cuneus (normal on the left and mild atrophy on the right) - insular cortex demonstrates a healthy morphology without signs of atrophy - mild-to-moderate atrophy of the left temporal lobe; normal-to-mild atrophy of the right temporal lobe; focal volume loss observed in the following subregions: planum temporale (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right), sup. temporal gyrus (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right) and fusiform gyrus (mild atrophy both left and right) - no clear atrophic alterations are visible in the limbic cortex For additional Regions of Interest: - mild atrophy of the left fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula); the right fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) is normal - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) appears within normal limits without apparent atrophy - mild atrophy of the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala); the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) is normal - the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) shows no notable changes suggestive of atrophy	AD	We have the following subject's personal information: - The subject is a male of 56.0 years old. - Subject's current marrietal status is: married. - He has 14.0 years of education - The subject is left-handed We have the following subject's family history information: - His mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 27. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 4.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 1. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e4,e4 with 2 copies of e4 allele.
FTLD_203813234_02431_MR_Sagittal_MP-Rage_br_raw_20230209101907239_I10183427	On a T1-weighted brain MRI we observed: For the subcortical structures: - moderate-to-severe atrophy of the left caudate and mild atrophy of the right caudate - mild bilateral atrophy of the amygdala - moderate bilateral atrophy of the putamen - severe atrophy of the left thalamus and moderate atrophy of the right thalamus - moderate-to-severe bilateral atrophy of the pallidum - severe atrophy of the left accumbens and mild-to-moderate atrophy of the right accumbens - mild-to-moderate atrophy of the left hippocampus For the ventricles: - severe enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - mild enlargement of the 4th ventricle - severe enlargement of the 3rd ventricle - mild enlargement of the external csf - severe enlargement of the left lateral ventricle and mild-to-moderate enlargement of the right lateral ventricle For the cerebral cortex: - mild-to-moderate atrophy of the left insular cortex; normal-to-mild atrophy of the right insular cortex; focal volume loss observed in the following subregions: frontal operculum (mild-to-moderate atrophy on the left and normal on the right) and central operculum (mild atrophy on the left and normal on the right) - no findings suggestive of atrophy are seen in the temporal lobe - occipital lobe demonstrates a healthy morphology without signs of atrophy - no evident atrophy or tissue thinning seen in the limbic cortex - parietal lobe appears within normal limits without apparent atrophy - frontal lobe appears within normal limits without apparent atrophy For additional Regions of Interest: - no findings suggestive of atrophy are seen in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) appears within normal limits without apparent atrophy	BV	We have the following subject's personal information: - The subject is a male of 55.0 years old. - He has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 16. - On the semantic categorical fluency test, the subject named 3 animals in 60 seconds. He named 2 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 0. - On the Number Span forward test, his longest span forward was 5. On the Number Span backward test, his longest span backward was 0. - On the Trail Making Test Part A, his total number of seconds to complete is 150, his number of commission errors is 0, his number of correct lines is 21. On the Trail Making Test Part B, his total number of seconds to complete is 300, his number of commission errors is 2, his number of correct lines is 4. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in irritability or lability, appetite and eating, a mild (noticeable, but not significant) change in delusions, anxiety, motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. His standard CDR Sum of Boxes score is 8.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 2.0 (moderate impairment). Description: Severely impaired in handling problems, similarities, and differences; social judgment usually impaired. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_301_S_10139_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20240617183514870_1_I10666918	On a T1-weighted brain MRI we observed: For the ventricles: - 3rd ventricle maintains its expected proportions without signs of enlargement - lateral ventricle maintains a typical volume without observable enlargement - mild enlargement of the left inf. lateral ventricle; the right inf. lateral ventricle is normal - no evident size increase noted in the 4th ventricle - no appreciable enlargement noted in the external csf For the subcortical structures: - no appreciable degenerative or atrophic changes observed in the caudate - pallidum appears within normal limits without apparent atrophy - the hippocampus shows no notable changes suggestive of atrophy - thalamus maintains a normal appearance with no observable atrophic features - putamen demonstrates a healthy morphology without signs of atrophy - no observable atrophic changes in the accumbens - amygdala maintains a normal appearance with no observable atrophic features For the cerebral cortex: - the insular cortex shows no notable changes suggestive of atrophy - frontal lobe maintains a normal appearance with no observable atrophic features - temporal lobe appears within normal limits without apparent atrophy - mild atrophy of the right occipital lobe; the left occipital lobe is normal; focal volume loss observed in the following subregions: middle occipital gyrus (mild-to-moderate atrophy on the left and normal on the right), inf. occipital gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) and calcarine cortex (normal on the left and mild atrophy on the right) - no observable atrophic changes in the limbic cortex - mild atrophy of the left parietal lobe; normal-to-mild atrophy of the right parietal lobe; focal volume loss observed in the following subregions: precuneus (mild atrophy both left and right) and angular gyrus (mild atrophy on the left and normal on the right) For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) appears within normal limits without apparent atrophy - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) appears within normal limits without apparent atrophy - medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) appears preserved, with no observable tissue loss - mild atrophy of the left medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus); the right medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) is normal	CN	We have the following subject's personal information: - The subject is a female of 59.7 years old. - Subject's current marrietal status is: married. - She has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following subject's family history information: - Her mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 18. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_130_S_6043_MR_Sagittal_3D_Accelerated_MPRAGE_br_raw_20200805115511270_99_S581424_I871899	On a T1-weighted brain MRI we observed: For the cerebral cortex: - parietal lobe maintains a normal appearance with no observable atrophic features - limbic cortex maintains a normal appearance with no observable atrophic features - the frontal lobe shows no notable changes suggestive of atrophy - insular cortex demonstrates a healthy morphology without signs of atrophy - temporal lobe appears within normal limits without apparent atrophy - occipital lobe maintains a normal appearance with no observable atrophic features For the ventricles: - mild bilateral enlargement of the lateral ventricle - external csf maintains a typical volume without observable enlargement - mild enlargement of the 3rd ventricle - no findings suggestive of enlargement are seen in the 4th ventricle - moderate bilateral enlargement of the inf. lateral ventricle For the subcortical structures: - mild bilateral atrophy of the putamen - mild bilateral atrophy of the pallidum - the amygdala shows no notable changes suggestive of atrophy - mild atrophy of the right thalamus; the left thalamus is normal - mild bilateral atrophy of the caudate - hippocampus appears preserved, with no observable tissue loss - mild atrophy of the right accumbens; normal-to-mild atrophy of the left accumbens For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) appears within normal limits without apparent atrophy - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a male of 78.9 years old. - Subject's current marrietal status is: married. - He has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 14. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_006_S_5153_MR_MPRAGE_br_raw_20130422151103640_137_S187543_I368152	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no evident atrophy or tissue thinning seen in the occipital lobe - no clear atrophic alterations are visible in the insular cortex - no findings suggestive of atrophy are seen in the parietal lobe - limbic cortex maintains a normal appearance with no observable atrophic features - mild atrophy of the right frontal lobe; the left frontal lobe is normal; focal volume loss observed in the following subregions: sup. frontal gyrus (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right), gyrus rectus (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), triangular inf. frontal gyrus (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right), subcallosal area (mild atrophy both left and right), anterior orbital gyrus (normal on the left and mild atrophy on the right), medial orbital gyrus (mild atrophy on the left and normal on the right) and supplementary motor cortex (normal on the left and mild atrophy on the right) - temporal lobe demonstrates a healthy morphology without signs of atrophy For the ventricles: - no findings suggestive of enlargement are seen in the 3rd ventricle - no appreciable enlargement noted in the 4th ventricle - no observable enlargement of the inf. lateral ventricle - no observable enlargement of the lateral ventricle - external csf maintains its expected proportions without signs of enlargement For the subcortical structures: - thalamus appears preserved, with no observable tissue loss - no observable atrophic changes in the amygdala - no findings suggestive of atrophy are seen in the pallidum - no evident atrophy or tissue thinning seen in the putamen - hippocampus maintains a normal appearance with no observable atrophic features - accumbens appears preserved, with no observable tissue loss - no findings suggestive of atrophy are seen in the caudate For additional Regions of Interest: - mild bilateral atrophy of the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - mild atrophy of the left salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)); the right salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) is normal - no appreciable degenerative or atrophic changes observed in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) appears within normal limits without apparent atrophy	CN	We have the following subject's personal information: - The subject is a male of 79.0 years old. - Subject's current marrietal status is: married. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 14. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_024_S_6005_MR_Accelerated_Sagittal_MPRAGE__br_raw_20170313165704125_136_S544988_I828694	On a T1-weighted brain MRI we observed: For the ventricles: - no evident size increase noted in the 4th ventricle - inf. lateral ventricle maintains a typical volume without observable enlargement - no clear enlargement or abnormal growth seen in the lateral ventricle - 3rd ventricle appears to be of normal dimensions, with no observable increase in size - mild enlargement of the external csf For the cerebral cortex: - mild atrophy of the left occipital lobe; normal-to-mild atrophy of the right occipital lobe; focal volume loss observed in the following subregions: calcarine cortex (mild-to-moderate atrophy both left and right) and sup. occipital gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right) - no appreciable degenerative or atrophic changes observed in the parietal lobe - no appreciable degenerative or atrophic changes observed in the limbic cortex - mild atrophy of the left frontal lobe; the right frontal lobe is normal; focal volume loss observed in the following subregions: sup. frontal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), triangular inf. frontal gyrus (normal on the left and mild atrophy on the right), opercular inf. frontal gyrus (mild atrophy on the left and normal on the right), precentral gyrus medial segment (mild atrophy on the left and normal on the right) and gyrus rectus (mild atrophy on the left) - insular cortex demonstrates a healthy morphology without signs of atrophy - temporal lobe appears preserved, with no observable tissue loss For the subcortical structures: - no appreciable degenerative or atrophic changes observed in the thalamus - pallidum maintains a normal appearance with no observable atrophic features - mild atrophy of the right amygdala; normal-to-mild atrophy of the left amygdala - moderate bilateral atrophy of the putamen - hippocampus appears within normal limits without apparent atrophy - accumbens appears preserved, with no observable tissue loss - mild-to-moderate atrophy of the left caudate and mild atrophy of the right caudate For additional Regions of Interest: - mild atrophy of the left fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula); the right fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) is normal - no appreciable degenerative or atrophic changes observed in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - no appreciable degenerative or atrophic changes observed in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) appears within normal limits without apparent atrophy	CN	We have the following subject's personal information: - The subject is a female of 67.5 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 20 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 22. On the Trail Making Test Part B, her total number of seconds to complete is 52. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_036_S_6916_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20250306201357951_1_I11142064	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the occipital lobe - moderate atrophy of the left temporal lobe and mild-to-moderate atrophy of the right temporal lobe; focal volume loss observed in the following subregions: inf. temporal gyrus (mild-to-moderate atrophy both left and right), temporal pole (mild atrophy both left and right) and sup. temporal gyrus (normal on the left and mild atrophy on the right) - mild atrophy of the left parietal lobe; normal-to-mild atrophy of the right parietal lobe; focal volume loss observed in the following subregions: angular gyrus (mild atrophy both left and right), postcentral gyrus (mild atrophy on the left and normal on the right) and supramarginal gyrus (mild atrophy on the left) - mild bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: medial orbital gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), medial frontal cortex (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), gyrus rectus (normal-to-mild atrophy on the left and mild atrophy on the right), middle frontal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), precentral gyrus medial segment (mild atrophy on the left and normal-to-mild atrophy on the right), precentral gyrus (mild atrophy on the left and normal on the right) and sup. frontal gyrus (normal on the left and mild atrophy on the right) - mild-to-moderate atrophy of the left insular cortex; normal-to-mild atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (mild-to-moderate atrophy on the left and mild atrophy on the right), posterior insula (mild-to-moderate atrophy on the left and mild atrophy on the right) and parietal operculum (mild atrophy on the left) - mild-to-moderate atrophy of the left limbic cortex and mild atrophy of the right limbic cortex; focal volume loss observed in the following subregions: entorhinal area (mild atrophy on the left and mild-to-moderate atrophy on the right), anterior cingulate gyrus (normal on the left and mild atrophy on the right), middle cingulate gyrus (mild atrophy on the left and normal on the right), posterior cingulate gyrus (mild atrophy on the left and normal on the right) and parahippocampal gyrus (mild atrophy on the left and normal on the right) For the ventricles: - mild enlargement of the 3rd ventricle - no clear enlargement or abnormal growth seen in the external csf - 4th ventricle maintains its expected proportions without signs of enlargement - severe bilateral enlargement of the lateral ventricle - severe bilateral enlargement of the inf. lateral ventricle For the subcortical structures: - pallidum demonstrates a healthy morphology without signs of atrophy - putamen maintains a normal appearance with no observable atrophic features - caudate appears within normal limits without apparent atrophy - moderate-to-severe bilateral atrophy of the amygdala - thalamus demonstrates a healthy morphology without signs of atrophy - moderate atrophy of the left hippocampus, moderate atrophy of the right hippocampus - mild atrophy of the left accumbens and mild-to-moderate atrophy of the right accumbens For additional Regions of Interest: - mild atrophy of the left fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula); the right fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) is normal - mild atrophy of the left salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) and mild-to-moderate atrophy of the right salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - moderate atrophy of the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) and mild-to-moderate atrophy of the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - mild-to-moderate atrophy of the left medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) and moderate atrophy of the right medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	AD	We have the following subject's personal information: - The subject is a male of 80.5 years old. - Subject's current marrietal status is: married. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following subject's family history information: - His mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 22. In his MMSE test, he has an orientation to time score of 0. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - The subject has a 32-item Multilingual Naming Test (MINT) total score of 0. - On the semantic categorical fluency test, the subject named 12 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 0. - On the Functional Activities Questionnaire (FAQ), the subject has difficulity, but does by himself, for heating water, making a cup of coffee, turning off the stove. The subject requires assitance for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for preparing a balanced meal, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 68. On the Trail Making Test Part B, his total number of seconds to complete is 164. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 1.0 (mild impairment). Description: Moderate memory loss, more marked for recent events; defect interferes with everyday activities. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
FTLD_203494939_02939_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10178263	On a T1-weighted brain MRI we observed: For the ventricles: - mild enlargement of the 3rd ventricle - no clear enlargement or abnormal growth seen in the inf. lateral ventricle - no observable enlargement of the 4th ventricle - moderate enlargement of the external csf - mild enlargement of the right lateral ventricle; normal-to-mild enlargement of the left lateral ventricle For the cerebral cortex: - mild-to-moderate atrophy of the right temporal lobe; the left temporal lobe is normal; focal volume loss observed in the following subregions: middle temporal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), temporal pole (mild atrophy both left and right), planum temporale (mild atrophy on the right) and inf. temporal gyrus (mild atrophy on the right) - mild atrophy of the left insular cortex and moderate atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (moderate atrophy on the left and moderate-to-severe atrophy on the right), frontal operculum (mild atrophy both left and right) and posterior insula (mild atrophy on the left and normal on the right) - no findings suggestive of atrophy are seen in the occipital lobe - parietal lobe demonstrates a healthy morphology without signs of atrophy - mild atrophy of the left frontal lobe and severe atrophy of the right frontal lobe; focal volume loss observed in the following subregions: gyrus rectus (moderate atrophy both left and right), medial orbital gyrus (moderate atrophy on the left and mild-to-moderate atrophy on the right), posterior orbital gyrus (mild-to-moderate atrophy both left and right), medial frontal cortex (mild atrophy on the left and mild-to-moderate atrophy on the right), frontal pole (mild atrophy on the left and mild-to-moderate atrophy on the right), anterior orbital gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), lateral orbital gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), sup. frontal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), sup. frontal gyrus medial segment (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), middle frontal gyrus (normal on the left and mild-to-moderate atrophy on the right), opercular inf. frontal gyrus (normal on the left and mild atrophy on the right), orbital inf. frontal gyrus (normal on the left and mild atrophy on the right) and triangular inf. frontal gyrus (mild atrophy on the right) - mild atrophy of the left limbic cortex and mild-to-moderate atrophy of the right limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (moderate atrophy on the left and mild-to-moderate atrophy on the right) For the subcortical structures: - mild bilateral atrophy of the putamen - mild atrophy of the right caudate; the left caudate is normal - no clear atrophic alterations are visible in the hippocampus - no appreciable degenerative or atrophic changes observed in the pallidum - mild atrophy of the right accumbens; normal-to-mild atrophy of the left accumbens - no clear atrophic alterations are visible in the thalamus - mild-to-moderate atrophy of the right amygdala; the left amygdala is normal For additional Regions of Interest: - mild-to-moderate atrophy of the right fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula); the left fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) is normal - severe bilateral atrophy of the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - mild atrophy of the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala); the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) is normal - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) demonstrates a healthy morphology without signs of atrophy	BV	We have the following subject's personal information: - The subject is a female of 59.0 years old. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 27. - On the semantic categorical fluency test, the subject named 9 animals in 60 seconds. She named 9 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 6. - On the Number Span forward test, her longest span forward was 5. On the Number Span backward test, her longest span backward was 4. - On the Trail Making Test Part A, her total number of seconds to complete is 45, her number of commission errors is 0, her number of correct lines is 24. On the Trail Making Test Part B, her total number of seconds to complete is 300, her number of commission errors is 18, her number of correct lines is 1. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in agitation or aggression, irritability or lability, nighttime behaviors, a moderate (significant, but not dramatic) change in delusions, anxiety, elation or euphoria, apathy or indifference, appetite and eating, a mild (noticeable, but not significant) change in motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 0.5 (questionnable impairment). Description: Slight impairment in these activities. * Home and hobbies: Score 1.0 (mild impairment). Description: Mild but definite impairment of function at home; more difficult chores abandoned; more complicated hobbies and interests abandoned. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 1.0 (mild impairment). Description: Mild but definite changes in behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_035_S_6730_MR_Accelerated_Sagittal_MPRAGE__br_raw_20190618111229546_35_S833186_I1176653	On a T1-weighted brain MRI we observed: For the subcortical structures: - no evident atrophy or tissue thinning seen in the putamen - hippocampus appears within normal limits without apparent atrophy - no observable atrophic changes in the pallidum - caudate demonstrates a healthy morphology without signs of atrophy - mild atrophy of the left amygdala; normal-to-mild atrophy of the right amygdala - accumbens appears preserved, with no observable tissue loss - thalamus appears within normal limits without apparent atrophy For the cerebral cortex: - the occipital lobe shows no notable changes suggestive of atrophy - no clear atrophic alterations are visible in the temporal lobe - no observable atrophic changes in the limbic cortex - mild atrophy of the left parietal lobe and mild-to-moderate atrophy of the right parietal lobe; focal volume loss observed in the following subregions: postcentral gyrus (mild atrophy both left and right), precuneus (normal-to-mild atrophy on the left and mild atrophy on the right) and supramarginal gyrus (normal on the left and mild atrophy on the right) - the insular cortex shows no notable changes suggestive of atrophy - no observable atrophic changes in the frontal lobe For the ventricles: - no evident size increase noted in the 4th ventricle - mild-to-moderate enlargement of the external csf - no appreciable enlargement noted in the inf. lateral ventricle - 3rd ventricle maintains a typical volume without observable enlargement - no evident size increase noted in the lateral ventricle For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) appears preserved, with no observable tissue loss - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - mild bilateral atrophy of the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	CN	We have the following subject's personal information: - The subject is a male of 74.0 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 25 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 40. On the Trail Making Test Part B, his total number of seconds to complete is 81. From genetic data, APOE genotype is e3,e2 with no e4 allele.
ADNI_129_S_6704_MR_Accelerated_Sag_IR-FSPGR___br_raw_20190401061925402_196_S811320_I1149034	On a T1-weighted brain MRI we observed: For the subcortical structures: - accumbens appears within normal limits without apparent atrophy - caudate maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the hippocampus - no findings suggestive of atrophy are seen in the amygdala - pallidum appears preserved, with no observable tissue loss - no observable atrophic changes in the thalamus - putamen maintains a normal appearance with no observable atrophic features For the ventricles: - no appreciable enlargement noted in the external csf - lateral ventricle appears within normal size limits with no apparent enlargement - no evident size increase noted in the 4th ventricle - no observable enlargement of the inf. lateral ventricle - no clear enlargement or abnormal growth seen in the 3rd ventricle For the cerebral cortex: - no observable atrophic changes in the frontal lobe - temporal lobe maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the limbic cortex - the occipital lobe shows no notable changes suggestive of atrophy - insular cortex appears within normal limits without apparent atrophy - parietal lobe appears preserved, with no observable tissue loss For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) demonstrates a healthy morphology without signs of atrophy - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) appears within normal limits without apparent atrophy	CN	We have the following subject's personal information: - The subject is a female of 65.4 years old. - Subject's current marrietal status is: married. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following subject's family history information: - Both of her parents are reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 28. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 9. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_013_S_4579_MR_MPRAGE_br_raw_20120410165848520_140_S146815_I296776	On a T1-weighted brain MRI we observed: For the subcortical structures: - pallidum appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the amygdala - accumbens maintains a normal appearance with no observable atrophic features - caudate appears preserved, with no observable tissue loss - no observable atrophic changes in the hippocampus - no clear atrophic alterations are visible in the thalamus - mild bilateral atrophy of the putamen For the cerebral cortex: - no appreciable degenerative or atrophic changes observed in the occipital lobe - mild atrophy of the right limbic cortex; normal-to-mild atrophy of the left limbic cortex - the temporal lobe shows no notable changes suggestive of atrophy - frontal lobe appears within normal limits without apparent atrophy - mild atrophy of the right parietal lobe; normal-to-mild atrophy of the left parietal lobe; focal volume loss observed in the following subregions: angular gyrus (mild atrophy on the left and normal on the right) - the insular cortex shows no notable changes suggestive of atrophy For the ventricles: - the 3rd ventricle shows no notable changes suggestive of enlargement - 4th ventricle appears to be of normal dimensions, with no observable increase in size - moderate enlargement of the left inf. lateral ventricle and mild enlargement of the right inf. lateral ventricle - lateral ventricle appears to be of normal dimensions, with no observable increase in size - no clear enlargement or abnormal growth seen in the external csf For additional Regions of Interest: - no evident atrophy or tissue thinning seen in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - no appreciable degenerative or atrophic changes observed in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - no appreciable degenerative or atrophic changes observed in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - mild bilateral atrophy of the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	CN	We have the following subject's personal information: - The subject is a male of 85.1 years old. - Subject's current marrietal status is: divorced. - He has 12.0 years of education (equivalent to high school or GRE) - The subject is left-handed We have the following subject's health history information: - He has quit smoking at the age of 45.He smoked a pack to a pack and a half a day. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 13. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_032_S_0400_MR_MPR____N3__Scaled_Br_20070118000329335_S13238_I36459	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild-to-moderate atrophy of the left temporal lobe and mild atrophy of the right temporal lobe; focal volume loss observed in the following subregions: inf. temporal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), middle temporal gyrus (mild atrophy on the left and normal on the right), transverse temporal gyrus (normal on the left and mild atrophy on the right) and temporal pole (mild atrophy on the left and normal on the right) - no appreciable degenerative or atrophic changes observed in the occipital lobe - mild atrophy of the right parietal lobe; normal-to-mild atrophy of the left parietal lobe; focal volume loss observed in the following subregions: angular gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) - mild atrophy of the left frontal lobe; the right frontal lobe is normal; focal volume loss observed in the following subregions: middle frontal gyrus (mild atrophy both left and right), precentral gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), medial frontal cortex (normal on the left and mild atrophy on the right) and frontal pole (mild atrophy on the right) - mild atrophy of the left limbic cortex; normal-to-mild atrophy of the right limbic cortex; focal volume loss observed in the following subregions: parahippocampal gyrus (mild atrophy both left and right), entorhinal area (mild atrophy on the left and normal on the right) and middle cingulate gyrus (mild atrophy on the left and normal on the right) - no appreciable degenerative or atrophic changes observed in the insular cortex For the subcortical structures: - mild atrophy of the left accumbens; the right accumbens is normal - mild-to-moderate atrophy of the left hippocampus, mild atrophy of the right hippocampus - amygdala appears preserved, with no observable tissue loss - no clear atrophic alterations are visible in the thalamus - mild atrophy of the left putamen; the right putamen is normal - mild-to-moderate atrophy of the left caudate and mild atrophy of the right caudate - pallidum demonstrates a healthy morphology without signs of atrophy For the ventricles: - moderate enlargement of the left lateral ventricle and mild enlargement of the right lateral ventricle - severe enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - mild-to-moderate enlargement of the 3rd ventricle - mild enlargement of the external csf - 4th ventricle maintains a typical volume without observable enlargement For additional Regions of Interest: - no clear atrophic alterations are visible in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) demonstrates a healthy morphology without signs of atrophy - mild-to-moderate atrophy of the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) and mild atrophy of the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - mild atrophy of the left medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) and mild-to-moderate atrophy of the right medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	AD	We have the following subject's personal information: - The subject is a male of 69.2 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 27. - On the semantic categorical fluency test, the subject named 15 animals in 60 seconds. He named 5 vegetables in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for shopping alone for clothes, household necessities, or groceries, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for assembling tax records, business affairs, or other paper, for playing a game of skill such as bridge or chess, working on a hobby, for remembering appointments, family occasions, holidays, medications. - On the Digit Span test of the Wechsler Memory Scale-Revised, his digit span forward length is 6, his digit span forward trials correct is 8, his digit span backward length is 4., his digit span forward trials correct is 4. - On the Trail Making Test Part A, his total number of seconds to complete is 132. On the Trail Making Test Part B, his total number of seconds to complete is 300. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in appetite and eating, a mild (noticeable, but not significant) change in depression or dysphoria, nighttime behaviors. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_116_S_4199_MR_Accelerated_Sagittal_MPRAGE__br_raw_20180411154509057_81_S675706_I984486	On a T1-weighted brain MRI we observed: For the ventricles: - mild enlargement of the external csf - 3rd ventricle maintains a typical volume without observable enlargement - lateral ventricle appears to be of normal dimensions, with no observable increase in size - no evident size increase noted in the 4th ventricle - no findings suggestive of enlargement are seen in the inf. lateral ventricle For the cerebral cortex: - mild-to-moderate atrophy of the left insular cortex; the right insular cortex is normal; focal volume loss observed in the following subregions: posterior insula (mild-to-moderate atrophy on the left and mild atrophy on the right) and anterior insula (mild-to-moderate atrophy on the left and normal on the right) - no appreciable degenerative or atrophic changes observed in the occipital lobe - temporal lobe maintains a normal appearance with no observable atrophic features - no observable atrophic changes in the frontal lobe - limbic cortex appears within normal limits without apparent atrophy - no findings suggestive of atrophy are seen in the parietal lobe For the subcortical structures: - no appreciable degenerative or atrophic changes observed in the accumbens - pallidum maintains a normal appearance with no observable atrophic features - mild-to-moderate bilateral atrophy of the putamen - the amygdala shows no notable changes suggestive of atrophy - mild bilateral atrophy of the thalamus - mild atrophy of the right caudate; normal-to-mild atrophy of the left caudate - hippocampus appears within normal limits without apparent atrophy For additional Regions of Interest: - no observable atrophic changes in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) demonstrates a healthy morphology without signs of atrophy - medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) maintains a normal appearance with no observable atrophic features - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) appears within normal limits without apparent atrophy	CN	We have the following subject's personal information: - The subject is a male of 65.7 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 26. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 8. - On the semantic categorical fluency test, the subject named 24 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 10. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 25. On the Trail Making Test Part B, his total number of seconds to complete is 44. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_177_S_6448_MR_Accelerated_Sagittal_MPRAGE__br_raw_20200919075020024_1_S961026_I1340855	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no clear atrophic alterations are visible in the insular cortex - mild bilateral atrophy of the occipital lobe; focal volume loss observed in the following subregions: calcarine cortex (moderate atrophy on the left and mild-to-moderate atrophy on the right), sup. occipital gyrus (mild atrophy both left and right) and middle occipital gyrus (mild atrophy on the right) - no findings suggestive of atrophy are seen in the limbic cortex - no findings suggestive of atrophy are seen in the temporal lobe - no evident atrophy or tissue thinning seen in the frontal lobe - mild atrophy of the right parietal lobe; normal-to-mild atrophy of the left parietal lobe; focal volume loss observed in the following subregions: postcentral gyrus (mild atrophy on the right) For the subcortical structures: - mild bilateral atrophy of the caudate - no findings suggestive of atrophy are seen in the pallidum - no appreciable degenerative or atrophic changes observed in the thalamus - putamen demonstrates a healthy morphology without signs of atrophy - hippocampus demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the amygdala - no evident atrophy or tissue thinning seen in the accumbens For the ventricles: - no clear enlargement or abnormal growth seen in the inf. lateral ventricle - mild enlargement of the external csf - no clear enlargement or abnormal growth seen in the 4th ventricle - 3rd ventricle appears within normal size limits with no apparent enlargement - no findings suggestive of enlargement are seen in the lateral ventricle For additional Regions of Interest: - no evident atrophy or tissue thinning seen in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - no evident atrophy or tissue thinning seen in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) maintains a normal appearance with no observable atrophic features - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a male of 70.0 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - The subject has a 32-item Multilingual Naming Test (MINT) total score of 0. - On the semantic categorical fluency test, the subject named 18 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 12. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 30. On the Trail Making Test Part B, his total number of seconds to complete is 55. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203260125_02526_MR_Sagittal_MP-Rage_br_raw_20230206161248652_I10181566	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild atrophy of the left temporal lobe; the right temporal lobe is normal; focal volume loss observed in the following subregions: fusiform gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), transverse temporal gyrus (mild atrophy on the right), planum temporale (normal-to-mild atrophy on the left and mild atrophy on the right) and sup. temporal gyrus (mild atrophy on the right) - limbic cortex appears preserved, with no observable tissue loss - mild bilateral atrophy of the insular cortex; focal volume loss observed in the following subregions: frontal operculum (mild atrophy both left and right) and parietal operculum (mild atrophy on the left and normal-to-mild atrophy on the right) - parietal lobe maintains a normal appearance with no observable atrophic features - moderate bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: precentral gyrus (mild atrophy on the left and moderate atrophy on the right), precentral gyrus medial segment (mild atrophy on the left and mild-to-moderate atrophy on the right), sup. frontal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), supplementary motor cortex (mild atrophy both left and right), middle frontal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), frontal pole (normal on the left and mild atrophy on the right), gyrus rectus (mild atrophy on the left and normal on the right), lateral orbital gyrus (mild atrophy on the left and normal on the right), sup. frontal gyrus medial segment (normal on the left and mild atrophy on the right) and medial frontal cortex (mild atrophy on the left) - occipital lobe appears preserved, with no observable tissue loss For the subcortical structures: - putamen appears within normal limits without apparent atrophy - mild atrophy of the left caudate and mild-to-moderate atrophy of the right caudate - mild bilateral atrophy of the accumbens - hippocampus appears preserved, with no observable tissue loss - pallidum maintains a normal appearance with no observable atrophic features - mild bilateral atrophy of the thalamus - no evident atrophy or tissue thinning seen in the amygdala For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - mild-to-moderate enlargement of the external csf - mild-to-moderate enlargement of the left lateral ventricle and moderate enlargement of the right lateral ventricle - mild enlargement of the 4th ventricle - severe enlargement of the 3rd ventricle For additional Regions of Interest: - mild-to-moderate atrophy of the left fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) and moderate atrophy of the right fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - mild atrophy of the left salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)); normal-to-mild atrophy of the right salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - no findings suggestive of atrophy are seen in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) maintains a normal appearance with no observable atrophic features	PNFA	We have the following subject's personal information: - The subject is a female of 78.0 years old. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 24. - On the semantic categorical fluency test, the subject named 5 animals in 60 seconds. She named 7 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, her total story units recalled (verbatim scoring) is 7. - On the Number Span forward test, her longest span forward was 4. On the Number Span backward test, her longest span backward was 3. - On the Trail Making Test Part A, her total number of seconds to complete is 150, her number of commission errors is 3, her number of correct lines is 2. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in depression or dysphoria, apathy or indifference, a mild (noticeable, but not significant) change in disinhibition, irritability or lability, appetite and eating. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 9.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 1.0 (mild impairment). Description: Moderate difficulty in handling problems, similarities, and differences; social judgment usually maintained. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 3.0 (severe impairment). Description: No significant function in the home. * Personal care: Score 2.0 (moderate impairment). Description: Requires much help with personal care; frequent incontinence. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_022_S_0219_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070712154620604_S12375_I59533	On a T1-weighted brain MRI we observed: For the subcortical structures: - no clear atrophic alterations are visible in the caudate - mild-to-moderate atrophy of the left hippocampus, mild atrophy of the right hippocampus - mild atrophy of the right pallidum; the left pallidum is normal - mild bilateral atrophy of the accumbens - putamen appears preserved, with no observable tissue loss - mild atrophy of the left amygdala and moderate-to-severe atrophy of the right amygdala - mild bilateral atrophy of the thalamus For the ventricles: - mild-to-moderate enlargement of the 3rd ventricle - no evident size increase noted in the external csf - moderate enlargement of the left inf. lateral ventricle and severe enlargement of the right inf. lateral ventricle - lateral ventricle appears within normal size limits with no apparent enlargement - 4th ventricle appears to be of normal dimensions, with no observable increase in size For the cerebral cortex: - mild atrophy of the right temporal lobe; the left temporal lobe is normal; focal volume loss observed in the following subregions: inf. temporal gyrus (normal on the left and mild atrophy on the right) and temporal pole (normal on the left and mild atrophy on the right) - no evident atrophy or tissue thinning seen in the frontal lobe - mild-to-moderate atrophy of the right limbic cortex; the left limbic cortex is normal; focal volume loss observed in the following subregions: entorhinal area (normal on the left and moderate atrophy on the right) and anterior cingulate gyrus (mild atrophy on the right) - mild atrophy of the right parietal lobe; normal-to-mild atrophy of the left parietal lobe; focal volume loss observed in the following subregions: sup. parietal lobule (normal-to-mild atrophy on the left and mild atrophy on the right) - no evident atrophy or tissue thinning seen in the insular cortex - no findings suggestive of atrophy are seen in the occipital lobe For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - mild-to-moderate atrophy of the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala); the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) is normal - the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) shows no notable changes suggestive of atrophy	AD	We have the following subject's personal information: - The subject is a male of 74.5 years old. We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 18 animals in 60 seconds. He named 13 vegetables in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for preparing a balanced meal, for remembering appointments, family occasions, holidays, medications. - On the Digit Span test of the Wechsler Memory Scale-Revised, his digit span forward length is 4, his digit span forward trials correct is 4, his digit span backward length is 3., his digit span forward trials correct is 4. - On the Trail Making Test Part A, his total number of seconds to complete is 30. On the Trail Making Test Part B, his total number of seconds to complete is 261. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in anxiety, irritability or lability, a mild (noticeable, but not significant) change in hallucinations, agitation or aggression. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_067_S_2301_MR_MPRAGE_br_raw_20140226111214774_170_S213307_I415424	On a T1-weighted brain MRI we observed: For the ventricles: - inf. lateral ventricle appears within normal size limits with no apparent enlargement - 4th ventricle maintains a typical volume without observable enlargement - no findings suggestive of enlargement are seen in the lateral ventricle - no findings suggestive of enlargement are seen in the external csf - no appreciable enlargement noted in the 3rd ventricle For the cerebral cortex: - no observable atrophic changes in the temporal lobe - frontal lobe appears within normal limits without apparent atrophy - no observable atrophic changes in the limbic cortex - insular cortex maintains a normal appearance with no observable atrophic features - mild atrophy of the left parietal lobe; normal-to-mild atrophy of the right parietal lobe; focal volume loss observed in the following subregions: postcentral gyrus medial segment (mild atrophy on the left and normal on the right) - the occipital lobe does not exhibit generalized atrophy; localized volume reductions - with varying degrees of severity - are observed in lingual gyrus (normal-to-mild atrophy on the left and moderate atrophy on the right) and inf. occipital gyrus (normal on the left and mild atrophy on the right) For the subcortical structures: - no clear atrophic alterations are visible in the pallidum - putamen appears within normal limits without apparent atrophy - thalamus appears preserved, with no observable tissue loss - no clear atrophic alterations are visible in the caudate - amygdala appears preserved, with no observable tissue loss - the hippocampus shows no notable changes suggestive of atrophy - mild atrophy of the left accumbens; the right accumbens is normal For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) appears within normal limits without apparent atrophy - no appreciable degenerative or atrophic changes observed in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - no observable atrophic changes in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - no clear atrophic alterations are visible in the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	CN	We have the following subject's personal information: - The subject is a male of 68.8 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 2. - The subject has a Boston Naming Test (BNT) total score of 29. - On the semantic categorical fluency test, the subject named 38 animals in 60 seconds. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 12. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for paying attention to and understanding a TV program, book, or magazine. - On the Trail Making Test Part A, his total number of seconds to complete is 26. On the Trail Making Test Part B, his total number of seconds to complete is 63. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.5 (questionnable impairment). Description: Fully oriented except for slight difficulty with time relationships. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_023_S_4020_MR_MPRAGE_br_raw_20110503145535673_39_S107436_I232428	On a T1-weighted brain MRI we observed: For the subcortical structures: - thalamus appears preserved, with no observable tissue loss - pallidum maintains a normal appearance with no observable atrophic features - accumbens appears within normal limits without apparent atrophy - hippocampus maintains a normal appearance with no observable atrophic features - caudate appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the amygdala - no appreciable degenerative or atrophic changes observed in the putamen For the cerebral cortex: - occipital lobe appears preserved, with no observable tissue loss - insular cortex appears within normal limits without apparent atrophy - the frontal lobe shows no notable changes suggestive of atrophy - mild atrophy of the left parietal lobe; the right parietal lobe is normal; focal volume loss observed in the following subregions: postcentral gyrus medial segment (mild-to-moderate atrophy on the left and mild atrophy on the right), postcentral gyrus (mild atrophy on the left and normal on the right) and sup. parietal lobule (normal on the left and mild atrophy on the right) - temporal lobe demonstrates a healthy morphology without signs of atrophy - the limbic cortex shows no notable changes suggestive of atrophy For the ventricles: - lateral ventricle appears within normal size limits with no apparent enlargement - no evident size increase noted in the external csf - the 3rd ventricle shows no notable changes suggestive of enlargement - inf. lateral ventricle appears to be of normal dimensions, with no observable increase in size - no findings suggestive of enlargement are seen in the 4th ventricle For additional Regions of Interest: - no findings suggestive of atrophy are seen in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - no clear atrophic alterations are visible in the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	CN	We have the following subject's personal information: - The subject is a male of 66.5 years old. - Subject's current marrietal status is: married. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is left-handed We have the following subject's health history information: - He has quit smoking at the age of 51.He smoked a pack to a pack and a half a day. - He has a remote/inactive history of alcool abuse. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In his MMSE test, he has an orientation to time score of 5. In his MMSE test, he has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, his total number of story units recalled is 12. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e2 with no e4 allele.
FTLD_203426391_02192_MR_Sagittal_MP-Rage_br_raw_20230209095858883_I10183320	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no findings suggestive of atrophy are seen in the insular cortex - no observable atrophic changes in the occipital lobe - moderate atrophy of the left frontal lobe; the right frontal lobe is normal; focal volume loss observed in the following subregions: middle frontal gyrus (mild atrophy both left and right), precentral gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), sup. frontal gyrus (mild-to-moderate atrophy on the left and normal on the right), medial frontal cortex (normal on the left and mild atrophy on the right) and supplementary motor cortex (mild atrophy on the left and normal on the right) - the temporal lobe shows no notable changes suggestive of atrophy - mild-to-moderate atrophy of the right parietal lobe; normal-to-mild atrophy of the left parietal lobe; focal volume loss observed in the following subregions: precuneus (mild atrophy both left and right), sup. parietal lobule (mild atrophy both left and right) and supramarginal gyrus (mild atrophy on the right) - mild atrophy of the left limbic cortex; normal-to-mild atrophy of the right limbic cortex; focal volume loss observed in the following subregions: parahippocampal gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), anterior cingulate gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) and entorhinal area (mild atrophy on the left and normal on the right) For the ventricles: - the lateral ventricle shows no notable changes suggestive of enlargement - no clear enlargement or abnormal growth seen in the 3rd ventricle - no appreciable enlargement noted in the 4th ventricle - no clear enlargement or abnormal growth seen in the inf. lateral ventricle - moderate enlargement of the external csf For the subcortical structures: - moderate atrophy of the left hippocampus, mild atrophy of the right hippocampus - the thalamus shows no notable changes suggestive of atrophy - accumbens appears within normal limits without apparent atrophy - pallidum maintains a normal appearance with no observable atrophic features - moderate atrophy of the left amygdala; the right amygdala is normal - mild atrophy of the left caudate; the right caudate is normal - mild-to-moderate atrophy of the left putamen; normal-to-mild atrophy of the right putamen For additional Regions of Interest: - mild-to-moderate atrophy of the left fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula); the right fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) is normal - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) appears preserved, with no observable tissue loss - mild atrophy of the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala); the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) is normal - mild-to-moderate atrophy of the left medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) and mild atrophy of the right medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	PNFA	We have the following subject's personal information: - The subject is a male of 71.0 years old. - He has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 30. - On the semantic categorical fluency test, the subject named 8 animals in 60 seconds. He named 2 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 6. - On the Number Span forward test, his longest span forward was 4. On the Number Span backward test, his longest span backward was 3. - On the Trail Making Test Part A, his total number of seconds to complete is 77, his number of commission errors is 1, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 300, his number of commission errors is 2, his number of correct lines is 16. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a moderate (significant, but not dramatic) change in agitation or aggression, irritability or lability, a mild (noticeable, but not significant) change in depression or dysphoria, nighttime behaviors. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.5, corresponding to questionnable impairment. His standard CDR Sum of Boxes score is 2.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.5 (questionnable impairment). Description: Slight impairment in solving problems, similarities, and differences. * Community affairs: Score 1.0 (mild impairment). Description: Unable to function independently at these activities, although may still be engaged in some; appears normal to casual inspection. * Home and hobbies: Score 0.5 (questionnable impairment). Description: Life at home, hobbies, and intellectual interests slightly impaired. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_301_S_10769_MR_Accelerated_Sagittal_MPRAGE_MSV21_br_raw_20250519191453242_1_I11282437	On a T1-weighted brain MRI we observed: For the cerebral cortex: - mild bilateral atrophy of the occipital lobe; focal volume loss observed in the following subregions: calcarine cortex (mild atrophy both left and right), occipital fusiform gyrus (mild atrophy on the left and normal on the right) and lingual gyrus (mild atrophy on the right) - no appreciable degenerative or atrophic changes observed in the parietal lobe - frontal lobe maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the temporal lobe - no findings suggestive of atrophy are seen in the insular cortex - the limbic cortex shows no notable changes suggestive of atrophy For the ventricles: - the 4th ventricle shows no notable changes suggestive of enlargement - mild-to-moderate bilateral enlargement of the lateral ventricle - mild enlargement of the left inf. lateral ventricle; normal-to-mild enlargement of the right inf. lateral ventricle - no findings suggestive of enlargement are seen in the external csf - mild enlargement of the 3rd ventricle For the subcortical structures: - caudate maintains a normal appearance with no observable atrophic features - amygdala demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the putamen - mild atrophy of the right accumbens; the left accumbens is normal - no findings suggestive of atrophy are seen in the pallidum - no findings suggestive of atrophy are seen in the thalamus - no findings suggestive of atrophy are seen in the hippocampus For additional Regions of Interest: - the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) shows no notable changes suggestive of atrophy - mild atrophy of the right salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)); the left salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) is normal - medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) appears within normal limits without apparent atrophy - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) demonstrates a healthy morphology without signs of atrophy	CN	We have the following subject's personal information: - The subject is a female of 63.5 years old. - Subject's current marrietal status is: married. - She has 15.0 years of education - The subject is right-handed We have the following subject's family history information: - Her mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 9. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_126_S_10166_MR_Accelerated_Sagittal_IR-FSPGR_MSV21_br_raw_20240724183952474_1_I10888803	On a T1-weighted brain MRI we observed: For the subcortical structures: - no appreciable degenerative or atrophic changes observed in the caudate - pallidum demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the accumbens - putamen maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the amygdala - hippocampus maintains a normal appearance with no observable atrophic features - no clear atrophic alterations are visible in the thalamus For the ventricles: - 3rd ventricle appears within normal size limits with no apparent enlargement - mild enlargement of the 4th ventricle - no findings suggestive of enlargement are seen in the lateral ventricle - mild-to-moderate enlargement of the external csf - no evident size increase noted in the inf. lateral ventricle For the cerebral cortex: - no observable atrophic changes in the occipital lobe - no evident atrophy or tissue thinning seen in the temporal lobe - no evident atrophy or tissue thinning seen in the insular cortex - limbic cortex demonstrates a healthy morphology without signs of atrophy - the frontal lobe shows no notable changes suggestive of atrophy - no clear atrophic alterations are visible in the parietal lobe For additional Regions of Interest: - no evident atrophy or tissue thinning seen in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - no observable atrophic changes in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - no clear atrophic alterations are visible in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - no findings suggestive of atrophy are seen in the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	CN	We have the following subject's personal information: - The subject is a female of 60.4 years old. - Subject's current marrietal status is: married. - She has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 29. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 19. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e3 with no e4 allele.
FTLD_203383767_03768_MR_Accelerated_Sagittal_MPRAGE_br_raw_20240_I10451140	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild-to-moderate atrophy of the left accumbens and moderate atrophy of the right accumbens - mild atrophy of the left putamen and mild-to-moderate atrophy of the right putamen - early/mild-grade volumetric reduction of the left hippocampus, early/mild-grade volumetric reduction of the right hippocampus - mild atrophy of the right thalamus; the left thalamus is normal - mild-to-moderate atrophy of the right amygdala; the left amygdala is normal - severe bilateral atrophy of the caudate - pallidum appears within normal limits without apparent atrophy For the cerebral cortex: - no evident atrophy or tissue thinning seen in the occipital lobe - mild atrophy of the left limbic cortex and mild-to-moderate atrophy of the right limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild-to-moderate atrophy both left and right), posterior cingulate gyrus (mild atrophy on the left and normal on the right), entorhinal area (mild atrophy on the right) and middle cingulate gyrus (mild atrophy on the right) - moderate atrophy of the left frontal lobe and moderate-to-severe atrophy of the right frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (moderate atrophy both left and right), gyrus rectus (mild-to-moderate atrophy on the left and moderate atrophy on the right), frontal pole (mild atrophy on the left and mild-to-moderate atrophy on the right), anterior orbital gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), medial orbital gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), medial frontal cortex (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right), posterior orbital gyrus (mild atrophy both left and right), opercular inf. frontal gyrus (mild-to-moderate atrophy on the left and normal on the right), sup. frontal gyrus (normal on the left and mild atrophy on the right), sup. frontal gyrus medial segment (normal on the left and mild atrophy on the right) and supplementary motor cortex (mild atrophy on the left and normal on the right) - mild atrophy of the left insular cortex and moderate atrophy of the right insular cortex; focal volume loss observed in the following subregions: anterior insula (mild atrophy on the left and mild-to-moderate atrophy on the right), central operculum (normal-to-mild atrophy on the left and mild-to-moderate atrophy on the right) and posterior insula (normal on the left and mild atrophy on the right) - mild atrophy of the left parietal lobe and mild-to-moderate atrophy of the right parietal lobe; focal volume loss observed in the following subregions: angular gyrus (mild atrophy both left and right) and precuneus (mild atrophy on the right) - mild-to-moderate atrophy of the left temporal lobe and moderate atrophy of the right temporal lobe; focal volume loss observed in the following subregions: temporal pole (mild-to-moderate atrophy on the left and moderate atrophy on the right), middle temporal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), fusiform gyrus (mild atrophy both left and right) and inf. temporal gyrus (mild atrophy on the left and normal on the right) For the ventricles: - severe bilateral enlargement of the lateral ventricle - mild enlargement of the 4th ventricle - moderate enlargement of the 3rd ventricle - moderate enlargement of the external csf - severe bilateral enlargement of the inf. lateral ventricle For additional Regions of Interest: - mild-to-moderate atrophy of the left fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) and mild atrophy of the right fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - moderate atrophy of the left salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) and moderate-to-severe atrophy of the right salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - mild-to-moderate atrophy of the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) and moderate atrophy of the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - mild atrophy of the left medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) and moderate atrophy of the right medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	BV	We have the following subject's personal information: - The subject is a male of 59.0 years old. - He has 16.0 years of education (equivalent to bachelor’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 16. - On the Number Span forward test, his longest span forward was 4. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in disinhibition, a moderate (significant, but not dramatic) change in apathy or indifference, irritability or lability, nighttime behaviors, a mild (noticeable, but not significant) change in agitation or aggression, depression or dysphoria, anxiety, elation or euphoria, motor disturbance, appetite and eating. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. His standard CDR Sum of Boxes score is 12.0. --- ## 📋 Detailed Domain Scores * Memory: Score 2.0 (moderate impairment). Description: Severe memory loss; only highly learned material retained; new material rapidly lost. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 3.0 (severe impairment). Description: Unable to make judgments or solve problems. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 2.0 (moderate impairment). Description: Requires much help with personal care; frequent incontinence. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 1.0 (mild impairment). Description: Moderate word-finding difficulty in speech; cannot name objects in environment; reduced phrase length and/or agrammatical speech and/or reduced comprehension in conversation and reading.
ADNI_023_S_6400_MR_Accelerated_Sagittal_MPRAGE__br_raw_20180530163448275_138_S690769_I1004030	On a T1-weighted brain MRI we observed: For the cerebral cortex: - occipital lobe maintains a normal appearance with no observable atrophic features - no evident atrophy or tissue thinning seen in the parietal lobe - no evident atrophy or tissue thinning seen in the limbic cortex - insular cortex demonstrates a healthy morphology without signs of atrophy - temporal lobe appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the frontal lobe For the ventricles: - no appreciable enlargement noted in the inf. lateral ventricle - no findings suggestive of enlargement are seen in the lateral ventricle - no observable enlargement of the 4th ventricle - external csf maintains a typical volume without observable enlargement - no clear enlargement or abnormal growth seen in the 3rd ventricle For the subcortical structures: - no findings suggestive of atrophy are seen in the putamen - no clear atrophic alterations are visible in the amygdala - no appreciable degenerative or atrophic changes observed in the caudate - no clear atrophic alterations are visible in the pallidum - no appreciable degenerative or atrophic changes observed in the thalamus - no findings suggestive of atrophy are seen in the accumbens - hippocampus appears preserved, with no observable tissue loss For additional Regions of Interest: - no clear atrophic alterations are visible in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - no appreciable degenerative or atrophic changes observed in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) maintains a normal appearance with no observable atrophic features - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a female of 64.3 years old. - Subject's current marrietal status is: married. - She has 12.0 years of education (equivalent to high school or GRE) - The subject is right-handed We have the following subject's family history information: - Her mother is reported as having cognitive impairement. We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 30. In her MMSE test, she has an orientation to time score of 5. In her MMSE test, she has an orientation to place score of 5.0. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 0. - On the Logical Memory Form IIA subtest of the Wechsler Memory Scale-Revised, her total number of story units recalled is 18. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. Her standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
ADNI_052_S_4959_MR_Accelerated_Sag_IR-FSPGR_br_raw_20130304164859456_143_S183633_I361953	On a T1-weighted brain MRI we observed: For the subcortical structures: - pallidum appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the hippocampus - amygdala demonstrates a healthy morphology without signs of atrophy - caudate maintains a normal appearance with no observable atrophic features - mild bilateral atrophy of the accumbens - mild atrophy of the right thalamus; the left thalamus is normal - no clear atrophic alterations are visible in the putamen For the cerebral cortex: - mild atrophy of the left temporal lobe; normal-to-mild atrophy of the right temporal lobe; focal volume loss observed in the following subregions: inf. temporal gyrus (mild atrophy on the left and normal-to-mild atrophy on the right) - no findings suggestive of atrophy are seen in the limbic cortex - no appreciable degenerative or atrophic changes observed in the frontal lobe - insular cortex appears within normal limits without apparent atrophy - no appreciable degenerative or atrophic changes observed in the parietal lobe - no clear atrophic alterations are visible in the occipital lobe For the ventricles: - no appreciable enlargement noted in the external csf - mild bilateral enlargement of the lateral ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - moderate-to-severe enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle For additional Regions of Interest: - no observable atrophic changes in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) appears within normal limits without apparent atrophy - mild atrophy of the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala); the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) is normal - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) maintains a normal appearance with no observable atrophic features	AD	We have the following subject's personal information: - The subject is a male of 77.5 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 30. - On the semantic categorical fluency test, the subject named 9 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for heating water, making a cup of coffee, turning off the stove. The subject has difficulity, but does by himself, for preparing a balanced meal, for paying attention to and understanding a TV program, book, or magazine. The subject requires assitance for playing a game of skill such as bridge or chess, working on a hobby, for keeping track of current events. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, his total number of seconds to complete is 26. On the Trail Making Test Part B, his total number of seconds to complete is 126. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
NIFD_1_S_0147_MR_T1_mprage_S3_DIS3D_br_raw_20140612224636364_53_S222067_I430635	On a T1-weighted brain MRI we observed: For the subcortical structures: - no observable atrophic changes in the putamen - no clear atrophic alterations are visible in the thalamus - mild atrophy of the right caudate; normal-to-mild atrophy of the left caudate - no appreciable degenerative or atrophic changes observed in the hippocampus - mild atrophy of the right pallidum; the left pallidum is normal - mild atrophy of the left accumbens and mild-to-moderate atrophy of the right accumbens - no appreciable degenerative or atrophic changes observed in the amygdala For the ventricles: - inf. lateral ventricle appears to be of normal dimensions, with no observable increase in size - the 4th ventricle shows no notable changes suggestive of enlargement - external csf appears within normal size limits with no apparent enlargement - mild enlargement of the 3rd ventricle - the lateral ventricle shows no notable changes suggestive of enlargement For the cerebral cortex: - no evident atrophy or tissue thinning seen in the occipital lobe - mild atrophy of the left insular cortex; the right insular cortex is normal; focal volume loss observed in the following subregions: anterior insula (mild atrophy on the left and normal on the right) - mild atrophy of the right temporal lobe; the left temporal lobe is normal; focal volume loss observed in the following subregions: inf. temporal gyrus (normal on the left and mild atrophy on the right) and fusiform gyrus (mild atrophy on the left) - mild-to-moderate atrophy of the left frontal lobe and mild atrophy of the right frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), opercular inf. frontal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), medial frontal cortex (normal-to-mild atrophy on the left and mild atrophy on the right), medial orbital gyrus (normal-to-mild atrophy on the left and mild atrophy on the right), precentral gyrus (normal on the left and mild atrophy on the right) and sup. frontal gyrus (mild atrophy on the left and normal on the right) - no appreciable degenerative or atrophic changes observed in the limbic cortex - no clear atrophic alterations are visible in the parietal lobe For additional Regions of Interest: - mild bilateral atrophy of the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - mild bilateral atrophy of the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) demonstrates a healthy morphology without signs of atrophy - no observable atrophic changes in the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	PNFA	We have the following subject's personal information: - The subject is a female of 68.0 years old. - She has 14.0 years of education We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 16. - The subject has a Montreal Cognitive Assessment (MoCA) total score, corrected for education, of 10. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 3. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. Her standard CDR Sum of Boxes score is 4.5. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
ADNI_041_S_5141_MR_MPRAGE_br_raw_20130419091107601_66_S187377_I367903	On a T1-weighted brain MRI we observed: For the ventricles: - 4th ventricle appears within normal size limits with no apparent enlargement - no clear enlargement or abnormal growth seen in the inf. lateral ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle - no findings suggestive of enlargement are seen in the lateral ventricle - no observable enlargement of the external csf For the subcortical structures: - the putamen shows no notable changes suggestive of atrophy - hippocampus appears within normal limits without apparent atrophy - thalamus appears within normal limits without apparent atrophy - no clear atrophic alterations are visible in the accumbens - no findings suggestive of atrophy are seen in the caudate - the amygdala shows no notable changes suggestive of atrophy - pallidum appears preserved, with no observable tissue loss For the cerebral cortex: - no findings suggestive of atrophy are seen in the limbic cortex - no findings suggestive of atrophy are seen in the insular cortex - no appreciable degenerative or atrophic changes observed in the occipital lobe - the parietal lobe shows no notable changes suggestive of atrophy - temporal lobe demonstrates a healthy morphology without signs of atrophy - frontal lobe maintains a normal appearance with no observable atrophic features For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) demonstrates a healthy morphology without signs of atrophy - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) appears preserved, with no observable tissue loss - medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) appears within normal limits without apparent atrophy - mild atrophy of the left medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus); the right medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) is normal	CN	We have the following subject's personal information: - The subject is a male of 76.8 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 28. - On the semantic categorical fluency test, the subject named 19 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject has difficulity, but does by himself, for remembering appointments, family occasions, holidays, medications. - On the Trail Making Test Part A, his total number of seconds to complete is 22. On the Trail Making Test Part B, his total number of seconds to complete is 90. From genetic data, APOE genotype is e3,e2 with no e4 allele.
FTLD_203037518_01813_MR_Sagittal_MP-Rage_br_raw_20230124205507143_I10178441	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild atrophy of the right caudate; normal-to-mild atrophy of the left caudate - no findings suggestive of atrophy are seen in the hippocampus - accumbens maintains a normal appearance with no observable atrophic features - no findings suggestive of atrophy are seen in the thalamus - pallidum appears within normal limits without apparent atrophy - amygdala appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the putamen For the cerebral cortex: - no findings suggestive of atrophy are seen in the parietal lobe - occipital lobe demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the frontal lobe - insular cortex appears preserved, with no observable tissue loss - no evident atrophy or tissue thinning seen in the limbic cortex - temporal lobe maintains a normal appearance with no observable atrophic features For the ventricles: - no clear enlargement or abnormal growth seen in the external csf - the inf. lateral ventricle shows no notable changes suggestive of enlargement - 3rd ventricle maintains its expected proportions without signs of enlargement - mild-to-moderate enlargement of the 4th ventricle - lateral ventricle appears to be of normal dimensions, with no observable increase in size For additional Regions of Interest: - no evident atrophy or tissue thinning seen in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - no findings suggestive of atrophy are seen in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	CN	We have the following subject's personal information: - The subject is a male of 42.0 years old. - He has 18.0 years of education (equivalent to master’s degree) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 25 animals in 60 seconds. He named 14 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 17. - On the Number Span forward test, his longest span forward was 9. On the Number Span backward test, his longest span backward was 8. - On the Trail Making Test Part A, his total number of seconds to complete is 16, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 56, his number of commission errors is 0, his number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
FTLD_203011813_02311_MR_Sagittal_MP-Rage_br_raw_20230124212826247_I10178654	On a T1-weighted brain MRI we observed: For the cerebral cortex: - occipital lobe appears preserved, with no observable tissue loss - the temporal lobe shows no notable changes suggestive of atrophy - mild-to-moderate atrophy of the left limbic cortex; normal-to-mild atrophy of the right limbic cortex; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild atrophy on the left and normal-to-mild atrophy on the right), parahippocampal gyrus (normal-to-mild atrophy on the left and mild atrophy on the right) and middle cingulate gyrus (mild atrophy on the left and normal on the right) - no findings suggestive of atrophy are seen in the parietal lobe - no observable atrophic changes in the frontal lobe - insular cortex appears preserved, with no observable tissue loss For the ventricles: - 4th ventricle appears within normal size limits with no apparent enlargement - no appreciable enlargement noted in the lateral ventricle - mild enlargement of the external csf - inf. lateral ventricle maintains its expected proportions without signs of enlargement - the 3rd ventricle shows no notable changes suggestive of enlargement For the subcortical structures: - thalamus demonstrates a healthy morphology without signs of atrophy - amygdala appears preserved, with no observable tissue loss - the putamen shows no notable changes suggestive of atrophy - accumbens demonstrates a healthy morphology without signs of atrophy - no findings suggestive of atrophy are seen in the caudate - the pallidum shows no notable changes suggestive of atrophy - the hippocampus shows no notable changes suggestive of atrophy For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) appears preserved, with no observable tissue loss - mild atrophy of the right salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)); the left salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) is normal - mild atrophy of the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala); the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) is normal - no evident atrophy or tissue thinning seen in the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	CN	We have the following subject's personal information: - The subject is a male of 53.0 years old. - He has 20.0 years of education (equivalent to doctorate) - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - On the semantic categorical fluency test, the subject named 37 animals in 60 seconds. He named 17 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 14. - On the Number Span forward test, his longest span forward was 6. On the Number Span backward test, his longest span backward was 7. - On the Trail Making Test Part A, his total number of seconds to complete is 21, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 40, his number of commission errors is 0, his number of correct lines is 24. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 0.0, corresponding to no impairment. His standard CDR Sum of Boxes score is 0.0. --- ## 📋 Detailed Domain Scores * Memory: Score 0.0 (no impairment). Description: No memory loss, or slight inconsistent forgetfulness. * Orientation: Score 0.0 (no impairment). Description: Fully oriented. * Judgment and problem-solving: Score 0.0 (no impairment). Description: Solves everyday problems, handles business and financial affairs well; judgment good in relation to past performance. * Community affairs: Score 0.0 (no impairment). Description: Independent function at usual level in job, shopping, volunteer and social groups. * Home and hobbies: Score 0.0 (no impairment). Description: Life at home, hobbies, and intellectual interests well maintained. * Personal care: Score 0.0 (no impairment). Description: Fully capable self-care. * Behavior, comportment, and personality: Score 0.0 (no impairment). Description: Socially appropriate behavior. * Language: Score 0.0 (no impairment). Description: No language difficulty, or occasional mild tip-of-the-tongue.
ADNI_067_S_5205_MR_MPRAGE_br_raw_20130617123032185_46_S192528_I376818	On a T1-weighted brain MRI we observed: For the ventricles: - mild bilateral enlargement of the lateral ventricle - 4th ventricle appears within normal size limits with no apparent enlargement - mild-to-moderate enlargement of the external csf - mild enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - 3rd ventricle maintains a typical volume without observable enlargement For the subcortical structures: - accumbens appears preserved, with no observable tissue loss - the hippocampus shows no notable changes suggestive of atrophy - mild-to-moderate atrophy of the left amygdala and mild atrophy of the right amygdala - no clear atrophic alterations are visible in the caudate - no findings suggestive of atrophy are seen in the thalamus - pallidum appears within normal limits without apparent atrophy - no appreciable degenerative or atrophic changes observed in the putamen For the cerebral cortex: - no observable atrophic changes in the limbic cortex - mild atrophy of the left insular cortex; normal-to-mild atrophy of the right insular cortex; focal volume loss observed in the following subregions: frontal operculum (mild atrophy on the left and normal-to-mild atrophy on the right), posterior insula (mild atrophy on the right) and parietal operculum (mild atrophy on the left) - mild-to-moderate atrophy of the right temporal lobe; the left temporal lobe is normal; focal volume loss observed in the following subregions: fusiform gyrus (mild-to-moderate atrophy on the right), planum temporale (mild atrophy on the left), middle temporal gyrus (normal on the left and mild atrophy on the right) and sup. temporal gyrus (mild atrophy on the right) - mild atrophy of the left parietal lobe and mild-to-moderate atrophy of the right parietal lobe; focal volume loss observed in the following subregions: supramarginal gyrus (mild atrophy on the left and mild-to-moderate atrophy on the right), angular gyrus (normal on the left and mild-to-moderate atrophy on the right) and precuneus (mild atrophy on the left and normal-to-mild atrophy on the right) - mild-to-moderate bilateral atrophy of the frontal lobe; focal volume loss observed in the following subregions: middle frontal gyrus (mild-to-moderate atrophy on the left and moderate atrophy on the right), sup. frontal gyrus (mild-to-moderate atrophy on the left and mild atrophy on the right), medial frontal cortex (mild atrophy both left and right), anterior orbital gyrus (mild atrophy both left and right), gyrus rectus (mild atrophy on the left) and posterior orbital gyrus (mild atrophy on the left) - occipital lobe demonstrates a healthy morphology without signs of atrophy For additional Regions of Interest: - no clear atrophic alterations are visible in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - mild atrophy of the left salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)); the right salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) is normal - mild atrophy of the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala); the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) is normal - mild atrophy of the right medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus); normal-to-mild atrophy of the left medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	AD	We have the following subject's personal information: - The subject is a female of 59.3 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 24. - On the semantic categorical fluency test, the subject named 6 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for paying attention to and understanding a TV program, book, or magazine. The subject has difficulity, but does by himself, for writing checks, paying bills, or balancing a checkbook. The subject requires assitance for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Trail Making Test Part A, her total number of seconds to complete is 150. From genetic data, APOE genotype is e3,e3 with no e4 allele.
ADNI_036_S_0672_MR_MPR__GradWarp__B1_Correction__N3__Scaled_Br_20070119235831844_S17131_I36938	On a T1-weighted brain MRI we observed: For the ventricles: - no clear enlargement or abnormal growth seen in the 4th ventricle - no clear enlargement or abnormal growth seen in the external csf - no findings suggestive of enlargement are seen in the inf. lateral ventricle - no findings suggestive of enlargement are seen in the 3rd ventricle - lateral ventricle maintains a typical volume without observable enlargement For the cerebral cortex: - no evident atrophy or tissue thinning seen in the parietal lobe - no appreciable degenerative or atrophic changes observed in the frontal lobe - no appreciable degenerative or atrophic changes observed in the insular cortex - no evident atrophy or tissue thinning seen in the temporal lobe - limbic cortex appears within normal limits without apparent atrophy - no evident atrophy or tissue thinning seen in the occipital lobe For the subcortical structures: - mild bilateral atrophy of the caudate - no clear atrophic alterations are visible in the putamen - the thalamus shows no notable changes suggestive of atrophy - no observable atrophic changes in the accumbens - no observable atrophic changes in the hippocampus - the pallidum shows no notable changes suggestive of atrophy - no observable atrophic changes in the amygdala For additional Regions of Interest: - the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) shows no notable changes suggestive of atrophy - no appreciable degenerative or atrophic changes observed in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - no clear atrophic alterations are visible in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) appears preserved, with no observable tissue loss	CN	We have the following subject's personal information: - The subject is a female of 62.1 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 28. - On the semantic categorical fluency test, the subject named 11 animals in 60 seconds. She named 15 vegetables in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has not difficulity for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for remembering appointments, family occasions, holidays, medications, for traveling out of the neighborhood, driving, or arranging to take public transportation. - On the Digit Span test of the Wechsler Memory Scale-Revised, her digit span forward length is 7, her digit span forward trials correct is 9, her digit span backward length is 6., her digit span forward trials correct is 9. - On the Trail Making Test Part A, her total number of seconds to complete is 35. On the Trail Making Test Part B, her total number of seconds to complete is 97. From genetic data, APOE genotype is e3,e2 with no e4 allele.
ADNI_016_S_4887_MR_Accelerated_SAG_IR-SPGR__br_raw_20120822093912566_54_S162209_I325642	On a T1-weighted brain MRI we observed: For the subcortical structures: - no clear atrophic alterations are visible in the accumbens - no clear atrophic alterations are visible in the pallidum - caudate maintains a normal appearance with no observable atrophic features - mild atrophy of the left hippocampus, mild-to-moderate atrophy of the right hippocampus - mild-to-moderate atrophy of the left amygdala and mild atrophy of the right amygdala - no findings suggestive of atrophy are seen in the thalamus - putamen appears preserved, with no observable tissue loss For the cerebral cortex: - no observable atrophic changes in the occipital lobe - no clear atrophic alterations are visible in the temporal lobe - no clear atrophic alterations are visible in the parietal lobe - no clear atrophic alterations are visible in the insular cortex - limbic cortex appears preserved, with no observable tissue loss - no appreciable degenerative or atrophic changes observed in the frontal lobe For the ventricles: - mild-to-moderate enlargement of the left lateral ventricle; the right lateral ventricle is normal - no clear enlargement or abnormal growth seen in the 4th ventricle - moderate enlargement of the left inf. lateral ventricle and mild enlargement of the right inf. lateral ventricle - mild enlargement of the 3rd ventricle - external csf maintains a typical volume without observable enlargement For additional Regions of Interest: - no evident atrophy or tissue thinning seen in the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) appears within normal limits without apparent atrophy - no observable atrophic changes in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - no clear atrophic alterations are visible in the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	AD	We have the following subject's personal information: - The subject is a male of 73.8 years old. We have the following results on the Neuropsychological Test Battery: - The subject has a Boston Naming Test (BNT) total score of 15. - On the semantic categorical fluency test, the subject named 17 animals in 60 seconds. - On the Functional Activities Questionnaire (FAQ), the subject has difficulity, but does by himself, for playing a game of skill such as bridge or chess, working on a hobby, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject requires assitance for shopping alone for clothes, household necessities, or groceries, for heating water, making a cup of coffee, turning off the stove, for preparing a balanced meal, for remembering appointments, family occasions, holidays, medications. The subject is dependent for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper. - On the Trail Making Test Part A, his total number of seconds to complete is 42. On the Trail Making Test Part B, his total number of seconds to complete is 300. From genetic data, APOE genotype is e3,e4 with 1 copy of e4 allele.
FTLD_203765060_03066_MR_Accelerated_Sagittal_MPRAGE_br_raw_20230_I10178114	On a T1-weighted brain MRI we observed: For the subcortical structures: - mild atrophy of the left thalamus; the right thalamus is normal - mild-to-moderate atrophy of the left caudate; the right caudate is normal - no findings suggestive of atrophy are seen in the hippocampus - moderate atrophy of the left accumbens and mild atrophy of the right accumbens - moderate atrophy of the left putamen; the right putamen is normal - mild-to-moderate atrophy of the left pallidum; the right pallidum is normal - severe atrophy of the left amygdala; the right amygdala is normal For the cerebral cortex: - severe atrophy of the left temporal lobe and mild atrophy of the right temporal lobe; focal volume loss observed in the following subregions: temporal pole (moderate-to-severe atrophy on the left and normal-to-mild atrophy on the right), middle temporal gyrus (moderate atrophy on the left and mild atrophy on the right), inf. temporal gyrus (mild-to-moderate atrophy on the left and normal-to-mild atrophy on the right), planum temporale (mild atrophy on the left), sup. temporal gyrus (mild-to-moderate atrophy on the left and normal on the right) and fusiform gyrus (mild-to-moderate atrophy on the left) - parietal lobe appears preserved, with no observable tissue loss - the frontal lobe shows no notable changes suggestive of atrophy - mild atrophy of the left insular cortex; the right insular cortex is normal; focal volume loss observed in the following subregions: parietal operculum (mild atrophy on the left), anterior insula (mild-to-moderate atrophy on the left), posterior insula (mild atrophy on the left) and frontal operculum (mild atrophy on the left and normal on the right) - no evident atrophy or tissue thinning seen in the occipital lobe - moderate atrophy of the left limbic cortex; the right limbic cortex is normal; focal volume loss observed in the following subregions: anterior cingulate gyrus (mild-to-moderate atrophy on the left and normal on the right), entorhinal area (mild-to-moderate atrophy on the left and normal on the right) and middle cingulate gyrus (mild atrophy on the left) For the ventricles: - severe enlargement of the left inf. lateral ventricle and moderate enlargement of the right inf. lateral ventricle - mild-to-moderate enlargement of the 4th ventricle - mild enlargement of the external csf - moderate-to-severe enlargement of the 3rd ventricle - moderate bilateral enlargement of the lateral ventricle For additional Regions of Interest: - fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) appears within normal limits without apparent atrophy - moderate atrophy of the left salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)); the right salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) is normal - severe atrophy of the left medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala); the right medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) is normal - no findings suggestive of atrophy are seen in the medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus)	BV	We have the following subject's personal information: - The subject is a male of 67.0 years old. - He has 14.0 years of education - The subject is right-handed We have the following results on the Neuropsychological Test Battery: - The subject has a 32-item Multilingual Naming Test (MINT) total score of 8. - On the semantic categorical fluency test, the subject named 2 animals in 60 seconds. He named 1 vegetables in 60 seconds. - On the Craft Story 21 Recall (Delayed) test, his total story units recalled (verbatim scoring) is 0. - On the Number Span forward test, his longest span forward was 5. On the Number Span backward test, his longest span backward was 4. - On the Trail Making Test Part A, his total number of seconds to complete is 33, his number of commission errors is 0, his number of correct lines is 24. On the Trail Making Test Part B, his total number of seconds to complete is 77, his number of commission errors is 0, his number of correct lines is 24. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a mild (noticeable, but not significant) change in apathy or indifference, disinhibition, irritability or lability. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 1.0, corresponding to mild impairment. His standard CDR Sum of Boxes score is 8.5. --- ## 📋 Detailed Domain Scores * Memory: Score 0.5 (questionnable impairment). Description: Consistent slight forgetfulness; partial recollection of events; 'benign' forgetfulness. * Orientation: Score 1.0 (mild impairment). Description: Moderate difficulty with time relationships; oriented for place at examination; may have geographic disorientation elsewhere. * Judgment and problem-solving: Score 2.0 (moderate impairment). Description: Severely impaired in handling problems, similarities, and differences; social judgment usually impaired. * Community affairs: Score 2.0 (moderate impairment). Description: No pretense of independent function outside the home; appears well enough to be taken to functions outside the family home. * Home and hobbies: Score 2.0 (moderate impairment). Description: Only simple chores preserved; very restricted interests, poorly maintained. * Personal care: Score 1.0 (mild impairment). Description: Requires assistance in dressing, hygiene, keeping of personal effects. * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 2.0 (moderate impairment). Description: Moderate to severe impairments in either speech or comprehension; has difficulty communicating thoughts; writing may be slightly more effective.
NIFD_1_S_0096_MR_T1_mprage_S3_DIS3D_br_raw_20170817133934845_74_S598211_I891811	On a T1-weighted brain MRI we observed: For the cerebral cortex: - no findings suggestive of atrophy are seen in the frontal lobe - no clear atrophic alterations are visible in the parietal lobe - no appreciable degenerative or atrophic changes observed in the occipital lobe - mild atrophy of the right insular cortex; normal-to-mild atrophy of the left insular cortex; focal volume loss observed in the following subregions: anterior insula (normal on the left and mild atrophy on the right) and frontal operculum (mild atrophy on the left and normal on the right) - the temporal lobe shows no notable changes suggestive of atrophy - limbic cortex appears preserved, with no observable tissue loss For the subcortical structures: - moderate atrophy of the right thalamus; the left thalamus is normal - amygdala appears preserved, with no observable tissue loss - accumbens demonstrates a healthy morphology without signs of atrophy - no evident atrophy or tissue thinning seen in the caudate - the hippocampus shows no notable changes suggestive of atrophy - pallidum maintains a normal appearance with no observable atrophic features - putamen appears within normal limits without apparent atrophy For the ventricles: - no findings suggestive of enlargement are seen in the inf. lateral ventricle - mild bilateral enlargement of the lateral ventricle - mild enlargement of the external csf - mild-to-moderate enlargement of the 3rd ventricle - no observable enlargement of the 4th ventricle For additional Regions of Interest: - mild bilateral atrophy of the fronto-opercular and motor speech-control network (broca's area, frontal operculum, precentral gyrus, supplementary motor cortex, anterior insula) - no findings suggestive of atrophy are seen in the salience and ventromedial prefrontal (vmpfc) fronto-insular complex (anterior insula (ains), anterior cingulate gyrus (acgg), orbitofrontal cortex (ofc), gyrus rectus (gre), subcallosal area (sca)) - no clear atrophic alterations are visible in the medial temporal lobe and limbic-paralimbic memory complex (temporal pole, inferior temporal gyrus, fusiform gyrus, parahippocampal gyrus, amygdala) - medial temporal lobe-default mode network (mtl-dmn) memory complex (hippocampus, entorhinal cortex, parahippocampal gyrus, precuneus, posterior cingulate, angular gyrus) appears preserved, with no observable tissue loss	BV	We have the following subject's personal information: - The subject is a male of 69.0 years old. - He has 18.0 years of education (equivalent to master’s degree) We have the following results on the Neuropsychological Test Battery: - The subject has a Mini Mental State Examination (MMSE) total score (using D-L-R-O-W) of 23. - The subject has a 15-item Geriatric Depression Scale (GDS) total score of 1. - On the Functional Activities Questionnaire (FAQ), the subject requires assitance for writing checks, paying bills, or balancing a checkbook, for assembling tax records, business affairs, or other paper, for shopping alone for clothes, household necessities, or groceries, for playing a game of skill such as bridge or chess, working on a hobby, for heating water, making a cup of coffee, turning off the stove, for keeping track of current events, for paying attention to and understanding a TV program, book, or magazine, for traveling out of the neighborhood, driving, or arranging to take public transportation. The subject is dependent for preparing a balanced meal, for remembering appointments, family occasions, holidays, medications. - In the Neuropsychiatric Inventory Questionnaire (NPI-Q), in the last month, the clinician notes a severe (very marked or prominent, dramatic) change in apathy or indifference, appetite and eating, a moderate (significant, but not dramatic) change in agitation or aggression, irritability or lability, motor disturbance. - The subject's overall status, assessed with the CDR Dementia Staging Instrument (CDR), is a global score of 2.0, corresponding to moderate impairment. His standard CDR Sum of Boxes score is 8.5. --- ## 📋 Detailed Domain Scores * Behavior, comportment, and personality: Score 2.0 (moderate impairment). Description: Moderate behavioral changes, affecting interpersonal relationships and interactions in a significant manner. * Language: Score 0.5 (questionnable impairment). Description: Consistent mild word-finding difficulties; simplification of word choice; circumlocution; decreased phrase length; and/or mild comprehension difficulties.

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